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시장보고서
상품코드
2018990
발열성 호중구 감소증 - 시장 인사이트, 역학, 시장 예측(2036년)Febrile Neutropenia - Market Insight, Epidemiology, and Market Forecast - 2036 |
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DelveInsight
발열성 호중구 감소증 시장 성장에 영향을 미치는 요인
암 발병률 상승
전 세계 암 환자 수의 증가가 발열성 호중구 감소증 시장을 크게 견인하고 있습니다. 이는 화학요법을 받는 많은 환자들이 호중구감소증을 경험하고 감염의 위험이 높기 때문입니다.
골수 억제 요법의 사용 증가
종양학 분야에서 화학요법, 표적 치료제, 병용요법의 사용이 확대되면서 호중구감소증 발생 확률이 높아져 발열성 호중구 감소증 예방 및 관리 솔루션에 대한 지속적인 수요가 발생하고 있습니다.
예방적 치료 도입 확대
예방 목적으로 과립구 집락 자극 인자(G-CSF)를 광범위하게 사용함으로써 합병증을 줄이고 환자 예후를 개선하여 치료 및 지지요법 환경에서 시장 성장을 촉진하고 있습니다.
바이오시밀러 확대
바이오시밀러G-CSF의 등장은 특히 비용에 민감한 시장에서 치료의 비용 효율성과 접근성을 향상시켜 보다 폭넓은 채택을 촉진하고 있습니다.
의료 인프라의 발전
의료 시설, 종양학 지원 서비스, 진단 접근성의 발전으로 발열성 호중구 감소증을 효과적으로 진단하고 관리할 수 있는 능력이 향상되었습니다.
발열성 호중구 감소증 치료제 시장은 예측 기간(2026-2036년) 동안 환자 수 증가, 기술 발전, 새로운 치료법의 등장 등 주요 촉진요인으로 인해 더욱 확대될 것으로 예상됩니다. 지속적인 연구와 헌신적인 노력으로 미래에는 더 효과적인 치료법, 그리고 궁극적으로 이 어려운 질병을 근절할 수 있는 희망이 열릴 것입니다. DelveInsight에 따르면, 주요 7개 시장의 발열성 호중구 감소증 시장 규모는 2026-2036년 예측 기간 동안 큰 변화가 있을 것으로 예상됩니다.
발열성 호중구 감소증의 경쟁 상황
발열성 호중구 감소증 시장의 경쟁 환경은 특히 과립구 집락 자극 인자 및 항감염증 치료제의 개발 및 상용화에 있어 종양학적 지지요법에 집중하는 일류 제약사의 존재가 특징입니다. 시장 경쟁은 치료의 비용 효율성을 높이고 환자의 접근성을 확대하는 브랜드 바이오의약품과 증가하는 바이오시밀러에 의해 촉진되고 있습니다. 각 업체들은 제품의 효능, 안전성 프로파일, 투여 편의성, 가격 책정 전략, 지리적 범위 등의 요소로 경쟁하고 있습니다. 지속적인 혁신, 기존 치료법의 라이프사이클 관리, 전략적 제휴, 신흥 시장 진출이 경쟁 구도를 형성하고 있으며, 예방 의료와 외래 환자 관리의 중요성이 강조되면서 시장에서의 포지셔닝에 더 많은 영향을 미치고 있습니다.
발열성 호중구 감소증의 주요 7개국(미국, 독일, 스페인, 이탈리아, 프랑스, 영국, 일본)에 대해 조사 분석했으며, 각국의 시장 규모와 예측, 각 치료법의 시장 점유율, 현재 치료법, 미충족 수요 등의 정보를 전해드립니다.
Febrile Neutropenia Market and Epidemiology Analysis
Factors impacting the Febrile Neutropenia Market Growth
Rising Incidence of Cancer
The global increase in cancer cases significantly drives the febrile neutropenia market, as a large proportion of patients undergoing chemotherapy experience neutropenia and are at high risk of infection.
Increased Use of Myelosuppressive Therapies
The expanding use of chemotherapy, targeted therapies, and combination regimens in oncology increases the likelihood of neutropenia, creating sustained demand for febrile neutropenia prevention and management solutions.
