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세계의 KRAS 저해제 시장 : 기회와 임상시험 전망

Global KRAS Inhibitors Market Opportunity & Clinical Trials Outlook 2025

리서치사 KuicK Research
발행일 2021년 01월 상품 코드 979967
페이지 정보 영문 125 Pages
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세계의 KRAS 저해제 시장 : 기회와 임상시험 전망 Global KRAS Inhibitors Market Opportunity & Clinical Trials Outlook 2025
발행일 : 2021년 01월 페이지 정보 : 영문 125 Pages

본 상품은 영문 자료로 한글과 영문목차에 불일치하는 내용이 있을 경우 영문을 우선합니다. 정확한 검토를 위해 영문목차를 참고해주시기 바랍니다.

KRAS 저해제는 시장에 관련된 훌륭한 연구개발 파이프라인에 의해 암 치료제 시장의 주요 신규 부문 중 하나라고 말할 수 있습니다.

세계의 KRAS 저해제(KRAS Inhibitor) 시장에 대해 조사분석했으며, 시장 기회, 시장 점유율, 임상시험 중인 약제, 시장 동향, 시장 역학, 향후 기회 전망에 대한 정보를 제공합니다.

목차

제1장 KRAS 저해제의 서론

제2장 암에서 KRAS 저해제의 역할

제3장 KRAS 저해제 : 작용기전

제4장 폐암을 표적으로 하는에서의 KRAS 저해제

  • 폐암에 대한 KRAS 저해제의 영향
  • 진행중인 연구개발

제5장 췌장암에서의 KRAS 저해제

  • 췌장암에서 KRAS 저해제의 역할
  • KRAS 저해제를 표적으로 하는 췌장암의 최근 진보

제6장 대장암에서의 KRAS 저해제

  • 대장암에 대한 KRAS 저해제의 가능성
  • 진행중인 연구개발

제7장 기타 암에 대한 KRAS 저해제

  • 혈액암 치료제로서 KRAS 저해제의 가능성
  • 전립선암에서의 KRAS 저해제
  • 위암에서의 KRAS 저해제
  • 자궁내막암에서의 KRAS 저해제
  • 뇌종양에서 KRAS 저해제의 역할

제8장 세계의 KRAS 단백질 저해제 임상시험 지표

  • 단계별
  • 국가별
  • 기업별
  • 적응증별
  • 환자별

제9장 세계의 KRAS 단백질 저해제 임상 파이프라인 : 기업별, 적응증별, 단계별

  • 연구
  • 전임상
  • Phase-I
  • Phase-I/II
  • Phase-II
  • Phase-III

제10장 세계의 KRAS 저해제 시장 분석 : 현재 시나리오

제11장 세계의 KRAS 저해제 시장 동향

제12장 세계의 KRAS 저해제 시장 역학

  • KRAS 저해제 시장 성장 촉진요인
  • KRAS 저해제 시장이 해결해야 할 과제

제13장 세계의 KRAS 저해제 시장 기회 전망

제14장 경쟁 구도

  • Amgen
  • Mirati Therapeutics
  • Revolution Medicines
  • Boehringer Ingelheim
  • Merck
  • Moderna
  • Silenseed
  • Johnson & Johnson
  • Eli Lilly
  • Oblique Therapeutics
  • Cotinga Pharmaceuticals
  • Codiak Biosciences
  • Gilead
LSH 21.01.13

