시장보고서
상품코드
2005192

중간엽줄기세포/치료용 신호전달 세포(MSCs) : 진전과 응용(2026년)

Mesenchymal Stem Cells / Medicinal Signaling Cells (MSCs) - Advances & Applications, 2026

발행일: | 리서치사: 구분자 BioInformant | 페이지 정보: 영문 381 Pages | 배송안내 : 즉시배송

    
    
    



가격
PDF (Single User License) help
PDF 보고서를 1명만 이용할 수 있는 라이선스입니다. 인쇄 가능하며 인쇄물의 이용 범위는 PDF 이용 범위와 동일합니다.
US $ 4,197 금액 안내 화살표 ₩ 6,297,000
PDF (Site License) help
PDF 보고서를 동일 사업장의 모든 분이 이용할 수 있는 라이선스입니다. 인쇄 가능하며 인쇄물의 이용 범위는 PDF 이용 범위와 동일합니다.
US $ 4,797 금액 안내 화살표 ₩ 7,197,000
PDF (Global License) help
PDF 보고서를 동일 기업의 모든 분이 이용할 수 있는 라이선스입니다. 인쇄 가능하며 인쇄물의 이용 범위는 PDF 이용 범위와 동일합니다.
US $ 4,997 금액 안내 화살표 ₩ 7,497,000
카드담기
※ 부가세 별도
※ 본 상품은 영문 자료로 한글과 영문 목차에 불일치하는 내용이 있을 경우 영문을 우선합니다. 정확한 검토를 위해 영문 목차를 참고해주시기 바랍니다.

주요 요약

MSC는 그 다재다능성과 다양한 응용 분야를 반영하여 중간엽줄기세포, 치료용 신호전달세포, 또는 간엽지지세포 등으로 불려온 다능성 세포입니다. MSC는 골아세포, 연골세포, 근육세포, 지방세포 등 다양한 세포 유형으로 분화할 수 있습니다. 조직 회복을 촉진하는 인자를 분비하고, 항염증 작용과 항섬유화 작용을 통해 미세 환경을 조절하는 독특한 능력으로 MSC는 재생의료에서 없어서는 안 될 존재로 자리매김하고 있습니다. 또한, 면역 회피 특성으로 인해 MSC는 동종 이식에 특히 적합합니다.

MSC는 재생의료, 화장품, 배양육 생산 등 다양한 산업에서 필수적인 원료로 활용되고 있습니다. 주요 응용 분야는 다음과 같습니다:

  • 근골격계 질환, 척수 손상, 심혈관계 질환에 대한 세포 치료.
  • 피부, 뼈, 혈관, 간 등 인공 조직 및 장기.
  • 화장품이나 스킨케어 제품에 활용되는 엑소좀, 성장인자 등 세포 유래 제품.
  • 근육 발달에 있어 MSC의 역할과 근육세포와 지방세포로 분화할 수 있는 능력을 활용한 배양육 생산.

전 세계적으로 12개의 MSC를 이용한 치료법이 다양한 적응증으로 승인되었으며, 대부분 한국, 일본, EU에 집중되어 있습니다.

구체적으로 한국에서는 5개의 제품이 승인된 상태입니다. Anterogen의 'Queencell', Pharmicell의 'Cellgram AMI', Anterogen의 'Cupistem', Medipost의 'Cartistem', 그리고 Corestem의 'NeuroNataR'입니다. 일본에서는 JCR Pharmaceuticals의 'Temcell HS'와 Nipro Corporation의 'Stemirac' 두 가지 제품이 승인되었습니다. 유럽 EMA는 Chiesi Farmaceutici의 'Holoclar'와 TiGenix/Takeda의 'Alofisel' 두 제품을 승인했습니다. 인도는 Stempeutics의 'Stempeucel' 1개 제품을 승인했습니다. 이란은 Cell Tech Pharmed가 개발한 'MesestroCell' 1개 제품을 승인했습니다. 마지막으로, 호주는 Mesoblast의 'Remestemcel-L' 1개 제품을 승인했습니다.

이러한 발전에도 불구하고, MSC(중간엽줄기세포) 기반 치료제로 미국 FDA의 승인을 받은 것은 아직 없지만, FDA는 메소블라스트의 'Remestemcel-L'에 대해 적극적으로 검토를 진행하고 있습니다.

화장품 시장에서도 MSC 유래 제품, 특히 엑소좀은 노화 방지 및 재생 능력을 활용하기 위해 빠르게 채택되고 있으며, L'Oreal과 Johnson & Johnson과 같은 기업들이 이 분야에 많은 투자를 하고 있습니다. 마찬가지로 배양육 기업들도 맛과 식감을 개선하기 위해 근육세포와 지방세포 생산에 MSC를 활용하고 있습니다. Upside Foods와 Good Meat의 배양 닭고기와 같은 획기적인 승인은 이 산업이 더욱 성장할 수 있는 길을 열었습니다.

MSC를 이용한 유전자 편집 기술도 확대되고 있으며, 항종양 유전자나 치료인자의 과발현이 가능해졌습니다. 또한 연구자들은 3D 프린팅과 인공 장기 제조에 MSC를 활용하는 방안도 모색하고 있으며, 향후 10년간 획기적인 발전이 기대되고 있습니다.

중요한 점은 Cynata Therapeutics와 같은 기업이 iPS 세포 유래 MSC 생산 기술을 선도적으로 개발하고 있으며, 이를 통해 대규모 치료제 개발이 가능해졌다는 점입니다. 현재 Cynata Therapeutics, Eterna Therapeutics, Implant Therapeutics, Bone Therapeutics, Brooklyn ImmunoTherapeutics, Fujifilm CDI, Citius Pharmaceuticals, Kiji Therapeutics 등 최소 8개사가 iPS세포 유래 MSC(iMSC) 치료제 개발에 참여하고 있습니다.

또한, ClinicalTrials.gov에는 MSC를 대상으로 한 1,670개 이상의 임상시험이 등록되어 있습니다. 이러한 임상 연구의 약 75%(4분의 3)가 재생의료(RM) 제품 개발에 MSC를 사용하고 있습니다. 약 14%의 연구에서 MSC가 질병 모델링에 사용되었습니다. 나머지 11%의 연구에서는 MSC가 신약 개발 및 세포 독성 시험 용도로 사용되고 있습니다.

이러한 시험의 과제는 증식 과정에서 MSC의 표현형과 기능성을 유지하는 것입니다. 그러나 지속적인 발전으로 인해 2040년까지 전 세계적으로 최소 50개 이상의 MSC 기반 제품이 승인될 것으로 예상되며, 연간 평균 3-4개의 새로운 제품이 승인될 것으로 전망되고 있습니다.

MSC 연구용 제품 주요 기업

최근 MSC를 이용한 조사용 제품에 대한 수요가 급증하고 있으며, 주요 공급업체들은 제품 라인업을 확대하고 있습니다. RoosterBio와 같은 기업들은 공급망 산업화, 표준화된 세포은행 제품 형태, 목적에 맞는 cGMP 준수 세포 및 배지 시스템을 통해 고품질 MSC에 대한 접근성을 확대하고 있습니다.

다른 주요 MSC 연구용 제품 공급업체로는 PromoCell, Lonza, Thermo Fisher Scientific, STEMCELL Technologies, Miltenyi Biotec, Bio-Techne(R&D Systems), ScienCell 연구소 및 ATCC 등이 있습니다.

도전과 기회

MSC의 상업화에는 확장성, 규제 당국의 승인과 같은 장벽이 존재하는 반면, 기회도 많이 존재합니다. MSC 기반 제품 시장은 연구, 치료, 화장품, 식품 산업 분야에서 괄목할 만한 성장이 예상됩니다.

빠르게 변화하는 상황에서 경쟁사에 대한 철저한 이해는 필수적입니다.

본 세계 전략 보고서에서는 MSC 관련 임상시험, 과학 논문, 특허, 자금 조달 사례 및 제휴 동향을 제시합니다. 또한 MSC 기반 치료제의 파이프라인을 소개하고, 시장의 기회와 위협을 파악하는 한편, 향후 방향성과 새로운 응용 분야를 모색하고 있습니다. 또한, 125개 주요 경쟁사들이 제공하는 혁신적인 MSC 제품, 서비스, 기술에 대한 정보도 공개하고 있습니다. 마지막으로 지역 및 사업 부문별로 분류된 세계 MSC 시장의 상세한 시장 규모 데이터와 2031년까지의 미래 예측을 제시합니다.

