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중간엽 줄기세포(MSC) : 진보 및 응용

Mesenchymal Stem Cells - Advances & Applications 2019

리서치사 BIOINFORMANT WORLDWIDE, LLC
발행일 2019년 07월 상품 코드 234291
페이지 정보 영문 223 Pages
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중간엽 줄기세포(MSC) : 진보 및 응용 Mesenchymal Stem Cells - Advances & Applications 2019
발행일 : 2019년 07월 페이지 정보 : 영문 223 Pages

중간엽 줄기세포(MSC: Mesenchymal Stem Cells) 시장을 조사했으며, 줄기세포 및 중간엽 줄기세포(MSC) 개요, 각종 종류, 임상적 용도 발전과 추이, 임상연구 및 임상개발 동향, 출시 제품 개요, 각종 용도 및 대응 질환 동향, 기업간 제휴, 주요 기업 및 제품 개요 등의 정보를 정리하여 전해드립니다.

제1장 보고서 개요

제2장 서론

제3장 첨단 의료 의약품(ATMP : ADVANCED THERAPY MEDICINAL PRODUCTS)

  • 주요 대상 분야
  • 출시된 ATMP 가격
  • FDA 승인 ATMP
  • EC 승인 ATMP

제4장 줄기세포 : 개요

  • 배성줄기세포(ESC)
  • 유도만응줄기세포(iPSC)
  • 줄기세포 유래 특수화 세포의 종류
  • 인체 줄기세포의 종류
    • 인간 배아줄기세포(hESC)
    • 생식줄기세포(EG세포)
    • 태아 줄기세포
    • 제대혈 줄기세포
  • 성체 줄기세포
    • 조혈모세포(HSC)
    • 중간엽 줄기세포(MSC)
    • 신경줄기세포(NSC)
  • 각종 줄기세포의 특징
  • 의료에서의 응용

제5장 간잎계 줄기세포(MSC) : 개요

  • MSC의 새로운 명칭
  • MSC의 기능
  • MSC의 소스
  • hMSC의 분리 및 배양
  • 각종 MSC 유형의 특징
  • hMSC로 치료 가능한 만성질환
  • MSC 세포 치료의 대상이 되는 일반 질환
  • 세포 치료에서 MSC의 이점
  • MSC와 다른 줄기세포 종류 비교
  • 자가 MSC(Autologous MSC)의 단점과 동종 MSC(Allogeneic MSC)의 장점
  • MSC의 작용기전
  • 조직 재생
  • 면역 조절
  • MSC 제조

제6장 MSC의 임상적 용도

  • GvHD
  • 심장혈관 수복
  • 간질환
  • 뼈/연골 질환을 위한 MSC
  • 승인을 획득한 MSC 제품
    • Cartistem
    • Stempeucel
    • MPC(Mesenchymal Precursor Cell) : Mesoblast
    • Cupistem
    • Prochymal
    • AlloStem
    • Cellgram-AMI
    • Osteocel Plus
    • Trinity Evolution
    • CardioRel
    • Temcell
  • MSC를 포함한 뼈기질
    • 비용
    • 조직공학에 의한 정형외과 제품 후보
  • 승인 획득 세포 치료 제품의 가격

제7장 줄기세포 연구 출판, 자금, 특허

  • MSC에 관한 과학논문
  • 세계의 줄기세포 연구
  • NIH MSC 연구 자금
  • 특허 환경

제8장 MSC 관련 임상시험 : 개요

  • 현재의 임상시험 시나리오
  • MSC 관련 임상시험의 지역 점유율
  • 임상시험 소스
  • 현재 시험중인 대응 질환
  • 현행 임상시험
  • 임상시험의 지금까지 성과
  • 대학 주도 주요 임상시험
  • 기업 주도 주요 임상시험
  • 심혈관질환
  • 골관절염
  • 창상 치유
  • 간질환
  • 폐질환
  • 안과장애
  • 신장장애
  • 당뇨병
  • 이식편대숙주질환(GvHD)
  • 염증성 장질환
  • 다발성 경화증
  • 특정 질환에서의 MSC 임상연구 상황
    • 이식편대술주질환(GvHD)
    • 골관절염(OA) & 류마티스 관절염(RA)
    • 염증성 기도 및 폐질환
    • 다발성 경화증(MS)
    • 염증성 장질환(IBD)
    • 유전자 조작 MSC

제9장 제휴 활동

제10장 시장 분석

제11장 기업 개요

LSH 18.01.29

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EXECUTIVE SUMMARY

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, and potentially other cell types. In addition to secreting factors that can stimulate tissue repair, MSCs can substantially alter their microenvironment, exerting effects that are both anti-inflammatory and anti-fibrotic. MSCs are advantageous over other stem cells types for a variety of reasons, including that they are immuno-privileged, making them an advantageous cell type for allogenic transplantation. MSCs appear to be an exceptionally promising tool for cell therapy, because of their unusual advantages, which include availability, expandability, transplantability, and ethical implications.

