3D 세포배양 : 기술과 세계 시장

Highlights:

The global market for 3D cell culture is estimated to increase from $4.6 billion in 2023 to reach $14.8 billion by 2028, at a compound annual growth rate (CAGR) of 26.5% from 2023 through 2028.

The global market for 3D cell culture for research segment is estimated to increase from $2.3 billion in 2023 to reach $7.8 billion by 2028, at a CAGR of 27.3% from 2023 through 2028.

The global market for 3D cell culture for bioprocessing segment is estimated to increase from $2.2 billion in 2023 to reach nearly $7.0 billion by 2028, at a CAGR of 25.7% from 2023 through 2028.

Report Scope:

This report aims to provide a comprehensive study of the global 3D cell culture technologies market. It provides a detailed description of the different types of healthcare interoperability solutions and their current and historical market revenues.

The scope of the report encompasses the major types of 3D cell culture which are being used by industry, academic researchers, government labs, and independent research groups. This includes the main inputs such as cell lines, media, sera, reagents, software, and instrumentation. It analyzes the current market status, examines future market drivers and presents forecasts of growth over the next five years.

The market structure has been reorganized for this edition. Also, more research was done on base case data for different product areas. The greater emphasis is on the different products used for 3D cell culture, but the report also investigates the market in terms of types of applications, end users and geographic regions.

Report Includes:

• 17 data tables and 105 additional tables
• An overview of the global market landscape related to the 3D cell cultures technologies
• In-depth analysis of global market trends, featuring historical revenue data for 2020-2022, estimated figures for 2023, as well as forecasts for 2028. This analysis includes projections of Compound Annual Growth Rates (CAGRs) spanning through 2028
• Evaluation of the current market size and revenue growth prospects specific to 3D cell cultures technologies, accompanied by a comprehensive market share analysis categorized by type, end user, and geographical region
• Information on analytical systems used in tissue and cell culture, cellomics, and human cancer model initiative (HCMI)
• Details about assay development for mesenchymal stem cells, In Vitro testing of adventitious agents and description of assays and assay kits
• A look at the main classes of models for researching cancer and other diseases, benefits of 3D models to cancer research and description of 3D engineered scaffolds
• Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities and discussion on the impact of COVID-19 on the world of cell culture
• Insights into U.S. regulatory status of bioprinted products; basic guidance for the regulation of biologics, regenerative medicine and xenotransplants
• Relevant patent analysis, including recent activity and a list of key patents
• Detailed profiles of leading market participants, providing a descriptive overview of their respective businesses, including Abcam PLC, Agilent Technologies Inc., Corning Inc., Merck KGAA, Beckman Coulter, and Synvivo Inc.

Table of Contents

Chapter 1 Introduction

• Study Goals and Objectives
• Reasons for Doing the Study
• Scope of Report
• What's New in This Report?
• Methodology and Information Sources
• Geographic Breakdown
• Segment Breakdown

Chapter 2 Summary and Highlights

• Market Outlook
• Market Summary

Chapter 3 Market Overview

• An Opening Comment on an Amazing Industry
• Industry Issues
• In Vitro versus In Vivo
• Dimensionality
• The Research Chain for 2D and 3D Cell Culture
• Best Practices
• Standardization
• Regulation
• Genomics Forcing the Hand of the FDA
• Leachables and Extractables
• Broad Issues
• Research Talent Shortages
• The Shifting International Picture
• Pace and Diversification of Innovation
• A Comment on the "Other" Areas of Cell Culture
• Omics Everywhere
• Is 2020 a Watershed Year for the Cell Culture Industry?
• Preliminary Market Analysis
• Cell Culture Market Growth Rate Estimates
• Assessing Large-Scale Media Consumption Needs
• Modeling Future Growth in Biopharmaceuticals
• Base Case for the Cell Culture Market
• Challenges in Projecting Sales and Growth
• Cell Culture Media Market Estimates
• Cell and Gene Therapy Bioprocessing Segment
• Evaluating Media Consumption for Biosimilars
• What About CDMOs?
• Microfluidics
• Bioreactors
• Internal Cell Culture Resources
• Is There Too Much Concentration of Ownership in Biotechnology?
• Characterizing Innovation in 3D Cell Culture
• Bioprinting Strategic Roadmap