Growing Adoption of Prophylactic Treatments
Wider use of granulocyte-colony stimulating factors (G-CSFs) for prevention has reduced complications and improved patient outcomes, strengthening market growth across treatment and supportive care settings.
Expansion of Biosimilars
The availability of biosimilar G-CSFs has improved treatment affordability and accessibility, particularly in cost-sensitive markets, encouraging broader adoption.
Improved Healthcare Infrastructure
Advancements in healthcare facilities, oncology support services, and access to diagnostics have enhanced the ability to diagnose and manage febrile neutropenia effectively.
DelveInsight's comprehensive report titled "Febrile Neutropenia Market Insights, Epidemiology, and Market Forecast - 2036" offers a detailed analysis of febrile neutropenia. The report presents historical and projected epidemiological data covering total incident cases of Febrile Neutropenia, etiology-specific cases of Febrile Neutropenia, severity-specific cases of Febrile Neutropenia, and treated cases of Febrile Neutropenia. In addition to epidemiology, the market report encompasses various aspects related to the patient population. These aspects include the diagnosis process, prescription patterns, physician perspectives, market accessibility, treatment options, and prospective developments in the market across seven major markets: the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan, spanning from 2022 to 2036.
The report analyzes the existing treatment practices and unmet medical requirements in Febrile Neutropenia. It evaluates the market potential and identifies potential business prospects for enhancing therapies or interventions. This valuable information enables stakeholders to make well-informed decisions regarding product development and strategic planning for the market.
Febrile Neutropenia Disease Understanding
Neutropenic fever is defined as a single oral temperature =101°F (38.3°C) or a sustained temperature =100.4°F (38°C) for over an hour, accompanied by an absolute neutrophil count (ANC) below 1500 cells/µL. It is considered severe when ANC falls below 500/µL and profound when below 100/µL. In many cases, the exact cause of infection remains unidentified, and the fever is classified as fever of unknown origin (FUO).
Neutropenic fever is the most frequent and serious complication in patients with hematologic cancers or those undergoing chemotherapy. It arises when an immunocompromised patient encounters an infection, often due to weakened immune defenses and damaged barriers like the gastrointestinal or sinus mucosa, allowing pathogens to invade.
Febrile Neutropenia Diagnosis:
The diagnosis of febrile neutropenia is primarily based on the presence of fever in a patient with neutropenia, typically defined as a single oral temperature >=38.3°C or a sustained temperature >=38.0°C for over one hour, along with an absolute neutrophil count below 500 cells/µL or expected to fall to this level. Prompt clinical evaluation is essential and includes a thorough history, physical examination, and assessment of risk factors related to recent chemotherapy. Initial investigations usually involve complete blood counts, blood cultures from peripheral and central lines, urine analysis, chest imaging if respiratory symptoms are present, and other site-specific cultures as indicated. Risk stratification tools help classify patients into low- or high-risk categories, guiding subsequent management decisions.
Febrile Neutropenia Treatment:
Treatment of febrile neutropenia is a medical emergency and should begin immediately after cultures are obtained, without waiting for results. Empirical broad-spectrum intravenous antibiotics with coverage against gram-negative organisms are initiated, especially in high-risk patients, while low-risk patients may be managed with oral antibiotics in an outpatient setting. Therapy is adjusted based on clinical response, culture results, and local resistance patterns. Supportive care includes the use of granulocyte-colony stimulating factors in selected patients, management of complications, and close monitoring of vital signs and blood counts. Antibiotic therapy is continued until the patient is afebrile and neutrophil recovery is achieved or an alternative diagnosis is established.
The epidemiology section of the febrile neutropenia market report offers information on the patient populations, including historical and projected trends for each of the seven major markets. Examining key opinion leader views from physicians or clinical experts can assist in identifying the reasons behind historical and projected trends. The diagnosed patient pool, their trends, and the underlying assumptions are all included in this section of the report.
This section also presents the data with relevant tables and graphs, offering a clear and concise view of the incidence of Febrile Neutropenia. Additionally, the report discloses the assumptions made during the analysis, ensuring data interpretation and presentation transparency. This epidemiological data is valuable for understanding the disease burden and its impact on the patient population across various regions.