Interest in therapeutic applications of human MSCs arises from their diverse ability to differentiate into a range of cell types, as well as their ability to migrate to sites of tissue injury/inflammation or tumor growth. MSCs are also well-suited for use in the exponential growth field of 3D printing, because of their capacity to form structural tissues. Growing attention is now being given to manufacturing technologies to support commercial-scale production of MSCs. Numerous market competitors are exploring commercialization strategies for MSC-derived extracellular vesicles (EVs) and exosomes, because these extracelluar “packages” represent a novel strategy for accessing the therapeutic effects of stem cells without the risks and difficulties of administering the cells to patients.

As the most common stem cell type being used within regenerative medicine, there is huge potential for growth within the MSC market. There are more than one-hundred thousand scientific publications published about MSCs, as well as 900+ MSC clinical trials underway worldwide, including trials within the U.S., E.U., China, Middle East, and South Korea. While many early-stage MSC trials have demonstrated safety and efficacy, only a small number have reached Phase III, indicating that a limited number of MSC products have near-term market potential and the therapeutic market for MSCs remains early-stage. As of 2019, ten MSC-based products have received regulatory approvals, including nine cell therapy approvals and one tissue engineering approval. Population aging and an increasing prevalence of chronic disease are also driving interest in MSC-based therapies, with Google Trend data revealing that MSC searches are more than twice as common as the next most common stem cell type.

The main objectives of this report are to provide the reader with the following details:

  • A brief overview of the MSC industry
  • Biological factors secreted by MSCs
  • The manufacturing process of MSCs
  • Bioreactors used in the manufacture of MSCs
  • Microcarriers used for the expansion of MSCs
  • Cost of manufacturing autologous and allogeneic MSCs
  • Services offered by CMOs/CDMOs in the manufacture of MSCs
  • Major diseases addressed by MSCs in the ongoing clinical trials
  • Consumption of MSCs for academic research, clinical trials, product development, and exosome production
  • Brief account of approved cell therapy, gene therapy and tissue engineering products
  • Details of approved MSC-based cell therapeutics
  • Recent business developments pertinent to MSCs
  • Market size determinations for MSCs and MSC-based products
  • Details of products and product candidates developed by companies which are focusing exclusively on MSCs

Key questions answered in the report are:

  • How many MSC-based products have been approved so far?
  • Which countries have approved the products?
  • What are the various names within the scientific literature to indicate MSCs?
  • What are the functions of MSCs?
  • Which tissue sources yield MSCs?
  • What cell types do the MSCs differentiate into?
  • What are the soluble factors secreted by MSCs and what functions do the soluble factors perform?
  • What types of bioreactors are used for culturing and expanding the MSCs?
  • How much do allogeneic and autologous MSCs cost?
  • Which are the major cell manufacturing facilities in the U.S.?
  • Which are the major cell manufacturing facilities in Europe?
  • What are the major disease types addressed by MSCs in the ongoing clinical trials?
  • What is the current consumption of MSCs in academic and preclinical settings?
  • What is the current consumption and future demand for MSCs for developing cell therapies?
  • What MSC-based products have been approved?
  • What is the global market size for MSCs being used within academic research, preclinical studies, clinical trials and product development?
  • What is the global market size for the approved MSC-based therapeutics from 2018 to 2025?
  • Who are the leading competitors involved with developing MSC-based therapeutics?

As the first and only market research firm to specialize in the stem cell industry, BioInformant has a unique understanding of the rapidly evolving MSC Industry. Founded in 2006, BioInformant has collected more than 13 years of historical data on the industry, providing it with a robust historical database of data on which to make future market projections. Headquartered in Washington, DC, BioInformant is strategically positioned near industry lawmakers, the National Institutes of Health (NIH), U.S. FDA, and the Maryland Biotech Corridor, among other critical resources. In addition to leveraging an experienced team of analysts, this experience provides BioInformant with access to Key Opinion Leaders (KOLs) from across the MSC sector, including dozens of executives who were interviewed for this report.