Chapter 4 Market, by Type

• Where Did Tissue and Cell Culture Start?
• History and Early Applications
• Invention of Tissue Culture
• Development of Sustained Cell Lines
• First Cell Culture Flask and Rigorous Techniques
• Lindbergh: The Cell Culture Equipment Pioneer
• Establishing Continuous Cell Lines
• Key Developments in Equipment
• Terminology and Concepts
• Tissue and Cell Culture Industry
• Tissue Culture and Cell Culture Definitions
• Cell Lines
• Care and Growth of Cell Culture Systems
• Media, Sera, and Reagents
• Gels and Scaffolds
• Microplates/Microtiter Plates
• Bioanalytical Instruments
• Bioanalytical Imaging
• Bioprinting
• Bioreactors
• Other Equipment for Cell Culture
• Adherent Approaches
• Traditional Roller Bottles
• Other Systems
• Information Technology: Software and Services for the Cell Culture Research Market
• Software for the Research Market in Cell Culture
• Software-Related Support Services
• Bioprocessing Consumables for Cell Culture
• Microcarriers for Large-Scale 3D Culture
• Sera for Large-Scale 3D Culture
• Media for Large-Scale 3D Culture
• Bioreactor Bags for Large-Scale 3D Culture
• Other
• Bioprocessing Equipment
• Analytical Equipment for Bioprocessing
• Automation Systems for Bioprocessing
• Support Equipment for Bioprocessing
• Aspects of Large-Scale Manufacturing of Biopharmaceuticals and Vaccines
• Suspension Proteins and Monoclonal Antibodies
• Adherent-Cell-Based Therapies and Vaccines
• Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues
• Vaccines
• Vaccine Development as a Catalyst
• Vaccines Developed Using Human Cell Strains
• Exosome Manufacturing
• Viral Vector Manufacturing
• Lentivirus Manufacturing
• Plasmid Manufacturing
• Cell Culture End Users
• Pharma/Biopharma
• Universities
• Government
• CROs/CDMOS
• Other
• Cell Culture Applications
• Drug Discovery
• Clinical Development
• Toxicology
• Basic Research
• Bioprocessing Development
• Other
• Regional Markets
• The Americas
• Europe
• Asia-Pacific
• Rest of the World

Chapter 5 Assays, Imaging and Analysis

• Assays
• Assay Development for Mesenchymal Stem Cells
• In Vitro Testing of Adventitious Agents
• Assays and Assay Kits
• Cell-Based Assays: Overview and Newer Developments
• Cells Used in Cell-Based Assays
• Notes on 3D Cell-Based Assays
• Kinetic Metabolism Assays
• Cell Proliferation
• Viability and Cytotoxicity
• Permeability Assays for Cell Viability and Survival
• Cell Invasion
• Cell Signaling and Communication
• Cytostatic
• Cell Death Assays
• Imaging Technology
• Imaging Assays
• Fluorescence as a Driver of Screening
• Analytical Systems Used in Tissue and Cell Culture
• Understanding "Cellomics"
• HCS Support of 3D Cell Culture
• NGS Discovery Pools
• Multiplex Assays
• Predictive Toxicology
• Neuro Safety
• The Omics Invasion
• Transcriptomics

Chapter 6 Regulation and Standardization

• U.S. Regulatory Status of Bioprinted Products
• Basic Guidance for the Regulation of Biologics
• Guidance for Regenerative Medicine
• Guidance for Xenotransplants
• Guidance for Regenerative Medicine: Emergency Approval
• Regulating Bioprinted Products

Chapter 7 3D Models for Cancer

• Disease Modeling
• Cancer
• Main Classes of Models for Researching Cancer and Other Diseases
• Cell Lines
• Spheroids and Organoids
• Genetically Engineered Mouse Model (GEMM)
• Patient-Derived Tumor Xenografts (PDXs)
• Overview: Cancer at the Cellular Level
• In Vivo (Animal) Testing Standard
• Empire of the Mouse
• Humanized Mice
• 2D Culture
• 3D Requirements
• Cell Number and Viability
• Migration and Invasion
• Unmet Needs: Angiogenesis and Immune System Evasion
• Benefits of 3D Models to Cancer Research
• Greater Distinction in Cell Morphology and Proliferation
• Greater Gene Expression and Cell Behavior
• Better Models of Cell Migration and Invasion
• Cell Heterogeneity
• Breast Cancer as a Driver of 3D Cultures
• Structure, Polarity and Apoptosis
• Melanoma as a Driver of 3D Cultures
• Moving to Spheroid Configurations
• 3D Systems in Cancer Research
• Multicellular Tumor Spheroids
• Multilayered Cell Cultures
• 3D Engineered Scaffolds
• Natural Materials
• Synthetic Materials
• Human Cancer Model Initiative (HCMI)
• Next-Generation Human Cancer Models
• Drug Sensitivity and Resistance
• Altered Signaling and Sensitivity
• Drug Resistance
• Cellular Signaling
• Cellular Signaling Mediated by Integrins
• Drug Screening
• Approaches and Endpoints
• Spheroid Applications
• Metastasis via 3D Cell Migration Model
• Metastasis via Lung-on-Chip
• Cancer Metabolism
• Future Horizons
• Metastases
• Co-culture
• Vascularization
• Cancer-Associated Fibroblasts
• Cancer Stem Cells
• Combination Therapies
• Biologics Development
• Tumor Recurrence
• Patient-Derived Cells
• Patient-Derived Tumor Xenografts (PDXs)
• Evolution of PDX Platforms

Chapter 8 Landscape for Toxicology and Drug Safety Testing

• Introduction
• Liver
• Toxicology Background
• Testing for Adverse Effects on the Skin
• New Assessment Methodologies Impact on 3D Cell Culture
• Toxicology Testing in Cosmetics
• Updated Regulatory Requirements
• Efficacy of Cosmetics and Cosmeceuticals
• Aspects of Cosmetic Toxicity Testing
• Skin Irritation
• Skin Corrosion
• Phototoxicity
• Skin Sensitization
• Eye Irritation
• Acute Systemic Toxicity
• Acute Toxicity Testing
• Cytotoxicity Assays for Acute Toxicity Testing
• Chronic and Repeated Dose Toxicity
• Carcinogenicity and Genotoxicity
• Overview
• In Vitro Methods: Background and Recent Developments
• Regulatory versus Drug Development Applications
• Efforts to Reduce False Positives
• Recent Innovations in Screening
• Future Challenge: Non-genotoxic Carcinogens
• Reproductive and Developmental Toxicity
• Background
• Following the Reproductive Cycle
• Development and Reproductive Tox Testing Types
• Zebrafish Model for Developmental Toxicity Screening
• Combination of Zebrafish and Stem Cells
• Biomedical Frontiers: Male Testis
• Endocrine Disruptor Screening
• Background
• Environmental Toxicology Impacts In Vitro Methods
• ToxCast and Tox 21 Initiatives
• Future Challenge: Thyroid Disruption
• BG1 Assay
• Toxicokinetics and ADME
• In Vitro Developments
• Metabolism
• Pharmacokinetics of Low-Turnover Compounds
• Organotypic Models
• 3D Models for Skin
• 3D Corneal System
• Absorption Barrier Models
• Gastrointestinal
• Lung
• Blood-Brain Barrier
• Real Architecture for 3D Tissue Barriers and Extracellular Matrix
• Liver Toxicity
• Uniqueness and Complexity of Liver
• Liver as a Key Driver for 3D Innovation
• In Vitro Liver Applications
• In Vivo Liver Function and Structure
• Liver Metabolism
• In Vitro Liver Models
• Co-cultures of Hepatocytes and Macrophages
• 3D Liver Models
• Bioprinted Liver Tissue
• Detected Hepatosphere Structures and Functionality
• Ideal Criteria
• Drug Resistance
• Transporter Studies
• Achieving Heterotypic Cell-Cell Contacts
• Unmet Needs and Future Drivers of Innovation
• Morphogen Signaling
• Multi-donor Liver Cells
• Kidney Toxicity Applications
• Future Challenge: Stem-Cell Derived Kidney Cells
• Bioprinted Kidney Tissue
• Pancreatic Toxicology Applications
• Cardiovascular Toxicity
• Commercial Avenue
• Collaboration with Regulators
• Cardiovascular Drug Discovery
• Microelectrode Arrays (MEAs) Based on Impedance
• Surrogate for Aortic Ring Assay via Bioprinted Magnetics
• Vasodilator Activity
• 3D Engineered Heart Tissues

