접촉성 피부염 시장 - 시장 인사이트, 역학, 시장 예측(2034년)

Key Highlights:

• Although patch testing remains the diagnostic gold standard, its application and interpretation continue to pose challenges. Management centers on allergen avoidance, supported by topical therapies, systemic treatments, and emerging biologics.
• Severe allergic contact dermatitis (ACD) is difficult to manage due to its recalcitrant nature. Advances in disease pathogenesis have led to novel therapies, with biologics such as dupilumab and small-molecule JAK inhibitors showing promise through broad cytokine pathway inhibition.
• There are various types of contact dermatitis, but the most prevalent ones are Irritant Contact Dermatitis (ICD) and ACD. ICD is the most common form and is caused when substances such as solvents or other chemicals irritate the skin. The exposure results into red, often more painful than itchy patches on the involved skin areas. On the other hand, ACD occurs when a substance triggers an immune response or when it comes in contact with a highly toxic substance. Nickel, perfumes, dyes, rubber (latex) products, topical medications and cosmetics frequently cause allergic contact dermatitis.
• A major limitation is the absence of direct comparative studies between emerging therapies and conventional treatments. Further research is also needed to identify predictive biomarkers to enable personalized management of ACD.
• Till date, there is no approved therapy specific for contact dermatitis. The treatment paradigm is mostly similar to that of Atopic dermatitis. Atopic dermatitis and contact dermatitis have similar symptoms, but the underlying cause is different. Atopic Dermatitis is generally considered as an auto-immune disorder.
• ACD is a complex T cell-mediated immune disorder triggered by specific allergens. While allergen avoidance and conventional treatments, such as topical corticosteroids, calcineurin inhibitors, and systemic immunosuppressants, can be effective, their utility is limited by adverse effects and incomplete responses.
• Limited pipeline activity provides huge unmet need and also an available opportunity to new pharma players planning to enter this treatment space.

DelveInsight's "Contact Dermatitis - Market Insight, Epidemiology and Market Forecast - 2034" report delivers an in-depth analysis of contact dermatitis epidemiology, market, and clinical development in contact dermatitis. In addition to this, the report provides historical and forecasted epidemiology and market data as well as a detailed analysis of the contact dermatitis market trends in the United States, EU4 (Germany, France, Italy, and Spain ), and the United Kingdom, and Japan.

The contact dermatitis market report provides real-world prescription pattern analysis, emerging drugs assessment, market share, and uptake/adoption pattern of individual therapies, as well as historical and forecasted contact dermatitis market size from 2020 to 2034 in 7MM. The report also covers current contact dermatitis treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's underlying potential.

Geography Covered:

• The United States
• EU4 (Germany, France, Italy, and Spain) and the United Kingdom
• Japan

Contact Dermatitis Understanding and Treatment Algorithm

Contact Dermatitis Overview

Contact dermatitis is an inflammatory skin condition characterized by eczema-like lesions. It can arise either from direct exposure to toxic substances or metal ions that damage the skin without triggering a T-cell response (irritant contact dermatitis) or from reactive chemicals that bind to skin proteins and activate both innate and adaptive immunity (allergic contact dermatitis). ICD represents a non-specific skin reaction to chemical injury, driven mainly by inflammatory mediators released from epidermal cells. In contrast, ACD is a type IV delayed hypersensitivity reaction caused by external allergens, with cytokine-T-cell interactions playing a central role. A variant known as photoallergic contact dermatitis presents lesions restricted to sun-exposed areas, even if the allergen contacts covered skin. Previously considered uncommon, allergic contact dermatitis is now recognized to be widespread, affecting nearly 20% of children.

Contact Dermatitis Diagnosis

The diagnosis of contact dermatitis is primarily based on a detailed history and thorough physical examination. Both irritant and allergic forms may become secondarily infected with bacteria, making bacterial cultures advisable if exudate, weeping, or crusting is present. When fungal infections such as tinea or Candida are suspected due to similar erythema and scaling, a potassium hydroxide (KOH) preparation is recommended, with fungal culture indicated if the KOH test is negative but clinical suspicion remains. Dermoscopy or microscopy can assist in identifying scabies or mites. Patch testing, photopatch testing, and open patch testing are used to diagnose contact dermatitis.

