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과제의 극복과 솔루션의 탐구 1월 12일∼13일 치료와 진단에 필요한 단백질의 대부분은 기존 호스트에서의 발현이 어렵고 폴딩 및 용해성, 글리코실화 등의 측면에서 문제를 안고 있으며, 호스트에 대해 독성을 가진 것도 있습니다. 이 부회에서는 단백질 과학 분야의 최신 성과가 소개되며, 이와 같은 과제를 극복하기 위한 식견 및 솔루션이 제시됩니다. 기조 프레젠테이션 Protein Expression in Drug Discovery – New Challenges, New Solutions Lorenz Mayr, Ph.D., Executive Director, CPC/EPP, Novartis Pharma AG Enhanced Glycoprotein Production in HEK-293 Cells Expressing Pyruvate Carboxylase Yves Durocher, Ph.D., Chemical Engineering, École Polytechnique de Montréal
용해성, 폴딩, 글리코실화 문제에 대처하기 위한 솔루션 Expression of Soluble Proteins by Linkage with Acidic Tags Richard Discipio, Ph.D., Research Scientist, Torrey Pines Institute for Molecular Studies Measurement of Protein Unfolding/Refolding Kinetics and Structural Characterization of Hidden Intermediates by NMR Relaxation Dispersion Derrick Meinhold, Ph.D., Research Associate, Department of Molecular Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute Effects of Cell Culture Conditions on Antibody N-Linked Glycosylation—What Affects High Mannose 5 Glycoform? Efren Pacis, Biologics Pharma Technical Development, Genentech, Inc.
막단백질에 관련된 문제의 해결 Restrained Expression: A Method to Overproduce Toxic Membrane Proteins by Exploiting Operator-Repressor Interactions Dinesh A. Yernool, Ph.D., Assistant Professor, Department of Biological Sciences, Purdue University Reprogramming Chaperone Pathways to Improve Membrane Protein Expression in Escherichia coli Francois Baneyx, Ph.D., Professor, Chemical Engineering, University of Washington, Seattle
단백질 응집의 캐릭터리제이션을 위한 해석법의 과제와 진보 Aggregates and Their Analysis: Some Perspectives and Lessons from Working with 100+ Products John Philo, Ph.D., Vice President, Director of Biophysical Chemistry, Alliance Protein Laboratories Addressing New Analytical Challenges in Protein Formulation Development Speaker to be Announced Characterization of Submicron Particle Distributions in Biologics Formulations Flaviu Gruia, Ph.D., Scientist, Analytical Biochemistry, MedImmune Characterization of Sub-Visible Particles in Therapeutic Protein Formulations Tobias Frommknecht, Ph.D., Formulation Scientist, pRED, Hoffmann-La Roche Ltd |