List of Figures

  • Figure 1-1: RAS Mutation - Frequency of KRAS Mutation v/s HRAS & NRAS Mutations
  • Figure 1-2: Historical Development of KRAS Inhibitors
  • Figure 2-1: KRAS Mutational Frequency by Organs (%)
  • Figure 2-2: Roles of KRAS Inhibitors in Cancer Treatment
  • Figure 3-1: General Mechanism of KRAS Inhibitors against Cancer
  • Figure 3-2: Targeting Approaches of KRAS Inhibitors
  • Figure 3-3: Direct Targeting of Mutant KRAS
  • Figure 3-4: Targets for Modifying the KRAS Membrane Association
  • Figure 4-1: Global - Newly Diagnosed Cases & Deaths related to Lung Cancer (Million), 2020
  • Figure 4-2: Global - Lung Cancer Incidence by Type (%), 2020
  • Figure 4-3: Impact of KRAS Inhibitor on Lung Cancer
  • Figure 4-4: Investigational KRAS Inhibitors for Lung Cancer
  • Figure 4-5: Codebreak 200 Trial - Study Initiation & Expected Completion Year
  • Figure 4-6: Codebreak 105 Trial - Study Initiation & Expected Completion Year
  • Figure 4-7: Codebreak 101 Trial - Study Initiation & Expected Completion Year
  • Figure 4-8: Krystal 7 trial - Study Initiation & Expected Completion Year
  • Figure 4-9: Krystal 1 trial - Study Initiation & Expected Completion Year
  • Figure 4-10: Krystal 2 trial - Study Initiation & Expected Completion Year
  • Figure 4-11: BI-1701963 Phase I Trial - Study Initiation & Expected Completion Year
  • Figure 4-12: mRNA-5671 Phase I Trial - Study Initiation & Expected Completion Year
  • Figure 4-13: Mechanism of BI-2852 against Lung Cancer
  • Figure 5-1: Global - Newly Diagnosed Cases & Deaths related to Pancreatic Cancer, 2020
  • Figure 5-2: Ideal Targets of Inhibiting KRAS Mutation of Pancreatic Cancer
  • Figure 5-3: Role of KRAS Inhibitors in Pancreatic Cancer
  • Figure 5-4: Investigational KRAS Inhibitors for Pancreatic Cancer
  • Figure 5-5: siG12D LODER Phase II Trial - Study Initiation & Expected Completion Year
  • Figure 5-6: iExosomes Phase I Trial - Study Initiation & Expected Completion Year
  • Figure 5-7: KRAS mTCR PBL Phase I/II Trial - Study Initiation & Expected Completion Year
  • Figure 6-1: Global - Newly Diagnosed Cases & Deaths related to Colon Cancer (Million), 2020
  • Figure 6 -: Global - Newly Diagnosed Cases & Deaths related to Rectum Cancer (Million), 2020
  • Figure 6-3: Ideal Targets for Inhibiting KRAS Mutation of Pancreatic Cancer
  • Figure 6-4: Investigational KRAS Inhibitors for Colorectal Cancer
  • Figure 7-1: Global - Newly Diagnosed Cases by Leading Types of Blood Cancer, 2020
  • Figure 7-2: Global - Newly Diagnosed Cases by Leading Types of Blood Cancer, 2020
  • Figure 7-3: Frequency of KRAS Mutation in Hematological Cancer (%)
  • Figure 7-4: Global - Newly Diagnosed Cases & Deaths related to Prostate Cancer (Million), 2020
  • Figure 7-5: Global - Number of Newly Diagnosed Gastric Cancer Cases & Deaths, 2020
  • Figure 7-6: Global - Number of Newly Diagnosed Cases of Endometrial Cancer by Type, 2020
  • Figure 7-7: Global - Number of Deaths of Endometrium Cancer by Type, 2020
  • Figure 7-8: Global - Newly Diagnosed Cases & Deaths related to Brain Cancer, 2020
  • Figure 8-1: Global - KRAS Protein inhibitors Clinical Trials by Phase, 2020 -2025
  • Figure 8-2: Global - KRAS Protein inhibitors Clinical Trials by Country, 2020 -2025
  • Figure 8-3: Global - KRAS Protein inhibitors Clinical Trials by Company, 2020 -2025
  • Figure 8-4: Global - KRAS Protein inhibitors Clinical Trials by Indication, 2020 -2025
  • Figure 8-5: Global - KRAS Protein inhibitors Clinical Trials by Patient Segment, 2020 -2025
  • Figure 12-1: Drivers for KRAS Inhibitor Market
  • Figure 12-2: Challenges for KRAS Inhibitor Market
  • Figure 12-3: Global - Estimated Monthly Treatment Cost of AMG 150 v/s Other Cell Signal Targeting Therapeutics
  • Figure 13-1:- US - Expected Monthly & Full Treatment Cost of KRAS Inhibitors (US$), November'2020
  • Figure 13-2: Global - Estimated KRAS Inhibitors Market (US$ Million), 2023 - 2025
  • Figure 13-3: US v/s Non US Markets - KRAS Inhibitors Market Share (%), 2023 - 2025

