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척추 중재시술 : 외과, 치환 및 신경 자극 기술 시장

Spinal Intervention: Markets for Surgical, Replacement and Neurostimulation Technologies

리서치사 BCC Research
발행일 2016년 12월 상품 코드 409481
페이지 정보 영문 181 Pages
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척추 중재시술 : 외과, 치환 및 신경 자극 기술 시장 Spinal Intervention: Markets for Surgical, Replacement and Neurostimulation Technologies
발행일 : 2016년 12월 페이지 정보 : 영문 181 Pages

본 상품은 영문 자료로 한글과 영문목차에 불일치하는 내용이 있을 경우 영문을 우선합니다. 정확한 검토를 위해 영문목차를 참고해주시기 바랍니다.

세계의 척추 외과 및 신경 자극 관련 중재적 제품 시장은 2016-2021년간 4.5%의 CAGR(연간 복합 성장률)로 추이하며, 2016년의 126억 달러에서 2021년에는 158억 달러 규모로 성장할 것으로 예측됩니다.

세계의 척추 외과·치환술·신경 자극 관련 중재적 제품 시장을 조사했으며, 시장 정의와 개요, 척추 외과 및 신경 자극 기술 대상 질환, 제품 카테고리·부문·지역별 시장 규모 추이와 예측, 주요 기업과 시장 점유율, 주요 제품·기술 상세 분석, 주요 제품 사례, R&D 동향, 기업 및 기업간 활동, 주요 기업 개요 등을 정리하여 전해드립니다.

제1장 서론

제2장 요약

제3장 시장 개요

  • 척추 외과 대상 질환
    • 퇴행성 추간판 질환
    • 추간판 탈출증
    • 척주 변형
    • 척추 외상
  • 신경 자극 기술 대상 질환
    • 만성 통증 관리
    • 신경계 질환
    • 심혈관질환
    • 위장 장애
    • 비뇨기·직장 장애
    • 수면무호흡증
    • 비만
    • 정신 장애

제4장 현재 시장 환경

  • 주요 시장 : 제품 종류별
    • 척추 관련 제품
    • 신경 자극
  • 주요 기업과 시장 점유율
    • 척추 관련 제품 : 경쟁 환경
    • 신경 자극 제품 : 경쟁 환경
  • 주요 시장 : 지역별
    • 척추 관련 제품 시장
    • 신경 자극 시장
    • 시장 동향·성장 촉진요인

제5장 척추 임플란트 제품·기술

  • 척추 고정
    • 척추 고정 시장
    • 재료 기술
    • 흉요추 관련 제품
    • 추체간 시스템
    • 경추 관련 제품
  • 최소침습성 척추 고정
    • 최소침습성 수술 시장
    • 신제품·기술
  • 추간판 치환
    • 추간판 치환 시장
    • 요추 추간판
    • 추간판
  • 동적 안정화
    • 현재 이용 가능한 제품
  • 생물학적 제제
    • 골이식편 대체물
    • MEDTRONIC INFUSE BONE GRAFT
    • MEDTRONIC INDUCTOS : 유럽에서의 발매 연기
    • DEPUY SYNTHES VIVIGEN CELLULAR BONE MATRIX
    • 합성 골이식편
  • 골절 수복
    • 골절 수복 시장
    • 현재 이용 가능한 제품

제6장 신경 자극 제품·기술

  • 기술적 진보
    • MRI의 적합성
    • 재충전 가능한 디바이스와 재충전 불가능한 디바이스
  • 척수 자극 제품
    • 현재 시장 환경
    • 척수 자극·보완 의료의 이용
  • 치료 옵션의 확대
    • 이용 가능한 척수 자극 제품
    • 최근 척수 자극 제품의 투입·하이라이트
    • 기존 척수 자극의 대체법
  • 뇌심부 자극
    • 최근의 치료 개선·새로운 적응증
    • 뇌심부 자극 시장
    • 경쟁 환경
    • 최근 제품 투입·하이라이트
    • 미주신경 자극
    • 미주신경 자극 시장
    • LIVANOVA의 VNS THERAPY
  • 위자극
    • MEDTRONIC의 ENTERRA THERAPY
    • INTRAPACE의 ABILITI SYSTEM
    • METACURE의 DIAMOND
  • 기타 신경 자극 형태
    • 천수신경자극
    • 대동맥압수용체 자극
    • 심수축능 조절
    • 설하신경 자극
    • 하부식도괄약근 자극 치료
    • 자율신경계 기술·익구개신경절 자극

제7장 제품·기술 파이프라인

  • 개발중인 디바이스
    • 주요 R&D 프로젝트
    • 신경 자극 제품 파이프라인
    • 현재 적응증
    • 새로운 적응증

제8장 산업 발전

  • M&A
    • M&A : 척추 관련 제품 시장
    • M&A : 신경 자극 시장
    • 전략적 제휴
    • 주요 대형 얼라이언스

제9장 기업 개요

  • 척추 제품 제조업체
    • ALPHATEC HOLDINGS
    • B. BRAUN/AESCULAP
    • DEPUY SYNTHES
    • GLOBUS MEDICAL
    • K2M
    • MEDTRONIC
    • NUVASIVE
    • ORTHOFIX INTERNATIONAL
    • STRYKER
    • ZIMMER BIOMET
  • 신경 자극 제품 제조업체
    • BOSTON SCIENTIFIC
    • CVRX
    • LIVANOVA
    • MEDTRONIC
    • NEUROPACE
    • NEVRO
    • ST. JUDE MEDICAL

도표

KSA 17.01.10

REPORT HIGHLIGHTS

The global market for spinal and neurostimulation intervention products is expected to reach $15.8 billion by 2021 from $12.6 billion in 2016, rising at a compound annual growth rate (CAGR) of 4.5% from 2016 through 2021.