목차

제1장 보고서 개요

  • 보고서 내용
  • 대상층
  • 본 보고서의 출처
  • 보고서의 목적
    • 최근 연구 진행 상황
    • 세계 MSC 시장 요약 제공
    • 상업화 기회에 대한 접근성
    • 주요 시장 진입 기업 식별 및 경쟁 환경 평가
    • 기존 및 새로운 트렌드 파악
    • MSC 시장에서의 중요한 기회와 위협 파악
  • 주요 요약
  • 소개

제2장 중간엽줄기세포(MSC) : 개요

  • 인간 중간엽줄기세포(hMSC) 안정화 기술
  • 중간엽줄기세포가 재생의료에 미치는 영향
  • MSC 명명법 타임라인
  • MSC 공급원
    • 골수 유래 중간엽줄기세포(BM-MSC)
    • 지방 유래 중간엽줄기세포(AD-MSC)
    • 제대혈 유래 중간엽줄기세포(UC-MSC)
    • iPSC 유래 중간엽줄기세포(iMSC)
  • 중간엽줄기세포의 세포 표면 마커
  • 중간엽줄기세포의 체외 분화능
  • 중간엽줄기세포에서 분비되는 수용성 인자
  • 중간엽줄기세포에 존재하는 줄기세포 유전자
  • MSC의 종류와 생물의학적 응용 분야
  • MSC의 특성에 중요한 유전자

제3장 MSC를 이용한 임상시험 현황

  • 지역별 MSC를 이용한 임상 연구
  • 현재 임상시험에 사용되고 있는 MSC의 공급원
  • 자가 및 동종 MSC의 임상시험 점유율
  • 질환 적응증별 MSC 기반 임상시험
  • 연구 단계별 MSC 기반 임상시험
  • MSC를 이용한 임상시험 선택하기
    • 근골격계 질환에 대한 MSC를 이용한 임상시험
    • 신경질환에 대한 MSC를 이용한 임상시험
    • MSC 유래 엑소좀을 이용한 임상시험
    • 임상시험에서 프라이밍 처리된 MSC
    • 비계 기반 MSC를 이용한 임상시험

제4장 중간엽줄기세포(MSCS) : 특허 동향

  • 관할권별 MSC 특허 공개 정보
  • MSC 특허 출원인
  • MSC 특허 발명자
  • MSC 특허권자
  • MSC 특허 출원의 법적 지위
  • MSC 유래 엑소좀 관련 특허
  • iPSC 유래 MSC(iMSC)에 관한 특허
  • 치료 유형별 MSC 특허

제5장 MSCS에 관한 발표된 과학 논문

  • PubMed.gov에 게재된 세포 치료의 MSC에 관한 논문
  • PubMed.gov에 게재된 MSC 기반 면역치료에 관한 논문
  • PubMed.gov에 게재된 유전자 치료에서 MSC에 관한 논문
  • PubMed.gov에 게재된 조직공학에서의 MSC에 관한 논문
  • PubMed.gov에 게재된 미용 의료에서의 MSC 관련 논문
  • 주요 질환에서의 MSC 적용에 관한 논문 발표 수
  • 개량형 MSC 관련 논문 발표
  • MSC 유래 엑소좀 관련 논문 발표 논문

제6장 MSC 제조 플랫폼 : 개요

  • 중간엽줄기세포 분리 방법
  • 세포 증식 : 재래식 배양에서 바이오리액터까지
    • 단층 배양 시스템
    • 바이오리액터를 이용한 세포 증식
    • 현재 사용되고 있는 바이오리액터
    • MSC 확장 시스템 : 개요
    • 기술별 배치당 세포 수
    • 세포 증식에 사용되는 마이크로캐리어
  • MSC의 다운스트림 공정
    • 세포 박리 및 분리(수확)
    • 세포 세척 및 농축
    • 안전성 및 효능 시험
    • 중간엽줄기세포와 섬유아세포를 구별하기 위한 표면 마커
  • 자체 및 동종 MSC 제조 : 비교
    • 동종 중간엽줄기세포 제조비용
    • 자체 MSC 제조 비용
    • 기증자 선별 및 검사 비용
    • 릴리스 테스트 비용
  • MSC의 대규모 제조
    • MSC 제조 플랫폼
    • 세포배양용기 스케일업
    • 배양 배지
    • 중간엽줄기세포 동결보존

제7장 세포 및 유전자 치료제 위탁생산

  • 인력 부족
  • 자동화의 필요성
  • 용량 제약
  • 더 큰 잠재력을 가진 CDMO 플랫폼
  • CMO/CDMO
    • 의약품 위탁생산기관(CMO)
    • 의약품 개발 및 제조 수탁기관(CDMO)
  • 제조시설의 지리적 분포
  • 아웃소싱의 지속적인 증가
  • 미국의 주요 CDMO(의약품 위탁생산개발기관)
  • 유럽의 주요 세포 및 유전자 치료제 CDMO
  • 유럽 내 위탁 제조 분야에서 영국의 우월성

제8장 MSC의 기능 향상을 위한 바이오엔지니어링 솔루션

  • 중간엽줄기세포의 저분자 프라이밍
  • MSC의 입자 공학
  • MSC 유전공학
  • 항암제 생산을 위한 바이오엔지니어링된 MSC의 사례
  • 신경질환에 대한 유전자 조작 MSC
  • 심혈관질환 치료를 위한 유전자 조작 중간엽줄기세포 개발
  • 폐 손상 치료를 위한 유전자 조작 중간엽줄기세포의 개발
  • 당뇨병 치료를 위한 유전자 조작 MSC
  • MSC 투여를 개선하기 위한 바이오엔지니어링 접근법

제9장 MSCS가 다루는 주요 질환

  • 자가면역질환에 대한 MSC를 이용한 연구
  • 심혈관질환에 대한 MSC를 이용한 연구
  • 신경퇴행성 질환에 대한 MSC를 이용한 연구
  • 뼈 및 연골 질환에 대한 MSC를 이용한 연구
  • GVHD에서 MSC를 이용한 연구
  • 크론병에서 MSC를 이용한 연구
  • 1형 당뇨병에 MSC를 이용한 연구
  • 전신성 홍반성 루푸스(SLE)에서 MSC를 이용한 연구
  • 파킨슨병에 MSC를 이용한 연구
  • 알츠하이머병에서 MSC를 이용한 연구
  • 신부전증에 MSC를 이용한 연구
  • 척수 손상에서 MSC를 이용한 연구
  • 중간엽줄기세포를 이용한 상처 치유에 관한 연구

제10장 MSC 분야의 최근 협력 관계(2020-2024년)

  • BioSolution Designs와 RoosterBio 제휴
  • CytoMed Therapeutics, Ltd.와 Sengkang General Hospital 제휴
  • REPROCELL과 Histocell 제휴
  • FUJIFILM Diosynth와 RoosterBio 제휴
  • RoosterBio와 AGC Biologics 제휴
  • RoosterBio와 ShiftBio 제휴
  • RoosterBio와 Univercells Technologies 제휴
  • Cynata와 Fujifilm 제휴
  • American CryoStem Corp.과 BioTherapeutic Lab Corp.제휴
  • RoosterBio와 Sartorius 제휴
  • American CryoStem과 CRADA 제휴
  • RoosterBio와 Sartorius Korea Biotech 제휴
  • Catalent와 BrainStorm 제휴
  • Cipla와 Stempeutics 제휴
  • Aethlon과 University of Pittsburgh 제휴
  • RoosterBio와 Senti Biosciences 제휴

제11장 세계 시장의 MSC 기반 제품

  • 승인된 MSC 요법
    • Queencell
    • Cellgram AMI
    • Cupistem
    • Cartistem
    • NeuroNataR
    • Holoclar
    • Prochymal / Ryoncil (remestemcel-L)
    • Temcell HS
    • Stempeucel
    • MesestroCell
    • Stemirac
    • Ruibosheng (amimestrocel)
  • 시판 바이오소재 담체 기반 MSC 및 MSC 전구 세포
    • Osteocel
    • AlloStem
    • Grafix
    • Cellentra VCBM
    • Trinity ELITE
    • Map3
    • BIO4
    • Trinity Evolution
    • Carticel
    • Chondron
    • DeNovo NT
    • Ossron
    • JACC
    • MACI
    • Ortho-ACI
    • Ossgrow
    • Cartigrow
  • MSC/MSC 유래 엑소좀을 포함한 국소용 화장품