As the world's first and only market research firm to specialize in the stem cell industry, BioInformant has conducted interviews with representatives from Cynata Therapeutics (first company to bring a iPSC-derived MSC therapeutic product into a clinical trial), RoosterBio (specializes in manufacturing tens of billions of MSCs in suspension bioreactors), Pluristem Therapeutics (commercializing placenta-derived mesenchymal-like adherent stromal cells in late-stage clinical trials), BioEden (leading company preserving MSCs derived from dental tissues), Regenexx (world's leading provider of MSC therapies for orthopedic applications), and more. With research cited by major news outlets that include the Wall Street Journal, Nature Biotechnology, Xconomy, and Vogue Magazine, BioInformant is your global leader in stem cell industry data.

TABLE OF CONTENTS

1. REPORT OVERVIEW

  • 1.1. Statement of the Report
  • 1.2. Executive Summary

2. INTRODUCTION

3. ADVANCED THERAPY MEDICINAL PRODUCTS (ATMPs)

  • 3.1. Major Therapeutic Areas of Interests in ATMPs Sector
  • 3.2. Price of Market-Stage ATMPs
  • 3.3. FDA-Approved ATMPs
  • 3.4. EC-Approved ATMPs

4. STEM CELLS: A BRIEF OVERVIEW

  • 4.1. Embryonic Stem Cells (ESCs)
  • 4.2. Induced Pluripotent Stem Cells (iPSCs)
  • 4.3. Types of Specialized Cells Derived from Stem Cells
  • 4.4. Types of Stem Cells in Human Body
    • 4.4.1. Human Embryonic Stem Cells (hESCs)
    • 4.4.2. Embryonic Germ Cells (EG-Cells)
    • 4.4.3. Fetal Stem Cells
    • 4.4.4. Umbilical Cord Stem Cells
  • 4.5. Adult Stem Cells
    • 4.5.1. Hematopoietic Stem Cells (HSCs)
    • 4.5.2. Mesenchymal Stem Cells (MSCs)
    • 4.5.3. Neural Stem Cells (NSCs)
  • 4.6. Characteristics of Different Types of Stem Cells
  • 4.7. Applications of Stem Cells in Medicine

5. MESENCHYMAL STEM CELLS (MSCs): A DETAILED OVERVIEW

  • 5.1. A New Name for MSCs
    • 5.1.1. History and Timeline of MSCs Nomenclature
  • 5.2. Functions of MSCs
  • 5.3. Sources of MSCs
  • 5.4. Isolation and Culturing of hMSCs
    • 5.4.1. Cell Surface Markers in MSCs
    • 5.4.2. In Vitro Differentiation Potential of MSCs
  • 5.5. Key Features of Different Types of MSCs
  • 5.6. Chronic Diseases Treatable by hMSCs
  • 5.7. Common Diseases Registered for MSC-Based Cell Therapy
  • 5.8. Advantages of MSCs in Cell Therapy
  • 5.9. Comparison of MSCs with Other Stem Cell Types
  • 5.10. Drawbacks of Autologous MSCs and Advantages of Allogeneic MSCs
    • 5.10.1. Application Strategies for Allogeneic MSCs
  • 5.11. Mechanism of Action of MSCs in Treating Diseases
  • 5.12. Tissue Regeneration
  • 5.13. Immune Modulation
  • 5.14. Manufacture of MSCs
    • 5.14.1. Safety and Potency Assays
    • 5.14.2. Surface Markers of MSC
    • 5.14.3. BM-MNC Isolation and Plating
    • 5.14.4. Passaging and Harvesting
    • 5.14.5. Cryopreservation of MSCs
    • 5.14.6. Donor Eligibility and Cell Collection
    • 5.14.7. Regulatory Framework of MSC Therapies
    • 5.14.8. Contract Development and Manufacturing Organizations (CDMO)

