구속성 펩타이드 의약품 시장 - 세계 및 지역별 분석 : 펩타이드 유형별, 제품별, 지역별 - 분석 및 예측(2024-2040년)

“Global Constrained Peptide Drugs Market to Reach $17.38 Billion by 2040.”

Industry Overview

The global constrained peptide drugs market revenue has been forecasted from 2024 to 2040, following the earliest launch of the first constrained peptide drug in the market. The market size is anticipated to be $0.06 billion in 2024 and is expected to reach $17.38 billion in 2040, growing at a CAGR of 38.94% during the forecast period 2025-2040.

Market Lifecycle Stage

The global constrained peptide drugs market is anticipated to witness tremendous growth during the forecast period 2025-2040, largely fuelled by the promise of a novel breakthrough constrained peptide pipeline, which is no longer restricted to receptor targets. Advancements in chemical technologies, the therapeutics' success of commercialized synthetic peptides in recent years, and the affordable pricing being realized by these biomolecules in a wide range of diseases are some additional factors attributing to the projected growth in the forecast period.

Impact

The impact analysis for the factors that significantly affect the market, namely, drivers, restraints, and opportunities, has been provided on a short-term and long-term basis. The short-term assessment considers the period between 2020 and 2025, and the long-term assessment considers the period between 2026 and 2040. Key developments and strategies that have been undertaken by some of the key players in this market have been accounted for evaluation of the impact analysis. Further, these key developments have been assessed to understand the future scope of integrating advancing technologies to enable superior outcomes. Additionally, approvals and launches from companies and patent bodies have also been considered while evaluating the dynamics of the global constrained peptide drugs market.

Impact of COVID-19

In December 2019, Wuhan, a city in the Hubei region of China, was the site of the first detection of the COVID-19 outbreak. Following the classification of COVID-19 as novel pneumonia due to a cluster of unexplained pneumonia cases, efforts to pinpoint the culprit causing the outbreak and outline its genomic sequence got underway right once. The virus has already spread to every country on the globe, and researchers, governments, and business leaders are working to find answers to the crisis at a scale and speed that has never been seen. Testing for SARS-CoV-2 in the populace is one of the main steps that has been put into place globally, among many other measures used to stop the spread of the disease.

The global constrained peptide drugs market is a research-oriented market, having a majority of products in clinical trial stages. It primarily consists of clinical-stage biopharmaceutical companies and global biopharmaceutical companies such as Bicycle Therapeutics PLC, Protagonist Therapeutics, Inc., Aileron Therapeutics, Inc., Polyphor, and Santhera Pharmaceuticals Holding. Since most of the products are in the clinical phase of drug development, constrained peptide drug companies had a low impact on the COVID-19 pandemic.

Although clinical trials were brought to pause because of the lockdowns imposed by governments across the world, causing a delay in the clinical trial timeline, and volunteers and patients were also not able to participate in the clinical trials due to the lockdown; however, few companies took the opportunity of the pandemic and initiated the development of potential drugs against COVID-19. For instance, UCB Pharma participated in the COVID-19 Moonshot, an initiative to expedite the development of an anti-viral for COVID-19. The company's Phase III investigational molecule Zilucoplan is being studied for acute respiratory distress syndrome associated with COVID-19. Another company, Polyphor Limited, is evaluating Balixafortide, a constrained peptide drug, against COVID-19 as it demonstrated strong efficacy in in-vitro models.

During the pre-COVID-19 period, the global constrained peptide drugs market observed 38 significant key developments. Out of the 38 key developments, the majority were funding activities, primarily focused on the development of novel antibiotics and support clinical trials of certain drugs in clinical phases. For example, in May 2019, Innosuisse awarded Polyphor Ltd. and the University of Zurich to escalate the development of novel antibiotics for treating infections caused by gram-negative bacteria. Furthermore, seven synergistic activities were undertaken in the global constrained peptide drugs market before COVID-19.

