|
시장보고서
상품코드
2018978
만성 콩팥병(CKD) : 시장 인사이트, 역학, 시장 예측(2036년)Chronic Kidney Disease - Market Insight, Epidemiology, and Market Forecast - 2036 |
||||||
DelveInsight
만성 콩팥병(CKD) 시장의 주요 촉진요인
CKD 유병률 상승
12elveInsight의 분석에 따르면, 2024년 주요 7개 시장의 CKD 환자 수는 약 8,200만 명, 총 진단 환자 수는 약 1,450만 명에 달할 것으로 예상했습니다. 노령 인구 증가로 인해 예측 기간(2025-2034년) 동안 이러한 환자 수는 더욱 증가할 것으로 예측됩니다.
적응 확대 가능성
현재 CKD 치료제는 적응증 확대 가능성이 있어 효능을 높이고 시장 성장을 크게 촉진할 수 있는 잠재력을 가지고 있습니다. 이는 새로운 증거들이 보다 광범위한 적응증과 다양한 환자군에서의 개선된 치료 결과를 뒷받침하고 있기 때문입니다.
바이오마커의 발전
KIM-1, NGAL과 같은 바이오마커의 발전으로 기존 방식에 비해 CKD의 조기 및 정확한 검출이 가능해져 적시에 개입하고 환자의 예후를 개선할 수 있는 가능성이 높아지고 있습니다.
CKD경쟁 구도
Novo Nordisk의 Ziltivekimab, AstraZeneca의 Zibotentan/Dapagliflozin과 Baxdrostat/dapagliflozin, Boehringer Ingelheim의 Vicadrostat+, Mineralys Therapeutics의 Lorundrostat, Prokidney의 Rilparencel Empagliflozin, Mineralys Therapeutics의 Lorundrostat, ProKidney의 Rilparencel 등 새로운 치료제의 출시가 시장에 긍정적인 영향을 미칠 것으로 예측됩니다.
만성 콩팥병(CKD)의 치료는 질병의 진행을 늦추고 증상을 관리하며 합병증을 예방하는 데 초점을 맞추었습니다. 식습관 개선, 규칙적인 운동, 금연 등 생활습관 개선이 기본입니다. 신장의 부담을 줄이기 위해 환자에게 소금, 칼륨, 단백질 섭취 제한을 권장하는 경우가 많습니다. 약물 치료는 CKD 관리에 있어 매우 중요한 역할을 합니다. 안지오텐신 전환효소(ACE) 억제제와 안지오텐신 II 수용체 길항제(ARB)는 일반적으로 고혈압을 조절하고 단백뇨를 감소시켜 질병의 진행을 늦추기 위해 처방되는 약물입니다. 스타틴은 고지혈증 관리에 사용되며, CKD 환자의 높은 심혈관 위험을 감소시킵니다.
당뇨병성 CKD 환자에게 혈당 조절은 필수적이며, 신보호 효과가 확인된 메트포르민이나 SGLT2 억제제 등의 약물이 필요한 경우가 많습니다. CKD의 흔한 합병증인 빈혈 치료에는 적혈구 조혈자극인자제제(ESA)와 철분제가 사용됩니다. 진행성 CKD의 경우, 신장 대체 요법이 필요할 수 있습니다. 신장 기능이 현저하게 저하된 경우, 혈액투석이나 복막투석이 신장의 여과 기능을 대신합니다. 말기신부전증(ESRD)의 경우 신장 이식이 정상적인 삶을 영위할 수 있는 최선의 선택이지만, 장기 거부반응을 예방하기 위해 평생 면역억제요법을 받아야 합니다.
만성 콩팥병(CKD)의 관리에는 혈압, 혈당, 콜레스테롤 수치 조절 등 근본적인 원인에 대한 대처도 포함됩니다. 정기적인 모니터링과 적절한 시기의 개입은 CKD 환자의 예후를 개선하고 삶의 질을 향상시키는 데 매우 중요합니다.
주요 7개국(미국, 독일, 스페인, 이탈리아, 프랑스, 영국, 일본)의 만성 콩팥병(CKD) 시장에 대해 조사 분석했으며, 각국 시장 규모와 예측, 각 치료법 시장 점유율, 현재 치료법, 미충족 수요 등의 정보를 전해드립니다.
DelveInsight's "Chronic Kidney Disease Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of the Chronic Kidney Disease, historical and forecasted epidemiology as well as the Chronic Kidney Disease therapeutics market trends in the United States, EU4 and the UK (Germany, France, Italy, Spain), and the United Kingdom, and Japan.
The Chronic Kidney Disease Treatment Market Report provides current treatment practices, emerging Chronic Kidney Disease therapies, market share of the individual therapies, current and forecasted 7MM Chronic Kidney Disease market size from 2022 to 2036. The Chronic Kidney Disease therapeutics market Report also covers current Chronic Kidney Disease treatment market practices, market drivers, market barriers, SWOT analysis, reimbursement and market access, and Chronic Kidney Disease unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Key Factors Driving the Chronic Kidney Disease Market
Rising CKD Prevalence
As per DelveInsight analysis, in 2024, there were approximately 82 million prevalent and nearly 14.5 million total diagnosed prevalent cases of CKD in the 7MM. These cases are projected to increase further during the forecast period (2025-2034), due to the increasing geriatric population.