6. MESENCHYMAL STEM CELLS (MSCs): APPLICATIONS

  • 6.1. MSCs for GvHD
  • 6.2. MSCs for Cardiovascular Repair
  • 6.3. MSCs for Liver Disease
  • 6.4. MSC for Bone/Cartilage Disease
  • 6.5. Approved MSC-Based Products
    • 6.5.1. Cartistem
    • 6.5.2. Stempeucel
    • 6.5.3. Mesenchymal Precursor Cells (MPCs) from Mesoblast
    • 6.5.4. Cupistem
    • 6.5.5. Prochymal
    • 6.5.6. AlloStem
    • 6.5.7. Cellgram-AMI
    • 6.5.8. Osteocel Plus
    • 6.5.9. Trinity Evolution
    • 6.5.10. CardioRel
    • 6.5.11. Temcell
  • 6.6. Bone Matrices Containing MSCs
    • 6.6.1. Cost of Bone Matrices Containing MSCs
    • 6.6.2. Tissue Engineered Orthopedic Product Candidates Containing MSCs
  • 6.7. Pricing of Approved Cell Therapy Products

7. STEM CELL RESEARCH PUBLICATIONS, FUNDING AND PATENTS

  • 7.1. Volume of Scientific Papers Published on MSCs
    • 7.1.1. Number of Publications on MSCs by Major Applications
  • 7.2. Stem Cell Research around the World
  • 7.3. NIH Funding for MSCs Research
  • 7.4. Stem Cell Patents Landscape

8. CLINICAL TRIALS INVOLVING MSCS: AN OVERVIEW

  • 8.1. Current Clinical Trial Scenario
  • 8.2. Geographical Share of MSC Clinical Trials
    • 8.2.1. Number of Clinical Trials using MSCs by Geography/Country
  • 8.3. Sources of MSCs for Current Clinical Trials
  • 8.4. Diseases Addressed by MSCs in the Ongoing Clinical Trials
  • 8.5. Active Clinical Trials using MSCs
  • 8.6. MSC Clinical Trial Outcomes, 2011-2016
  • 8.7. Selected Clinical Trials Sponsored by Universities
    • 8.7.1. Celal Bayar University (NCT02824393)
    • 8.7.2. University of Jordan (NCT02118519)
    • 8.7.3. Ankara University (NCT03106662)
    • 8.7.4. University Hospital of Liege (NCT00504803)
    • 8.7.5. Acibadem University (NCT02285673)
    • 8.7.6. University of Sao Paulo (NCT01297972)
    • 8.7.7. Cairo University (NCT02387749)
  • 8.8. Selected Clinical Trials Sponsored by Cell Therapy Companies
    • 8.8.1. Scinow Biotechnology Co., Ltd. (NCT03184935)
    • 8.8.2. Mesoblast Ltd. (NCT00294112)
    • 8.8.3. Cellular Biomedicine Group Ltd. (NCT01809769)
    • 8.8.4. Alliancells Bioscience Corporation Ltd. (NCT01573923)
    • 8.8.5. Pharmicell Co., Ltd. (NCT01676441)
    • 8.8.6. Shenzhen Hometcorn Biotechnology Co., Ltd.
    • 8.8.7. Sclnow Biotechnology Co., Ltd. (NCT03180450)
  • 8.9. Clinical Trials using MSCs for Cardiovascular Diseases
    • 8.9.1. Corporate Investment in Cardiovascular Diseases using MSC Therapy
      • 8.9.1.1. MPC-150-IM from Mesoblast
      • 8.9.1.2. CLBS10 from Caladrius
      • 8.9.1.3. C-Cure from Celyad
      • 8.9.1.4. Ixmyelocel-T from Vericel
      • 8.9.1.5. MultiStem from Athersys
  • 8.10. MSCs for Osteoarthritis
  • 8.11. MSCs in Wound Healing
  • 8.12. MSCs for Liver Diseases
  • 8.13. MSCs for Lung Disorders
  • 8.14. Clinical Trials using MSCs for Eye Disorders
  • 8.15. MSCs for Kidney Disorders
  • 8.16. MSCs for Diabetes
  • 8.17. MSCs for Graft vs. Host Disease (GvHD)
  • 8.18. MSCs for Inflammatory Bowel Diseases
  • 8.19. MSCs for Multiple Sclerosis
  • 8.20. Status of MSC Clinical Research in Specific Diseases
    • 8.20.1. Graft v. Host Disease (GvHD)
    • 8.20.2. OA & RA
    • 8.20.3. Inflammatory Airway and Pulmonary Diseases
    • 8.20.4. Multiple Sclerosis (MS)
    • 8.20.5. Inflammatory Bowel Disease (IBD)
    • 8.20.6. Genetically Engineered MSCs