Market Segmentation:

Segmentation 1: by Peptide Type

• Disulfide-Rich Peptides (DRPs)
• Cyclic Peptides

Based on peptide type, the disulfide-rich peptides (DRPs) segment is anticipated to dominate the global constrained peptide drugs market in 2040 as the segment includes the pipeline-constrained peptide with either limited existing treatment options or no approved drugs for the disease.

Segmentation 2: by Region

• North America
• Europe
• Asia-Pacific

The North America region is anticipated to dominate the global constrained peptide drugs market (by region) during the forecast period 2025-2040. The reasons contributing to the high demand for constrained peptide drugs in North America are the increasing prevalence of target indications and the early launch of pipeline products in the U.S. and Canada.

Segmentation 3: by Potential Product

• BT5528
• Rusfertide (PTG-300)
• PN-943
• PN-235
• Zilucoplan (RA101495)

Segmentation 4: by Company

Based on the company, the global constrained peptide drugs market is dominated by 15 major companies.

Recent Developments in the Global Constrained Peptide Drugs Market

• In August 2021, Protagonist Therapeutics Inc. declared the resolution of its collaboration agreement with Zealand Pharma through the reduction of future milestone payments, sales milestones, and royalties owed to Zealand Pharma regarding Protagonist Therapeutics Inc.'s product candidate rusfertide under the terms of the 2012 collaboration agreement between the companies.

• In April 2021, Union Chimique Belge S.A. (UCB) anticipated the release of phase 3 key results for generalized myasthenia gravis (gMG) in the fourth quarter of 2021 and discontinued further development of zilucoplan for immune-mediated necrotizing myopathy (IMNM).

• In September 2021, Polyphor Limited and EnBiotix announced the successful closing of the purchase agreement for EnBiotix to acquire the inhaled antibiotic murepavadin.

• In November 2020, Pepscan Therapeutics B.V. was granted a license for the use of the proprietary CLIPS technology offered by Bicycle Therapeutics plc. The peptide-constraining technology would further help in the development of the company's products named BT1718 and THR-149.

• In June 2020, Santhera Pharmaceuticals secured a financing commitment of up to $22.1 million from a fund managed by Highbridge Capital Management.

Demand - Drivers and Limitations

The following are the demand drivers for the global constrained peptide drugs market:

• Enhanced Binding Affinity and Cellular Uptake
• Development of Synthetic Constraining Method
• Limitations with Conventional Peptides
• Increasing Government and Private Funding

The market is expected to face some limitations due to the following challenges:

• Increased Competition from Biologics
• Risk of Immunogenic Effects and Unsatisfactory ADME Properties

How can this report add value to an organization?

Workflow/Innovation Strategy: The global constrained peptide drugs market has been segmented (by product) into five candidates, i.e., BT5528, Rusfertide (PTG-300), Zilucoplan (RA101495), PN-235, and PN-943. Over the past decade, peptide drug discovery and development has witnessed a renaissance and scientific thrust as the industry has come to acknowledge the capability of peptide therapeutics in addressing unmet medical needs and the potential of this class of molecules to become a significant accompaniment or even favored alternative treatment to biologics and small molecules.

Peptide therapeutics have demonstrated a novel and selective yet safe mode of action for a wide range of indications. The existing and future development of constrained peptide drugs will continue to burgeon upon the strengths of constrained peptides and innovative technologies employed in the discovery and development, including peptide drug conjugates, multifunctional peptides, and cell-penetrating peptides. Furthermore, limitations associated with presently available peptides have resulted in an urgent need for new design, administration, and synthesis in peptide therapeutics, thereby leading to advancements in the development of constrained peptides.

Growth/Marketing Strategy: Constrained peptides provide noteworthy advantages over linear peptides. An increase in interest in the field of constrained peptides due to the properties they offer led to advancements in peptide synthesis technologies. Companies such as PeptiDream Inc., Pepticom Ltd., Bicycle Therapeutics plc, and Polyphor Limited offer proprietary drug development and constrained peptide synthesis technologies. PeptiDream Inc.'s proprietary Peptide Discovery Platform System (PDPS) technology is used to synthesize synthetic non-native peptide libraries expeditiously, which helps in identifying peptides that can be used as potential drugs for a disease.