Potential for Label Expansion
Current therapies for CKD have the potential for label expansion, enhancing efficacy, and driving significant market growth, as emerging evidence supports broader indications and improved outcomes in diverse patient populations.
Advancements in Biomarkers
Advancements in biomarkers such as KIM-1 and NGAL enable earlier and more precise detection of CKD compared to traditional methods, enhancing the potential for timely intervention and improved patient outcomes.
CKD Competitive Landscape
The expected launch of emerging therapies, such as Novo Nordisk's (Ziltivekimab), AstraZeneca's (Zibotentan/Dapagliflozin and Baxdrostat/dapagliflozin), Boehringer Ingelheim (Vicadrostat + Empagliflozin), Mineralys Therapeutics (Lorundrostat), ProKidney's (Rilparencel), and others, are expected to create a positive impact on the market.
Chronic Kidney Disease Understanding & Algorithm
Chronic Kidney Disease is a long-term condition characterized by a gradual loss of kidney function over time. It is commonly caused by diabetes and hypertension, which damage the blood vessels in the kidneys. Symptoms often include fatigue, swelling, and changes in urination. CKD progresses through five stages, from mild damage (stage 1) to kidney failure (stage 5), also known as end-stage renal disease (ESRD). Early detection through blood and urine tests is crucial for managing the disease.
Chronic Kidney Disease Diagnosis
Chronic Kidney Disease is often diagnosed through a combination of blood tests, urine tests, and imaging studies. The primary blood test used is the glomerular filtration rate (GFR), which measures how well the kidneys are filtering waste from the blood. A GFR below 60 mL/min/1.73 m2 for three months or more indicates CKD. Urine tests, such as albumin-to-creatinine ratio (ACR), check for the presence of protein in the urine, which can be an early sign of kidney damage. Imaging studies, including ultrasound or CT scans, are used to visualize the kidneys and detect abnormalities in size, shape, and structure.
Additionally, a thorough medical history and physical examination are crucial. Physicians look for risk factors like diabetes, hypertension, and a family history of kidney disease. Blood pressure measurements and a comprehensive metabolic panel can provide further insights. In some cases, a kidney biopsy may be performed to determine the exact cause of kidney damage. Early diagnosis and monitoring are essential for managing CKD, preventing progression, and reducing complications. Regular follow-ups and appropriate interventions, including lifestyle changes and medications, are vital to improving patient outcomes.
Further details related to diagnosis are provided in the chronic kidney disease drugs market report...
Chronic Kidney Disease Treatment
Chronic Kidney Disease treatment aims to manage symptoms, slow progression, and reduce complications. It typically includes lifestyle changes such as a balanced diet low in sodium, regular exercise, and cessation of smoking. Medications may be prescribed to control blood pressure, blood sugar, and cholesterol. Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) are often used to protect kidney function. For advanced CKD, dialysis or kidney transplantation may be necessary. Regular monitoring and early intervention are crucial to managing CKD effectively. Collaborative care involving nephrologists, dietitians, and primary care providers enhances treatment outcomes.
Further details related to treatment are provided in the chronic kidney disease therapies report...
As the Chronic Kidney Disease market is derived using a patient-based model, the Chronic Kidney Disease epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by, Total Prevalent Cases of Chronic Kidney Disease, Total Diagnosed Prevalent Cases of Chronic Kidney Disease, Gender-specific Diagnosed Prevalent Cases of Chronic Kidney Disease, Age-specific Diagnosed Prevalent cases of Chronic Kidney Disease, Complication-specific Prevalent Cases of Chronic Kidney Disease, Severity-specific Diagnosed Prevalent cases of Chronic Kidney Disease, and Etiology-specific Diagnosed Prevalent cases of Chronic Kidney Disease in the 7MM covering, the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2022 to 2036.
Recent Developments in the Chronic Kidney Disease Market:
The drug chapter segment of the Chronic Kidney Disease therapeutics market report encloses a detailed analysis of Chronic Kidney Disease off-label Chronic Kidney Disease therapies and late-stage (Phase-III and Phase-II) Chronic Kidney Disease therapies analysis. It also helps to understand the Chronic Kidney Disease clinical trials details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest Chronic Kidney Disease news and press releases.
Chronic Kidney Disease Marketed Drugs
KERENDIA is a nonsteroidal mineralocorticoid receptor antagonist (MRA) indicated to reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure in adult patients with Chronic Kidney Disease associated with type 2 diabetes. In February 2022, KERENDIA was granted market authorization by the European Commission for the treatment of chronic kidney disease (with albuminuria) associated with Type 2 diabetes mellitus in adults.
INVOKANA (canagliflozin) is a prescription medicine used with diet and exercise to lower blood sugar in adults with type 2 diabetes. INVOKANA, is the class of medications called sodium glucose co-transporter 2 (SGLT2) inhibitors, approved in the United States in 2013. The label was expanded to cover more indications such as diabetic kidney disease in the subsequent years in the US along with EU and Japan.