제12장 시장 분석

  • MSC 요법 시장 규모
  • 중간엽줄기세포(MSC)의 세계 수요

제13장 기업 개요

  • Advancells
  • Aegle Therapeutics
  • AGC Biologics
  • AlloSource, Inc.
  • Ambulero
  • American CryoStem Corporation
  • American Type Culture Collection(ATCC)
  • Amniotics
  • Andelyn Biosciences
  • Anemocyte Srl
  • Anterogen, Co., Ltd.
  • Avid Bioservices, Inc.
  • Bacthera
  • Baylx, Inc.
  • BioCardia
  • BioCentriq
  • BioEden, Inc.
  • Bioinova s.r.o
  • BioRestorative Therapies
  • Bioscience Institute S.p.A
  • Blue Horizon International, LLC
  • Boehringer Ingelheim BioXellence
  • Bonus Biogroup, Ltd.
  • BrainStorm Cell Therapeutics, Inc.
  • Catalent
  • CCRM
  • Cell2Cure ApS
  • Cell Care Therapeutics
  • Cellcolabs
  • CELLeBRAIN
  • Cellipont Bioservices
  • Celprogen, Inc.
  • CellProthera
  • CellResearch Corporation, Pte, Ltd.
  • Cell Surgical Network(CSN)
  • Celltex Therapeutics Corporation
  • CellTherapies
  • Cellular Biomedicine Group
  • Charles River Laboratories
  • CHIESI Farmaceutici S.p.A
  • Citius Pharmaceuticals, Inc.
  • CorestemChemon, Inc.
  • Creative Bioarray
  • Creative Medical Technology Holdings, Inc.
  • Curia Global, Inc
  • Cynata Therapeutics, Ltd
  • Cytovance Biologics
  • Defined Bioscience, Inc.
  • Direct Biologics
  • eQcell, Inc.
  • Excellos
  • Exosla Therapeutics
  • EXOSOMEplus
  • Exothera
  • Fujifilm Diosynth Biotechnologies
  • Future Cell Japan, Co., Ltd
  • Genezen
  • GenScript Biotech Corporation
  • Hope Biosciences, LLC
  • Implant Therapeutics, Inc
  • INCELL Corporation LLC
  • InGeneron GmbH
  • Invitrx Therapeutics
  • Japan Tissue Engineering, Co., Ltd.(J-TEC)
  • JCR Pharmaceuticals, Co., Ltd.
  • Jointechlabs
  • Kangstem Biotech, Co., Ltd
  • Kimera Labs
  • LifeCell
  • Longeveron
  • Lonza Group, Ltd
  • Lorem Cytori USA, Inc.
  • MEDPOST
  • Mesoblast, Ltd.
  • Millipore Sigma
  • NecstGen
  • NextCell
  • NIPRO Corporation
  • Novadip Biosciences
  • Novus Biologicals, LLC
  • NuVasive
  • OCT Therapies & Research Pvt., Ltd
  • OmniaBio, Inc.
  • Orthocell, Ltd
  • Orthofix Medical, Inc.
  • Ossium Health
  • Personal Cell Sciences Corporation
  • Personalized Stem Cells, Inc.
  • Pfizer CentreOne
  • Pluri Biotech, Ltd.
  • Porton Advanced
  • Prometheus Life Technologies
  • PromoCell GmbH
  • PuREC, Co., Ltd.
  • Regrow Biosciences
  • Reliance Life Sciences, Pvt., Ltd.
  • Remedy Cell, Ltd.
  • Rentschler Biopharma
  • REPROCELL USA, Inc
  • Resilence
  • RESTEM, LLC
  • RHEACELL GmbH & Co., KG
  • Richter-HELM
  • RoosterBio, Inc.
  • RTI Surgical
  • RoslinCT
  • Samsung Biologics
  • San Bio, Co., Ltd.
  • Smith & Nephew, Inc.
  • StemBioSys, Inc.
  • STEMCELL Technologies, Inc
  • Stemedica Cell Technologies, Inc.
  • Stemmatters
  • StemMedical
  • Stempeutics Research Pvt., Ltd
  • StromaBio AB
  • TaiwanBio Therapeutics, Co., Ltd.
  • Takeda Pharmaceutical, Co., Ltd
  • Tempo Bioscience
  • ThermoFisher Scientific
  • Vericel Corporation
  • Wuxi App Tec
  • Xintela AB

그림목차

표목차

KSM 26.04.29

EXECUTIVE SUMMARY

MSCs are multipotent cells that have been referred to as mesenchymal stem cells, medicinal signaling cells, and mesenchymal stromal cells, reflecting their versatility and diverse applications. MSCs can differentiate into a variety of cell types, such as osteoblasts, chondrocytes, myocytes, and adipocytes. Their unique ability to secrete factors that promote tissue repair and modulate their microenvironment with anti-inflammatory and anti-fibrotic effects makes them essential in regenerative medicine. Furthermore, their immuno-evasive properties make MSCs particularly suitable for allogenic transplantation.

MSCs serve as vital raw materials across numerous industries, including regenerative medicine, cosmeceuticals, and cultured meat production. Key applications include:

  • Cell-based therapies for musculoskeletal diseases, spinal injuries, and cardiovascular conditions.
  • Engineered tissues and organs, such as skin, bone, blood vessels, and liver.
  • Cell-derived products, such as exosomes and growth factors, utilized in cosmetics and skincare.
  • Cultured meat production, leveraging MSCs' role in muscle development and their ability to differentiate into muscle and fat cells.

Globally, 12 MSC-based therapies have been approved for various indications, with the majority concentrated in South Korea, Japan, and the EU.

Specifically, the Republic of Korea has approved five products: Queencell from Anterogen, Cellgram AMI from Pharmicell, Cupistem from Anterogen, Cartistem from Medipost, and NeuroNataR from Corestem. Japan has approved two products: Temcell HS from JCR Pharmaceuticals and Stemirac from Nipro Corporation. The EMA in Europe has approved two products: Holoclar from Chiesi Farmaceutici and Alofisel from TiGenix/Takeda. India has approved one product: Stempeucel from Stempeutics. Iran has approved one product: MesestroCell developed by Cell Tech Pharmed. Finally, Australia has approved one product: Remestemcel-L from Mesoblast.

Despite this progress, no MSC-based therapeutic have yet received U.S. FDA approval, although the FDA is actively reviewing Mesoblast's Remestemcel-L.

The cosmeceutical market is also rapidly adopting MSC-derived products, particularly exosomes, to leverage their anti-aging and regenerative properties, with companies like L'Oreal and Johnson & Johnson investing heavily in this space. Similarly, cultured meat companies are utilizing MSCs for producing muscle and fat cells, enhancing taste and texture. Groundbreaking approvals, such as lab-grown chicken by Upside Foods and Good Meat, have paved the way for further growth in this industry.

MSC-based gene editing is expanding, enabling the overexpression of antitumor genes and therapeutic factors. Researchers are also exploring the use of MSCs in 3D printing and engineered organ production, with breakthroughs anticipated in the next decade.

Importantly, companies like Cynata Therapeutics are pioneering iPSC-derived MSC production technologies, enabling large-scale therapeutic development. Today there are at least eight companies who are involved with the development of iPSC-derived MSCs therapeutics (iMSCs), including Cynata Therapeutics, Eterna Therapeutics, Implant Therapeutics, Bone Therapeutics, Brooklyn ImmunoTherapeutics, Fujifilm CDI, Citius Pharmaceuticals, and Kiji Therapeutics.

There are also over 1,670 clinical trials involving MSCs are registered on ClinicalTrials.gov. Nearly 75% (three-quarters) of these clinical studies are using MSCs for the development of regenerative medicine (RM) products. Approximately 14% of the studies are using MSCs for disease modeling. The remaining 11% of the studies are using MSCs for drug discovery and cytotoxicity testing applications.

Challenges in these trials include maintaining MSC phenotype and functionality during expansion. However, ongoing advancements suggest a promising future, with projections for at least 50 globally approved MSC-based products by 2040, averaging 3-4 new approvals annually.

Key Players in MSC Research Products

The demand for MSC-based research products has surged in recent years, with major suppliers expanding their portfolios. Companies like RoosterBio have increased the access to quality MSCs through supply chain industrialization, standardized cell bank product forms, and fit-for-purpose cGMP-compatible cells and media systems.

Other leading MSC research product suppliers include PromoCell, Lonza, Thermo Fisher Scientific, STEMCELL Technologies, Miltenyi Biotec, Bio-Techne (R&D Systems), ScienCell Research Laboratories, and the ATCC.

Challenges and Opportunities

While MSC commercialization faces hurdles-such as scalability and regulatory approval-opportunities abound. The market for MSC-based products is poised for notable growth across the research, therapeutic, cosmetic, and food industries.

Within this rapidly changing landscape, having a thorough understanding of the competition is essential.

This global strategic report presents rates of MSC clinical trials, scientific publications, patents, funding events, and collaborations. It presents the pipeline for MSC-based therapeutics, identifies market opportunities and threats, and explores future directions and emerging applications. It reveals innovative MSC products, services, and technologies offered by 125 leading competitors. Finally, it presents detailed market size figures for the global MSC market, segmented by geography and business segment with future forecasts through 2031.

