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신경줄기세포 및 전구세포 제품의 전략적 개발

Strategic Development of Neural Stem & Progenitor Cell Products 2018

리서치사 BIOINFORMANT WORLDWIDE, LLC
발행일 2018년 01월 상품 코드 227599
페이지 정보 영문 210 Pages
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신경줄기세포 및 전구세포 제품의 전략적 개발 Strategic Development of Neural Stem & Progenitor Cell Products 2018
발행일 : 2018년 01월 페이지 정보 : 영문 210 Pages

이 페이지에 게재되어 있는 내용은 최신판과 약간 차이가 있을 수 있으므로 영문목차를 함께 참조하여 주시기 바랍니다. 기타 자세한 사항은 문의 바랍니다.

한글목차

신경줄기세포(Neural Stem Cell) 및 전구세포(Progenitor Cell) 제품 시장에 대해 조사했으며, 줄기세포 종류와 개요, 주요 적응증별 이환율과 현재 치료제·치료법, 개발 단계별 임상연구 및 임상시험 동향, 주요 기업 개요 등의 정보를 전해드립니다.

제1장 보고서 개요

제2장 서론

제3장 줄기세포 : 개요

  • 배아줄기세포(ES세포)
  • 유도만능줄기세포(iPS세포)
  • 줄기세포로부터 추출되는 특수 세포의 각종 종류
  • 인간줄기세포의 각종 종류
    • 인간배아줄기세포(hESC)
    • 배아생식세포(EG-Cell)
    • 태아줄기세포
    • 제대줄기세포
  • 성체줄기세포
    • 조혈모세포(HSCs)
    • 중간엽줄기세포(MSC)
    • 신경줄기세포(NSC)
  • 줄기세포 각종 종류의 특징
  • 세포 치료 분야의 임상 연구 건수 : 지역별
    • 임상시험수 : 세포 종류별
    • 임상연구수 : 적응증별

제4장 신경줄기세포(NSC) : 개요

  • NSC의 소스
  • 각종 소스 유래 NSC의 기초 특성
  • 신경변성질환용 태아줄기세포 이식
  • 성체신경줄기세포(aNSC) 치료
    • 현재 치료 상황

제5장 NSC의 이용으로 치료될 가능성이 있는 변성질환

  • 신경변성질환의 기존 치료법
  • 신경변성질환의 NSC 어프로치와 기존 어프로치
  • 이론과 실천의 큰 격차
  • NSC에 의한 세포요법 어프로치의 각종 종류
  • NSC 이식에 의해 얻을 수 있을 가능성이 있는 치료 효과
  • 가장 최근의 임상시험
  • 기타 임상시험
  • 신경발달장애와 세포요법

제6장 척수손상(SCI)과 세포요법

  • 척수손상의 이환율
  • 신경 레벨과 손상 정도
  • 연간 치료비 및 생애 치료비 : 미국
  • 척수손상 치료제 및 치료법
  • CIRM의 자금 공급
  • 세포요법
  • 신경 재생을 위한 SCI 모델과 그 유효성
  • 임상시험 리스트

제7장 알츠하이머병

  • 이환율
  • 미국의 65세 이상 이환 인구 예측
  • 미국의 치료비 : 지불자별
  • 현재 이용 가능한 치료제
  • CIRM의 자금 공급
  • 줄기세포 이식

제8장 파킨슨병

  • 이환율
  • CIRM의 자금 공급
  • 현재 치료제
  • 세포요법의 가능성
  • 유전자 치료

제9장 루게릭병(ALS)

  • 이환율
  • 대증요법
  • CIRM의 자금 공급
  • ALS의 줄기세포 치료에 주력하는 기업
  • 세포요법

제10장 다발성 경화증(MS)

  • 이환율
  • 치료제
  • 신경줄기세포의 적용
  • 내인성 신경줄기세포의 성장인자에 의한 자극
  • CIRM의 자금 공급

제11장 뇌졸중

  • 이환율
  • 현재 이용 가능한 치료제
  • 줄기세포 치료
  • 실험적 연구에 이용되고 있는 각종 줄기세포
  • 진행중인 임상시험
  • CIRM의 자금 공급