This report provides:

  • An overview of the global markets for surgical, replacement, and neurostimulation technologies as they relate to spinal intervention.
  • Analyses of global market trends, with data from 2015, estimates for 2016, and projections of compound annual growth rates (CAGRs) through 2021.
  • Coverage of several types of surgical procedure currently available for the treatment of spinal diseases and injury, including spinal fusion, disc replacement, facet replacement and kyphoplasty, all of which use different products and technologies, and have different advantages and drawbacks.
  • Analyses of the market in terms of key product and technology areas, major manufacturers and factors influencing market growth and demand.
  • Key corporate activities, including such a mergers & acquisitions, strategic alliances and research & development.
  • Profiles of major players in the industry.

SCOPE OF REPORT

The report provides an analysis of the markets for spinal and neurostimulation products, including trends and sales to 2021. It analyzes the market in terms of key product and technology areas, major manufacturers and factors influencing market growth.

Manufacturers of neurostimulation and spinal technologies are discussed and analyzed based on product types, market share and key corporate activities, including a mergers and acquisitions, strategic alliances, and research and development. In addition to neurostimulation products used for the treatment of spinal conditions, the report looks at the wider neurostimulation industry in order to provide a more comprehensive analysis of the overall market and growth opportunities for companies operating in this field.

The report also includes an in-depth analysis of new products and technologies in development, as well as the development of new products that can address a growing number of therapeutic indications.

Excluded from the scope of the report are spinal soft goods, bracing products and externally worn neurostimulation devices.

ANALYST'S CREDENTIALS

Joanne Maddox is an experienced healthcare industry analyst specializing on the medical device and diagnostics markets. She has 16 years of experience working specifically in this niche area. Her work has included competitor and market insight, due diligence assistance, market forecasting and trend analysis of the medical devices industry, with a key focus on orthopedic and spinal technologies, implantable electronic devices, diagnostics, medical imaging and wound care.

Table of Contents

CHAPTER 1 - INTRODUCTION

  • STUDY GOALS AND OBJECTIVES
  • REASONS FOR DOING THE STUDY
  • SCOPE OF REPORT
  • INTENDED AUDIENCE
  • INFORMATION SOURCES
  • ANALYST'S CREDENTIALS
  • RELATED BCC RESEARCH REPORTS
  • BCC RESEARCH WEBSITE
  • DISCLAIMER

CHAPTER 2 - SUMMARY

  • SUMMARY TABLE: GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY CATEGORY, THROUGH 2021 ($ MILLIONS)
  • SUMMARY FIGURE: GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY MAJOR CATEGORY, 2015-2021 ($ MILLIONS)

CHAPTER 3 - MARKET OVERVIEW

  • TABLE 1: NUMBER OF SPINAL SURGERIES PERFORMED IN THE U.S., 2010 AND 2015
  • FIGURE 1: NUMBER OF SPINAL SURGERIES PERFORMED IN THE U.S., 2010 AND 2015
  • APPLICATIONS FOR SPINAL SURGERIES
    • DEGENERATIVE DISC DISEASE
    • SPINAL DISC HERNIATION
    • SPINAL DEFORMITY
    • SPINAL TRAUMA
  • APPLICATIONS FOR NEUROSTIMULATION TECHNOLOGIES
    • TABLE 2: NEUROSTIMULATION: PREVALENCE OF ADDRESSABLE CONDITIONS IN THE U.S., 2015 (NO. OF CASES)
    • CHRONIC PAIN MANAGEMENT
    • FIGURE 2: LOCATION OF CHRONIC PAIN IN THE U.S.
    • NEUROLOGICAL DISORDERS
      • Essential Tremor
      • Parkinson's Disease
      • Dystonia
      • Epilepsy
      • Chronic Migraine and Headache
    • CARDIOVASCULAR DISEASE
      • Hypertension
        • FIGURE 3: GLOBAL RATE OF UNCONTROLLED HYPERTENSION, 1980 AND 2008 (MILLIONS)
      • Heart Failure
    • GASTROINTESTINAL DISORDERS
    • URINARY AND RECTAL DISORDERS
    • SLEEP APNEA
    • OBESITY
      • FIGURE 4: PERCENTAGE OF POPULATION WITH OBESITY IN THE U.S., 1999-2014 (%)
    • PSYCHIATRIC DISORDERS