"Global KRAS Inhibitors Market Opportunity & Clinical Trials Outlook 2025" Report Highlights:

  • KRAS Inhibitors Market Opportunity: > USD 1 Billion by 2025
  • Initially US To Dominate KRAS Inhibitors Market: >90% Market Share
  • Number of KRAS Inhibitors In Trials: > 20 Drugs
  • Highest Phase of Clinical Development: Phase-III Study
  • Solid Tumors Targeted Drugs Dominating The Clinical Trials
  • Global KRAS Inhibitors Market Trends & Dynamics
  • Global KRAS Inhibitors Market Future Opportunity Outlook

The accelerating pace of the cancer cases at global level has led to the arrival of a unique and application-based therapy market, known as KRAS inhibitors. In the past few years, the therapy has been able to show favorable response involving the cell cycle, which is the ultimate target of the cancer cells for continue its proliferation and division in the patients. A cluster of innovative drugs that target KRAS protein has been developed by the researchers and bunch of novel product candidate targeting KRAS protein is currently active in the clinical trials. It can be stated for KRAS inhibitors that it is among the top emerging sectors of the cancer therapeutics market which is due to the splendid research and development pipeline associated with the market. The entire market associated with KRAS inhibitors, in a very short period of time has been able to shift the entire cancer landscape, thus resulting in the standard care of cancer treatment with appropriate opportunities to the patients and the investors.

The drugs developed under the market, inhibits KRAS protein and further the important signaling pathways, ultimately leading to the cell cycle arrest and killing of the cancer cells. Such switching on and off of the cell cycle with the help of hundreds of KRAS inhibitors developed by the researchers is estimated to improve the overall paradigm for efficient targeting, minimal side-effect development, increased effectiveness and efficiency against different types of tumor antigens. The overall increase in the spending for research-based formulas for KRAS inhibitors is also estimated to develop a market that is worth trillions of dollars and decrease the burden that is getting reflected in the cancer therapeutics market with respect to efficient targeting of the cancer cells.

Despite having numerous challenges which were set by the already driven cancer therapies in the market such as chemotherapy or radiation therapy, the novel KRAS inhibitor market has made its impact on the overall running paradigm of cancer therapeutics at global level. The pharmaceutical research sector affiliated with KRAS inhibitor market has weathered down the complex challenges of developing drug candidates with 100% efficacy.

Now-a-days, the KRAS inhibitor market at global level is getting adjoined with novel techniques and technologies that are apparently leading to reinventing the entire cancer market and research-based sector. No doubt, the entire market has led to an opening of novel frontiers that could unravel the complex mechanism of cancer cells and how it could get regulated by controlling the proteins responsible for cell cycle. In addition to this, some of the parameters that are leading to the exponential growth of the market in the past few years include: healthcare benefits associated with the drug candidates and increased awareness about the side-effects of old and traditional cancer therapies such as chemotherapy.

As per the "Global KRAS Inhibitors Market Opportunity & Clinical Trials Outlook 2025" report findings, it can be estimated that the market is completely getting catalyzed by the increased applications of healthcare benefits and variety of disruptive technologies and drug candidates that are available in the market for different types of tumor antigens. In the novel cancer therapeutics market, partly driven by KRAS inhibitor is believed to be overcoming all the challenges that were difficult to crack before the arrival of the KRAS inhibitor therapy.