TABLE OF CONTENTS

1. REPORT OVERVIEW

  • 1.1 Statement of the Report
  • 1.2 Target Demographic
  • 1.3 Sources for this Report
  • 1.4 Purpose of the Report
    • 1.4.1 Survey Recent Advancements
    • 1.4.2 Provide a Summary of the Global MSC Market
    • 1.4.3 Access Opportunities for Commercialization
    • 1.4.4 Identify Major Market Players and Evaluate the Competitive Environment
    • 1.4.5 Identify Existing and Emerging Trends
    • 1.4.6 Identify Critical Opportunities and Threats within the MSC Market
  • 1.5 Executive Summary
  • 1.6 Introduction

2. MESENCHYMAL STEM CELLS (MSCs): AN OVERVIEW

  • 2.1 Stabilization of Human MSCs (hMSCs) as a Technology
  • 2.2 The Impact of MSCs on Regenerative Medicine
  • 2.3 Timeline of MSC Nomenclature
  • 2.4 Sources of MSCs
    • 2.4.1 Bone Marrow-Derived MSCs (BM-MSCs)
    • 2.4.2 Adipose-Derived MSCs (AD-MSCs)
    • 2.4.3 Umbilical Cord-Derived MSCs (UC-MSCs)
    • 2.4.4 iPSC-Derived MSCs (iMSCs)
  • 2.5 Cell Surface Markers in MSCs
  • 2.6 In vitro Differentiation Potentials of MSCs
  • 2.7 Soluble Factors Secreted by MSCs
  • 2.8 Stemness Genes Present in MSCs
  • 2.9 Types of MSCs and their Biomedical Applications
  • 2.10 Genes that are Pivotal for MSCs' Properties

3. MSC-BASED CLINICAL TRIAL LANDSCAPE

  • 3.1 MSC-Based Clinical Studies by Geography
  • 3.2 Sources of MSCs used in Current Clinical Trials
  • 3.3 Share of Autologous & Allogeneic MSCs Clinical Trials
  • 3.4 MSC-Based Clinical Trials by Disease Indication
  • 3.5 MSC-Based Clinical Trials by Phase of Study
  • 3.6 Select MSC-Based Clinical Trials
    • 3.6.1 MSC-Based Clinical Trials for Musculoskeletal Disorders
    • 3.6.2 MSC-Based Clinical Trials for Neurological Disorders
    • 3.6.3 Clinical Trials involving MSC-Derived Exosomes
    • 3.6.4 Primed MSCs in Clinical Trials
    • 3.6.5 Clinical Trials involving Scaffold-Based MSCs

4. MESENCHYMAL STEM CELLS (MSCS): PATENT LANDSCAPE

  • 4.1 MSC Patent Publications by Jurisdiction
  • 4.2 MSC Patent Applicants
  • 4.3 MSC Patent Inventors
  • 4.4 MSC Patent Owners
  • 4.5 Legal Status of MSC Patent Applications
  • 4.6 MSC-Derived Exosome Patents
    • 4.6.1 MSC-Derived Exosome Patents by Jurisdiction
    • 4.6.2 MSC-Derived Exosome Patent Applicants
    • 4.6.3 MSC-Derived Exosome Patent Inventors
    • 4.6.4 MSC-Derived Exosome Patent Owners
    • 4.6.5 Legal Status of MSC-Derived Exosome Patents
  • 4.7 Patents for iPSC-Derived MSCs (iMSCs)
    • 4.7.1 iPSC-Derived MSC Patents by Jurisdiction
    • 4.7.2 iPSC-Derived MSC Patent Owners
  • 4.8 MSC Patents by Therapy Type

5. PUBLISHED SCIENTIFIC PAPERS ON MSCS

  • 5.1 PubMed.gov Published Papers on MSCs in Cell Therapy
  • 5.2 PubMed.gov Published Papers on MSC-Based Immunotherapies
  • 5.3 PubMed.gov Published Papers on MSCs in Gene Therapy
  • 5.4 PubMed.gov Published Papers on MSCs in Tissue Engineering
  • 5.5 PubMed.gov Published Papers on MSCs in Aesthetics
  • 5.6 Number of Published Papers on the Applications of MSCs in Major Diseases
  • 5.7 Published Papers on Modified MSCs
  • 5.8 Published Papers on MSC-Derived Exosomes

6. MSC MANUFACTURING PLATFORMS: AN OVERVIEW

  • 6.1 Methods of Isolations of MSCs
  • 6.2 Cell Expansion: Conventional Cultures to Bioreactors
    • 6.2.1 Monolayer Culture Systems
    • 6.2.2 Bioreactor-Based Cell Expansion
      • 6.2.2.1 Stirred Tank Bioreactor
      • 6.2.2.2 Rocking Bioreactor
      • 6.2.2.3 Hollow Fiber Bioreactors
      • 6.2.2.4 Fixed-Bed Bioreactor
    • 6.2.3 Bioreactors in Current Use
      • 6.2.3.1 Automated Platforms
      • 6.2.3.2 Miniaturized Bioreactors
      • 6.2.3.3 Verical-Wheel Bioreactors
    • 6.2.4 MSC Expansion Systems: A Snapshot
    • 6.2.5 Number of Cells per batch by Technologies
    • 6.2.6 Microcarriers used for Cell Expansion
  • 6.3 Downstream Processing of MSCs
    • 6.3.1 Cell Detachment and Separation (Harvesting)
    • 6.3.2 Cell Washing and Concentration
    • 6.3.3 Safety and Potency Assays
    • 6.3.4 Surface Markers for Distinguishing MSCs from Fibroblasts
  • 6.4 Autologous & Allogeneic MSC Manufacturing: A Comparison
    • 6.4.1 Cost of Manufacturing Allogeneic MSCs
    • 6.4.2 Cost of Manufacturing Autologous MSCs
    • 6.4.3 Cost of Donor Screening & Testing
    • 6.4.4 Cost of Release Testing
  • 6.5 Large Scale Manufacturing of MSCs
    • 6.5.1 MSC Manufacturing Platforms
      • 6.5.1.1 Quantum Cell Expansion System
      • 6.5.1.2 CliniMACS Prodigy
      • 6.5.1.3 NANT 001
      • 6.5.1.4 CellQualia
      • 6.5.1.5 Cocoon
      • 6.5.1.6 Xuri Cell Expansion System W25
    • 6.5.2 Scaling Up of Cell Culture Vessels
      • 6.5.2.1 CellSTACK Multilayered Flasks
      • 6.5.2.2 Nunc Cell Factory Systems
      • 6.5.2.3 HYPERFlask Vessels
      • 6.5.2.4 HYPERStack
      • 6.5.2.5 CellCube System
    • 6.5.3 Culture Medium
      • 6.5.3.1 Expansion Ratios Achieved with Different Culture Media
    • 6.5.4 Cryopreservation of MSCs

7. CELL & GENE THERAPY CONTRACT MANUFACTURING

  • 7.1 Staff Shortage
  • 7.2 Need for Automation
  • 7.3 Capacity Constraints
  • 7.4 CDMO Platforms with Greater Potentials
    • 7.4.1 Type of CDMOs Used by Sponsors
  • 7.5 CMOs/CDMOs
    • 7.5.1 Contract Manufacturing Organizations (CMOs)
      • 7.5.1.1 Major Services Offered by CMOs
    • 7.5.2 Contract Development and Manufacturing Organizations (CDMOs)
      • 7.5.2.1 Major CDMOs
      • 7.5.2.2 Major Services offered by CDMOs
  • 7.6 Geographic Distribution of Manufacturing Facilities
  • 7.7 Continued Rise of Outsourcing
    • 7.7.1 Specific Areas of Outsourcing
    • 7.7.2 Select Services for Outsourcing
    • 7.7.3 Expected Rate of Outsourcing Increase
  • 7.8 Major CDMOs in the U.S.
  • 7.9 Major Cell & Gene Therapy CDMOs in Europe
  • 7.10 UK's Dominance in European Contract Manufacturing
    • 7.10.1 GMP Manufacturing in U.K.
    • 7.10.2 Cleanroom Footprint in UK
    • 7.10.3 Cell Therapy Process Capabilities in U.K.
    • 7.10.4 U.K.'s Gene Therapy Process Capabilities
    • 7.10.5 Future CDMO Capacity and Expansion within the UK

8. BIOENGINEERING SOLUTIONS TO BOOST MSC FUNCTIONALITY

  • 8.1 Small Molecule Priming of MSCs
  • 8.2 Particle Engineering of MSCs
    • 8.2.1 Materials used in Microparticles (MPs) Fabrication
  • 8.3 Genetic Engineering of MSCs
    • 8.3.1 Engineered MSCs as Living Drug Factories
  • 8.4 Examples of Bioengineered MSCs to Produce Anticancer Therapeutics
  • 8.5 Engineered MSCs for Neurological Conditions
  • 8.6 Engineered MSCs for Cardiovascular Diseases
  • 8.6 Engineered MSCs for Lung Injury
  • 8.7 Engineered MSCs for Diabetes
  • 8.8 Bioengineering Approaches to Improve MSC Administration

9. MAJOR DISEASES ADDRESSED BY MSCS

  • 9.1 Studies Using MSCs for Autoimmune Diseases
  • 9.2 Studies using MSCs for Cardiovascular Diseases
  • 9.3 Studies using MSCs for Neurodegenerative Diseases
  • 9.4 Studies using MSCs for Bone & Cartilage Diseases
  • 9.5 Studies using MSCs in GvHD
  • 9.6 Studies using MSCs in Crohn's Disease
  • 9.7 Studies using MSCs in Type 1 Diabetes
  • 9.8 Studies using MSCs in Systemic Lupus Erythematosus (SLE)
  • 9.9 Studies using MSCs in Parkinson's Disease
  • 9.10 Studies using MSCs in Alzheimer's Disease
  • 9.11 Studies using MSCs in Kidney Failure
  • 9.12 Studies using MSCs in Spinal Cord Injury
  • 9.13 Studies using MSCs for Wound Healing