Competitive Strategy: Key players in the global constrained peptide drugs market have been analyzed and profiled in the study, including manufacturers involved in new product development, acquisitions, expansions, and strategic collaborations. Moreover, a detailed competitive benchmarking of the players operating in the global constrained peptide drugs market has been done to help the reader understand how players stack against each other, presenting a clear market landscape. Additionally, comprehensive competitive strategies such as partnerships, agreements, and collaborations will aid the reader in understanding the untapped revenue pockets in the market.

Table of Contents

1 Definition

• 1.1 Inclusion and Exclusion Criteria

2 Research Scope

• 2.1 Target Audience
• 2.2 Key Questions Answered in the Report

3 Research Methodology

• 3.1 Constrained Peptides: Research Methodology
• 3.2 Primary Data Sources
• 3.3 Secondary Data Sources
• 3.4 Market Estimation Model
• 3.5 Criteria for Company Profiling

4 Markets Overview

• 4.1 Introduction
  • 4.1.1 Structure and Design of Constrained Peptides
  • 4.1.2 Types of Constrained Peptides
• 4.2 Evolution of Constrained Peptides
• 4.3 Development of Constrained Peptides as Drugs
• 4.4 Potential Therapy Areas
• 4.5 Value Chain-Key Stakeholders
• 4.6 Key Industry Trends (by Region)
• 4.7 Key Industry Trends by Route of Administration
• 4.8 Key Industry Trends-Technological Advancements
• 4.9 Current Market Size and Growth Potential, $Billion, 2024-2040
• 4.1 COVID-19 Impact on Global Constrained Peptides Drugs Market
  • 4.10.1 Impact on Constrained Peptide Drugs Companies
  • 4.10.2 Clinical Trial Disruptions and Resumptions

5 Characteristics of Conformationally Constrained Peptides

• 5.1 Properties of Conformationally Constrained Peptides
• 5.2 Synthesis of Constrained Peptides
  • 5.2.1 Chemical Peptide Ligation and Bridging
  • 5.2.2 Chemical Linkage of Peptides onto Scaffolds (CLIPS)
  • 5.2.3 Peptide Stapling
  • 5.2.4 Peptide Discovery Platform System (PDPS)
  • 5.2.5 Liquid Phase Peptide Synthesis (LPPS)
  • 5.2.6 Solid Phase Peptide Synthesis (SPPS)
• 5.3 Advances in Peptide Technology
  • 5.3.1 Synthesis of Peptides Using Microflow Technology
  • 5.3.2 Microwave-Assisted Solid-Phase Peptide Synthesis
• 5.4 Peptide Display and Selection System

6 Industry Insights

• 6.1 Overview
• 6.2 Challenges in Constrained Peptides Regulatory Approval Pathway
• 6.3 Regulatory Scenario of Constrained Peptides
• 6.4 Legal Requirements and Frameworks in the U.S.
  • 6.4.1 Clinical Trial Authorization
  • 6.4.2 Marketing Authorization
  • 6.4.3 U.S. FDA Guidelines for NDA Submission
  • 6.4.4 Post-Authorization Regulations
• 6.5 Legal Requirements and Frameworks in Europe
  • 6.5.1 EMA Drug License Application Process
  • 6.5.2 Centralized Procedure
  • 6.5.3 Decentralized Procedure
  • 6.5.4 Mutual-Recognition Procedure
  • 6.5.5 National Procedure
• 6.6 Legal Requirements and Frameworks in Asia-Pacific
  • 6.6.1 Legal Requirements and Frameworks in Japan
• 6.7 Reimbursement Scenario
  • 6.7.1 Reimbursement Scenario for Autoimmune Diseases
  • 6.7.2 Reimbursement Scenario for Cancer
  • 6.7.3 Reimbursement Scenario for Rare Diseases