제12장 시장 분석

  • 현재 줄기세포 상황
  • 주요 임상적 마일스톤
  • 세계의 세포요법 제품 시장 등

제13장 주요 기업 개요

  • Asterias Biotherapeutics Inc.
  • Atherdsys Inc.
  • Axiogenesis AG
  • AxoGen Inc.
  • BrainStorm Cell Therapeutics
  • Cellular Dynamics International
  • Celther Polska
  • Cellartis AB
  • CellCure Neurosciences Ltd.
  • Cellular Dynamics International Inc.
  • Celvive Inc.
  • EMD Millipore Corp.
  • International Stem Cell Corp.
  • Kadimastem Ltd.
  • Living Cell Technologies Ltd.
  • MEDIPOST
  • Neuralstem Inc.
  • NeuroGeneration Inc.
  • Neurona Therapeutics Inc.
  • Ocata Therapeutics Inc.
  • Opexa Therapeutics Inc.
  • ReNeuron PLC
  • RhinoCyte Inc.
  • Roslin Cells Ltd.
  • SanBio Inc.
  • Saneron CCEL Therapeutics Inc.
  • StemCells Inc.
  • StemBioSys Inc.
  • Stemedica Cell Technologies Inc.
  • STEMCELL Technologies Inc.
  • Talisman Therapeutics Ltd.
  • Xcelthera Inc.

부록

도표

KSM 16.08.22

영문목차

Executive Summary

Neurogenesis is the process by which neurons are created. This process is most active during pre-natal development when neurogenesis is responsible for populating the growing brain. Neural stem cells (NSCs) are the self-renewing, multipotent cells that differentiate into the main phenotypes of the nervous system. These cell types include neurons, astrocytes, and oligodendrocytes. Neural progenitor cells (NPCs) are the progeny of stem cell division that normally undergo a limited number of replication cycles in vivo.

In 1992, Reynolds and Weiss were the first to isolate neural stem cells from the striatal tissue of adult mice brain tissue, including the subventricular zone, which is a neurogenic area. Since then, neural progenitor and stem cells have been isolated from various areas of the adult brain, including non-neurogenic areas like the spinal cord, and from other species, including humans.

During the development of the nervous system, neural progenitor cells can either stay in the pool of proliferating undifferentiated cells or exit the cell cycle and differentiate. The past twenty years have seen great advances in neural stem cell research and applications. Researchers have isolated NSCs, which have demonstrated pluripotency and the ability to differentiate into many different immune system cell types.

In addition, NSCs can be regulated both in vitro and in vivo, which represent different commercial product opportunities. Neural stem cells have become of profound interest to the research community due to their potential to be used in drug discovery and delivery applications, as well as for tools of neural toxicology assessment.

NSC transplantation also represents a ground-breaking approach for treating a range of chronic neurological diseases and acute CNS injuries, including Parkinson's, Alzheimer's and spinal cord injury, among other conditions.

Furthermore, neural stem and progenitor cells offer the potential to safely carry out pharmacology assessment for drugs designed to impact brain function or physiology. As tests on human cells become increasingly feasible, the potential grows for companies to develop disease-specific cell assays. As novel drug delivery agents, neural stem cells also show promise in killing gliomas and other cancers.

To facilitate research resulting from these advances, a large and diverse market has emerged for neural stem cell products and services. One thriving component of the neural stem cell marketplace is the market for research tools and supplies. Among these research supply companies, dominant competitors include Thermo Fisher Scientific, Merck Millipore, Cellular Dynamics International (a FujiFilm Company), Ncardia, and STEMCELL Technologies, among others.

While the number of adult stem cell therapies entering clinical trials continues to expand, the development of neural stem cell therapies has been affected by barriers to entry that include patent restrictions, dominance of current competitors, and the complexity of neural stem cell applications. Despite these limitations, more than a dozen companies are pursuing preclinical and clinical programs using neural stem and progenitor cells as tools to address human injury and disease.

Pharmaceutical companies are also demonstrating intense interest in neural stem and progenitor cells. Because of their plasticity, ability to develop into the main phenotypes of the nervous system, and unlimited capacity for self-renewal, NSCs have been proposed for use in a variety of pharmaceutical applications, including:

  • Neurotoxicity testing
  • Cellular therapies to treat central nervous system (CNS) conditions
  • Neural tissue engineering and repair
  • Drug target validation and testing
  • Personalized medicine

For this reason, utilization of neural stem cell products by the pharmaceutical sector represents a thriving segment of the global marketplace. Of interest to this community is the use of neural stem cells to heal tissues that have a naturally limited capacity for renewal, including the human brain and spinal cord tissue.