10. RECENT COLLABORATIONS WITHIN THE MSC SECTOR, 2020-2024

  • 10.1 Collaboration between BioSolution Designs & RoosterBio
  • 10.2 Collaboration between CytoMed Therapeutics, Ltd. & Sengkang General Hospital
  • 10.3 Collaboration between REPROCELL & Histocell
  • 10.4 Collaboration between FUJIFILM Diosynth & RoosterBio
  • 10.5 RoosterBio's Collaboration with AGC Biologics
  • 10.6 RoosterBio's Partnership with ShiftBio
  • 10.7 RoosterBio's Partnership with Univercells Technologies
  • 10.8 Collaboration between Cynata & Fujifilm
  • 10.9 Collaboration between American CryoStem Corp. & BioTherapeutic Lab Corp.
  • 10.10 RoosterBio's Collaboration with Sartorius
  • 10.11 Collaboration between American CryoStem and CRADA
  • 10.12 RoosterBio's Collaboration with Sartorius Korea Biotech
  • 10.13 Collaboration between Catalent & BrainStorm
  • 10.14 Collaboration between Cipla & Stempeutics
  • 10.15 Aethlon's Collaboration with University of Pittsburgh
  • 10.16 RoosterBio's Collaboration with Senti Biosciences

11. MSC-BASED PRODUCTS IN THE GLOBAL MARKET

  • 11.1 Approved MSC Therapies
    • 11.1.1 Queencell
    • 11.1.2 Cellgram AMI
    • 11.1.3 Cupistem
    • 11.1.4 Cartistem
    • 11.1.5 NeuroNataR
    • 11.1.6 Holoclar
    • 11.1.7 Prochymal / Ryoncil (remestemcel-L)
    • 11.1.8 Temcell HS
    • 11.1.9 Stempeucel
    • 11.1.10 MesestroCell
    • 11.1.11 Stemirac
    • 11.1.12 Ruibosheng (amimestrocel)
  • 11.2 Marketed Biomaterial Carrier-Based MSCs & MSC Progenitors
    • 11.2.1 Osteocel
    • 11.2.2 AlloStem
    • 11.2.3 Grafix
    • 11.2.4 Cellentra VCBM
    • 11.2.5 Trinity ELITE
    • 11.2.6 Map3
    • 11.2.7 BIO4
    • 11.2.8 Trinity Evolution
    • 11.2.9 Carticel
    • 11.2.10 Chondron
    • 11.2.11 DeNovo NT
    • 11.2.12 Ossron
    • 11.2.13 JACC
    • 11.2.14 MACI
    • 11.2.15 Ortho-ACI
    • 11.2.16 Ossgrow
    • 11.2.17 Cartigrow
  • 11.3 Topical Cosmetic Products Containing MSCs/MSC-Derived Exosomes

12. MARKET ANALYSIS

  • 12.1 Market Size for MSC Therapies
  • 12.2 Global Demand for Mesenchymal Stem Cells (MSCs)
    • 12.2.1 Global Demand for MSCs in Academic and Preclinical Studies
    • 12.2.2 Global Demand for MSCs in Clinical Trials
    • 12.2.3 Global Demand for MSCs for Developing MSC Therapeutics
    • 12.2.4 Global Demand for MSCs to Develop Exosome Products
    • 12.2.5 Global Demand for MSCs in Emerging Industries
    • 12.2.6 Global Market for Mesenchymal Stem Cells (MSCs)
    • 12.2.7 Global MSC Market by Application