Chronic Kidney Disease Emerging Drugs
Zibotentan/Dapagliflozin, developed by AstraZeneca, is an investigational oral combination therapy being evaluated for adults with CKD. It combines zibotentan, an endothelin receptor antagonist, with dapagliflozin, an SGLT2 inhibitor, aiming to improve kidney outcomes by targeting complementary pathways involved in CKD progression.
Vicadrostat (BI 690517) + Empagliflozin, developed by Boehringer Ingelheim, is an investigational combination therapy being evaluated for adults with CKD. It combines vicadrostat, an aldosterone synthase inhibitor, with empagliflozin, an SGLT2 inhibitor, to target complementary pathways involved in CKD progression.
Lorundrostat: Mineralys Therapeutics
Lorundrostat, developed by Mineralys Therapeutics, is an investigational oral aldosterone synthase inhibitor being evaluated for adults with CKD. It works by selectively inhibiting aldosterone production, targeting hormonal pathways involved in CKD progression.
Chronic Kidney Disease treatment focuses on slowing disease progression, managing symptoms, and preventing complications. Lifestyle modifications are fundamental, including dietary changes, regular exercise, and smoking cessation. Patients are often advised to limit salt, potassium, and protein intake to reduce kidney workload. Pharmacological interventions play a critical role in managing CKD. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are commonly prescribed to control hypertension and reduce proteinuria, thereby slowing disease progression. Statins are used to manage hyperlipidemia, reducing cardiovascular risks, which are heightened in CKD patients.
Blood glucose control is essential for diabetic CKD patients, often requiring medications such as metformin and SGLT2 inhibitors, which have shown kidney-protective effects. Erythropoiesis-stimulating agents (ESAs) and iron supplements are used to treat anemia, a common complication of CKD.Advanced CKD may necessitate renal replacement therapies. Hemodialysis and peritoneal dialysis help perform the kidney's filtering functions when renal function is significantly impaired. For end-stage renal disease (ESRD), kidney transplantation offers the best chance for a normal life, though it requires lifelong immunosuppressive therapy to prevent organ rejection.
Managing Chronic Kidney Disease also involves addressing underlying causes, such as controlling blood pressure, blood sugar, and cholesterol levels. Regular monitoring and timely interventions are crucial to improving outcomes and enhancing the quality of life for CKD patients.
This section focuses on the uptake rate of potential Chronic Kidney Disease drugs expected to launch in the market during 2022-2036. For example, KBP-5074 in the US is expected to be launched by 2026 with a peak share of 5%. KBP-5074 is anticipated to take 7 years to peak with a medium uptake.
Key Medications in chronic renal failure therapeutics market include multiple inhibitors as well as different drugs such as: Lisinopril, Enalapril, Ramipril, Losartan, Valsartan, Irbesartan, Dapagliflozin, Canagliflozin, Empagliflozin, Liraglutide, Semaglutide, Dulaglutide and others.
Chronic Kidney Disease Pipeline Development Activities
The chronic kidney disease Pipeline drugs market report provides insights into Chronic Kidney Disease clinical trails within Phase III, Phase II, and Phase I stage. It also analyzes key Chronic Kidney Disease Companies involved in developing targeted therapeutics.
Pipeline Development Activities
The chronic renal failure therapeutics market report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Chronic Kidney Disease emerging therapies and the chronic kidney disease prevalence.
KOL Views
To keep up with current chronic renal failure market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Chronic Kidney Disease evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from University of Arizona College of Medicine, Phoenix, the US, Department of Renal Transplantation, Mayo Clinic - Minnesota, Rochester, the US, Mayo Clinic - Minnesota, Rochester, the US; Universite Cheikh Anta Diop de Dakar, Senegal, France, Universite Claude Bernard, Lyon, France; Health Economics and Outcomes Research Ltd., Cardiff, Wales, the UK, Kings College Hospital, NHS Foundation Trust, the UK, Endocrinology, Diabetes, and Internal Medicine, Bermuda Hospitals Board, the UK; National University in Niigata, Japan; and others.
Delveinsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps understand and validate current and emerging therapies, treatment patterns, or Chronic Kidney Disease market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.
Chronic Kidney Disease Therapeutics Market Qualitative Analysis
We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple approved and emerging chronic renal failure therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Chronic Kidney Disease Therapeutics Market Access and Reimbursement
The high cost of therapies for the treatment is a major factor restraining the growth of the global Chronic Kidney Disease drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment. The Chronic renal failure therapeutics market report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Chronic Kidney Disease Treatment Market Report Scope
Key Questions Answered In The Chronic Kidney Disease Market Report:
Chronic Kidney Disease Drugs Market Insights
Chronic Kidney Disease Epidemiology Insights
Current Chronic Kidney Disease Treatment Market Scenario, Marketed Drugs, and Emerging Therapies
Reasons to Buy the Chronic Kidney Disease Drugs Market Forecast Report