Key Findings from Febrile Neutropenia Epidemiological Analyses and Forecast
Febrile Neutropenia Market Segmentation
DelveInsight's 'Febrile Neutropenia Market Insights, Epidemiology, and Market Forecast - 2036' report provides a detailed outlook of the current and future febrile neutropenia market, segmented within countries, by therapies, and by classes. Further, the market of each region is then segmented by each therapy to provide a detailed view of the current and future market share of all therapies.
Febrile Neutropenia Market Size by Countries
The febrile neutropenia market size is assessed separately for various countries, including the United States, EU4 (Germany, France, Italy, and Spain), the UK, and Japan. In 2025, the United States held a significant share of the overall 7MM (Seven Major Markets) febrile neutropenia market, primarily attributed to the country's higher incidence of the condition and the elevated cost of the available treatments. This dominance is projected to persist, especially with the potential early introduction of new products.
Febrile Neutropenia Market Size by Therapies
Febrile Neutropenia Market Size by Therapies is categorized into current and emerging markets for the study period 2022-2036.
Febrile Neutropenia Drug Analysis
Febrile Neutropenia Marketed Drugs
ROLVEDON (eflapegrastim-xnst): Assertio Holdings/Spectrum Pharmaceuticals
ROLVEDON (eflapegrastim-xnst) is a long-acting granulocyte colony-stimulating factor (G-CSF) with a novel formulation. Spectrum has received an indication to decrease the incidence of infection, as manifested by febrile neutropenia, in adult patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with clinically significant incidence of febrile neutropenia.
RYZNEUTA (efbemalenograstim alfa-vuxw): Evive Biotechnology/Acrotech Biopharma
RYZNEUTA is a leukocyte growth factor indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in adult patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. RYZNEUTA is the first non-pegylated granulocyte colony-stimulating factor approved by both the US FDA.
Febrile Neutropenia Emerging Drugs
Plinabulin: BeyondSpring
Plinabulin is a first-in-class, small-molecule selective immunomodulating microtubule-binding agent (SIMBA) that exerts both anti-cancer and hematopoietic protective effects. Unlike traditional G-CSFs, plinabulin works through a differentiated mechanism by promoting dendritic cell maturation, modulating immune response, and protecting hematopoietic stem/progenitor cells from chemotherapy-induced damage, thereby reducing the incidence of febrile neutropenia.
The drug has been primarily investigated for the prevention of chemotherapy-induced neutropenia in combination with G-CSF, demonstrating clinical benefit in reducing the duration of severe neutropenia and improving immune recovery in patients receiving myelosuppressive chemotherapy. The drug has received Breakthrough Therapy Designation (BTD) for the chemotherapy-induced neutropenia indication from the US FDA.
Plinabulin has completed Phase III clinical development; however, in 2022, the US FDA issued a Complete Response Letter (CRL) citing the need for additional clinical data, particularly to confirm clinical benefit in reducing febrile neutropenia risk. As a result, its regulatory approval has been delayed. As of now, there have been no publicly available major regulatory or clinical updates reported post-2022.
AKT-011: Akthelia Pharmaceuticals
AKT-011, is a first-in-class, orally administered small-molecule immunomodulator currently in preclinical development for the prevention of febrile neutropenia. The drug is designed to act locally in the gastrointestinal tract by enhancing epithelial barrier integrity and upregulating innate immune defense mechanisms, thereby preventing bacterial translocation, a key driver of infection and sepsis in neutropenic patients.
As per company's 2023 pipeline, the candidate is advancing through preclinical stages up to IND-enabling activities, with Phase I expected to begin around 2024, followed by subsequent clinical development for febrile neutropenia; however, no recent updates are currently available.
The febrile neutropenia therapeutics market is further expected to increase by the major drivers, such as the rising incidence population, technological advancements, and upcoming therapies in the forecast period (2026-2036).With ongoing research and continued dedication, the future holds hope for even more effective treatments and, ultimately, a cure for this challenging condition. According to DelveInsight, the Febrile Neutropenia market in the 7MM is expected to change significantly during the forecast period 2026-2036.