Furthermore, development of new drugs is extremely costly and the success rate of bringing new compounds to the market is unpredictable. Therefore, it is crucial that pharmaceutical companies minimize late-stage product failures, including unexpected neurotoxic effects, that can arise when candidate drugs enter the clinical testing stages. It is desirable to test candidate drugs using in vitro assays of high human relevance as early as possible. Because neural stem cells have the potential to differentiate into nearly all the main phenotypes of the nervous system, they represent an ideal cell type from which to design such neural screening assays.

Growth into stem cell research has exploded over the past several decades, and the market to supply neural stem cell products and therapies has grown to meet this demand. Claim this 210-page global strategic report to reveal the current and future needs of the NSC marketplace, so you can focus your marketing efforts on profitable products, in promising research areas, within lucrative domestic and international markets.

Table of Contents

1. REPORT OVERVIEW

  • 1.1 Statement of the Report
  • 1.1 Executive Summary

2. INTRODUCTION

3. STEM CELLS: A BRIEF OVERIVEW

  • 3.1 Embryonic Stem Cells
  • 3.2 Induced Pluripotent Stem Cells
  • 3.3 Types of Specialized Cells Derived from Stem Cells
  • 3.4 Types of Stem Cells in the Human Body
    • 3.4.1 Human Embryonic Stem Cells
    • 3.4.2 Embryonic Germ Cells
    • 3.4.3 Fetal Stem Cells
    • 3.4.4 Umbilical Cord Stem Cells
  • 3.5 Adult Stem Cells
    • 3.5.1 Hematopoietic Stem Cells
    • 3.5.2 Mesenchymal Stem Cells
    • 3.5.3 Neural Stem Cells
      • 3.5.3.1 NSCs' Capacity to Migrate and Engraft
      • 3.5.3.2 Characterization of NSCs
      • 3.5.3.3 Major Three Neuronal Lineages from NSCs
  • 3.6 Characteristics of Different Types of Stem Cells

4. NEURAL STEM CELLS: AN OVERVIEW

  • 4.1 Sources of NSCs
  • 4.2 Basal Properties of NSCs Obtained from Different Sources
    • 4.2.1 BMSCs as a Sourse for NSC-Like Cells
    • 4.2.2 UCBSCs: Express Pro-Neural Genes and Neural Markers
    • 4.2.3 ESCs as a Source for NSCs
    • 4.2.4 iPSCs as a Source of NSCs
      • 4.2.4.1 Methods Used to Produce iPSCs
      • 4.2.4.2 Chemicals Used for Neural Differentiation of iPSCs
      • 4.2.4.3 Small-Molecule-Based Culture Protocols for Inducing hPSCs Differentiation
      • 4.2.4.4 Compounds Used for NSC Proliferation
      • 4.2.4.5 Synthetic Compounds Used to Induce NSC Differentiation into Neurons
      • 4.2.4.6 Natural Products Affecting NSC Survival, Proliferation, and Differentiation
  • 4.3 Fetal Stem Cell Transplantation for Neurodegenerative Diseases
  • 4.4 Adult Human Neural Stem Therapeutics
    • 4.4.1 Current Therapeutic Status of aNSCs

5. DEGENERATIVE DISEASES WITH POSSIBLE CURE USING NSCS

  • 5.1 Conventional Treatments for Neurodegenerative Diseases
  • 5.2 NSC-Based and Traditional Approaches for Neurodenerative Diseases
  • 5.3 The Wide Gap Between Theory and Practice in NSC Applications
  • 5.4 Types of NSCs Used for Cell Therapy Approaches
    • 5.4.1 Fetal and Adult-Derived NSCs
    • 5.4.2 NSCs from Pluripotent Stem Cells
  • 5.5 Possible Therapeutic Actions of Grafted NSCs in Neurodegenerative Diseases
  • 5.6 Most Recent Clinical Trials Using NSCs for Neurological Disorders
    • 5.6.1 Possible Outcome of Clinical Trials
  • 5.7 Other Clinical Trials Using NSCs for Neurodegenerative Diseases
  • 5.8 Neurodevelopmental Disorders and Cell Therapy
    • 5.8.1 Clinical Trials for Neurodevelopmental Disorders