9. PARTNERING ACTIVITIES IN CELL THERAPY SECTOR

  • 9.1. Collaboration between Lonza and Nikon
  • 9.2. Hitachi's Purchase of PCT from Caladrius Biosciences
  • 9.3. Collaboration between Regeneus Ltd. and Asahi Glass. Co. on Progenza
  • 9.4. Collaboration between RepliCel Life Sciences and Shiseido Co., Ltd.
  • 9.5. Collaboration between SanBio Life Sciences and Sumitomo
  • 9.6. Partnership and License Agreement between Healios K.K. and Athersys Inc.
  • 9.7. Cell Therapy Ltd.'s License to Daiichi Sankyo
  • 9.8. TiGenix's License to Takeda Pharmaceuticals
  • 9.9. Celyad's License to Ono Pharmaceuticals
  • 9.10. Collaboration Kolon Life Sciences and Mitsubishi Tanabe
  • 9.11. Collaboration between Steminent Biotherapeutics and ReproCELL Inc.
  • 9.12. Kite Pharma's Partnership with Daiichi Sankyo
  • 9.13. Acquisition of Cellular Dynamics by Fujifilm Holdings
  • 9.14. License Agreement between Cynata Therapeutics and Fujifilm
  • 9.15. Gilead to Acquire Kite Pharma
  • 9.16. Big Pharma's Strategy in Advanced Therapy Sector
    • 9.16.1. Collaboration between Sangamo and Pfizer
    • 9.16.2. Acquisition of 3D Printing Systems from Tissue Regeneration Systems by DePuy Synthes Products (J&J)
    • 9.16.3. New JLABS Opened by J&J
    • 9.16.4. Collaboration between GSK and Miltenyl Biotec
  • 9.17. Big Pharma's Interest in Cell Therapy
    • 9.17.1. GlaxoSmithKline (GSK)
    • 9.17.2. Pfizer
    • 9.17.3. Novartis
    • 9.17.4. AstraZeneca
    • 9.17.5. Roche
    • 9.17.6. Johnson & Johnson
    • 9.17.7. Sanofi
  • 9.18. Big Pharma Strategy in Advanced Therapies
    • 9.18.1. Value of Big Pharma Deals in Cell and Gene Therapy
  • 9.19. Recent Events in Advanced Therapies Sector
  • 9.20. Geographical Distribution of Cell Therapy Companies