Febrile Neutropenia Competitive Landscape
The competitive landscape of the febrile neutropenia market is characterized by the presence of established pharmaceutical companies focused on supportive oncology care, particularly in the development and commercialization of granulocyte-colony stimulating factors and anti-infective therapies. Market competition is driven by branded biologics and a growing number of biosimilars that enhance treatment affordability and expand patient access. Companies compete on factors such as product efficacy, safety profiles, dosing convenience, pricing strategies, and geographic reach. Ongoing innovation, lifecycle management of existing therapies, strategic collaborations, and expansion into emerging markets continue to shape competition, while increasing emphasis on preventive care and outpatient management further influences market positioning.
Key Febrile Neutropenia Companies
The leading Febrile Neutropenia companies developing therapies include -
This section focuses on the sales uptake of potential febrile neutropenia drugs that have recently been launched or are anticipated to be launched in the febrile neutropenia market between 2022 and 2036. It estimates the market penetration of febrile neutropenia drugs for a given country, examining their impact within and across classes and segments. It also touches upon the financial and regulatory decisions contributing to the probability of success (PoS) of the drugs in the febrile neutropenia market.The emerging febrile neutropenia therapies are analyzed based on various attributes such as safety and efficacy in randomized clinical trials, order of entry and other market dynamics, and the unmet need they fulfill in the Febrile Neutropenia market.
Febrile Neutropenia Clinical Trials Analysis
The Febrile Neutropenia pipeline report offers an analysis of Febrile Neutropenia clinical trials within Phase II and III stages and examines companies involved in developing targeted therapeutics for febrile neutropenia. It provides valuable insights into the advancements and progress of potential treatments in clinical development for this condition.
Febrile Neutropenia Pipeline Development Activities
The Febrile Neutropenia clinical trials analysis report covers information on collaborations, acquisition and merger, licensing, patent details, and other information for emerging febrile neutropenia therapies.
Febrile Neutropenia Market Access and Reimbursement
DelveInsight's 'Febrile Neutropenia Market Insights, Epidemiology, and Market Forecast - 2034' report provides a descriptive overview of the market access and reimbursement scenario of febrile neutropenia.
This section includes a detailed analysis of the country-wise healthcare system for each therapy, enlightening the market access, reimbursement policies, and health technology assessments.
Latest KOL Views on Febrile Neutropenia
To keep up with current febrile neutropenia market trends and fill gaps in secondary findings, we interview KOLs and SMEs' working in the febrile neutropenia domain. Their opinion helps understand and validate current and emerging therapies and treatment patterns or febrile neutropenia market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the febrile neutropenia unmet needs.
Febrile Neutropenia Competitive Intelligence Analysis
We conduct a Competitive and Market Intelligence analysis of the febrile neutropenia market, utilizing various Competitive Intelligence tools such as SWOT analysis and Market entry strategies. The inclusion of these analyses is contingent upon data availability, ensuring a comprehensive and well-informed assessment of the market landscape and competitive dynamics.
Key Questions Answered In The Febrile Neutropenia Market Report:
Reasons to buy Febrile Neutropenia Market Forecast Report
The primary goals in treating febrile neutropenia are to promptly control infection, restore neutrophil counts, and prevent complications like sepsis. Management involves early broad-spectrum antibiotics, fever resolution, and immune stabilization to reduce morbidity and hospital stay. Long-term strategies include prophylactic antimicrobials, G-CSF support, and chemotherapy optimization, with a focus on improving quality of life and reducing recurrence.
Managing febrile neutropenia is challenging due to its rapid onset, varied infectious etiologies, and the immunocompromised state of patients. Diagnosis is complicated by nonspecific symptoms and difficulty in identifying the infection source. Long-term management is hindered by chemotherapy-induced bone marrow suppression, rising antimicrobial resistance, and limited access to supportive treatments like G-CSF. Financial burden, poor adherence, and comorbidities further complicate sustained infection control.
Key factors driving the growth of the febrile neutropenia market include rising cancer rates, broader use of myelosuppressive chemotherapy, and heightened awareness of infection risks. Advances in long-acting G-CSF, rapid diagnostics, and the availability of biosimilars have improved prevention and access. Increased healthcare investment and favorable reimbursement are also fueling market growth.
The report will provide comprehensive insights into the current febrile neutropenia market landscape, emerging therapies, competitive dynamics, regulatory requirements, and market access considerations, enabling informed decision-making, strategic planning, and optimization of business strategies to capitalize on market opportunities and drive growth.