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시장보고서
상품코드
1462285
BRII-835+BRII-179 시장 규모, 예측, 신약 인사이트(2032년)BRII-835 + BRII-179 Market Size, Forecast, and Emerging Insight - 2032 |
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BRII-836(VIR-2218)은 HBV를 표적으로 하는 피하투여형 siRNA로, 효과적인 면역반응을 자극하고 HBV와 HDV에 대한 직접적인 항바이러스 활성을 가지고 있습니다. 이 siRNA는 안정성을 높이고 오프타깃 활성을 최소화하는 ESC(Enhanced Stabilization Chemistry Plus) 기술이 적용된 최초의 임상용 siRNA로, 잠재적으로 치료 지수를 향상시킬 수 있는 잠재력을 가지고 있습니다.
또한 BRII-179(VBI-2601)는 Pre-S1, Pre-S2, S의 HBV 표면 항원을 발현하고 B세포와 T세포 면역증강을 유도하도록 설계된 새로운 재조합 단백질 기반 HBV 면역치료제 후보물질입니다. 백신으로부터 BRII-179(VBI-2601)의 라이선스를 획득하여 중국 본토, 중국 홍콩, 마카오, 대만 등 라이선스 지역에서 BRII-179(VBI-2601)에 대한 상업적 권리를 획득했습니다.
두 약제 모두 HBV 환자에서 기전이 입증되어 있으며, 병용투여시 기능적 치유를 기대할 수 있습니다. 이 약제는 siRNA 유전자 침묵을 통해 면역억제성 바이러스 항원을 제거하고, 면역요법 백신을 통해 숙주 HBV 특이적 면역을 자극하고 회복시키는 이중 작용기전을 포함하고 있습니다.
주요 7 시장(미국·독일·프랑스·이탈리아·스페인·영국·일본)과 중국 시장에서 B형 만성 간염용 BRII-835+BRII-179에 대해 조사분석했으며, 작용기서, 용법과 용량, 연구개발 활동에 관한 인사이트, 매출의 예측 등을 제공하고 있습니다.
"BRII-835 + BRII-179 Market Size, Forecast, and Emerging Insight - 2032" report provides comprehensive insights about BRII-835 + BRII-179 for chronic hepatitis B in the seven major markets and China. A detailed picture of the BRII-835 + BRII-179 for chronic hepatitis B in the 7MM, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, Japan, and China for the study period 2019 -2032 is provided in this report along with a detailed description of the BRII-835 + BRII-179 for chronic hepatitis B. The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the BRII-835 + BRII-179 market forecast analysis for chronic hepatitis B in the 7MM and China, SWOT, analysts' views, comprehensive overview of market competitors, and brief about other emerging therapies in chronic hepatitis B.
BRII-836 (VIR-2218) is an investigational subcutaneously administered HBV-targeting siRNA that can stimulate an effective immune response and have direct antiviral activity against HBV and HDV. It is the first siRNA in the clinic to include Enhanced Stabilization Chemistry Plus (ESC+) technology to enhance stability and minimize off-target activity, which potentially can result in an increased therapeutic index.
Also, BRII-179 (VBI-2601) is a novel recombinant, protein-based HBV immunotherapeutic candidate that expresses the Pre-S1, Pre-S2, and S HBV surface antigens and is designed to induce enhanced B-cell and T-cell immunity. Brii Bio licensed BRII-179 (VBI-2601) from VBI Vaccines in December 2018, providing Brii Bio with commercial rights to BRII-179 (VBI-2601) in the licensed territories of Mainland China, China Hong Kong, Macau, and Taiwan.
Both agents have demonstrated proof of mechanism in HBV patients; a combination might be a potential functional cure. It encompasses dual mechanisms of action, removing immunosuppressive viral antigens by siRNA gene silencing followed by stimulating and restoring the host HBV-specific immunity with an immunotherapeutic vaccine.
The report provides insights into:
The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.
BRII-835 + BRII-179 Analytical Perspective by DelveInsight
This report provides a detailed market assessment of BRII-835 + BRII-179 for chronic hepatitis B in the seven major markets, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, Japan, and China. This segment of the report provides forecasted sales data from 2027 to 2032.
The report provides the clinical trials information of BRII-835 + BRII-179 for chronic hepatitis B covering trial interventions, trial conditions, trial status, start and completion dates.