CHAPTER 4 - CURRENT MARKET ENVIRONMENT

  • TABLE 3: GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY CATEGORY, THROUGH 2021 ($ MILLIONS)
  • FIGURE 5: GLOBAL MARKET SHARES OF SPINAL AND NEUROSTIMULATION, BY CATEGORY, 2015 (%)
  • MAJOR MARKETS BY PRODUCT TYPE
    • SPINAL PRODUCTS
      • TABLE 4: GLOBAL MARKET FOR SPINAL DEVICES, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
      • FIGURE 6: GLOBAL MARKET SHARES OF SPINAL DEVICES, BY PRODUCT, 2015 (%)
    • NEUROSTIMULATION
      • TABLE 5: GLOBAL MARKET FOR NEUROSTIMULATION, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
      • FIGURE 7: GLOBAL MARKET SHARE OF NEUROSTIMULATION, BY PRODUCT, 2015 (%)
  • MAJOR COMPANIES AND MARKET SHARE
    • SPINAL PRODUCTS COMPETITIVE LANDSCAPE
      • TABLE 6: GLOBAL MARKET FOR SPINAL PRODUCTS, BY MAJOR COMPANIES, THROUGH 2015 ($ MILLIONS)
      • FIGURE 8: GLOBAL COMPANY MARKET SHARES OF SPINAL DEVICES, 2015 (%)
      • TABLE 7: U.S. MARKET FOR MAJOR SPINAL DEVICES, BY COMPANY, THROUGH 2015 ($ MILLIONS)
      • FIGURE 9: U.S. COMPANY MARKET SHARES OF SPINAL DEVICES, 2015 (%)
      • TABLE 8: MARKET SHARES OUTSIDE THE U.S. FOR MAJOR SPINAL DEVICES, BY COMPANY, THROUGH 2015 ($ MILLION)
      • FIGURE 10: COMPANY MARKET SHARES OUTSIDE THE U.S. FOR MAJOR SPINAL DEVICES, 2015 (%)
    • NEUROSTIMULATION PRODUCTS COMPETITIVE LANDSCAPE
      • TABLE 9: GLOBAL MARKET FOR NEUROSTIMULATION, BY MAJOR COMPANIES, THROUGH 2015 ($ MILLIONS)
      • FIGURE 11: GLOBAL MARKET SHARES OF NEUROSTIMULATION, BY MAJOR COMPANIES, 2015 (%)
  • MAJOR MARKETS BY REGION
    • THE SPINAL PRODUCTS MARKET
      • TABLE 10: GLOBAL MARKET FOR SPINAL DEVICES, BY REGION, THROUGH 2021 ($ MILLIONS)
      • FIGURE 12: GLOBAL MARKET SHARES OF SPINAL DEVICES, BY REGION, 2015 (%)
    • NEUROSTIMULATION MARKET
      • TABLE 11: GLOBAL MARKET FOR NEUROSTIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
      • FIGURE 13: GLOBAL MARKET SHARES OF NEUROSTIMULATION, BY REGION, 2015 (%)
    • MARKET TRENDS AND GROWTH DRIVERS