Contact Dermatitis Treatment

Treatment of contact dermatitis focuses on avoidance of offending agents, symptom relief, and skin barrier restoration. Avoidance of the irritant or allergen is essential, with patients advised to minimize sun exposure in cases of photosensitive contact dermatitis. Supportive care includes cool compresses, wet-to-dry dressings, calamine or oatmeal baths, and systemic or topical antihistamines to relieve pruritus. Topical corticosteroids are the mainstay of treatment, with mid- to high-potency formulations (e.g., triamcinolone 0.1% ointment, betamethasone valerate 0.1% cream) used for mild to moderate disease, applied 1-2 times daily. Oral corticosteroids may be administered as a short course (7-14 days) for severe, extensive, or blistering dermatitis. Topical calcineurin inhibitors (pimecrolimus, tacrolimus) are used in sensitive areas or for patients requiring steroid-sparing therapy, as they do not cause skin thinning. Topical antibiotics are indicated only in cases of secondary bacterial infection, while systemic immunosuppressants (e.g., cyclosporine, methotrexate, azathioprine, mycophenolate mofetil) are reserved for refractory cases. Moisturizers and barrier repair creams help restore normal skin texture and prevent recurrence, with nonirritating formulations recommended. Phototherapy may be employed for patients whose dermatitis does not respond to standard therapies. Proper identification of triggers, through patient history or patch testing, is critical to prevent recurrence, and additional measures such as protective gloves, barrier clothing, and immediate washing after exposure are recommended.

Contact Dermatitis Epidemiology

As the market is derived using a patient-based model, the contact dermatitis epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by total diagnosed prevalent cases of contact dermatitis, type-specific diagnosed prevalent cases of contact dermatitis, gender-specific diagnosed prevalent cases of contact dermatitis, age-specific diagnosed prevalent cases of contact dermatitis, in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), and the United Kingdom, and Japan from 2020 to 2034.

• In the US, contact dermatitis accounts for 90%-95% of all occupational skin disease cases.
• Contact dermatitis is estimated to account for 4%-7% of all annual dermatology consultations.
• The prevalence of ACD in the general population has been reported to be as high as 20%, with 5%-10% experiencing clinical symptoms at least once annually.
• In Spain, women were found to become sensitized at a younger age than men.

Contact Dermatitis Drug Chapters

The drug chapter segment of the contact dermatitis report encloses a detailed analysis of contact dermatitis marketed drugs and late-stage (Phase III, Phase II/III, Phase II, Phase I/II, and Phase I) pipeline drugs. The marketed drugs segment encloses drugs such as EB01 Cream (Edesa Biotech), PDC-AP (Hapten Sciences), and others. It also helps understand the contact dermatitis clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

Emerging Drugs

EB01 (Daniluromer) Cream: Edesa Biotech

EB01 is a potential first-in-class, topical vanishing cream containing a novel, non-steroidal anti-inflammatory compound. EB01 exerts its anti-inflammatory activity through the inhibition of certain pro-inflammatory enzymes known as secretory phospholipase 2, or sPLA2. These enzymes are secreted by immune cells upon their activation and produce arachidonic acid via phospholipid hydrolysis, which, in turn, initiates a broad inflammatory cascade.

According to the company, EB01 is a Phase III ready asset for use as a potential therapy for moderate-to-severe chronic ACD.

PDC-APB: Hapten Sciences

PDC-APB is a small molecule that acts like a vaccine to prevent the excruciating itching and rash caused by exposure to urushiol (yoo-ROO-she-ol) oil in poison ivy, poison oak, and poison sumac plants. The company has completed manufacturing of the active pharmaceutical ingredient for human clinical trials. Hapten filed an Investigational New Drug (IND) Application in 2015. In 2017, Hapten has completed two Phase I safety studies in healthy subjects and is planning a third study to assess safety and biologic activity in subjects with proven sensitivity to urushiol as measured by patch testing.

According to clinical trials, the Phase I trial of PDC-APB is in unknown status from 2021.

Contact Dermatitis Market Outlook

The treatment landscape for contact dermatitis is centered on symptom management, trigger avoidance, and skin barrier restoration. Topical corticosteroids remain the mainstay therapy, with potency selected based on severity and lesion location, while high-potency formulations are reserved for more severe or resistant cases. Topical calcineurin inhibitors, such as tacrolimus and pimecrolimus, serve as steroid-sparing alternatives, particularly for sensitive areas like the face and flexures or for long-term use. Emollients and barrier repair therapies are widely used as adjuncts to restore skin integrity and prevent flare-ups, including ceramide-based creams and lipid-replenishing ointments. In severe or widespread cases, systemic therapies such as short courses of oral corticosteroids may be employed, and antihistamines are sometimes used to alleviate itching, though they do not modify disease progression. Avoidance of triggers through patient education and, when appropriate, patch testing, remains fundamental to management. Overall, the market is largely driven by recurring use of these standard therapies, with strong demand for topical corticosteroids, steroid-sparing alternatives, and barrier repair products, particularly in regions with high awareness of dermatologic care and increasing prevalence due to environmental and occupational exposures. No approved treatment exists, necessitating off-label use of medications, and limited pipeline activity further constrains the market outlook.