7 Market Dynamics

• 7.1 Impact Analysis
• 7.2 Market Drivers
  • 7.2.1 Enhanced Binding Affinity and Cellular Uptake
  • 7.2.2 Development of Synthetic Constraining Methods
  • 7.2.3 Limitations with Conventional Peptides
  • 7.2.4 Increasing Government and Private Funding
    • 7.2.4.1 Funding by Private Companies
    • 7.2.4.2 Funding by Public Companies
    • 7.2.4.3 Funding by Government Institutions
• 7.3 Market Restraints
  • 7.3.1 Increased Competition from Biologics
  • 7.3.2 Risk of Immunogenic Effects and Unsatisfactory ADME Properties
• 7.4 Market Opportunities
  • 7.4.1 Role of Constrained Peptides in Drug Discovery
  • 7.4.2 Various Applications in CNS Disease Studies and Anti-Cancer Therapy

8 Competitive Landscape

• 8.1 Competitive Landscape Overview
  • 8.1.1 Key Developments
  • 8.1.2 Regulatory and Legal Activities
  • 8.1.3 Mergers and Acquisitions
  • 8.1.4 Synergistic Activities
  • 8.1.5 Funding Activities
  • 8.1.6 Clinical Developments

9 Global Constrained Peptides Drugs Market (by Pipeline), $Million, 2024-2040

• 9.1 Constrained Peptide Drugs Clinical Trial Design
  • 9.1.1 Potential Phase II Drugs
  • 9.1.2 BT5528
    • 9.1.2.1 Product Profile
    • 9.1.2.2 Study Design (Phase I/II)
    • 9.1.2.3 Efficacy, Safety, and Tolerability Data (Phase I)
    • 9.1.2.4 BT5528 Preclinical Studies
  • 9.1.3 PN-943
    • 9.1.3.1 Product Profile
    • 9.1.3.2 Study Design (Phase II)
    • 9.1.3.3 Efficacy, Safety, and Tolerability Data (Phase II)
  • 9.1.4 PN-235
    • 9.1.4.1 Product Profile
    • 9.1.4.2 Study Design (Phase IIb)
    • 9.1.4.3 Efficacy, Safety, and Tolerability Data (Phase IIb)
  • 9.1.5 Rusfertide (PTG-300)
    • 9.1.5.1 Product Profile
    • 9.1.5.2 Study Design (Phase II)
    • 9.1.5.3 Efficacy, Safety, and Tolerability Data (Phase IIa)
  • 9.1.6 Potential Phase III drugs
  • 9.1.7 Zilucoplan (RA101495)
    • 9.1.7.1 Product Profile
    • 9.1.7.2 Study Design (Phase III)
    • 9.1.7.3 Efficacy, Safety, and Tolerability Data (Phase III)
    • 9.1.7.4 Zilucoplan Pharmacokinetics and Pharmacodynamics Profile (Phase I)
  • 9.1.8 Rusfertide (PTG-300)
    • 9.1.8.1 Product Profile
    • 9.1.8.2 Study Design (Phase III)
    • 9.1.8.3 Efficacy, Safety, and Tolerability Data (Phase II)
• 9.2 Global Constrained Peptides Drugs Market Pipeline Analysis, $Million, 2024-2040
  • 9.2.1 Pre-Clinical
    • 9.2.1.1 Probability of Success
  • 9.2.2 Clinical (Phase I-III)
    • 9.2.2.1 Probability of Success
    • 9.2.2.2 Cost of API Manufacturing (CDMOs)

10 Global Constrained Peptides Drugs Market (by Peptide Type), $Million, 2024-2040

• 10.1 Global Constrained Peptide Drugs Market (by Peptide Type), $Billion, 2024-2040
  • 10.1.1 Overview
  • 10.1.2 Cyclic Peptides
  • 10.1.3 Disulfide-Rich Peptides (DRPs)