CHAPTER 5 - SPINAL IMPLANT PRODUCTS AND TECHNOLOGIES

  • SPINAL FUSION
    • THE FUSION MARKET
      • TABLE 12: GLOBAL MARKET FOR SPINAL FUSION, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
      • FIGURE 14: GLOBAL MARKET SHARES OF SPINAL FUSION, BY PRODUCT, 2015 (%)
      • TABLE 13: GLOBAL MARKET FOR SPINAL FUSION, BY REGION, THROUGH 2021 ($ MILLIONS)
      • FIGURE 15: GLOBAL MARKET SHARES OF SPINAL FUSION, BY REGION, 2015 (%)
    • MATERIALS TECHNOLOGY
      • Polyetheretherketone
      • K2M's Lamellar 3D Titanium Technology
      • Orthofix International's FORZA PTC (Peek Titanium Composite) Spacer System
      • Spineart's Ti-LIFE Technology
      • Amedica's Silicon Nitride Technology
      • SeaSpine's NanoMetalene
      • B. Braun/Aesculap's PlasmaporeXP Coating
      • Zimmer Biomet's Trabecular Metal Technology
    • THORACOLUMBAR PRODUCTS
      • TABLE 14: KEY THORACOLUMBAR PRODUCTS AVAILABLE IN THE MARKET
      • New Products and Technologies
        • Alphatec Spine's Arsenal System
        • DePuy Synthes' Expedium Verse Spinal System
        • Globus Medical's Creo
        • K2M's MESA 2 Deformity Spinal System
        • K2M's Nile Alternative Fixation Spinal System
        • Medtronic's CD Horizon Fenestrated Screw Set
        • Medtronic's Vertex Reconstruction System
        • NuVasive's Integrated Global Alignment (iGA) Platform
    • INTERBODY SYSTEMS
      • TABLE 15: KEY INTERBODY PRODUCTS AVAILABLE IN THE MARKET
      • New Products and Technologies
        • Aesculap's4 TSpace PEEK Interbody System
        • Aesculap's ProSpaceXP Interbody System
        • Alphatec Spine's Battalion Universal Spacer System
        • Amedica's Valeo II Lateral Lumbar (LL) Interbody Fusion Device
        • Globus Medical's RISE-L
        • Globus Medical's Monument
        • Globus Medical's SILC Fixation System
        • K2M's Cascadia Products
        • Medtronic's Divergence Stand Alone Interbody Cage
        • Orthofix' Forza PTC (Peek Titanium Composite) Spacer System
        • SeaSpine's Hollywood VI NanoMetalene Interbody Device
        • Spineart's JULIETTi System
        • Spinal Elements' Expandable Interbody Fusion Devices
        • Spine Wave's Velocity L Expandable Interbody Device and XLR II Lateral Access System
        • Vertebral Body Replacements
          • Aesculap's Modulift Vertebral Body Replacement
          • K2M's Capri Corpectomy Cage System
          • NuVasive's X-Core Mini Cervical Corpectomy System
    • CERVICAL SPINAL PRODUCTS
      • DePuy Synthes' Synapse Occipital-Cervical-Thoracic System
      • K2M's Mesa Mini Spinal System and Denali Mini Spinal System
      • K2M's Pyrenees Mono Cervical Plate
      • Medtronic's DIVERGENCE System
      • Medtronic's Zevo Anterior Cervical Plate System.
      • Zimmer Biomet's Optio-C Anterior Cervical Plate
      • RTI Surgical's Streamline OCT System
      • Zimmer Biomet's Virage OCT System
  • MINIMALLY INVASIVE SPINAL FUSION
    • THE MINIMALLY INVASIVE SURGERY MARKET
      • TABLE 16: GLOBAL MARKET FOR MINIMALLY INVASIVE VS. TRADITIONAL SPINAL FUSION, THROUGH 2021 (UNIT)
      • FIGURE 16: GLOBAL MARKET SHARES OF MINIMALLY INVASIVE VS. TRADITIONAL SPINAL FUSION, 2015 (%)
    • NEW PRODUCTS AND TECHNOLOGIES
      • TABLE 17: KEY MINIMALLY INVASIVE SPINAL SURGERY PRODUCTS
      • Aesculap's S4 Element MIS System
      • LDR Holding's ROI-C Titanium-Coated Cervical Cage
      • K2M's Everest Minimally Invasive (MI) XT Spinal System
      • Medtronic's CD Horizon Solera Voyager Spinal System
      • Medtronic's Oblique Lateral Interbody Fusion Platform
      • NuVasive's Maximum Access Surgery Products
      • Orthofix International's Phoenix Minimally Invasive Spinal Fixation System
  • TOTAL DISC REPLACEMENT
    • THE TOTAL DISC REPLACEMENT MARKET
      • TABLE 18: GLOBAL MARKET FOR TOTAL DISC REPLACEMENT, BY PRODUCT, THROUGH 2021 (UNIT)
      • FIGURE 17: GLOBAL MARKET SHARES OF TOTAL DISC REPLACEMENT, BY PRODUCT, 2015 (%)
      • TABLE 19: GLOBAL MARKET FOR TOTAL DISC REPLACEMENT, BY REGION, THROUGH 2021 (UNIT)
      • FIGURE 18: GLOBAL MARKET SHARES OF TOTAL DISC REPLACEMENT, BY REGION, 2015 (%)
    • LUMBAR DISCS
      • Currently Available Products
        • Aesculap's activL Artificial Disc
        • DePuy Synthes' ProDisc-L
    • CERVICAL DISCS
      • TABLE 20: CURRENTLY AVAILABLE CERVICAL DISC REPLACEMENTS
      • Currently Available Products
        • Aesculap's Activ-C
        • DePuy Synthes' ProDisc-C
          • Clinical Data
      • Globus Medical's Secure-C
      • K2M's Rhine Cervical Disc System
      • LDR Holding's (Zimmer Biomet) Mobi-C Cervical Disc Replacement Device
        • Clinical Data
      • Medtronic's Prestige LP Cervical Disc System
        • Clinical Data
      • Spinal Kinetics' M6-C
  • DYNAMIC STABILIZATION
    • CURRENTLY AVAILABLE PRODUCTS
      • Medtronic's X-STOPPK
      • Zimmer Biomet's Dynesys Dynamic Stabilization System
  • BIOLOGICS
    • BONE GRAFT SUBSTITUTES
    • MEDTRONIC'S INFUSE BONE GRAFT
    • EUROPEAN MARKETING SUSPENSION OF MEDTRONIC'S INDUCTOS
    • DEPUY SYNTHES' VIVIGEN CELLULAR BONE MATRIX
    • SYNTHETIC BONE GRAFTS
      • Alphatec's Neocore Osteoconductive Matrix
      • NuVasive's AttraX Putty
      • Orthofix International's Trinity Evolution
  • FRACTURE REPAIR
    • THE FRACTURE REPAIR MARKET
      • TABLE 21: GLOBAL MARKET FOR SPINAL TRAUMA, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
      • FIGURE 19: GLOBAL MARKET SHARES OF SPINAL TRAUMA, BY PRODUCT, 2015 (%)
    • CURRENTLY AVAILABLE PRODUCTS
      • TABLE 22: CURRENTLY AVAILABLE TREATMENTS FOR VERTEBRAL COMPRESSION FRACTURES
      • Medtronic and Kyphon Balloon Kyphoplasty
      • Cement and Cement Delivery Systems
        • DePuy Synthes' Confidence Spinal Cement System
        • Biomet's VCF Products
        • Styker's Cortoss Bone Augmentation Material
        • Spineology's OptiMesh

