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세계의 G단백질 연결 수용체(GPCR) 타기팅 시장(2021-2028년)

Global G-Protein Coupled Receptor (GPCR) Targeting Market - 2021-2028

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세계의 G단백질 연결 수용체(GPCR) 타기팅 시장(2021-2028년) Global G-Protein Coupled Receptor (GPCR) Targeting Market - 2021-2028
발행일 : On Demand Report 페이지 정보 : 영문 180 Pages

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세계의 G단백질 연결 수용체(GPCR) 타기팅 시장을 분석했으며, 시장의 기본 구조 및 주요 촉진·억제요인, 제품별·어세이 유형별·용도별 및 지역별 시장 동향 전망, 주요 기업의 개요 등에 대해 조사하여 전해드립니다.

목차

제1장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 분석 방법·범위

제2장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 시장의 정의와 개요

제3장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 개요

제4장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 시장 역학

  • 시장에 대한 영향요인
    • 촉진요인
    • 억제요인
    • 시장 기회
    • 영향 분석

제5장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 업계 분석

  • Porter의 산업 분석
  • 시장 기회
  • 공급망 분석
  • 가격 분석
  • 규제 분석
  • 미충족 요구

제6장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 신종 코로나바이러스 감염증(COVID-19) 분석

  • COVID-19의 시장에 관한 분석
    • COVID-19 이전/과거 시장 시나리오
    • 현재 COVID-19/현재 시장 시나리오
    • COVID-19 이후/향후 시장 시나리오
  • COVID-19 중 가격 동향
  • 수요·공급 스펙트럼
  • 감염 확대시 시장에 대한 정부 구상
  • 제조업체의 전략적 구상
  • 결론

제7장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 제품별

  • 서론
    • 시장 규모 분석·전년 대비 성장률 분석(%) : 제품별
    • 시장 매력 지수 : 제품별
  • 세포주
    • 서론
    • 시장 규모 분석(금액, 2018-2028년)·전년 대비 성장률 분석(%)(2020-2028년)
  • 검출 키트
  • 세포배양 시약
  • 리간드

제8장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 어세이 유형별

  • 서론
  • cAMP 기능 어세이
  • 칼슘 기능 어세이
  • B-아레스틴 기능 어세이
  • 방사성 리간드 결합·GTP 감마 S 기능 어세이
  • 내재화 어세이
  • 트래피킹 어세이
  • 기타 어세이

제9장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 용도별

  • 서론
  • 암연구
  • CNS 연구
  • 대사 연구
  • 심혈관 연구
  • 호흡기 연구
  • 염증 연구
  • 기타 용도

제10장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 지역별

  • 서론
  • 북미
    • 서론
    • 지역 시장 고유의 동향
    • 시장 규모 분석·전년 대비 성장률 분석(%) : 제품별
    • 시장 규모 분석·전년 대비 성장률 분석(%) : 어세이 유형별
    • 시장 규모 분석·전년 대비 성장률 분석(%) : 용도별
    • 시장 규모 분석·전년 대비 성장률 분석(%) : 국가별
  • 유럽
  • 남미
  • 아시아태평양
  • 중동·아프리카

제11장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 경쟁 구도

  • 주요 발전과 전략
  • 기업 점유율 분석
  • 제품 벤치마킹
  • 주목할 만한 주요 기업
  • 파괴적 기술을 가진 기업
  • 스타트업 기업

제12장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : 기업 개요

  • Thermo Fisher Scientific
    • 기업 개요
    • 제품 포트폴리오·개요
    • 주요 하이라이트
    • 재무 개요
  • Abcam plc
  • Enzo Life Sciences, Inc
  • Promega Corporation
  • PerkinElmer Inc
  • Eurofins DiscoverX Products
  • WuXi AppTec(HD Biosciences Co. Ltd)
  • BioInvenu Inc
  • Danaher Corporation(Molecular Devices LLC)
  • Merck KGaA 등

제13장 세계의 G단백질 연결 수용체(GPCR) 타기팅 시장 : DataM

KSA 22.01.26

Market Overview

The global G-protein coupled receptor (GPCR) targeting market size was worth US$ XX million in 2020 and is estimated to reach US$ XX million by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).

G-protein coupled receptor (GPCR), also called seven-transmembrane receptor or heptahelical receptor, is a protein located in the cell membrane that binds extracellular substances and transmits signals from these substances to an intracellular molecule called a G protein (guanine nucleotide-binding protein). They are found in the cell membranes of many organisms, including mammals, plants, microorganisms, and invertebrates. Some examples of GPCRs include beta-adrenergic receptors, which bind epinephrine, prostaglandin E2 receptors, which bind inflammatory substances called prostaglandins; and rhodopsin, which contains a photoreactive chemical called retinal, which response to light signals received by rod cells in the eye.