10. MARKET ANALYSIS

11. COMPANY PROFILES

  • 11.1. AdiCyte
  • 11.2. AdiSave
  • 11.3. AlloSource Inc.
    • 11.3.1. AlloStem
  • 11.4. American CryoStem Corporation
    • 11.4.1. Clinical Adipose-Tissue Platform
  • 11.5. Anterogen Co., Ltd.
    • 11.5.1. Cupistem Injection
  • 11.6. Apceth Biopharma GmbH
    • 11.6.1. Apceth's Allogeneic MSC Platform
    • 11.6.2. Apceth's Genetically-Engineered MSCs
  • 11.7. Athersys Inc.
    • 11.7.1. MultiStem
  • 11.8. Astarte Biologics Inc.
  • 11.9. BioCardia Inc.
    • 11.9.1. Product Pipeline
  • 11.10. BioRestorative Therapies Inc.
    • 11.10.1. brtxDISC
    • 11.10.2. ThermoStem Program
  • 11.11. Bone Therapeutics SA
    • 11.11.1. Collaborators
  • 11.12. Brainstorm Cell Therapeutics
    • 11.12.1. NurOwn Technology
  • 11.13. Caladrius Biosciences Inc.
    • 11.13.1. CLBS03
    • 11.13.2. CLBS12
  • 11.14. Capricor Therapeutics Inc.
    • 11.14.1. CAP-1002
    • 11.14.2. CAP-2003
  • 11.15. Cell Applications Inc.
  • 11.16. Cell Cure Neurosciences Ltd.
    • 11.16.1. OpRegen
  • 11.17. CellGenix Technologie Transfer GmbH
    • 11.17.1. Cell Types Offered
    • 11.17.2. CellGro Cytokines
    • 11.17.3. Serum-Free Media
    • 11.17.4. Supplements and Cells
  • 11.18. CellProthera SAS
    • 11.18.1. ProtheraCytes
  • 11.19. Celltex Therapeutics Corporation
  • 11.20. Cellular Dynamics International Inc.
  • 11.21. Celprogen Inc.
  • 11.22. Cell Therapies Pty Ltd.
    • 11.22.1. Contract Manufacturing Services
    • 11.22.2. Apheresis Management Services
    • 11.22.3. Clinical Trial Support Services
    • 11.22.4. Consultancy & Advisory Services
  • 11.23. Celvive Inc.
    • 11.23.1. The StemCell Bag
  • 11.24. Cesca Therapeurics Inc.
    • 11.24.1. CAR-TXpress
    • 11.24.2. AutoXpress (AXP)
    • 11.24.3. Point-of-Care Solutions for Cell-Based Therapies (PXP)
    • 11.24.4. CellXpress
  • 11.25. Celyad SA
  • 11.26. Cyagen Biosciences Inc.
    • 11.26.1. Cells
    • 11.26.2. Media
  • 11.27. Cynata Therapeucics Ltd.
    • 11.27.1. Cymerus Platform Technology
  • 11.28. Cytori Therapeutics Inc.
    • 11.28.1. Cytori Cell Therapy
  • 11.29. Escape Therapeutics Inc.
  • 11.30. Future Health BioBank
  • 11.31. Gamida Cell Ltd.
    • 11.31.1. NAM Technology
    • 11.31.2. NiCord
    • 11.31.3. Cordin
    • 11.31.4. NAM-NK Cells
  • 11.32. Intercytex Ltd.
    • 11.32.1. ICH-RHY
  • 11.33. International Stem Cell Corp.
  • 11.34. Invitrx Therapeutics Inc.
    • 11.34.1. Therapeutic Procedures
    • 11.34.2. Invitra ECM Suspension
    • 11.34.3. Cosmetic Procedures
  • 11.35. JCR Pharmaceuticals Co., Ltd.
    • 11.35.1. Temcell HS Inj.
  • 11.36. Kadimastem Ltd.
    • 11.36.1. Solution for Diabetes
    • 11.36.2. Solution for Neurodegenerative Diseases
  • 11.37. Kiadis Pharma N.V.
    • 11.37.1. ATIR101
    • 11.37.2. ATIR201
  • 11.38. Kite Pharma Inc.
    • 11.38.1. Kite Pharma's Research
  • 11.39. Life Sciences Inc.
    • 11.39.1. Technology
    • 11.39.2. RCT-01
    • 11.39.3. RCS-01
    • 11.39.4. RCH-01
    • 11.39.5. RCI-02
  • 11.40. Living Cell Technologies Ltd.
    • 11.40.1. NTCELL
  • 11.41. Lonza Group Ltd.
  • 11.42. Magenta Therapeutics Inc.
    • 11.42.1. Magenta's Stem Cell Platform
  • 11.43. Medeor Therapeutics Inc.
    • 11.43.1. MDE-10X
  • 11.44. Medipost Co., Ltd.
    • 11.44.1. Cartistem
    • 11.44.2. Pneumostem
    • 11.44.3. Neurostem
  • 11.45. Mesoblast Inc.
    • 11.45.1. MPC-150-IM
    • 11.45.2. MPC-300-IV
    • 11.45.3. MPC-06-ID
    • 11.45.4. MSC-100-IV
    • 11.45.5. Temcell HS Injection
  • 11.46. NuVasive Inc.
    • 11.46.1. Osteocel
  • 11.47. Neuralstem Inc.
    • 11.47.1. NSI-189
  • 11.48. Octane Biotech Inc.
    • 11.48.1. Turn-Key Production System for Cell and Tissue Therapy
    • 11.48.2. Automated Bioreactors
    • 11.48.3. Atomically Enhanced Implants
    • 11.48.4. Drug-Enhanced Implants
    • 11.48.5. Cell-Enhanced Implants
  • 11.49. Organogenesis Inc.
    • 11.49.1. Apligraf
    • 11.49.2. Dermagraft
  • 11.50. Orthofix International N.V.
    • 11.50.1. BioStim
    • 11.50.2. Biologics
      • 11.50.2.1. Trinity ELITE
      • 11.50.2.2. Trinity Evolution
      • 11.50.2.3. VersaShield
      • 11.50.2.4. Collage
      • 11.50.2.5. AlloQuent
  • 11.51. Osiris Therapeutics Inc.
    • 11.51.1. Grafix
    • 11.51.2. BIO4
    • 11.51.3. Stravix
    • 11.51.4. Cartiform
  • 11.52. OxStem Ltd.
  • 11.53. PharmaCell B.V.
  • 11.54. Pharmicell Co. Ltd.
    • 11.54.1. Cellgram-AMI
  • 11.55. Pluristem Therapeutics Inc.
    • 11.55.1. PLX Products
    • 11.55.2. PLX-PAD
    • 11.55.3. PLX-R18
    • 11.55.4. Prochymal
  • 11.56. Precious Cells International Ltd.
    • 11.57. Promethera Biosciences S.A.
    • 11.57.1. HepaStem for ACLF
    • 11.57.2. HepaStem for NASH
    • 11.57.3. H2Stem
    • 11.57.4. Heparesc
  • 11.58. Provia Laboratories, LLC
    • 11.59. Regen BioPharma Inc.
    • 11.59.1. HemaXellerate (Phase I/II)
  • 11.60. Regeneus Ltd.
    • 11.60.1. Progenza
    • 11.60.2. RGSH4K
    • 11.60.3. Secretions
  • 11.61. Reliance Life Sciences Pvt. Ltd.
    • 11.61.1. CardioRel
  • 11.62. Reneuron Group plc
    • 11.62.1. CTX Cell Line
    • 11.62.2. hRPC
    • 11.62.3. Exosome Platform
  • 11.63. Stemedica Cell Technologies Inc.
    • 11.63.1. BioSmart Technology
    • 11.63.2. Clinical Pipeline
  • 11.64. StemGen Therapeutics
    • 11.64.1. Lipokraft
    • 11.64.2. Lipokraft Advance
    • 11.64.3. Amniokraft
  • 11.65. Stempeutics Research Pvt. Ltd.
    • 11.65.1. Stempeucel
    • 11.65.2. Stempeucare
    • 11.65.3. Stempeutron
  • 11.66. Stratatech Corp.
    • 11.66.1. StrataGraft
    • 11.66.2. ExpressGraft
  • 11.67. ThermoFischer Scientific Inc.
  • 11.68. TiGenix N.V.
    • 11.68.1. TiGenix's Pipeline
  • 11.69. U.S. Stem Cell Inc.
    • 11.69.1. MyoCell
    • 11.69.2. MyoCell SDF-1
    • 11.69.3. AdipoCell
  • 11.70. Vericel Corporation
    • 11.70.1. Ixmyelocel-T
    • 11.70.2. MACI
    • 11.70.3. Epicel
    • 11.70.4. Carticel
  • 11.71. ViaCyte Inc.
    • 11.71.1. VC-01
    • 11.71.2. VC-02
  • 11.72. Xintea AB
    • 11.72.1. XINMARK
  • 11.73. Zen-Bio Inc.