11 Global Constrained Peptides Drugs Market (by Potential Products), $Million, 2024-2040

• 11.1 Overview
  • 11.1.1 BT5528
    • 11.1.1.1 API Manufacturing (Outsource)
    • 11.1.1.2 API Demand Forecast 2024-2040
    • 11.1.1.3 Cost of Outsourcing
  • 11.1.2 Zilucoplan (RA101495)
    • 11.1.2.1 API Manufacturing (In-House)
    • 11.1.2.2 API Demand Forecast 2024-2040
  • 11.1.3 Rusfertide (PTG-300)
    • 11.1.3.1 API Manufacturing (Outsource)
    • 11.1.3.2 API Demand Forecast 2024-2040
    • 11.1.3.3 Cost of Outsourcing
  • 11.1.4 PN-943
    • 11.1.4.1 API Manufacturing (Outsource)
    • 11.1.4.2 API Demand Forecast 2024-2040
    • 11.1.4.3 Cost of Outsourcing
  • 11.1.5 PN-235
    • 11.1.5.1 API Manufacturing (Outsource)
    • 11.1.5.2 API Demand Forecast 2024-2040
    • 11.1.5.3 Cost of Outsourcing

12 Global Constrained Peptides Drugs Market (by Country), $Million, 2024-2040

• 12.1 Global Constrained Peptide Drugs Market (by Country), $Billion, 2024-2031
  • 12.1.1 North America
    • 12.1.1.1 U.S.
    • 12.1.1.2 Canada
  • 12.1.2 Europe
    • 12.1.2.1 U.K.
    • 12.1.2.2 Germany
    • 12.1.2.3 France
    • 12.1.2.4 Italy
    • 12.1.2.5 Spain
  • 12.1.3 Asia-Pacific
    • 12.1.3.1 Japan