13. COMPANY PROFILES

  • 13.1 Advancells
    • 13.1.1 MSC-Derived Exosome Therapy
  • 13.2 Aegle Therapeutics
    • 13.2.1 Dystrophic Epidermolysis Bullosa
    • 13.2.2 Burns/Scarring
    • 13.2.3 Additional Indications
  • 13.3 AGC Biologics
    • 13.3.1 Cell Therapy Manufacturing
    • 13.3.2 Services
  • 13.4 AlloSource, Inc.
    • 13.4.1 Allografts with Tissue-Derived MSCs
    • 13.4.2 Products
      • 13.4.2.1 AlloConnex
      • 13.4.2.2 AlloFuse & AlloFuse Plus DBM
      • 13.4.2.3 AlloFlex Plus
      • 13.4.2.4 AlloFuse Cervical Grafts
      • 13.4.2.5 AlloFuse Fiber and Fiber Boats
      • 13.4.2.6 AlloFuse Select CM
  • 13.5 Ambulero
    • 13.5.1 Supercharged MSCs
    • 13.5.2 Ambulero's Pipeline
  • 13.6 American CryoStem Corporation
    • 13.6.1 Adult Stem Cell Storage Service
    • 13.6.2 Products Offered
      • 13.6.2.1 CELLECT
      • 13.6.2.2 ACSelerateMAX
      • 13.6.2.3 ATCELL
  • 13.7 American Type Culture Collection (ATCC)
    • 13.7.1 Stem Cell Products
  • 13.8 Amniotics
    • 13.8.1 Technology
    • 13.8.2 Product Pipeline
  • 13.9 Andelyn Biosciences
    • 13.9.1 Andelyn's Solutions
  • 13.10 Anemocyte S.r.l
    • 13.10.1 GMP Capacity
    • 13.10.2 Product Types
    • 13.10.3 Manufacturing Services
  • 13.11 Anterogen, Co., Ltd.
    • 13.11.1 Products
      • 13.11.1.1 Cupistem Injection
      • 13.11.1.2 Queencell
  • 13.12 Avid Bioservices, Inc.
    • 13.12.1 Services
  • 13.13 Bacthera
    • 13.13.1 Services
  • 13.14 Baylx, Inc.
    • 13.14.1 Technology
    • 13.14.2 Product Pipeline
      • 13.14.2.1 BX-U001 for Rheumatoid Arthritis
  • 13.15 BioCardia
    • 13.15.1 Product Pipeline
  • 13.16 BioCentriq
    • 13.16.1 Clinical Manufacturing Services
    • 13.16.2 Process Development Services
  • 13.17 BioEden, Inc.
  • 13.18 Bioinova s.r.o
    • 13.18.1 Products
    • 13.18.2 Services
      • 13.18.2.1 Storage & Transportation Solution
      • 13.18.2.2 Cryopreservation
      • 13.18.2.3 Autologous Therapy
      • 13.18.2.4 Allogeneic Therapy
  • 13.19 BioRestorative Therapies
    • 13.19.1 BRTX-100
    • 13.19.2 ThermoStem
  • 13.20 Bioscience Institute S.p.A
    • 13.20.1 Aesthetic Stem Cells
      • 13.20.1.1 LIPOSKILL for Skin Rejuvenation
      • 13.20.1.2 LIPOSKILL PLUS for Face Reshaping
      • 13.20.1.3 LIPOSKILL PLUS for Breast Augmentation
      • 13.20.1.4 LIPOSKILL PLUS for Buttock Enhancement
      • 13.20.1.5 LIPOSKILL PLUS for Reduction of Scars and Stretch Marks
      • 13.20.1.6 HAIRSKILL for Hair Loss Treatment
      • 13.20.1.7 GYNSKILL for Vulvo-Vaginal Rejuvenation
    • 13.20.2 Regenerative Stem Cells
      • 13.20.2.1 ORTHOSKILL for Regenerative Orthopedics
      • 13.20.2.2 OVOSKILL for Early Menopause Treatment
      • 13.20.2.3 ANDROSKILL for Erectile Dysfunction Treatment
      • 13.20.2.4 Anti-Aging IV Therapy
      • 13.20.2.5 XEROSTOMIA Treatment
      • 13.20.2.6 Empty Nose Syndrome (ENS) Treatment
      • 13.20.2.7 Stem Cell Therapy for Body Performance
  • 13.21 Blue Horizon International, LLC
    • 13.21.1 BHI's Stem Cell Division
  • 13.22 Boehringer Ingelheim BioXellence
    • 13.22.1 Services
  • 13.23 Bonus Biogroup, Ltd.
    • 13.23.1 BonoFill
    • 13.23.2 MesenCure
  • 13.24 BrainStorm Cell Therapeutics, Inc.
    • 13.24.1 NurOwn Technology
    • 13.24.2 Manufacturing of NurOwn
    • 13.24.3 BrainStorm's Clinical Trials
  • 13.25 Catalent
    • 13.25.1 Cell Therapy Process Development
    • 13.25.2 Cell Therapy CGMP Manufacturing
  • 13.26 CCRM
  • 13.27 Cell2Cure ApS
    • 13.27.1 Product
      • 13.27.1.1 Mode of Action
      • 13.27.1.2 Manufacture
  • 13.28 Cell Care Therapeutics
    • 13.28.1 Platform
    • 13.28.2 CCT-101
  • 13.29 Cellcolabs
    • 13.29.1 Ordering Cells
  • 13.30 CELLeBRAIN
    • 13.30.1 Core Technology
    • 13.30.2 CELLeBRAIN's Product Pipeline
  • 13.31 Cellipont Bioservices
    • 13.31.1 Cellipont's Capabilities
    • 13.33.2 Cellipont's Cell Expertise
  • 13.34 Celprogen, Inc.
    • 13.34.1 Products
    • 13.34.2 Services
  • 13.35 CellProthera
    • 13.35.1 ProtheraCytes
    • 13.35.2 Technology: StemXpand
  • 13.36 CellResearch Corporation, Pte, Ltd.
    • 13.36.1 Umbilical Cord Lining Stem Cells
    • 13.36.2 CALECIM
  • 13.37 Cell Surgical Network (CSN)
    • 13.37.1 Technology: The Time Machine 3.0 Auto
    • 13.37.2 Time Machine Process
  • 13.38 Celltex Therapeutics Corporation
    • 13.38.1 Therapy Services
  • 13.39 CellTherapies
    • 13.39.1 Services
    • 13.39.2 Contract Manufacturing
    • 13.39.3 Apheresis Management
    • 13.39.4 Clinical Trial Support
  • 13.40 Cellular Biomedicine Group
  • 13.41 Charles River Laboratories
    • 13.41.1 Cell Therapy Manufacturing Services
  • 13.42 CHIESI Farmaceutici S.p.A
    • 13.42.1 Holoclar
  • 13.43 Citius Pharmaceuticals, Inc.
    • 13.43.1 Stem Cell Platform
  • 13.44 CorestemChemon, Inc.
    • 13.44.1 Neuronata-R inj.
  • 13.45 Creative Bioarray
    • 13.45.1 MSC Services
    • 13.45.2 MSC Isolation and Expansion Services
    • 13.45.3 MSC Characterization Services
    • 13.45.4 MSC Differentiation Services
  • 13.46 Creative Medical Technology Holdings, Inc.
    • 13.46.1 Rapid Autologous Therapies
    • 13.46.2 Creative Medical's Preclinical and Clinical Pipeline
  • 13.47 Curia Global, Inc
    • 13.47.1 Services
  • 13.48 Cynata Therapeutics, Ltd.
    • 13.48.1 Cymerus Platform
      • 13.48.1.1 CYP-001
      • 13.48.1.2 CYP-004
      • 13.48.1.3 Cymerus MSCs for ARDS
      • 13.48.1.4 CYP-006TK
  • 13.49 Cytovance Biologics
    • 13.49.1 GMP Manufacturing
  • 13.50 Defined Bioscience, Inc.
    • 13.50.1 Products
      • 13.50.1.1 Applications in Stem Cells
      • 13.50.1.2 Applications in Cultivated Meat
  • 13.51 Direct Biologics
    • 13.51.1 ExoFlo
  • 13.52 eQcell, Inc.
    • 13.52.1 Innovation
  • 13.53 Excellos
  • 13.54 Exosla Therapeutics
  • 13.55 EXOSOMEplus
  • 13.56 Exothera
    • 13.56.1 Exoscan Process Analysis Services
    • 13.56.2 Process Design & Development Services
    • 13.56.3 GMP Manufacturing Services
  • 13.57 Fujifilm Diosynth Biotechnologies
    • 13.57.1 Cell & Gene Therapy Services
  • 13.58 Future Cell Japan, Co., Ltd.
    • 13.58.1 Conditioned Media from UC-MSCs
  • 13.59 Genezen
    • 13.59.1 Genezen's Capabilities
  • 13.60 GenScript Biotech Corporation
    • 13.60.1 Cell Therapy Product Solutions
      • 13.60.1.1 CytoSinct Nanobeads
      • 13.60.1.2 CytoSinct Manual Separator System
      • 13.60.1.3 CytoSinct 1000
  • 13.61 Hope Biosciences, LLC
    • 13.61.1 Adult Stem Cell Banking
    • 13.61.2 Newborn Stem Cell Banking
    • 13.61.3 Sponsored Clinical Trials
  • 13.62 Implant Therapeutics, Inc.
    • 13.62.1 Services
  • 13.63 INCELL Corporation LLC
    • 13.63.1 Product Line
    • 13.63.2 Cell & Tissue Products
    • 13.63.3 Tissue Collections & Kit Products
    • 13.63.4 Storage of Cell & Tissue Products
  • 13.64 InGeneron GmbH
    • 13.64.1 Transpose RT Process
    • 13.64.2 Adipose-Derived Regenerative Cells (ADRCs)
  • 13.65 Invitrx Therapeutics
    • 13.65.1 Reluma
  • 13.66 Japan Tissue Engineering, Co., Ltd. (J-TEC)
    • 13.66.1 JACC
  • 13.67 JCR Pharmaceuticals, Co., Ltd.
    • 13.67.1 TEMCELL HS Inj.
  • 13.68 Jointechlabs
    • 13.68.1 Products
      • 13.68.1.1 MiniTC
      • 13.68.1.2 Mini-Stem
    • 13.68.2 Jointech's Products in Pipeline
      • 13.68.2.1 JTL-T-01 (Osteoarthritis Clinical Therapy)
      • 13.68.2.2 JTL-T-02 (Wounds Clinical Therapy)
  • 13.69 Kangstem Biotech, Co., Ltd.
    • 13.69.1 Stem Cell Therapeutics
    • 13.69.2 Stem Cell Therapy
  • 13.70 Kimera Labs
    • 13.70.1 Vive
    • 13.70.2 Luxir
  • 13.71 LifeCell
    • 13.71.1 Large-Scale Manufacturing of MSCs
  • 13.72 Longeveron
    • 13.72.1 Lomecel-B
    • 13.72.2 Clinical Pipeline
  • 13.73 Lonza Group, Ltd
    • 13.73.1 Sell& Gene Technologies Segment
    • 13.73.2 Bioscience Segment
    • 13.73.3 Personalized Medicines Segment
  • 13.74 Lorem Cytori USA, Inc.
    • 13.74.1 Celution System
    • 13.74.2 Cytori Cell Therapy
  • 13.75 MEDPOST
    • 13.75.1 Products
      • 13.75.1.1 CARTISTEM
      • 13.75.1.2 PNEUMOSTEM
      • 13.75.1.3 SMUP-IA-01
      • 13.75.1.4 SMUP-IV-01
  • 13.76 Mesoblast, Ltd.
    • 13.76.1 Technology Platform
    • 13.76.2 Intellectual Property Estate
    • 13.76.3 Product Candidates
      • 13.76.3.1 Revascor
      • 13.76.3.2 MPC-06-ID
      • 13.76.3.3 Remestemcel-L
      • 13.76.3.4 MPC-300-IV
  • 13.77 Millipore Sigma
    • 13.77.1 Cell Culture & Analysis Products
  • 13.78 NecstGen
    • 13.78.1 Cell Therapy Development & Manufacturing
    • 13.78.2 Viral Vector Development & Manufacturing
    • 13.78.3 Cleanroom Rental
  • 13.79 NextCell
    • 13.79.1 ProTrans
    • 13.79.2 Cellaviva
    • 13.79.3 NextCell's Products in Pipeline
  • 13.80 NIPRO Corporation
    • 13.80.1 Stemirac
  • 13.81 Novadip Biosciences
    • 13.81.1 The 3M3 Platform
    • 3.81.2 Products
      • 13.81.2.1 3MAUTO
      • 13.81.2.2 3MALLO
      • 13.81.2.3 3MEXO
  • 13.82 Novus Biologicals, LLC
  • 13.83 NuVasive
    • 13.83.1 Osteocel Portfolio
      • 13.83.1.1 Osteocel Plus
      • 13.83.1.2 Osteocel Pro
  • 13.84 OCT Therapies & Research Pvt., Ltd
  • 13.85 OmniaBio, Inc.
    • 13.85.1 Services
      • 13.85.1.1 Process Development
      • 13.85.1.2 GMP Manufacturing
      • 13.85.1.3 Analytical Development
      • 13.85.1.4 Regulatory Guidance
  • 13.86 Orthocell, Ltd.
    • 13.86.1 OrthoACI
  • 13.87 Orthofix Medical, Inc.
    • 13.87.1 Trinity Elite
    • 13.87.2 Trinity Evolution
  • 13.88 Ossium Health
    • 13.88.1 Platform
    • 13.88.2 Applications
      • 13.88.2.1 Hematologic Diseases
      • 13.88.2.2 Organ Transplant Rejection
      • 13.88.2.3 Musculoskeletal Defects
    • 13.88.3 Products
      • 13.88.3.1 OssiGraft Prime
      • 13.88.3.2 OssiGraft
      • 13.88.3.3 GMP Human Mesenchymal Stem Cells
      • 13.88.3.4 GMP Human Selected CD34+ Cells
      • 13.88.3.5 RUO Mesenchymal Stem Cells
      • 13.88.3.6 RUO Human Selected CD34+ Cells
  • 13.89 Personal Cell Sciences Corporation
    • 13.89.1 Autokine CM
    • 13.89.2 Products
  • 13.90 Personalized Stem Cells, Inc.
    • 13.90.1 Personalized Stem Cells for Knee Osteoarthritis
  • 13.91 Pfizer CentreOne
    • 13.91.1 Manufacturing
  • 13.92 Pluri Biotech, Ltd.
    • 13.92.1 PLX Products
  • 13.93 Porton Advanced
    • 13.93.1 Cell Therapy Services
    • 13.93.2 LVV Services
    • 13.93.3 PLX-PAD
    • 13.93.4 PLX-R18
    • 13.93.5 PLX-Immune
  • 13.94 Prometheus Life Technologies
    • 13.94.1 Organoids
  • 13.95 PromoCell GmbH
    • 13.95.1 Products
  • 13.96 PuREC, Co., Ltd.
    • 13.96.1 PuREC Solution for Hypophosphatasia
    • 13.96.2 PuREC Solution for Spinal Canal Stenosis
  • 13.97 Regrow Biosciences
    • 13.97.1 Ossgrow
    • 13.97.2 Cartigrow
  • 13.98 Reliance Life Sciences, Pvt., Ltd.
    • 13.98.1 Regenerative Medicine Products
  • 13.99 Remedy Cell, Ltd.
    • 13.99.1 Proprietary Platform
    • 13.99.2 Drug Candidate: RC-0315
  • 13.100 Rentschler Biopharma
    • 13.100.1 Services
  • 13.101 REPROCELL USA, Inc.
    • 13.101.1 Services
    • 13.101.2 Products
  • 13.102 Resilence
    • 13.102.1 Resilience's Capabilities
  • 13.103 RESTEM, LLC
    • 13.103.1 Umbilical Cord Lining Stem Cells (ULSCs)
    • 13.103.2 Muscular Dystrophy - Clinical Trial
    • 13.103.3 Dermatomyositis & Polymyositis - Clinical Trial
    • 13.103.3 Heart Failure - Clinical Trial
  • 13.104 RHEACELL GmbH & Co., KG
    • 13.104.1 Technology
    • 13.104.2 ABCB5+MSCs
  • 13.105 Richter-HELM
    • 13.105.1 Services
  • 13.106 RoosterBio, Inc.
    • 13.106.1 Technology
    • 13.106.2 Products
      • 13.106.2.1 Human Mesenchymal Stem Cells (hMSCs)
    • 13.106.3 Genetic Engineering Tools
      • 13.106.3.1 Genetic Engineering Media
    • 13.106.4 Cell Culture Media & Supplements
    • 13.106.5 Cell & Media Kits
    • 13.106.6 MSC-Derived Exosomes
    • 13.106.7 cGMP CliniControl Products
    • 13.106.8 Process Development Services
    • 13.106.9 hMSC Analytical Services
  • 13.107 RTI Surgical
    • 13.107.1 Map3
  • 13.108 RoslinCT
    • 13.108.1 Services
      • 13.108.1.1 Process Development
      • 13.108.1.2 GMP Manufacturing
      • 13.108.1.3 Quality Control
      • 13.108.1.4 Quality & Regulations
      • 13.108.1.5 Product Storage & Logistics
    • 13.108.2 RoslinCT-Lykan Bioscience Combine
  • 13.109 Samsung Biologics
    • 13.109.1 Contract Manufacturing Capabilities
  • 13.110 San Bio, Co., Ltd.
    • 13.110.1 SB623
  • 13.111 Smith & Nephew, Inc.
    • 13.111.1 Grafix
  • 13.112 StemBioSys, Inc.
    • 13.112.1 CELLvo Matrix Technology
    • 13.112.2 CELLVO hAD-MSCs
    • 13.112.3 CELLvo hBM-MSCs
    • 13.112.4 CELLvo hWJ-MSCs
    • 13.112.5 CELLvo Amniotic Membrane MSCs
  • 13.113 STEMCELL Technologies, Inc.
    • 13.113.1 Products
      • 13.113.1.1 MSC & MSC Progenitor Cell Research Products
  • 13.114 Stemedica Cell Technologies, Inc.
    • 13.114.1 BioSmart Technology
    • 13.114.2 Research & Development
  • 13.115 Stemmatters
  • 13.116 StemMedical
    • 13.116.1 Stemform Procedure
    • 13.116.2 Therapeutics Development
  • 13.117 Stempeutics Research Pvt., Ltd.
    • 13.117.1 Stempeucel
  • 13.118 StromaBio AB
    • 13.118.1 MSC Platform
  • 13.119 TaiwanBio Therapeutics, Co., Ltd.
  • 13.120 Takeda Pharmaceutical, Co., Ltd.
    • 13.120.1 Alofisel
  • 13.121 Tempo Bioscience
    • 13.121.1 Tempo iMSCs
  • 13.122 ThermoFisher Scientific
    • 13.122.1 CDMO Services for Cell Therapy
  • 13.123 Vericel Corporation
    • 13.123.1 MACI
  • 13.124 Wuxi App Tec
    • 13.124.1 CTDMO Services
  • 13.125 Xintela AB
    • 13.125.1 Technology Platform
    • 13.125.2 Stem Cell Products
      • 13.125.2.1 XSTEM
      • 13.125.2.2 EQSTEM
      • 13.125.2.3 Cancer Therapy