CHAPTER 6 - NEUROSTIMULATION PRODUCTS AND TECHNOLOGIES

  • TECHNOLOGICAL DEVELOPMENTS
    • MRI COMPATIBILITY
      • TABLE 23: NUMBER OF MRI SCANS PERFORMED IN THE U.S., 1995-2015 (PER 1,
    • OF THE POPULATION)
      • FIGURE 20: NUMBER OF MRI SCANS PERFORMED IN THE U.S., 1995-2015 (PER 1,000 OF THE POPULATION)
    • RECHARGEABLE AND NONRECHARGEABLE DEVICES
  • SPINAL CORD STIMULATION PRODUCTS
    • CURRENT MARKET LANDSCAPE
      • TABLE 24: GLOBAL MARKET FOR SPINAL CORD STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
      • FIGURE 21: GLOBAL MARKET SHARES OF SPINAL CORD STIMULATION, BY REGION, 2015 (%)
    • USES OF SPINAL CORD STIMULATION AND COMPLEMENTARY THERAPIES
  • IMPROVED THERAPY OPTIONS
    • SPINAL CORD STIMULATION PRODUCTS ON THE MARKET
      • TABLE 25: CURRENTLY AVAILABLE SPINAL CORD STIMULATION PRODUCTS
    • RECENT SPINAL CORD STIMULATION PRODUCT LAUNCHES AND HIGHLIGHTS
      • Boston Scientific's Precision Spectra System and Illumina 3D Technology
        • Clinical Data
      • Boston Scientific's Precision Novi and MultiWave Technology
      • Boston Scientific's Precision Montage MRI System
      • Medtronic's Spinal Cord Stimulation Products
      • Nevro's Senza System and HF10 Therapy
        • Clinical Data
      • Nuvectra's Algovita System
      • St. Jude Medical's Proclaim Elite and Burst Stimulation
        • Burst Stimulation Clinical Data
        • Invisible Trial System
      • St. Jude Medical's MRI-Safe Systems
      • Stimwave Technologies' Freedom Systems
      • Freedom-8A SCS System
    • ALTERNATIVES TO TRADITIONAL SPINAL CORD STIMULATION
      • St. Jude Medical's Axium System for Dorsal Root Ganglion Stimulation
        • ACCURATE Clinical Study
      • Peripheral Nerve Stimulation
        • Stimwave's StimQ Peripheral Nerve Stimulator System
  • DEEP BRAIN STIMULATION
    • RECENT THERAPY IMPROVEMENTS AND NEW INDICATIONS FOR USE
    • THE DEEP BRAIN STIMULATION MARKET
      • TABLE 26: GLOBAL MARKET FOR DEEP BRAIN STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
      • FIGURE 22: GLOBAL MARKET SHARES OF DEEP BRAIN STIMULATION, BY REGION, 2015 (%)
    • COMPETITIVE LANDSCAPE
      • TABLE 27: CURRENTLY AVAILABLE DEEP BRAIN STIMULATION PRODUCTS
    • RECENT DEEP BRAIN STIMULATION PRODUCT LAUNCHES AND HIGHLIGHTS
      • Boston Scientific's Vercise Deep Brain Stimulation System
      • Boston Scientific's Vercise Primary Cell (PC) Deep Brain Stimulation System
      • Medtronic's Activa Systems
        • FIGURE 23: PATIENTS RECEIVING MEDTRONIC DBS THERAPY IN THE U.S. AND EUROPE, 2015, (NUMBER OF PATIENTS)
        • Expanded Approval for Parkinson's Disease Patients
        • Medtronic DBS Therapy for Refractory Epilepsy
        • Expanded Approval for Use With MRI
        • SureTune2 Software
        • TYRX Absorbable Antibacterial Envelope
      • NeuroPace's RNS System
        • Clinical Data
      • St. Jude Medical's Infinity Deep Brain Stimulation System
    • VAGUS NERVE STIMULATION
      • TABLE 28: GLOBAL MARKET FOR VAGUS NERVE STIMULATION, BY COMPANY, 2010-2015 ($ MILLIONS)
    • VAGUS NERVE STIMULATION MARKET
      • TABLE 29: GLOBAL MARKET FOR VAGUS NERVE STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
      • FIGURE 24: GLOBAL MARKET SHARES OF VAGUS NERVE STIMULATION, BY REGION, 2015 (%)
    • LIVANOVA'S VNS THERAPY
      • TABLE 30: CYBERONICS: VNS THERAPY UNIT SALES, YEAR ENDED APRIL 2010-2015
      • FIGURE 25: CYBERONICS: VNS THERAPY UNIT SALES, YEAR ENDED APRIL 2010-2015
      • FIGURE 26: CYBERONICS: SHARE OF VNS THERAPY UNIT SALES, BY REGION, YEAR ENDED APRIL 2015 (%)
      • VNS for the Treatment of Epilepsy
        • AspireSR Generator
      • VNS for the Treatment of Depression
      • Vitaria System for the Treatment of Heart Failure
      • EntroMedics' Maestro Rechargeable System and vBloc Therapy
        • Clinical Data
  • GASTRIC STIMULATION
    • MEDTRONIC'S ENTERRA THERAPY
    • INTRAPACE'S ABILITI SYSTEM
    • METACURE'S DIAMOND
  • OTHER FORMS OF NEUROSTIMULATION
    • SACRAL NERVE STIMULATION
      • Medtronic's InterStim System
        • Both products have FDA-approved labeling for 1.5 Tesla MRI head scans.
    • AORTIC BARORECEPTOR STIMULATION
      • CVRx's Barostim
    • CARDIAC CONTRACTILITY MODULATION
      • Impulse Dynamics' Optimizer IVs
    • HYPERGLOSSAL NEUROSTIMULATION
      • Inspire Medical Systems
    • LOWER ESOPHAGEAL SPHINCTER STIMULATION THERAPY
      • EndoStim's EndoStim Therapy
    • AUTONOMIC TECHNOLOGIES AND SPHENOPALATINE GANGLION STIMULATION