13 Company Profiles

• 13.1 Overview
• 13.2 Aileron Therapeutics, Inc.
  • 13.2.1 Company Overview
  • 13.2.2 Role of Aileron Therapeutics, Inc. in the Global Constrained Peptide Drugs Market
  • 13.2.3 Current Status and Policies for Investigational Drugs
  • 13.2.4 Key Competitors of the Company
  • 13.2.5 Financials
  • 13.2.6 Key Insights about the Financial Health of the Company
  • 13.2.7 Corporate Strategies
    • 13.2.7.1 Synergistic Activities
    • 13.2.7.2 Funding Activity
  • 13.2.8 Business Strategies
    • 13.2.8.1 Clinical Development
  • 13.2.9 Analyst Perspective
• 13.3 Bicycle Therapeutics plc
  • 13.3.1 Company Overview
  • 13.3.2 Role of Bicycle Therapeutics plc in the Global Constrained Peptide Drugs Market
  • 13.3.1 Current Status and Policies for Investigational Drugs
  • 13.3.2 Key Competitors of the Company
  • 13.3.3 Financials
  • 13.3.4 Key Insights about the Financial Health of the Company
  • 13.3.5 Corporate Strategies
    • 13.3.5.1 Synergistic Activities
    • 13.3.5.2 Funding
  • 13.3.6 Business Strategies
    • 13.3.6.1 Clinical Developments
    • 13.3.6.2 Regulatory and Legal
  • 13.3.7 Analyst Perspective
• 13.4 Spexis AG
  • 13.4.1 Company Overview
  • 13.4.2 Role of Spexis AG in the Global Constrained Peptide Drugs Market
  • 13.4.3 Current Status and Policies for Investigational Drugs
  • 13.4.4 Key Competitors of the Company
  • 13.4.5 Financials
  • 13.4.6 Key Insights about the Financial Health of the Company
  • 13.4.7 Corporate Strategies
    • 13.4.7.1 Funding
    • 13.4.7.2 Mergers and Acquisitions
    • 13.4.7.3 Synergistic activities
  • 13.4.8 Business Strategies
    • 13.4.8.1 Regulatory and Legal
  • 13.4.9 Analyst Perspective
• 13.5 Protagonist Therapeutics Inc.
  • 13.5.1 Company Overview
  • 13.5.2 Role of Protagonist Therapeutics Inc. in the Global Constrained Peptide Drugs Market
  • 13.5.3 Current Status and Policies for Investigational Drugs
  • 13.5.4 Key Competitors of the Company
  • 13.5.5 Financials
  • 13.5.6 Key Insights about the Financial Health of the Company
  • 13.5.7 Corporate Strategies
    • 13.5.7.1 Funding
    • 13.5.7.2 Synergistic Activities
  • 13.5.8 Business Strategies
    • 13.5.8.1 Clinical Developments
    • 13.5.8.2 Regulatory and legal
  • 13.5.9 Analyst Perspective
• 13.6 Santhera Pharmaceuticals
  • 13.6.1 Company Overview
  • 13.6.2 Role of Santhera Pharmaceuticals in the Global Constrained Peptide Drugs Market
  • 13.6.3 Current Status and Policies for Investigational Drugs
  • 13.6.4 Key Competitors of the Company
  • 13.6.5 Financials
  • 13.6.6 Corporate Strategies
    • 13.6.6.1 Funding
  • 13.6.7 Business Strategies
    • 13.6.7.1 Clinical Developments
  • 13.6.8 Analyst Perspective
• 13.7 Union Chimique Belge S.A. (UCB)
  • 13.7.1 Company Overview
  • 13.7.2 Role of Union Chimique Belge S.A. (UCB) in the Global Constrained Peptide Drugs Market
  • 13.7.3 Current Status and Policies for Investigational Drugs
  • 13.7.4 Key Competitors of the Company
  • 13.7.5 Financials
  • 13.7.6 Key Insights about the Financial Health of the Company
  • 13.7.7 Corporate Strategies
    • 13.7.7.1 Mergers and Acquisitions
  • 13.7.8 Business Strategies
    • 13.7.8.1 Clinical Developments
    • 13.7.8.2 Regulatory and legal
  • 13.7.9 Analyst Perspective
• 13.8 Creative Peptides
  • 13.8.1 Company Overview
  • 13.8.2 Role of Creative Peptides in the Global Constrained Peptide Drugs Market
  • 13.8.3 Key Competitors of the Company
  • 13.8.4 Analyst Perspective
• 13.9 Biosynth (Pepscan)
  • 13.9.1 Company Overview
  • 13.9.2 Role of Biosynth (Pepscan) in the Global Constrained Peptide Drugs Market
  • 13.9.3 Key Competitors of the Company
  • 13.9.4 Corporate Strategies
    • 13.9.4.1 License
  • 13.9.5 Business Strategies
    • 13.9.5.1 Product Launch
  • 13.9.6 Analyst Perspective
• 13.1 Pepticom Ltd.
  • 13.10.1 Company Overview
  • 13.10.2 Role of Pepticom Ltd. in the Global Constrained Peptide Drugs Market
  • 13.10.3 Analyst Perspective
• 13.11 PeptiDream, Inc.
  • 13.11.1 Company Overview
  • 13.11.2 Role of PeptiDream, Inc. in the Global Constrained Peptide Drugs Market
  • 13.11.3 Key Competitors of the Company
  • 13.11.4 Financials
  • 13.11.5 Corporate Strategies
    • 13.11.5.1 Synergistic Activities
  • 13.11.6 Analyst Perspective
• 13.12 Bio-Synthesis Inc
  • 13.12.1 Company Overview
  • 13.12.2 Role of Bio-Synthesis Inc in the Global Constrained Peptide Drugs Market
  • 13.12.3 Key Competitors of the Company
  • 13.12.4 Analyst Perspective
• 13.13 CPC Scientific Inc.
  • 13.13.1 Company Overview
  • 13.13.2 Role of CPC Scientific Inc. in the Global Constrained Peptide Drugs Market
  • 13.13.3 Key Competitors of the Company
  • 13.13.4 Analyst Perspective
• 13.14 Emerging Companies
  • 13.14.1 Circle Pharma
    • 13.14.1.1 Platform
    • 13.14.1.2 Pipeline Products
  • 13.14.2 Zealand Pharma
    • 13.14.2.1 ZP10000 (Preclinical)
      • 13.14.2.1.1 Product Profile
  • 13.14.3 Chugai Pharmaceutical Co., Ltd.
    • 13.14.3.1 Mid-Size Molecule Technology