INDEX OF FIGURES

  • FIGURE 2.1: Mesenchymal Stem Cells and Their Derivatives
  • FIGURE 3.1: Number of Registered MSC-Based Clinical Trials, 1995- Jan, 2025
  • FIGURE 3.2: MSC-Based Clinical Trials by Region
  • FIGURE 3.3: MSC-Based Clinical Trials by Cell Source, Jan- 2025
  • FIGURE 3.4: Share of Autologous & Allogeneic MSCs in Clinical Trials
  • FIGURE 3.5: MSC-Based Clinical Trials by Indication
  • FIGURE 3.6: Percent Share of MSC-Based Clinical Trials by Phase of Study
  • FIGURE 4.1: MSC Patent Publications Over Time, 2000-Jan 7, 2025
  • FIGURE 4.2: MSC-Derived Exosome Patent Publications over Time
  • FIGURE 4.3: iPSC-Derived MSCs Patent Publications over Time
  • FIGURE 4.4: MSC Patents by Applications
  • FIGURE 5.1: Published Papers in PubMed.gov on Mesenchymal Stem Cells (MSCs)
  • FIGURE 5.2: PubMed.gov Published Papers on MSCs in Cell Therapy
  • FIGURE 5.3: PubMed.gov Published Papers on MSC-Based Immunotherapies
  • FIGURE 5.4: PubMed.gov Published Papers on MSCs in Gene Therapy
  • FIGURE 5.5: PubMed.gov Published Papers on MSCs in Tissue Engineering
  • FIGURE 5.6: PubMed.gov Published Papers on MSCs in Aesthetics
  • FIGURE 5.7: PubMed Published Papers on Major Ten Diseases addressed by MSCs
  • FIGURE 5.8: Number of Published Papers on Modified MSCs
  • FIGURE 5.9: Number of Published Papers on MSC-Derived Exosomes
  • FIGURE 6.1: Advantages and Disadvantages of Autologous & Allogeneic MSCs
  • FIGURE 6.2: Monolayer Culture Systems
  • FIGURE 6.3: Stirred Tank Bioreactor
  • FIGURE 6.4: Rocking Bioreactor or Wave Bioreactor
  • FIGURE 6.5: Hollow Fiber Bioreactor
  • FIGURE 6.6: Fixed-Bed Reactor
  • FIGURE 6.7: CompacT SelecT System from Sartorius
  • FIGURE 6.8: DASbox Mini Bioreactor System
  • FIGURE 6.9: PBS-80 Vertical-Wheel Bioreactor
  • FIGURE 6.10: Number of Cells per batch by Technologies
  • FIGURE 6.11: Overview of Bioprocessing Strategies for Large-Scale Production of MSCs
  • FIGURE 7.1: CDMO Platforms with Greater Potentials
  • FIGURE 7.2: Type of CDMOs Used by Sponsors
  • FIGURE 7.3: Major Services Offered by CMOs
  • FIGURE 7.4: Major Services used by Sponsors from CDMOs
  • FIGURE 7.5: Geographic Distribution of Manufacturing Facilities, 2017-2027
  • FIGURE 7.6: Percent Share of Outsourcing
  • FIGURE 7.7: Select Services for Outsourcing
  • FIGURE 7.8: Changing Priorities in Outsorcing Services between 2023 and 2025
  • FIGURE 7.9: Cleanroom Footprint in UK, 2018-2023
  • FIGURE 7.10: Cell Therapy Process Capabilities in U.K.
  • FIGURE 7.11: Gene Therapy Process Capabilities in U.K.
  • FIGURE 8.1: Bioengineering Solutions to Boost the Innate Functions of MSCs
  • FIGURE 8.2: Bioengineering Approaches to MSC Administration
  • FIGURE 9.1: Major Diseases Addresses by MSCs in Clinical Trials
  • FIGURE 9.2: Percentage Share of Autoimmune Diseases using MSCs in Clinical Trials
  • FIGURE 9.3: Percent Share of MSCs by Source in Trials for Cardiovascular Diseases
  • FIGURE 9.4: Percent Shares of Neurological Diseases in Clinical Trials using MSCs
  • FIGURE 9.5: Percent Shares of MSC-Based Musculoskeletal Studies by Source
  • FIGURE 12.1: Global Market for MSC-Based Therapeutics, 2023-2031
  • FIGURE 12.2: Global Market for Mesenchymal Stem Cells (MSCs)
  • FIGURE 12.3: Market Share of MSCs by Application
  • FIGURE 13.1: CELLeBRAIN's Core Technology
  • FIGURE 13.2: CALECIM
  • FIGURE 13.3: Schematic Diagram of CytoSinct Nanobeads
  • FIGURE 13.4: CytoSinct 1000
  • FIGURE 13.5: Why-iPSC Derived MSCs (iMSCs)
  • FIGURE 13.6: MiniTC
  • FIGURE 13.7: Mini-Stem