List of Figures

  • Figure 3.1: Major Indications of Advanced Therapy Clinical Trials
  • Figure 4.1: Differentiation of Stem Cells into Adult Specialized Cells
  • Figure 4.2: Differentiation of Embryonic Stem Cells into Adult Specialized Cells
  • Figure 4.3: Differentiation of Induced Pluripotent Stem Cells into Adult Specialized Cells
  • Figure 4.4: Types of Specialized Cells Derived from Stem Cells
  • Figure 4.5: Applications of Stem Cells
  • Figure 5.1: Types of Common Diseases Registered for MSC-Based Cell Therapy
  • Figure 5.2: Some Mechanisms of MSCs in Therapeutic Application
  • Figure 5.3: Steps in the Manufacturing Process of MSCs
  • Figure 6.1: Clinical Trials of MSCs Classified by Disease Type
  • Figure 7.1: Stem Cell Research Publications Landscape
  • Figure 7.2: Number of Published Scientific Papers on MSCs
  • Figure 7.3: Number of Publications on MSCs by Major Applications
  • Figure 8.1: Currently Active Clinical Trials using MSCs
  • Figure 8.2: MSC-Based Clinical Trials by Geography
  • Figure 8.3: Sources of MSCs used in Current Clinical Trials
  • Figure 8.4: Diseases Addressed by MSCs in the Ongoing Clinical Trials
  • Figure 9.1: Value of Deals Undertaken by Big Pharma in Gene and Cell Therapy Sector
  • Figure 9.2: Geographical Distribution of Cell Therapy Companies
  • Figure 10.1: Global Market for Mesenchymal Stem Cells and Products through 2022