Contact Dermatitis Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2025-2034, which depends on the competitive landscape, safety, and efficacy data, along with the order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.

Drug Class Insight

sPLA2 inhibitors

sPLA2 inhibitors target secretory phospholipase A2, an enzyme that hydrolyzes membrane phospholipids to release arachidonic acid, a precursor of pro-inflammatory mediators such as prostaglandins and leukotrienes. By blocking sPLA2 activity, these agents reduce the production of these inflammatory lipids, thereby attenuating inflammation, tissue damage, and pain signaling. EB01 Cream, a topical formulation in this class, delivers localized sPLA2 inhibition, providing anti-inflammatory and analgesic effects while minimizing systemic exposure, offering a targeted approach for managing inflammatory and pain-related conditions.

Contact Dermatitis Pipeline Activities

The report provides insights into different therapeutic candidates in Phase III and Phase II stages. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for contact dermatitis emerging therapies.

KOL Views

To keep up with the real-world scenario in current and emerging market trends, we take opinions from Key Industry Leaders working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on the evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including Medical/scientific writers, Professors, and Others.

DelveInsight's analyst contacted dermatitis connected with 10+ KOLs to gather insights; however, interviews were conducted with 5+ KOLs in the 7MM. Centers such as Harvard Medical School, Duke University, University of Michigan, and Sarcoma Oncology Center etc., were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or contact dermatitis market trends.

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of gaps in disease diagnosis, patient awareness, physician acceptability, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

In efficacy evaluation for contact dermatitis, both primary and secondary outcome measures are assessed; for instance, primary endpoints often include reduction in infarct size, improvement in tissue viability, and preservation of organ function, while secondary outcomes may involve biomarkers of oxidative stress, inflammatory response, and overall survival rates.

Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Market Access and Reimbursement

Reimbursement may be referred to as the negotiation of a price between a manufacturer and payer that allows the manufacturer access to the market. It is provided to reduce the high costs of contact dermatitis and make the essential drugs affordable. Health technology assessment (HTA) plays an important role in reimbursement decision-making and recommending the use of a drug. These recommendations vary widely throughout the seven major markets, even for the same drug. In the US healthcare system, both Public and Private health insurance coverage are included. Also, Medicare and Medicaid are the largest government-funded programs in the US. The major healthcare programs including Medicare, Medicaid, Health Insurance Program (CHIP), and the state and federal health insurance marketplaces are overseen by the Centers for Medicare & Medicaid Services (CMS). Other than these, Pharmacy Benefit Managers (PBMs), and third-party organizations that provide services, and educational programs to aid patients are also present.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of currently used therapies, programs making accessibility easier and out-of-pocket costs contact dermatitis more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Scope of the Report:

• The report covers a segment of key events, an executive summary, descriptive overview of contact dermatitis, explaining its causes, signs and symptoms, pathogenesis, and currently available therapies.
• Comprehensive insight has been provided into the epidemiology segments and forecasts contact dermatitis, the future growth potential of diagnosis rate, and disease progression along treatment guidelines.
• Additionally, an all-inclusive account of both the current and emerging therapies, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
• A detailed review of the contact dermatitis market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
• The report provides an edge while developing business strategies, by understanding trends, through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM contact dermatitis market.

Contact Dermatitis Report Insights

• Patient Population
• Therapeutic Approaches
• Contact Dermatitis Pipeline Analysis
• Contact Dermatitis Market Size and Trends
• Existing and Future Market Opportunity

Contact Dermatitis Report Key Strengths

• 10-Years Forecast
• 7MM Coverage
• Contact Dermatitis Epidemiology Segmentation
• Key Cross Competition
• Conjoint analysis
• Drugs Uptake and Key Market Forecast Assumptions

Contact Dermatitis Report Assessment

• Current Treatment Practices
• Unmet Needs
• Pipeline Product Profiles
• Market Attractiveness
• Qualitative Analysis (SWOT and Conjoint Analysis)

FAQs:

• What is the historical and forecasted contact dermatitis patient pool/patient burden in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan?
• Which combination treatment approaches will have a significant impact on the contact dermatitis drug treatment market size?
• How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
• What are the current and emerging options for the treatment of contact dermatitis?
• How many companies are developing therapies for the treatment of contact dermatitis?
• What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitations of existing therapies?
• Patient acceptability in terms of preferred treatment options as per real-world scenarios?
• What are the country-specific accessibility issues of expensive, recently approved therapies?