CHAPTER 7 - PRODUCT AND TECHNOLOGY PIPELINE

  • SPINAL PRODUCT PIPELINE DEVICES
    • TABLE 31: SPINAL PRODUCT PIPELINE HIGHLIGHTS
    • KEY SPINAL RESEARCH AND DEVELOPMENT PROJECTS
      • LDR Holdings' InterBRIDGE
      • LDR's New Minimal Implant Volume (MIVo) Spinal Implants
      • Amedica's 3D Printed Silicon Nitride Implants
      • RTI Surgical and Oxford Performance Materials
      • Axiomed's Freedom Lumbar Disc and Freedom Cervical Disc
      • Spinal Biologics Pipeline
        • B. Braun's TETEC Biologics Products
        • Mesoblast's MPC-06-ID
        • ISTO Technologies' NuQu Cell-Based Therapy
        • SpineOvations' DiscSeal
        • Amedica's Biologically Enhanced Implants
    • NEUROSTIMULATION PRODUCT PIPELINE
      • TABLE 32: NEUROSTIMULATION PRODUCT PIPELINE HIGHLIGHTS
    • CURRENT INDICATIONS FOR USE
      • Spinal Cord and Peripheral Nerve Stimulation
        • Neuros Medical's Altius System High Frequency Nerve Block
        • Boston Scientific and Chronic Migraine
      • Deep Brain Stimulation
        • Aleva Neurotherapeutics' Directional Deep Brain Stimulation
        • Deep Brain Innovations' Temporally Optimized Patterned Stimulation (TOPS)
        • Medtronic and Sapiens Steering Brain Stimulation
      • Vagus Nerve Stimulation
        • LivaNova's Development Pipeline
        • Enopace Biomedical's Harmony System
      • Aortic Baroreceptor Stimulation
        • CVRx's Barostim for Heart Failure
      • Hypoglossal Neurostimulation
        • ImThera Medical's THN Sleep Therapy
        • Nyxoah's Nyxoah System
    • NEW INDICATIONS AND NEUROSTIMULATION THERAPIES
      • TABLE 33: NEW INDICATIONS AND NEUROSTIMULATION THERAPIES
      • Vagus Nerve Stimulation for New Indications
        • LivaNova - Vagus Nerve Stimulation for Heart failure
        • Entromedics' Development Pipeline
      • Respicardia's remede System for Central Sleep Apnea
      • MicroTransponder's VNS Therapy for Stroke and Tinnitus
        • Vivistim System
        • Serenity System for Tinnitus
      • Neurosigma's Trigeminal Nerve Stimulation Technology

CHAPTER 8 - INDUSTRY DEVELOPMENTS

  • MERGERS AND ACQUISITIONS
    • MERGERS AND ACQUISITIONS IN THE SPINAL PRODUCTS MARKET
      • Recent Transactions in the Spinal Products Industry
        • TABLE 34: RECENT MERGERS AND ACQUISITIONS IN THE SPINAL PRODUCTS MARKET
      • SeaSpine and NLT Spine
      • Global Medical and Alphatec Holdings' International Operations
      • Zimmer Bioment and LDR Holding
      • Stryker and CareFusion Vertebral Compression Fracture Portfolio
      • Zimmer and Biomet
      • Globus Medical and Transplant Technologies of Texas Ltd.
    • MERGERS AND ACQUISITIONS IN THE NEUROSTIMULATION MARKET
      • Recent Transactions in the Neurostimulation Products Industry
        • TABLE 35: RECENT MERGERS AND ACQUISITIONS IN THE NEUROSTIMULATION MARKET
      • Abbott and St. Jude Medical
      • Sorin and Cyberonics
      • St. Jude Medical and Spinal Modulation
      • Medtronic and Sapiens Steering Brain Stimulation
      • Medtronic and TYRX
    • STRATEGIC ALLIANCES
      • TABLE 36: RECENT ALLIANCES IN THE MARKET
    • MAJOR AND RECENT ALLIANCES
      • Amedica and Celling Biosciences
      • RTI Surgical and Oxford Performance Materials
      • LDR Holding and Poly-Shape
      • Medtronic and Samsung Electronics America
      • DePuy Synthes and AO Foundation
      • Boston Scientific and Brainlab
      • Stimwave Technologies and Epimed International
      • LDR Holding and Sentio
      • DePuy Synthes and LifeNet Health
      • DePuy Synthes and Brainlab
      • Orthofix International and Musculoskeletal Transplant Foundation
      • Nevro, Venturi Group and the Mayo Foundation for Medical Education and Research
      • K2M and Spinal LLC

CHAPTER 9 - COMPANY PROFILES

  • SPINAL PRODUCT MANUFACTURERS
    • ALPHATEC HOLDINGS
    • B. BRAUN/AESCULAP
    • DEPUY SYNTHES
    • GLOBUS MEDICAL
    • K2M
    • MEDTRONIC
    • NUVASIVE
    • ORTHOFIX INTERNATIONAL
    • STRYKER
    • ZIMMER BIOMET
  • NEUROSTIMULATION PRODUCT MANUFACTURERS
    • BOSTON SCIENTIFIC
    • CVRX
    • LIVANOVA
    • MEDTRONIC
    • NEUROPACE
    • NEVRO
    • ST. JUDE MEDICAL

LIST OF TABLES

  • SUMMARY TABLE: GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY CATEGORY, THROUGH 2021 ($ MILLIONS)
    • TABLE 1: NUMBER OF SPINAL SURGERIES PERFORMED IN THE U.S., 2010 AND 2015
    • TABLE 2: NEUROSTIMULATION: PREVALENCE OF ADDRESSABLE CONDITIONS IN THE U.S., 2015 (NO. OF CASES)
    • TABLE 3: GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY CATEGORY, THROUGH 2021 ($ MILLIONS)
    • TABLE 4: GLOBAL MARKET FOR SPINAL DEVICES, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
    • TABLE 5: GLOBAL MARKET FOR NEUROSTIMULATION, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
    • TABLE 6: GLOBAL MARKET FOR SPINAL PRODUCTS, BY MAJOR COMPANIES, THROUGH 2015 ($ MILLIONS)
    • TABLE 7: U.S. MARKET FOR MAJOR SPINAL DEVICES, BY COMPANY, THROUGH 2015 ($ MILLIONS)
    • TABLE 8: MARKET SHARES OUTSIDE THE U.S. FOR MAJOR SPINAL DEVICES, BY COMPANY, THROUGH 2015 ($ MILLION)
    • TABLE 9: GLOBAL MARKET FOR NEUROSTIMULATION, BY MAJOR COMPANIES, THROUGH 2015 ($ MILLIONS)
    • TABLE 10: GLOBAL MARKET FOR SPINAL DEVICES, BY REGION, THROUGH 2021 ($ MILLIONS)
    • TABLE 11: GLOBAL MARKET FOR NEUROSTIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
    • TABLE 12: GLOBAL MARKET FOR SPINAL FUSION, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
    • TABLE 13: GLOBAL MARKET FOR SPINAL FUSION, BY REGION, THROUGH 2021 ($ MILLIONS)
    • TABLE 14: KEY THORACOLUMBAR PRODUCTS AVAILABLE IN THE MARKET
    • TABLE 15: KEY INTERBODY PRODUCTS AVAILABLE IN THE MARKET
    • TABLE 16: GLOBAL MARKET FOR MINIMALLY INVASIVE VS. TRADITIONAL SPINAL FUSION, THROUGH 2021 (UNIT)
    • TABLE 17: KEY MINIMALLY INVASIVE SPINAL SURGERY PRODUCTS
    • TABLE 18: GLOBAL MARKET FOR TOTAL DISC REPLACEMENT, BY PRODUCT, THROUGH 2021 (UNIT)
    • TABLE 19: GLOBAL MARKET FOR TOTAL DISC REPLACEMENT, BY REGION, THROUGH 2021 (UNIT)
    • TABLE 20: CURRENTLY AVAILABLE CERVICAL DISC REPLACEMENTS
    • TABLE 21: GLOBAL MARKET FOR SPINAL TRAUMA, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
    • TABLE 22: CURRENTLY AVAILABLE TREATMENTS FOR VERTEBRAL COMPRESSION FRACTURES
    • TABLE 23: NUMBER OF MRI SCANS PERFORMED IN THE U.S., 1995-2015 (PER 1,000 OF THE POPULATION)
    • TABLE 24: GLOBAL MARKET FOR SPINAL CORD STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
    • TABLE 25: CURRENTLY AVAILABLE SPINAL CORD STIMULATION PRODUCTS
    • TABLE 26: GLOBAL MARKET FOR DEEP BRAIN STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
    • TABLE 27: CURRENTLY AVAILABLE DEEP BRAIN STIMULATION PRODUCTS
    • TABLE 28: GLOBAL MARKET FOR VAGUS NERVE STIMULATION, BY COMPANY, 2010-2015 ($ MILLIONS)
    • TABLE 29: GLOBAL MARKET FOR VAGUS NERVE STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
    • TABLE 30: CYBERONICS: VNS THERAPY UNIT SALES, YEAR ENDED APRIL 2010-2015
    • TABLE 31: SPINAL PRODUCT PIPELINE HIGHLIGHTS
    • TABLE 32: NEUROSTIMULATION PRODUCT PIPELINE HIGHLIGHTS
    • TABLE 33: NEW INDICATIONS AND NEUROSTIMULATION THERAPIES
    • TABLE 34: RECENT MERGERS AND ACQUISITIONS IN THE SPINAL PRODUCTS MARKET
    • TABLE 35: RECENT MERGERS AND ACQUISITIONS IN THE NEUROSTIMULATION MARKET
    • TABLE 36: RECENT ALLIANCES IN THE MARKET