6. SPINAL CORD INJURY AND CELL THERAPY

  • 6.1 Incidence of Spinal Cord Injury
  • 6.2 Neurological Level and Extent of Lesion in Spinal Cord Injuries
  • 6.3 Annual and Lifetime Cost of Treating SCI Patients in the US
  • 6.4 Medications and Other Treatments for Spinal Cord Injury
  • 6.5 CIRM Funding for Spinal Cord Injury
  • 6.6 Cell Therapy for Spinal Cord Injury
    • 6.6.1 Studies in Animal Models of Cell Therapy for SCI
      • 6.6.1.1 Preclinical Trials Using MSCs for SCI
      • 6.6.1.2 Preclinical Trials Using NPCs for SCI
      • 6.6.1.3 Preclinical Studies Using Olfactory Ensheathing Cells for SCI
      • 6.6.1.4 Preclinical Studies Using SCs for SCI
  • 6.7 SCI Models and Effectiveness of Neuronal Regeneration
  • 6.8 Clinical Trials Using Stem Cells for Spinal Cord Injury

7. ALZHEIMER'S DISEASE

  • 7.1 Incidence of Alzheimer's Disease
  • 7.2 Projected Number of People Aged 65 and Older with Alzheimer's Disease in the US
  • 7.3 Cost of Care by Payment Source for US Alzheimer's Patients
    • 7.3.1 Total Cost of Health Care, Long-Term Care, and Hospice for US AD Patients
  • 7.4 Currently Available Medications for Alzheimer's Disease
  • 7.5 CIRM Funding for Alzheimer's Research
  • 7.6 Transplantation of Stem Cells for AD
    • 7.6.1 Gene Therapy for AD

8. PARKINSON'S DISEASE

  • 8.1 Incidence of Parkinson's Disease
  • 8.2 CIRM Grants Targeting Parkinson's Disease
  • 8.3 Current Medications for PD
  • 8.4 Potential for Cell Therapy in Parkinson's Disease
  • 8.5 Gene Therapy for PD

9. AMYOTROPHIC LATERAL SCLEROSIS

  • 9.1 Incidence of ALS
  • 9.2 Symptomatic Treatments in ALS Patients
  • 9.3 CIRM Grants Targeting ALS
  • 9.4 Companies Focusing on Stem Cell Therapy for ALS
  • 9.5 Cell Therapy for ALS

10. MULTIPLE SCLEROSIS

  • 10.1 Incidence of MS
  • 10.2 Medications for MS
  • 10.3 Neural Stem Cells' Application in Multiple Sclerosis
  • 10.4 Stimulation of Endogenous NSCs with Growth Factors for MS Treatment
  • 10.5 CIRM Grants Targeting MS

11. STROKE

  • 11.1 Incidence of Stroke
  • 11.2 Currently Available Medication for Stroke
  • 11.3 Stem Cell-Based Therapies for Stroke
  • 11.4 Various Stem Cell Types Used in Stroke Experimental Studies
  • 11.5 Ongoing Clinical Trials for Stroke Using Stem Cells
  • 11.6 CIRM Grants Targeting Stroke

12. MARKET ANALYSIS

  • 12.1 Current Stem Cell Landscape
    • 12.1.1 Number of Stem Cell Product Candidates
    • 12.1.2 Commercial Stem Cell Therapy Development by Geography
    • 12.1.3 Commercially Attractive Therapeutic Areas
    • 12.1.4 Major Companies Investing in Stem Cell Industry
    • 12.1.5 Venturing of Big Pharma into Stem Cell Therapy Sector
  • 12.3 Major Clinical Milestones in Cell Therapy Sector
    • 12.3.1 TiGenics' Cx601
    • 12.3.2 Mesoblast Ltd. and JCR Pharmaceuticals Co., Ltd.
    • 12.3.3 Chiesi's Holocar
    • 12.3.4 ReNeuron's Retinitis Pigmentosa Cell Therapy Candidate
    • 12.3.5 Orphan Drug Designation to Pluristem's PLX-PAD Cells
  • 12.4 Major Anticipated Cell Therapy Clinical Data Events in 2016
  • 12.5 Global Market for Cell Therapy Products
    • 12.5.1 Global Market for Neural Stem Cells