Table of Contents

1. Introduction to KRAS Inhibitors

  • 1.1 Overview
  • 1.2 Evolution of KRAS Inhibitors

2. Role of KRAS Inhibitors in Cancer

3. KRAS Inhibitors - Mode of Action

4. KRAS Inhibitors For Targeting Lung Cancer

  • 4.1 Impact of KRAS Inhibitors on Lung Cancer
  • 4.2 Ongoing Research & Development
    • 4.2.1 AMG 510 (Sotorasib)
    • 4.2.2 MRTX849 (Adagrasib)
    • 4.2.3 Other Investigational KRAS Inhibitors for Lung Cancer

5. KRAS Inhibitors in Pancreatic Cancer

  • 5.1 Role of KRAS Inhibitors in Pancreatic Cancer
  • 5.2 Recent Advancement in Pancreatic Cancer Targeting KRAS Inhibitors

6. KRAS Inhibitors for Colorectal Cancer

  • 6.1 Potential of KRAS Inhibitors Against Colorectal Cancer
  • 6.2 Ongoing Research & Development

7. KRAS inhibitors For Other Cancers

  • 7.1 Potential of KRAS Inhibitors as Hematological Cancer Therapeutics
  • 7.2 KRAS inhibitors in Prostate Cancer
  • 7.3 KRAS Inhibitors for Gastric Cancer
  • 7.4 KRAS Inhibition in Endometrium Cancer
  • 7.5 Role of KRAS Inhibitors in Brain Cancer

8. Global KRAS Protein inhibitors Clinical Trials Indicators

  • 8.1 By Phase
  • 8.2 By Country
  • 8.3 By Company
  • 8.4 By Indication
  • 8.5 By Patient Segment

9. Global KRAS Protein Inhibitors Clinical Pipeline By Company, Indication & Phase

  • 9.1 Research
  • 9.2 Preclinical
  • 9.3 Phase-I
  • 9.4 Phase-I/II
  • 9.5 Phase-II
  • 9.6 Phase-III

10. Global KRAS Inhibitors Market Analysis: Current Scenario

11. Global KRAS Inhibitors Market Trends

  • 11.1 Revolution Medicines' KRAS-G12(ON) Inhibitor Shows Prominent Anti-Tumor Activity
  • 11.2 Boehringer Ingelheim & Mirati Therapeutics Collaborated to Study Combinational KRAS Inhibitor Therapy
  • 11.3 Merck Signed a Licensing Deal with Taiho & Astex for Developing KRAS Targeting Therapies
  • 11.4 Strata Collaborated with Mirati Therapeutics for Conducting Trial of MRTX849
  • 11.5 Revolution Medicine Collaborated with Amgen to Evaluate SHP2 & KRAS Inhibitors Combinational Therapy
  • 11.6 Oncogenuity - New Player in KRAS Inhibitor Development
  • 11.7 Miratis & Novartis Collaborated to Assess KRAS Inhibitor Based Combinational Therapy

12. Global KRAS Inhibitors Market Dynamics

  • 12.1 Driving Factors for KRAS Inhibitor Market
  • 12.2 Challenges for KRAS Inhibitors Market

13. Global KRAS Inhibitors Market Future Opportunity Outlook

14. Competitive Landscape

  • 14.1 Amgen
  • 14.2 Mirati Therapeutics
  • 14.3 Revolution Medicines
  • 14.4 Boehringer Ingelheim
  • 14.5 Merck
  • 14.6 Moderna
  • 14.7 Silenseed
  • 14.8 Johnson & Johnson
  • 14.9 Eli Lilly
  • 14.10 Oblique Therapeutics
  • 14.11 Cotinga Pharmaceuticals
  • 14.12 Codiak Biosciences
  • 14.13 Gilead
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