Chapter 9 Market Breakdown by Region

• Introduction
• North America
• United States
• Canada
• Europe
• Germany
• United Kingdom
• Asia-Pacific
• China
• Japan
• India
• South Korea
• Singapore
• Rest of the World

Chapter 10 Stem Cell Landscape

• A History of Stem Cells
• Major and Minor Research Areas for Stem Cells
• 3D Stem Cell Culture Systems
• Plate or Culture Dish
• Spinner Flask and Rotating Wall Vessel
• Perfusion Bioreactor and Microcarrier Systems
• Shortcomings
• Microfluidics and Stem Cells
• Short Review of Stem Cell Biology
• Embryogenesis
• Growth, Structure and Morphology of Stem Cells
• Stem Cell Differentiation
• Stem Cell Differentiation versus Proliferation
• Extracellular Matrix and Stem Cells
• Soluble Factors
• Manufacturing Stem Cells
• Controlling Embryoid Body Formation
• Forced Aggregation Cultures
• Hanging-Drop Approach
• Applications
• Stem Cell Markers for High-Throughput Screening
• Teratomas and the Teratoma Assay
• Fujifilm (Cellular Dynamics Inc.)
• Stem Cell Research Breakthroughs
• Stem Cells for Neuroscience Discovery and Development
• Example: Alzheimer's Research
• Background: B-Amyloid Cascade Hypothesis
• Human iPSC-Derived Models
• New 3D Model
• Other Advantages of 3D
• Envisioned Applications
• Other 3D Neuro Applications
• Stem Cells for Cardiovascular Discovery
• Stem Cells for the Development of Regenerative Medicine
• Background: Allogenic versus Autologous
• MicroRNAs
• Induced Pluripotent Stem Cells (IPS)

Chapter 11 Regenerative Medicine: Organ Transplants and Skin Substitutes

• Regenerative Medicine
• Need for Organ Transplants
• Applications in Regenerative Medicine
• Investments in Regenerative Medicine
• Skin Substitutes Industry
• Tissue Culture Allograft and Autograft Products
• Tissue Engineering in Regenerative Medicine

Chapter 12 Company Profiles

• 3D BIOPRINTING SOLUTIONS
• 3D BIOTEK LLC
• 4D TECHNOLOGY CORP.
• ABCAM PLC
• AKRON BIOTECH
• AGILENT TECHNOLOGIES INC.
• ALPCO
• AMSBIO
• BECKMAN COULTER INC.
• BIOINSPIRED SOLUTIONS
• BIOTIME INC.
• BIOVISION INC.
• CELL APPLICATIONS INC.
• CELLINK
• CORNING INC.
• CYPROTEX
• CYTIVA
• CYTOO SA
• EMD MILLIPORE / MERCK KGAA
• EMULATE INC.
• ENVISIONTEC INC.
• EPITHELIX
• EUROFINS SAS
• GREINER BIO-ONE INTERNATIONAL GMBH
• HAMILTON ROBOTICS
• HUB ORGANOIDS
• HUREL CORP.
• INSPHERO
• INVITROCUE
• KIYATEC INC.
• LIFENET HEALTH
• LOREM VASCULAR / CYTORI THERAPEUTICS INC.
• MATTEK
• MIMETAS INC.
• ORGANOVO HOLDINGS INC.
• PERKINELMER INC.
• PLASTICELL LTD.
• PLURISTEM THERAPEUTICS INC.
• POIETIS
• PROMEGA CORP.
• SEAHORSE BIOSCIENCE
• STEMCELL TECHNOLOGIES
• STRATATECH CORP.
• SYNVIVO INC.
• TAP BIOSYSTEMS
• TECAN TRADING AG
• ZEN-BIO INC.