LIST OF FIGURES

  • SUMMARY FIGURE: GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY MAJOR CATEGORY, 2015-2021 ($ MILLIONS)
    • FIGURE 1: NUMBER OF SPINAL SURGERIES PERFORMED IN THE U.S., 2010 AND 2015
    • FIGURE 2: LOCATION OF CHRONIC PAIN IN THE U.S.
    • FIGURE 3: GLOBAL RATE OF UNCONTROLLED HYPERTENSION, 1980 AND 2008 (MILLIONS)
    • FIGURE 4: PERCENTAGE OF POPULATION WITH OBESITY IN THE U.S., 1999-2014 (%)
    • FIGURE 5: GLOBAL MARKET SHARES OF SPINAL AND NEUROSTIMULATION, BY CATEGORY, 2015 (%)
    • FIGURE 6: GLOBAL MARKET SHARES OF SPINAL DEVICES, BY PRODUCT, 2015 (%)
    • FIGURE 7: GLOBAL MARKET SHARE OF NEUROSTIMULATION, BY PRODUCT, 2015 (%)
    • FIGURE 8: GLOBAL COMPANY MARKET SHARES OF SPINAL DEVICES, 2015 (%)
    • FIGURE 9: U.S. COMPANY MARKET SHARES OF SPINAL DEVICES, 2015 (%)
    • FIGURE 10: COMPANY MARKET SHARES OUTSIDE THE U.S. FOR MAJOR SPINAL DEVICES, 2015 (%)
    • FIGURE 11: GLOBAL MARKET SHARES OF NEUROSTIMULATION, BY MAJOR COMPANIES, 2015 (%)
    • FIGURE 12: GLOBAL MARKET SHARES OF SPINAL DEVICES, BY REGION, 2015 (%)
    • FIGURE 13: GLOBAL MARKET SHARES OF NEUROSTIMULATION, BY REGION, 2015 (%)
    • FIGURE 14: GLOBAL MARKET SHARES OF SPINAL FUSION, BY PRODUCT, 2015 (%)
    • FIGURE 15: GLOBAL MARKET SHARES OF SPINAL FUSION, BY REGION, 2015 (%)
    • FIGURE 16: GLOBAL MARKET SHARES OF MINIMALLY INVASIVE VS. TRADITIONAL SPINAL FUSION, 2015 (%)
    • FIGURE 17: GLOBAL MARKET SHARES OF TOTAL DISC REPLACEMENT, BY PRODUCT, 2015 (%)
    • FIGURE 18: GLOBAL MARKET SHARES OF TOTAL DISC REPLACEMENT, BY REGION, 2015 (%)
    • FIGURE 19: GLOBAL MARKET SHARES OF SPINAL TRAUMA, BY PRODUCT, 2015 (%)
    • FIGURE 20: NUMBER OF MRI SCANS PERFORMED IN THE U.S., 1995-2015 (PER 1,000 OF THE POPULATION)
    • FIGURE 21: GLOBAL MARKET SHARES OF SPINAL CORD STIMULATION, BY REGION, 2015 (%)
    • FIGURE 22: GLOBAL MARKET SHARES OF DEEP BRAIN STIMULATION, BY REGION, 2015 (%)
    • FIGURE 23: PATIENTS RECEIVING MEDTRONIC DBS THERAPY IN THE U.S. AND EUROPE, 2015, (NUMBER OF PATIENTS)
    • FIGURE 24: GLOBAL MARKET SHARES OF VAGUS NERVE STIMULATION, BY REGION, 2015 (%)
    • FIGURE 25: CYBERONICS: VNS THERAPY UNIT SALES, YEAR ENDED APRIL 2010-2015
    • FIGURE 26: CYBERONICS: SHARE OF VNS THERAPY UNIT SALES, BY REGION, YEAR ENDED APRIL 2015 (%)
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