INDEX OF TABLES

  • TABLE 2.1: Timeline of MSC Nomenclature
  • TABLE 2.2: Sources of MSCs
  • TABLE 2.3: Advantages & Disadvantages of BM-MSCs
  • TABLE 2.4: Advantages & Disadvantages of AD-MSCs
  • TABLE 2.5: Advantages & Disadvantages of Umbilical Cord MSCs (UC-MSCs)
  • TABLE 2.6: Companies Developing iMSC Products
  • TABLE 2.7: Positive & Negative Markers in MSCs from Different Sources
  • TABLE 2.8: in vitro Differentiation Potentials of MSCs
  • TABLE 2.9: Soluble Factors Secreted by MSCs
  • TABLE 2.10: Some Typical "Stemness" Genes of MSCs
  • TABLE 2.11: Types of MSCs and their Biomedical Applications
  • TABLE 2.12: Genes that are Pivotal for MSCs' Properties
  • TABLE 3.1: MSC-Based Clinical Trials by Cell Source
  • TABLE 3.2: Select MSC-Based Clinical Trials
  • TABLE 3.3: Select MSC-Based Clinical Trials for Musculoskeletal Disorders
  • TABLE 3.4: Select MSC-Based Clinical Trials for Neurological Disorders
  • TABLE 3.5: Select Clinical Trials involving MSC-Derived Exosomes
  • TABLE 3.6: Primed MSCs in Clinical Trials
  • TABLE 3.7: Clinical Trials involving Scaffold-Based MSCs
  • TABLE 4.1: MSC Patent Records by Jurisdiction, January 7, 2025
  • TABLE 4.2: MSC Patent Applicants, January 7, 2025
  • TABLE 4.3: MSC Patent Inventors
  • TABLE 4.4: MSC Patent Owners
  • TABLE 4.5: Legal Status of MSC Patent Applications
  • TABLE 4.6: MSC-Derived Exosome Patents by Jurisdiction
  • TABLE 4.7: MSC-Derived Exosome Patent Applicants
  • TABLE 4.8: MSC-Derived Exosome Patent Inventors
  • TABLE 4.9: MSC-Derived Exosome Patent Owners
  • TABLE 4.10: Legal Status of MSC-Derived Exosome Patents
  • TABLE 4.11: iPSC-Derived MSC Patent Applications by Jurisdiction, August 2024
  • TABLE 4.12: iPSC-Derived MSC Patent Owners
  • TABLE 4.13: MSC Patents by Applications
  • TABLE 5.1: PubMed Published Papers on Major Ten Diseases addressed by MSCs
  • TABLE 5.2: Number of Published Papers on Modified MSCs
  • TABLE 5.3: Number of Published Papers on MSC-Derived Exosomes
  • TABLE 6.1: Methods of Isolations of MSCs
  • TABLE 6.2: A Snapshot of Commercially Available Culture Systems
  • TABLE 6.3: Microcarriers used for Cell Expansion
  • TABLE 6.4: Basic Assays for MSCs
  • TABLE 6.5: Cell Surface Markers on MSCs & Fibroblasts: A Comparison
  • TABLE 6.6: Cost of Manufacturing Allogeneic MSCs
  • TABLE 6.7: Cost of Manufacturing Autologous MSCs
  • TABLE 6.8: Media Used for GMP Grade MSC Production
  • TABLE 6.9: Expansion Ratios Achieved with Different Culture Media
  • TABLE 6.10: Commercially Available Controlled Freezing Systems for MSCs
  • TABLE 7.1: Top Ten CDMO Companies in 2003 & 2027
  • TABLE 7.2: GMP Capacities of U.S.-Based CDMOs
  • TABLE 7.3: GMP Capacities of European CDMOs
  • TABLE 7.4: MHRA-Licensed Manufacturing Facilities
  • TABLE 7.5: Cleanroom Footprint in UK, 2019-2023
  • TABLE 8.1: Examples of Priming Strategies in Animal Models
  • TABLE 8.2: Materials used in Microparticles (MPs) Fabrication
  • TABLE 8.3: Genetic Engineering Method used in MSCs
  • TABLE 8.4: Examples of Bioengineered MSCs as Living Drug Factories
  • TABLE 8.5: Examples of Oncology Indications being Studied using Engineered MSCs
  • TABLE 8.6: Effects of Engineered MSCs in Neurological Indications
  • TABLE 9.1: Select MSC-Based Clinical Trials for Autoimmune Diseases
  • TABLE 9.2: Select MSC-Based Clinical Trials for Cardiovascular Diseases
  • TABLE 9.3: Select MSC-Based Clinical Studies for Neurological Diseases
  • TABLE 9.4: Select MSC-Based Studies for Musculoskeletal Disorders
  • TABLE 9.5: Select Ongoing Studies using MSCs for GvHD
  • TABLE 9.6: Studies using MSCs in Crohn's Diseases
  • TABLE 9.7: Select Studies using MSCs in Type 1 Diabetes
  • TABLE 9.8: Select Studies using MSCs in Systemic Lupus Erythematosus (SLE)
  • TABLE 9.9: Select Studies using MSCs in Parkinson's Disease
  • TABLE 9.10: Select Ongoing Studies using MSCs in Alzheimer's Disease
  • TABLE 9.11: Select Ongoing Studies using MSCs in Kidney Failure
  • TABLE 9.12: Select Studies using MSCs in Spinal Cord Injury
  • TABLE 9.13: Select Studies using MSCs for Wound Healing
  • TABLE 11.1: Currently Available MSC Therapies
  • TABLE 11.2: Queencell - Product Information
  • TABLE 11.3: Cellgram AMI - Product Information
  • TABLE 11.4: Cupistem - Product Information
  • TABLE 11.5: Cartistem - Product Information
  • TABLE 11.6: NeuroNataR - Product Information
  • TABLE 11.7: Holoclar - Product Information
  • TABLE 11.8: Prochymal/Ryoncil (Remestemcel-L) - Product Information
  • TABLE 11.9: Temcell HS - Product Information
  • TABLE 11.10: Stempeucel - Product Information
  • TABLE 11.12: MesestroCell - Product Information
  • TABLE 11.13: Stemirac - Product Information
  • TABLE 11.14: Currently Marketed Biomaterial-Based MSCs & MSC Progenitors
  • TABLE 11.15: Osteocel - Product Information
  • TABLE 11.16: AlloStem - Product Information
  • TABLE 11.17: Grafix - Product Information
  • TABLE 11.18: Cellentra VCBM - Product Information
  • TABLE 11.19: Trinity ELITE - Product Information
  • TABLE 11.20: Map3 - Product Information
  • TABLE 11.21: Bio4 - Product Information
  • TABLE 11.22: Trinity Evolution - Product Information
  • TABLE 11.23: Carticel - Product Information
  • TABLE 11.24: Chondron - Product Information
  • TABLE 11.25: DeNovo NT - Product Information
  • TABLE 11.26: Ossron - Product Information
  • TABLE 11.27: JACC - Product Information
  • TABLE 11.28: MACI - Product Information
  • TABLE 11.29: Ortho-ACI - Product Information
  • TABLE 11.30: Ossgrow - Product Information
  • TABLE 11.31: Cartigrow - Product Information
  • TABLE 11.32: Commercially Available Skincare Cosmetics with MSC-Derived Exosomes
  • TABLE 12.1: Global Market for MSC-Based Therapeutics, 2024-2031
  • TABLE 12.2: Global Market for Mesenchymal Stem Cells (MSCs),2024-2031
  • TABLE 13.1: Aegle's Product Pipeline
  • TABLE 13.2: Ambulero's Product Pipeline
  • TABLE 13.3: Amniotics' Product Pipeline
  • TABLE 13.4: Baylx's Product Pipeline
  • TABLE 13.5: BioCardia's Product Pipeline
  • TABLE 13.6: Bonus Biogroup's Product Pipeline
  • TABLE 13.7: BrainStorm's Clinical Trials
  • TABLE 13.8: CELLeBRAIN's Product Pipeline
  • TABLE 13.9: CellProthera's Preclinical and Clinical Pipeline
  • TABLE 13.10: Celltex's Clinical Trials
  • TABLE 13.11: Corestem's Product Pipeline
  • TABLE 13.12: Creative Medical's Preclinical and Clinical Pipeline
  • TABLE 13.13: Regulatory Proteins found in ExoFlo
  • TABLE 13.14: Hopes Clinical Trial Pipeline using HB-adMSC
  • TABLE 13.15: Kangstem's Sponsor Initiated Clinical Trials
  • TABLE 13.16: Longeveron's Clinical Pipeline
  • TABLE 13.17: NextCell's Products in Pipeline
  • TABLE 13.18: Novadip's Product Pipeline
  • TABLE 13.19: RHEACELL's Products in Pipeline
  • TABLE 13.20: San Bio's Product Pipeline
  • TABLE 13.21: Stemedica's Product Pipeline
  • TABLE 13.22: Stempeutics' Product Development Status
  • TABLE 13.23: Xintela's Product Pipeline
샘플 요청 목록
0 건의 상품을 선택 중
목록 보기
전체삭제