Market Dynamics

The global G-protein coupled receptor (GPCR) targeting market growth is driven by the rising number of cancer cases, rising prevalence of lifestyle-related issues, such as cardiovascular infections, and respiratory issues. G-protein coupled receptors (GPCRs) are exceptionally helpful in the innovative work of newer medication substances. Furthermore, the increasing government funding for R&D activities in drug discovery and development is anticipated to drive the market growth.

Growing demand for GPCR assays in drug discovery studies expected to drive the market growth

GPCRs respond to a wide range of external stimulus and are a part of several disease etiologies. The wide application of techniques, such as High-Throughput Screening (HTS), combinatorial chemistry, and medicinal chemistry, has led to identifying ligands that modulate the target's activity. This, in turn, has resulted in the effective identification of pharmaceutically relevant drug candidates, which drives the adoption of these receptors in the drug discovery processes. The presence of many approved drugs and drugs under clinical and preclinical studies, which target these receptors, boosts the demand for GPCR screening assays in drug development. Moreover, an increasing number of allosteric modulators, biological drugs, and biased agonists that target these receptors accelerate the demand for associated assays.

Moreover, advancements in the computational approaches to streamline receptor structure contribute to the development of effective drug discovery methods. Researchers from the University of Southern California, the Skolkovo Institute of Science & Technology, and the Moscow Institute of Physics & Technology designed a thermally stable GPCR by a computational method to formulate new drugs.

Companies in the market focus more on research to explore the novel biological functions of the approved and withdrawn drug candidates so that these can be used for other indications as well. Research-based on a custom-designed oligonucleotide GPCR chip by Arena Pharmaceuticals has identified a relative expression of more than seven hundred receptors of high therapeutic importance. This research would be further utilized for the discovery of small molecules.

Complexity in purification of GPCRs is likely to hinder the market growth

The purification of GPCRs is complicated by a number of factors including low abundance, poor stability and structural plasticity leading to multiple conformations. Despite this, several non-rhodopsin GPCR structures have been solved from protein purified using a broadly similar strategy of single or multiple affinity steps. These factors are likely to hamper the market growth.

COVID-19 Impact Analysis

The pandemic COVID-19 viral infection is often associated with severe respiratory and neurological complications, cardiovascular problems, microvascular and endothelial disorders, and gastrointestinal diseases. According to the journal published in PubMed, assumed that GPCR-fAABs play an essential role in developing and maintaining post-COVID symptoms. These GPCR-fAABs persistently stimulate their corresponding receptors, and the fAABs themselves inhibit the receptors' normal, physiological, cell-protective desensitisation.

In other diseases, such as idiopathic dilated cardiomyopathy (here it is the autoantibody targeting the beta1-adrenoceptor), GPCR-fAABs play a significant role in the pathogenesis of the disease. Additionally, removing these fAABs by immunoadsorption led to an improvement in cardiac function and a significant increase in survival rate. These factors are expected to drive the demand for GPCR targeting market.

Segment Analysis

The cancer research segment is expected to hold the largest share in this market segment

More than 700 genes are identified as the G-protein coupled receptors, which form the most significant protein superfamily in the human genome. GPCRs play a vital role in interfering with various physiological events, from sensory modulations to hormonal responses. Recently, a key focus on basic and clinical investigators demonstrated that signaling through GPCRs affects the multiple aspects of cancer biology, such as invasion, migration, and vascular remolding. Hence, the development of GPCR-targeted drugs will provide a novel therapeutic strategy in treating various types of cancers. As GPCR signaling is an important contributor to tumor growth and metastasis, discerning how G protein-coupled receptor kinases (GRKs) regulate GPCR activity in cancer cells may significantly improve the understanding of tumorigenesis and oncogenesis and help develop novel anti-cancer therapies.

Geographical Analysis

North America region holds the largest market share of global G-protein coupled receptor (GPCR) targeting market

The Asia-Pacific region is expected to grow at a significant rate during the forecast period, owing to the economic development of the countries, such as China and India, along with the increasing government investment in the biotechnology and biopharmaceutical sector, increasing life expectancy, rising per capita income, and unmet market needs in the region. Additionally, Asia Pacific is anticipated to be the fastest-growing regional market due to the presence of several emerging companies, such as Sosei Heptares, and NB Health Laboratory. The number of growth initiatives undertaken by the companies to improve their market presence drives regional growth.