Companies Mentioned:

  • AdiCyte
  • AdiSave
  • Alliancells Bioscience Corporation Ltd.
  • AlloSource Inc.
  • American CryoStem Corporation
  • Ankara University
  • Anterogen Co., Ltd.
  • Apceth Biopharma GmbH
  • Asahi Glass. Co.
  • Astarte Biologics Inc.
  • AstraZeneca
  • Athersys Inc.
  • Big Pharma
  • BioCardia Inc.
  • BioRestorative Therapies Inc.
  • Bone Therapeutics SA
  • Brainstorm Cell Therapeutics
  • Cairo University
  • Caladrius Biosciences Inc.
  • Capricor Therapeutics Inc.
  • Celal Bayar University
  • Cell Applications Inc.
  • Cell Cure Neurosciences Ltd.
  • Cell Therapies Pty Ltd.
  • Cell Therapy Ltd.
  • CellGenix Technologie Transfer GmbH
  • CellProthera SAS
  • Celltex Therapeutics Corporation
  • Cellular Biomedicine Group Ltd.
  • Cellular Dynamics International Inc.
  • Celprogen Inc.
  • Celvive Inc.
  • Celyad SA
  • Cesca Therapeurics Inc.
  • Cyagen Biosciences Inc.
  • Cynata Therapeucics Ltd.
  • Cytori Therapeutics Inc.
  • Daiichi Sankyo
  • Escape Therapeutics Inc.
  • Fujifilm
  • Fujifilm Holdings
  • Future Health BioBank
  • Gamida Cell Ltd.
  • Gilead
  • GlaxoSmithKline (GSK)
  • GSK
  • Healios K.K.
  • Hitachi
  • Intercytex Ltd.
  • International Stem Cell Corp.
  • Invitrx Therapeutics Inc.
  • J&J
  • JCR Pharmaceuticals Co., Ltd.
  • Johnson & Johnson
  • Kadimastem Ltd.
  • Kiadis Pharma N.V.
  • Kite Pharma Inc.
  • Kolon Life Sciences
  • Life Sciences Inc.
  • Living Cell Technologies Ltd.
  • Lonza Group Ltd.
  • Magenta Therapeutics Inc.
  • Medeor Therapeutics Inc.
  • Medipost Co., Ltd.
  • Mesoblast Ltd.
  • Miltenyl Biotec
  • Mitsubishi Tanabe
  • Neuralstem Inc.
  • Nikon
  • Novartis
  • NuVasive Inc.
  • Octane Biotech Inc.
  • Ono Pharmaceuticals
  • Organogenesis Inc.
  • Orthofix International N.V.
  • Osiris Therapeutics Inc.
  • OxStem Ltd.
  • Pfizer
  • PharmaCell B.V.
  • Pharmicell Co. Ltd.
  • Pluristem Therapeutics Inc.
  • Precious Cells International Ltd.
  • Promethera Biosciences S.A.
  • Provia Laboratories, LLC
  • Regen BioPharma Inc.
  • Regeneus Ltd.
  • Reliance Life Sciences Pvt. Ltd.
  • Reneuron Group plc
  • RepliCel Life Sciences
  • ReproCELL Inc.
  • Roche
  • SanBio Life Sciences
  • Sangamo
  • Sanofi
  • Scinow Biotechnology Co., Ltd.
  • Shenzhen Hometcorn Biotechnology Co., Ltd.
  • Shiseido Co., Ltd.
  • Stemedica Cell Technologies Inc.
  • StemGen Therapeutics
  • Steminent Biotherapeutics
  • Stempeutics Research Pvt. Ltd.
  • Stratatech Corp.
  • Sumitomo
  • Takeda Pharmaceuticals
  • ThermoFischer Scientific Inc.
  • TiGenix N.V.
  • Tissue Regeneration Systems by DePuy Synthes Products (J&J)
  • U.S. Stem Cell Inc.
  • University Hospital of Liege
  • University of Jordan
  • University of Sao Paulo
  • Vericel Corporation
  • ViaCyte Inc.
  • Xintea AB
  • Zen-Bio Inc.
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