13. SELECTED COMPANY PROFILES

  • 13.1 Asterias Biotherapeutics, Inc.
    • 13.1.1 AST-OPC1
  • 13.2 Athersys Inc
    • 13.2.1 MultiStem Programs
    • 13.2.2 Ischemic Stroke
    • 13.2.3 Clinical Programs (Stroke Phase II)
  • 13.3 Axiogenesis AG / Pluriomics (Merged to form Ncardia)
    • 13.3.1 Peri.4U - Human iPS Cell-Derived Peripheral Neurons
    • 13.3.2 Dopa.4U - Human iPS Cell-Derived Dopaminergic Neurons
    • 13.3.3 CNS.4U-Human iPS Cell-Derived Central Nervous System Cells
    • 13.3.4 Astro.4U-Human iPS Cell-Derived Astrocytes
  • 13.4 AxoGen, Inc
    • 13.4.1 Avance Nerve Graft
    • 13.4.2 AxoGuard Nerve Connector
    • 13.4.3 AxoGuard Nerve Protector
    • 13.4.4 AxoTouch Two-Point Discriminator
  • 13.5 BrainStorm Cell Therapeutics
    • 13.5.1 NurOwn in the Clinic
  • 13.6 Cellular Dynamics International, Inc.
    • 13.6.1 iCell Neurons
    • 13.6.2 iCell Astrocytes
    • 13.6.3 iCell DopaNeurons
  • 13.7 Celther Polska
    • 13.7.1 Cell Lines
  • 13.8 Cellartis AB
    • 13.8.1 hESC-Derived Mesenchymal Progenitor Cells
    • 13.8.2 Human Neural Stem Cells
    • 13.8.3 Culture System for iPSC
  • 13.9 CellCure Neurosciences Ltd.
    • 13.9.1 Technology
    • 13.9.2 New Candidate Treatment for Retinal Diseases
  • 13.10 Celvive, Inc.
    • 13.10.1 Spinal Cord Injury
    • 13.10.2 Research and Development
  • 13.11 Merck Millipore
    • 13.11.1 Human Neural Stem Lines
  • 13.12 International Stem Cell Corporation
    • 13.12.1 Neural Stem Cells
  • 13.13 Kadimastem Ltd.
    • 13.13.1 Drug Discovery for Neural Diseases
    • 13.13.2 Human Oligodendrocyte Drug-Screening Assays
  • 13.14 Living Cell Technologies Limited
    • 13.14.1 NTCELL
  • 13.15 MEDIPOST
    • 13.15.1 NEUROSTEM
  • 13.16 Neuralstem Inc.
    • 13.16.1 NSI-566 for ALS
    • 13.16.2 NSI-566 for SCI
    • 13.16.3 NSI-566 for Ischemic Stroke
  • 13.17 NeuroGeneration Inc.
    • 13.17.1 Drug Discovery
    • 13.17.2 Biotherapeutics
  • 13.18 Neurona Therapeutics Inc.
    • 13.18.1 Technology
  • 13.19 Ocata Therapeutics Inc. (Acquired by Astellas Pharma for $379M in Nov. 2015)
    • 13.19.1 Focus on Neuroscience
  • 13.20 Opexa Therapeutics, Inc
    • 13.20.1 Tcelna
    • 13.20.2 OPX-212
    • 13.20.3 Abili-T Clinical Study
  • 13.21 ReNeuron Group PLC
    • 13.21.1 Products and Technologies
    • 13.21.3 Human Retinal Progenitor Cells
    • 13.21.4 Exosome Platform
    • 13.21.5 ReNcell Products
  • 13.22 RhinoCyte, Inc.
    • 13.22.1 Research
  • 13.23 Roslin Cells Ltd.
    • 13.23.1 Custom iPSC Generation
  • 13.24 SanBio, Inc.
    • 13.24.1 SB623
    • 13.24.2 SB618
  • 13.25 Saneron CCEL Therapeutics Inc.
    • 13.25.1 U-CORD-CELL Program
    • 13.25.2 SERT-CELL Program
  • 13.26 StemCells, Inc.
    • 13.26.1 Clinical Programs
    • 13.26.2 HuCNS-SC (human neural stem cells)
    • 13.26.3 Proof of Concept
    • 13.26.4 Proof of Safety and Initial Efficacy
    • 13.26.5 Spinal Cord Injury
    • 13.26.6 Age-Related Macular Degeneration
    • 13.26.7 Pelizaeus-Merzbacher Disease
    • 13.26.8 Neuronal Ceroid Lipofuscinosis
  • 13.27 Stemedica Cell Technologies, Inc.
    • 13.27.1 Technology
    • 13.27.2 Products
      • 13.27.2.1 Stemedyne-MSC
      • 13.27.2.2 Stemedyne-NSC
      • 13.27.2.3 Stemedyne-RPE
  • 13.28 STEMCELL Technologies, Inc.
    • 13.28.1 Cell Culture Media for NSC and Progenitor Cells
  • 13.29 Talisman Therapeutics Ltd.
  • 13.30 Xcelthera INC
    • 13.30.1 Technology Platforms
    • 13.30.2 PluriXcel-DCS Technology
    • 13.30.3 PluriXcel-SMI Technology
    • 13.30.4 PlunXcel-SMI Neuron Technology
    • 13.30.5 PluriXcel-SMI Heart Technology
    • 13.30.6 Products
      • 13.30.6.1 Xcel-hNuP
      • 13.30.6.2 Xcel-hNu
      • 13.30.6.3 Xcel-hCardP
      • 13.30.6.4 Xcel-hcM