Competitive Landscape

The global G-protein coupled receptor targeting market is highly competitive with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Abcam plc, Enzo Life Sciences, Inc, Promega Corporation, PerkinElmer Inc, Thermo Fisher Scientific, Eurofins DiscoverX Products, WuXi AppTec (HD Biosciences Co. Ltd), BioInvenu Inc, Danaher Corporation (Molecular Devices LLC) and Merck KGaA. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the immuno oncology assays globally. For instance, in June 2018, Amgen's erenumab secured the FDA approval as the first G-protein coupled receptor-targeted antibody.

Global G-Protein Coupled Receptor (GPCR) Targeting Market - Key Companies to Watch

Thermo Fisher Scientific Inc

Overview: Thermo Fisher Scientific Inc is one of the world leaders in serving science, with annual revenue of approximately $40 billion. It has global team of more than 100,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.

Product Portfolio: It includes products like Tango GPCR Assay System, GeneBLAzer Assays for GPCRs etc.

Tango GPCR Assay System: The Tango GPCR Assay System is a proprietary platform based upon ligand binding to a specific G protein-coupled receptor (GPCR) that triggers desensitization, a process mediated by the recruitment of protease-tagged arrestin proteins to the activated receptor.

Why Purchase the Report?

  • Visualize the composition of the G-Protein Coupled Receptor (GPCR) Targeting market segmentation by Product, End-user, Application and Region highlighting the key commercial assets and players.
  • Identify commercial opportunities in G-Protein Coupled Receptor (GPCR) Targeting market by analyzing trends and co-development deals.
  • Excel data sheet with thousands of data points of G-Protein Coupled Receptor (GPCR) Targeting market - level 4/5 segmentation.
  • PDF report with the most relevant analysis cogently put together after exhaustive qualitative interviews and in-depth market study.
  • Product mapping in excel for the key product of all major market players

The global G-Protein Coupled Receptor (GPCR) Targeting market report would provide an access to an approx. 61 market data table, 53 figures and 180 pages.

Target Audience

  • Service Providers/ Buyers
  • Industry Investors/Investment Bankers
  • Education & Research Institutes
  • Research Professionals
  • Emerging Companies
  • Manufacturers

Market Segmentation

Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Product

  • Cell Lines
  • Detection Kits
  • Cell Culture Reagents
  • Ligands

Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Assay Type

  • cAMP Functional Assays
  • Calcium Functional Assays
  • B-Arrestin Functional Assays
  • Radioligand Binding and GTPγS Functional Assays
  • Internalization Assays
  • Trafficking Assays
  • Other Assays

Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Application

  • Cancer Research
  • CNS Research
  • Metabolic Research
  • Cardiovascular Research
  • Respiratory Research
  • Inflammation Research
  • Other Application

Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Region

  • North America
  • Europe
  • Asia-Pacific
  • Middle East & Africa
  • South America

Table of Contents

1. Global G-Protein Coupled Receptor (GPCR) Targeting Market Methodology and Scope

  • 1.1. Research Methodology
  • 1.2. Research Objective and Scope of the Report

2. Global G-Protein Coupled Receptor (GPCR) Targeting Market - Market Definition and Overview

3. Global G-Protein Coupled Receptor (GPCR) Targeting Market - Executive Summary

  • 3.1. Market Snippet by Product
  • 3.2. Market Snippet by Assay Type
  • 3.3. Market Snippet by Application
  • 3.4. Market Snippet by Region

4. Global G-Protein Coupled Receptor (GPCR) Targeting Market - Market Dynamics

  • 4.1. Market Impacting Factors
    • 4.1.1. Drivers
      • 4.1.1.1. Growing demand for GPCR assays in drug discovery studies
    • 4.1.2. Restraints:
      • 4.1.2.1. Complexity in purification of GPCRs
    • 4.1.3. Opportunity
    • 4.1.4. Impact Analysis

5. Global G-Protein Coupled Receptor (GPCR) Targeting Market - Industry Analysis

  • 5.1. Porter's Five Forces Analysis
  • 5.2. Opportunities
  • 5.3. Supply Chain Analysis
  • 5.4. Pricing Analysis
  • 5.5. Regulatory Analysis
  • 5.6. Unmet Needs

6. Global G-Protein Coupled Receptor (GPCR) Targeting Market - COVID-19 Analysis

  • 6.1. Analysis of Covid-19 on the Market
    • 6.1.1. Before COVID-19 Market Scenario
    • 6.1.2. Present COVID-19 Market Scenario
    • 6.1.3. After COVID-19 or Future Scenario
  • 6.2. Pricing Dynamics Amid Covid-19
  • 6.3. Demand-Supply Spectrum
  • 6.4. Government Initiatives Related to the Market During Pandemic
  • 6.5. Manufacturers Strategic Initiatives
  • 6.6. Conclusion

7. Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Product

  • 7.1. Introduction
    • 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Segment
    • 7.1.2. Market Attractiveness Index, By Product Segment
  • 7.2. Cell Lines*
    • 7.2.1. Introduction
    • 7.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 7.3. Detection Kits
  • 7.4. Cell Culture Reagents
  • 7.5. Ligands

8. Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Assay Type

  • 8.1. Introduction
    • 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-user
    • 8.1.2. Market Attractiveness Index, By End-user
  • 8.2. cAMP Functional Assays*
    • 8.2.1. Introduction
    • 8.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 8.3. Calcium Functional Assays
  • 8.4. B-Arrestin Functional Assays
  • 8.5. Radioligand Binding and GTPγS Functional Assays
  • 8.6. Internalization Assays
  • 8.7. Trafficking Assays
  • 8.8. Other Assays

9. Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Application

  • 9.1. Introduction
    • 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application Segment
    • 9.1.2. Market Attractiveness Index, By Application Segment
  • 9.2. Cancer Research*
    • 9.2.1. Introduction
    • 9.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 9.3. CNS Research
  • 9.4. Metabolic Research
  • 9.5. Cardiovascular Research
  • 9.6. Respiratory Research
  • 9.7. Inflammation Research
  • 9.8. Other Application

10. Global G-Protein Coupled Receptor (GPCR) Targeting Market - By Region

  • 10.1. Introduction
    • 10.1.1. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028, By Region
    • 10.1.2. Market Attractiveness Index, By Region
  • 10.2. North America
    • 10.2.1. Introduction
    • 10.2.2. Key Region-Specific Dynamics
    • 10.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Assay Type
    • 10.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.2.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.2.6.1. U.S.
      • 10.2.6.2. Canada
      • 10.2.6.3. Mexico
  • 10.3. Europe
    • 10.3.1. Introduction
    • 10.3.2. Key Region-Specific Dynamics
    • 10.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Assay Type
    • 10.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.3.6.1. Germany
      • 10.3.6.2. U.K.
      • 10.3.6.3. France
      • 10.3.6.4. Italy
      • 10.3.6.5. Spain
      • 10.3.6.6. Rest of Europe
  • 10.4. South America
    • 10.4.1. Introduction
    • 10.4.2. Key Region-Specific Dynamics
    • 10.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Assay Type
    • 10.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.4.6.1. Brazil
      • 10.4.6.2. Argentina
      • 10.4.6.3. Rest of South America
  • 10.5. Asia Pacific
    • 10.5.1. Introduction
    • 10.5.2. Key Region-Specific Dynamics
    • 10.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Assay Type
    • 10.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.5.6.1. China
      • 10.5.6.2. India
      • 10.5.6.3. Japan
      • 10.5.6.4. Australia
      • 10.5.6.5. Rest of Asia Pacific
  • 10.6. Middle East and Africa
    • 10.6.1. Introduction
    • 10.6.2. Key Region-Specific Dynamics
    • 10.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Assay Type
    • 10.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application

11. Global G-Protein Coupled Receptor (GPCR) Targeting Market - Competitive Landscape

  • 11.1. Key Developments and Strategies
  • 11.2. Company Share Analysis
  • 11.3. Product Benchmarking
  • 11.4. Key Companies to Watch
  • 11.5. Company with disruptive technology
  • 11.6. Start Up Companies

12. Global G-Protein Coupled Receptor (GPCR) Targeting Market- Company Profiles

  • 12.1. Thermo Fisher Scientific*
    • 12.1.1. Company Overview
    • 12.1.2. Product Portfolio and Description
    • 12.1.3. Key Highlights
    • 12.1.4. Financial Overview
  • 12.2. Abcam plc
  • 12.3. Enzo Life Sciences, Inc
  • 12.4. Promega Corporation
  • 12.5. PerkinElmer Inc
  • 12.6. Eurofins DiscoverX Products
  • 12.7. WuXi AppTec (HD Biosciences Co. Ltd)
  • 12.8. BioInvenu Inc
  • 12.9. Danaher Corporation (Molecular Devices LLC)
  • 12.10. Merck KGaA

LIST NOT EXHAUSTIVE

13. Global G-Protein Coupled Receptor (GPCR) Targeting Market - DataM

  • 13.1. Appendix
  • 13.2. About Us and Services
  • 13.3. Contact Us
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