림프구활성화 유전자 3 단백질 : 파이프라인 리뷰

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림프구활성화 유전자 3 단백질(LAG-3)을 표적으로 한 치료제 개발 파이프라인의 현황과 최신 업데이트에 의한 각 개발 단계 비교 분석, 기업 및 연구기관에 의해 개발중인 치료제, 치료제 평가, 후기 단계 및 중지된 프로젝트에 관한 정보 등을 최신 뉴스 및 발표와 함께 정리하여 전해드립니다.

서론

• 조사 범위

림프구활성화 유전자 3 단백질(LAG-3) 개요

치료제 개발

• 개발중인 제품 : 개발 단계별
• 개발중인 제품 : 치료 영역별
• 개발중인 제품 : 증상별
• 기업에서 개발중인 제품

치료제 평가

• 작용기서별
• 투여 경로별
• 분자 유형별

치료제 개발에 참여하고 있는 기업

• Boehringer Ingelheim GmbH
• Bristol-Myers Squibb Company
• Crescendo Biologics Ltd
• Enumeral Biomedical Holdings Inc
• GlaxoSmithKline Plc
• Icell Kealex Therapeutics
• Incyte Corp
• MacroGenics Inc
• Merck & Co Inc
• Novartis AG
• Prima BioMed Ltd
• Regeneron Pharmaceuticals Inc
• Sutro Biopharma Inc
• Symphogen A/S
• Tesaro Inc
• Trellis Bioscience Inc
• Xencor Inc

약제 개요

휴지중인 프로젝트

제품 개발 마일스톤

• 주요 뉴스와 프레스 릴리스

부록

도표

List of Tables

• Number of Products under Development by Stage of Development, H2 2019
• Number of Products under Development by Therapy Areas, H2 2019
• Number of Products under Development by Indications, H2 2019
• Number of Products under Development by Indications, H2 2019 (Contd..1), H2 2019
• Number of Products under Development by Indications, H2 2019 (Contd..2), H2 2019
• Number of Products under Development by Companies, H2 2019
• Number of Products under Development by Companies, H2 2019 (Contd..1)
• Products under Development by Companies, H2 2019
• Products under Development by Companies, H2 2019 (Contd..1), H2 2019
• Products under Development by Companies, H2 2019 (Contd..2), H2 2019
• Products under Development by Companies, H2 2019 (Contd..3), H2 2019
• Products under Development by Companies, H2 2019 (Contd..4), H2 2019
• Products under Development by Companies, H2 2019 (Contd..5), H2 2019
• Products under Development by Companies, H2 2019 (Contd..6), H2 2019
• Products under Development by Companies, H2 2019 (Contd..7), H2 2019
• Products under Development by Companies, H2 2019 (Contd..8), H2 2019
• Number of Products by Stage and Mechanism of Actions, H2 2019
• Number of Products by Stage and Route of Administration, H2 2019
• Number of Products by Stage and Molecule Type, H2 2019
• Pipeline by Abeome Corp, H2 2019
• Pipeline by Avacta Life Sciences Ltd, H2 2019
• Pipeline by BJ Bioscience Inc, H2 2019
• Pipeline by Boehringer Ingelheim International GmbH, H2 2019
• Pipeline by Bristol-Myers Squibb Co, H2 2019
• Pipeline by Crescendo Biologics Ltd, H2 2019
• Pipeline by Eli Lilly and Co, H2 2019
• Pipeline by F-star Biotechnology Ltd, H2 2019
• Pipeline by F. Hoffmann-La Roche Ltd, H2 2019
• Pipeline by Fountain Biopharma Inc, H2 2019
• Pipeline by GigaGen Inc, H2 2019
• Pipeline by GlaxoSmithKline Plc, H2 2019
• Pipeline by I-Mab Biopharma Co Ltd, H2 2019
• Pipeline by ILGEN Inc, H2 2019
• Pipeline by Immutep Ltd, H2 2019
• Pipeline by Incyte Corp, H2 2019
• Pipeline by Innovent Biologics Inc, H2 2019
• Pipeline by Leads Biolabs Inc, H2 2019
• Pipeline by Leidos Health, H2 2019
• Pipeline by Lipid Genomics Inc, H2 2019
• Pipeline by MacroGenics Inc, H2 2019
• Pipeline by Merck & Co Inc, H2 2019
• Pipeline by Novartis AG, H2 2019
• Pipeline by Regeneron Pharmaceuticals Inc, H2 2019
• Pipeline by Shanghai Henlius Biotech Inc, H2 2019
• Pipeline by Stcube Inc, H2 2019
• Pipeline by Sutro Biopharma Inc, H2 2019
• Pipeline by Symphogen A/S, H2 2019
• Pipeline by Xencor Inc, H2 2019
• Pipeline by Y-Biologics, H2 2019
• Dormant Projects, H2 2019

List of Figures

• Number of Products under Development by Stage of Development, H2 2019
• Number of Products under Development by Therapy Areas, H2 2019
• Number of Products under Development by Top 10 Indications, H2 2019
• Number of Products by Mechanism of Actions, H2 2019
• Number of Products by Stage and Mechanism of Actions, H2 2019
• Number of Products by Routes of Administration, H2 2019
• Number of Products by Stage and Routes of Administration, H2 2019
• Number of Products by Molecule Types, H2 2019
• Number of Products by Stage and Molecule Types, H2 2019

Summary

Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Lymphocyte-activation gene 3 or LAG-3 is a protein encoded by the LAG3 gene. It is involved in the maturation and activation of dendritic cells and lymphocyte activation. It binds to HLA class-II antigens.

Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) pipeline Target constitutes close to 34 molecules. The molecules developed by companies in Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical, Discovery and Unknown stages are 2, 5, 7, 1, 13, 5 and 1 respectively. Report covers products from therapy areas Oncology, Central Nervous System, Immunology, Cardiovascular, Gastrointestinal and Infectious Disease which include indications Solid Tumor, Non-Small Cell Lung Cancer, Melanoma, Gastric Cancer, Adenocarcinoma Of The Gastroesophageal Junction, Diffuse Large B-Cell Lymphoma, Head And Neck Cancer Squamous Cell Carcinoma, Metastatic Melanoma, Triple-Negative Breast Cancer (TNBC), Cervical Cancer, Hepatocellular Carcinoma, Lymphoma, Ovarian Cancer, Small-Cell Lung Cancer, Colon Carcinoma, Colorectal Cancer, Endometrial Cancer, Esophageal Cancer, Gastroesophageal (GE) Junction Carcinomas, Hematological Tumor, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Malignant Mesothelioma, Metastatic Colorectal Cancer, Metastatic Hepatocellular Carcinoma (HCC), Metastatic Renal Cell Carcinoma, Non-Hodgkin Lymphoma, Advanced Malignancy, Autoimmune Disorders, Bile Duct Cancer (Cholangiocarcinoma), Bladder Cancer, Blood Cancer, Breast Cancer, Cardiovascular Disease, Chronic Inflammation, Chronic Lymphocytic Leukemia (CLL), Epithelial Ovarian Cancer, Fallopian Tube Cancer, Glioblastoma Multiforme (GBM), Gliosarcoma, Inflammatory Bowel Disease, Kidney Cancer (Renal Cell Cancer), Liposarcoma, Merkel Cell Carcinoma, Metastatic Ovarian Cancer, Metastatic Pancreatic Cancer, Metastatic Transitional (Urothelial) Tract Cancer, Multiple Myeloma (Kahler Disease), Multiple Sclerosis, Nasopharyngeal Cancer, Neuroendocrine Tumors, Peritoneal Cancer, Prostate Cancer, Recurrent Glioblastoma Multiforme (GBM), Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Renal Cell Carcinoma, Rheumatoid Arthritis, Soft Tissue Sarcoma and Transitional Cell Carcinoma (Urothelial Cell Carcinoma).

The latest report Lymphocyte Activation Gene 3 Protein - Pipeline Review, H2 2019, outlays comprehensive information on the Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) targeted therapeutics development with respective active and dormant or discontinued projects.

The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Scope

• The report provides a snapshot of the global therapeutic landscape for Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3)
• The report reviews Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
• The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
• The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
• The report reviews key players involved in Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) targeted therapeutics and enlists all their major and minor projects
• The report assesses Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
• The report summarizes all the dormant and discontinued pipeline projects
• The report reviews latest news and deals related to Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) targeted therapeutics

Reasons to buy

• Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
• Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
• Identify and understand the targeted therapy areas and indications for Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3)
• Identify the use of drugs for target identification and drug repurposing
• Identify potential new clients or partners in the target demographic
• Develop strategic initiatives by understanding the focus areas of leading companies
• Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
• Devise corrective measures for pipeline projects by understanding Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) development landscape
• Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

List of Tables

List of Figures

• Introduction
• Global Markets Direct Report Coverage
• Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Overview
• Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Therapeutics Development
• Products under Development by Stage of Development
• Products under Development by Therapy Area
• Products under Development by Indication
• Products under Development by Companies
• Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Therapeutics Assessment
• Assessment by Mechanism of Action
• Assessment by Route of Administration
• Assessment by Molecule Type
• Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Companies Involved in Therapeutics Development
• Abeome Corp
• Avacta Life Sciences Ltd
• BJ Bioscience Inc
• Boehringer Ingelheim International GmbH
• Bristol-Myers Squibb Co
• Crescendo Biologics Ltd
• Eli Lilly and Co
• F-star Biotechnology Ltd
• F. Hoffmann-La Roche Ltd
• Fountain Biopharma Inc
• GigaGen Inc
• GlaxoSmithKline Plc
• I-Mab Biopharma Co Ltd
• ILGEN Inc
• Immutep Ltd
• Incyte Corp
• Innovent Biologics Inc
• Leads Biolabs Inc
• Leidos Health
• Lipid Genomics Inc
• MacroGenics Inc
• Merck & Co Inc
• Novartis AG
• Regeneron Pharmaceuticals Inc
• Shanghai Henlius Biotech Inc
• Stcube Inc
• Sutro Biopharma Inc
• Symphogen A/S
• Xencor Inc
• Y-Biologics
• Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Drug Profiles
• (nivolumab + relatlimab) - Drug Profile
• Product Description
• Mechanism Of Action
• R&D Progress
• AM-0003 - Drug Profile
• Product Description
• Mechanism Of Action
• R&D Progress
• AVA-021 - Drug Profile
• Product Description
• Mechanism Of Action
• R&D Progress
• Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Dormant Products
• Lymphocyte Activation Gene 3 Protein (Protein FDC or CD223 or LAG3) - Product Development Milestones
• Featured News & Press Releases
• Appendix
• Methodology
• Coverage
• Secondary Research
• Primary Research
• Expert Panel Validation
• Contact Us
• Disclaimer