APPENDIX

  • Appendix 1: Globally Distributed Stem Cell and Cell Therapy Companies

INDEX OF FIGURES

  • FIGURE 3.4: Types of Specialized Cells Derived from Stem Cells
  • FIGURE 3.5: Major Three Neural Lineages from Neural Stem Cells
  • FIGURE 3.6: Structure of a Neuron
  • FIGURE 3.7: Structure of Astrocytes
  • FIGURE 3.8: Structure of Oligodendrocytes
  • FIGURE 5.1: Approaches for Neural Stem Replacement for Neurodevelopmental Disorders
  • FIGURE 6.1: Causes of Spinal Cord Injuries
  • FIGURE 6.2: Neurological Level and Extent of Lesion in Spinal Cord Injuries
  • FIGURE 6.3: Types and Share of Different Types of Stem Cells Used in SCI Clinical Trials
  • FIGURE 7.1: Ages of People with Alzheimer's Disease in the US
  • FIGURE 7.2: Number of People Aged 65 and Older with Alzheimer's Disease in the US, 2050
  • FIGURE 7.3: Cost of Care by Payment Source for US Alzheimer's Patients
  • FIGURE 12.1: Stem Cell Therapy Development
  • FIGURE 12.2: Number of Therapies by Phase
  • FIGURE 12.3: Global Market for NSCs, Through 2022
  • TABLE 3.1: NSCs, NPCs, and their Lineage-Specific Markers
  • TABLE 3.2: Characteristics of Different Types of Stem Cells
  • TABLE 4.1: Sources of NSCs and Advantages and Disadvantages in their Applications
  • TABLE 4.2: Different Types of NSCs and their Basal Properties
  • TABLE 4.3: Advantages and Disadvantages of iPSCs Utilization
  • TABLE 4.4: Methods Used to Generate iPSCs
  • TABLE 4.5: Chemicals Used for Neural Differentiation of iPSCs
  • TABLE 4.6 Small-Molecule-Based Culture Protocols for Inducing hPSCs Differentiation
  • TABLE 4.7: Compounds Used in Neural Stem Cell Research
  • TABLE 4.8: Synthetic Compounds Used to Induce NSC Differentiation into Neurons
  • TABLE 4.9: Natural Products Known to Affect NSC Survival, Proliferation, and Differentiation
  • TABLE 4.10: Ongoing Clinical Trials of Fetal Stem Cell Transplantation for Neurological Diseases
  • TABLE 4.11: The Various Methods of Isolation, Culture, and Expansion of aNSCs
  • TABLE 4.12: Preclinical Results (Rat) of aNSCs against Neurodegenerative Diseases
  • TABLE 4.13: Trial ID & Title of Clinical Trials of aNSCs against Neurodegenerative Diseases
  • TABLE 4.14: Trial ID, Cell Source, Location, and Phases of Current Clinical Trials of aNSCs
  • TABLE 5.1: Conventional Treatments for Alzheimer's, Parkinson's, and Huntington's Diseases
  • TABLE 5.2: NSC-Based Approaches for Neurodegenerative Diseases
  • TABLE 5.3: Some Recent Clinical Trials Using NSCs for Treating Neurological Diseases
  • TABLE 5.4: NCT Numbers & Titles of Clinical Trials Using NSCs for Neurodegenerative Diseases
  • TABLE 5.5: Status of Different Clinical Trials Using NSCs for Neurodegenerative Diseases
  • TABLE 5.6: NCT Number and Titles of Clinical Trials for Neurodevelopmental Disorders
  • TABLE 5.7: Status of Clinical Trials Using NSCs for Neurodevelopmental Diseases
  • TABLE 6.1: Annual and Lifetime Cost of Treating SCI Patients in the US