Reasons to buy:

• The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the contact dermatitis market.
• Insights on patient burden/disease Incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
• Distribution of historical and current patient share based on real-world prescription data along with reported sales of approved products in the US, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.
• Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
• Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
• Highlights of access and reimbursement policies of approved therapies, barriers to accessibility of expensive off-label therapies, and patient assistance programs.
• To understand Key Opinion Leaders' perspectives around the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
• Detailed insights on the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.

Table of Contents

1. Key Insights

2. Report Introduction

3. Epidemiology and Market Forecast Methodology

4. Contact Dermatitis: Market Overview at a Glance

• 4.1. Market Size (%) of Contact Dermatitis in 2024
• 4.2. Market Size (%) of Contact Dermatitis in 2034

5. Executive Summary

6. Key Events

7. Disease Background and Overview: Contact Dermatitis

• 7.1. Introduction
• 7.2. Causes
• 7.3. Pathophysiology
• 7.4. Symptoms
• 7.5. Risk Factor
• 7.6. Diagnosis

8. Treatment and Management

• 8.1. Treatment Guidelines

9. Epidemiology and Patient Population

• 9.1. Key Findings
• 9.2. Assumptions and Rationale
• 9.3. Total Diagnosed Prevalent cases of Contact Dermatitis in the 7MM
• 9.4. The United States
  • 9.4.1. Total Diagnosed Prevalent Cases of Contact Dermatitis in the United States
  • 9.4.2. Type-specific Diagnosed Prevalent Cases of Contact Dermatitis in the United States
  • 9.4.3. Age-specific Diagnosed Prevalent Cases of Contact Dermatitis in the United States
  • 9.4.5. Gender-specific Diagnosed Prevalent Cases of Contact Dermatitis in the United States
• 9.5. EU4 and the UK
  • 9.5.1. Total Diagnosed Prevalent Cases of Contact Dermatitis in EU4 and the UK
  • 9.5.2. Type-specific Diagnosed Prevalent Cases of Contact Dermatitis in EU4 and the UK
  • 9.5.3. Age-specific Diagnosed Prevalent Cases of Contact Dermatitis in EU4 and the UK
  • 9.5.4. Gender-specific Diagnosed Prevalent Cases of Contact Dermatitis in EU4 and the UK
• 9.6. Japan
  • 9.6.1. Total Diagnosed Prevalent Cases of Contact Dermatitis in Japan
  • 9.6.2. Type-specific Diagnosed Prevalent Cases of Contact Dermatitis in Japan
  • 9.6.3. Age-specific Diagnosed Prevalent Cases of Contact Dermatitis in Japan
  • 9.6.4. Gender-specific Diagnosed Prevalent Cases of Contact Dermatitis in Japan

10. Patient Journey of Contact Dermatitis

11. Emerging Therapies of Contact Dermatitis

• 11.1. Key Cross Competition
• 11.2. EB01 Cream: Edesa Biotech
  • 11.2.1. Product Description
  • 11.2.2. Other Development Activities
  • 11.2.3. Clinical Development Activities
  • 11.2.4. Safety and Efficacy
  • 11.2.5. Analyst View
• 11.3. PDC-APB: Hapten Sciences
  • 11.2.1. Product Description
  • 11.2.2. Other Development Activities
  • 11.2.3. Clinical Development Activities
  • 11.2.4. Safety and Efficacy
  • 11.2.5. Analyst View

12. Contact Dermatitis: 7MM

• 12.1. Key Findings
• 12.2. Market Outlook
• 12.3. Conjoint Analysis
• 12.4. Key Market Forecast Assumptions
  • 12.4.1. Cost Assumptions and Rebates
  • 12.4.2. Pricing Trends
  • 12.4.3. Analogue Assessment
  • 12.4.4. Launch Year and Therapy Uptake
• 12.5. Total Contact Dermatitis Market Analysis: 7MM
• 12.6. United States
  • 12.6.1. Total Market Size of Contact Dermatitis in the United States
  • 12.6.2. Market Size of Contact Dermatitis by Therapies in the United States
• 12.7. EU4 and the UK
  • 12.7.1. Total Market Size of Contact Dermatitis in EU4 and the UK
  • 12.7.2. Market Size of Contact Dermatitis by Therapies in EU4 and the UK
• 12.8. Japan
  • 12.8.1. Total Market Size of Contact Dermatitis in Japan
  • 12.8.2. Market Size of Contact Dermatitis by Therapies in Japan

13. Unmet Needs of Contact Dermatitis

14. SWOT Analysis of Contact Dermatitis

15. KOL Views of Contact Dermatitis

16. Market Access and Reimbursement

• 16.1. United States
• 16.2. EU4 and the UK
• 16.3. Japan

17. Appendix

• 17.1. Bibliography
• 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight