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Pursuing Next-Generation Therapeutic Antibodies as the Next Source of Blockbuster Drugs
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Decision Resources, Inc. ¿¡¼ 2011³â 06¿ù ¿¡ ¹ßÇàÇÑ ¡¸´ÙÀ½ ºí·Ï¹ö½ºÅÍ ÀǾàǰ ¿ø·á·Î¼ÀÇ Â÷¼¼´ë Ä¡·á¿ë Ç×ü Ãß±¸¡¹ º¸°í¼´Â US $4,600 ºÎÅÍ ±¸¸Å °¡´ÉÇÕ´Ï´Ù.
Â÷¼¼´ë Ç×ü´Â ±âÁ¸ ´Ü¹éÁú Ä¡·áÁ¦ À¯»çǰ »Ó¸¸ ¾Æ´Ï¶ó ´Ü¹éÁú °øÇÐ(Protein Engineering)À» ÀÌ¿ëÇÑ Á¦Ç°µµ ¸¸µé¾î³»°í ÀÖ½À´Ï´Ù. ´ÜÀÏŬ·ÐÇ×ü Ä¡·áÁ¦³ª Ç×ü Ä¡·áÁ¦ÀÇ ¼º°øÀº Á¦¾àȸ»ç¿¡°Ô »õ·Î¿î ºí·Ï¹ö½ºÅÍ ÀǾàǰÀ» °³¹ßÇÒ ¼ö ÀÖµµ·Ï ¶Ù¾î³ Ư¼ºÀ» °¡Áø Â÷¼¼´ë Ç×ü¸¦ °³¹ßÇÏ°Ô ÇÏ´Â °è±â°¡ µÇ°í ÀÖ½À´Ï´Ù.
Ä¡·á¿ë Ç×ü(Therapeutic Antibodies) ½ÃÀåÀÇ ¸ÅÃâ, ±âÁ¸ ´ÜÀÏŬ·ÐÇ×üÀÇ ÀÌÁ¡, ¼±µµ¹°Áú ÃÖÀûÈ, Â÷¼¼´ë Ç×üÀÇ ÇâÈÄ Àü¸Á µîÀÇ Á¤º¸¸¦ ÀüÇØµå¸³´Ï´Ù.
1. °³¿ä
2. ¼·Ð
3. Ç×ü ´ÜÆí(Antibody Fragments)°ú ÀÌÇü
4. ¸é¿ª±Û·ÎºÒ¸°G(IgG) Ç×üÀÇ ÀϹÝÀû Ư¼º
- Fab Á¶°¢(Fab Fragments)
- Single-Chain Variable Region Fragments(scFv)
- Single-Domain Antibodies(dAbs)
- FC À¶ÇÕ ´Ü¹éÁú(Fc Fusion Proteins)
5. ´Ù°¡(Multivalent), ´ÙÁ߯¯¼º(Multispecific), Multimodular Ç×ü
- ´Ù°¡(Multivalent), ´ÙÁ߯¯¼º(Multispecific) Ç×ü
- Multimodular Ç×ü
6. Antibody Mimetics
7. T¼¼Æ÷ ¼ö¿ëü Ä¡·áÁ¦(T-Cell Receptor Therapeutics)
8. ¼±µµ¹°Áú ÃÖÀûÈ(Lead Optimization)
9. Â÷¼¼´ë Ç×üÀÇ ÇâÈÄ Àü¸Á
10. µµÇ¥
LSH
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