  • TABLE 6.2: Oral Medications and Other Treatment Options for SCI
  • TABLE 6.3: CIRM's Grants Targeting Spinal Cord Injury
  • TABLE 6.4: Genes Used for Engineering Cells
  • TABLE 6.5: Preclinical SPI Trials Using iPSCs/ESCs for SCI
  • TABLE 6.6: Preclinical Spinal Cord Injury Trials Using Mesenchymal Stromal Cells
  • TABLE 6.7: Preclinical Spinal Cord Injury Trials Using NSCs/NPCs
  • TABLE 6.8: Preclinical SCI Trials Using Olfactory Ensheathing Cells
  • TABLE 6.9: Preclinical SCI Trials Using Schwann Cells
  • TABLE 6.10: SCI Models and Effectiveness of Neuronal Regeneration
  • TABLE 6.11: Clinical Trials in Different Countries for SCI
  • TABLE 7.1: Total Cost of Health Care, Long-Term Care, and Hospice for US Alzheimer's Patients
  • TABLE 7.2: Currently Available Pharmacologic Therapies for Alzheimer's Disease
  • TABLE 7.3: CIRM Funding for Alzheimer's Research
  • TABLE 7.4: Stem Cell Therapy for AD in Mice Models
  • TABLE 7.5: Gene Therapy for AD
  • TABLE 8.1: CIRM Grants Targeting Parkinson's Disease
  • TABLE 8.2: Medications for Motor Symptoms in PD
  • TABLE 8.3: Advantages and Disadvantages of Stem Cell Types Used in PD
  • TABLE 8.4: Approaches Used in Current Gene Therapy Clinical Trials for PD
  • TABLE 9.1: Symptomatic Treatments in ALS Patients
  • TABLE 9.2: CIRM Grants Targeting ALS
  • TABLE 9.4: Companies Focusing on Various Strategies for ALS
  • TABLE 9.6: Examples of Clinical Trials for Amyotrophic Lateral Sclerosis
  • TABLE 10.1: Currently Available Medications for MS
  • TABLE 10.2: Available Studies Related to the Use of NSCs for Multiple Sclerosis
  • TABLE 10.3: Growth Factors and Secreted Molecules Used for Stimulating Endogenous NSCs
  • TABLE 10.4: CIRM Grants Targeting MS
  • TABLE 11.1: An Overview of NSC Transplantation Experiments in Ischemic Stroke Models
  • TABLE 11.2: Representative Experimental Studies of Various Cell-Based Therapies for Stroke
  • TABLE 11.3: Ongoing Clinical Trials of Cell-Based Therapies for Stroke
  • TABLE 11.4: CIRM Grants Targeting Stroke
  • TABLE 12.1: Number of Therapies by Phase
  • TABLE 12.2: Stem Cell Product Candidates in Various Stages by Therapeutic Area
  • TABLE 12.3: Stem Cell Therapies in Phase III and Pre-Registration as of 2015
  • TABLE 12.4: Companies with Active Stem Cell Therapy Pipelines
  • TABLE 12.5: Big Pharma's Involvement in Stem Cell Sector
  • TABLE 12.6: Major Anticipated Cell Therapy Clinical Data Events
  • TABLE 12.7: Global Market for Neural Stem Cells (NSCs), Through 2022
  • TABLE 13.1: Neuralstem Inc.'s Cell Therapy Products in Development
  • TABLE 13.2: Opexa's Product Pipeline
  • TABLE 13.3: ReNeuron's Pipeline Candidates
  • TABLE 13.4: SanBio's Product Pipeline
  • TABLE 13.5: STEMCELL Technologies' Cell Culture Media for NSCs
  • TABLE App. 1.1: Stem Cell and Cell Therapy Companies
  • TABLE App. 2.1: Sixty US Spine Surgeons on the Forefront of Biologics and Stem Cells
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