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시장보고서
상품코드
2019006
폐 전이를 동반한 연부조직 육종(STS) - 시장 인사이트, 역학, 시장 예측(2036년)Soft Tissue Sarcoma with Lung Metastases - Market Insight, Epidemiology, and Market Forecast - 2036 |
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DelveInsight
연부조직 육종(STS)의 발병률 증가와 진단 능력의 향상은 시장 성장의 주요 촉진요인입니다. 고해상도 CT 스캔, PET 영상 등 영상 기술의 발전으로 폐 전이의 조기 발견이 크게 향상되어 적시에 개입할 수 있게 되었고, 치료 대상 환자군이 확대되고 있습니다.
새로운 표적 치료제, 티로신 키나아제 억제제, 면역치료제의 개발은 전이성 연부조직 육종(STS)의 치료 환경을 변화시켰습니다. 이러한 치료법은 기존 화학요법 대비 생존율 향상과 내약성 개선을 가져와 채택 증가와 시장 확대를 촉진하고 있습니다.
분자 프로파일링과 바이오마커에 기반한 치료 선택에 대한 관심이 높아지면서, 폐 전이가 동반된 STS에서 개별화된 치료 접근법이 지지받고 있습니다. 정밀의료는 치료 순서의 최적화, 반응률 향상, 질병 조절 기간의 연장을 가능하게 하여 시장 성장을 견인하고 있습니다.
임상적 초점은 전신요법, 전이절제술, 정위적 방사선치료(SBRT)를 포함한 다각적인 접근법을 통해 폐 전이를 적극적으로 관리하는 것으로 옮겨가고 있습니다. 이러한 통합적 치료 접근법은 환자의 치료 결과를 개선하고 첨단 치료 옵션에 대한 수요를 증가시키고 있습니다.
제약사 및 생명공학 기업들은 STS와 같은 희귀 및 진행성 암에 대한 연구개발에 대한 투자를 확대하고 있습니다. 전이성 질환을 표적으로 하는 신약 및 병용요법 파이프라인의 확장은 시장 전망을 더욱 견고하게 하고 있습니다.
임상의와 환자의 인식이 높아지고 전문 육종 센터에 대한 접근성이 개선되면서 진단율과 치료율이 향상되고 있습니다. 여러 전문 분야에 걸친 치료 모델은 최적의 질병 관리를 지원하며 시장의 지속적인 성장에 기여하고 있습니다.
유리한 규제 프레임워크와 희귀질환 치료제에 대한 특혜가 STS 치료제의 혁신을 촉진하고 있습니다. 신속한 승인과 시장 독점권의 혜택은 신규 진입 기업을 끌어들여 장기적인 시장 확대를 뒷받침하고 있습니다.
Annamycin, IP-001 등 여러 종류의 신약 후보물질의 발전이 기대되고 있어 향후 선택의 폭이 다소 확대될 가능성이 있습니다. 그러나 STS-LM의 전반적인 개발 상황은 여전히 제약이 있어 미충족 수요가 큰 것으로 나타났습니다.
국소 연부조직 육종(STS) 환자의 표준 치료법은 종양학적 절제 범위를 확보한 광범위한 외과적 절제술입니다. 반면 전이성 병변이 있는 STS 환자에게는 전신 화학요법이나 방사선 치료를 시행하며, 경우에 따라서는 원발성 종양이나 전이성 병변의 절제술을 시행하기도 합니다. 독소루비신은 1차 선택적 완화 화학요법으로서 폐 전이가 있는 대부분의 STS 환자들에게 치료 옵션으로 권장되고 있습니다. 폐 전이 절제술은 폐 전이를 동반한 연부조직 육종(STS) 환자 관리의 표준적인 접근법이며, 발표된 여러 연구에 따르면 이 수술을 받은 환자의 5년 전체 생존율(OS)이 43%-50.9%에 이르는 것으로 나타났습니다. 또한, 마츠오카 등은 사지의 원발성 종양을 외과적으로 절제하면 전이성 연부조직 육종(STS) 환자의 생존율을 향상시킬 수 있다고 보고했습니다. 이러한 환자들의 임상 결과를 개선하기 위한 노력에도 불구하고, 예후는 여전히 좋지 않습니다.
현재 폐 전이를 동반한 연부조직 육종(STS)에 대해 명시적으로 승인된 치료법은 없습니다. 전이성 연부조직 육종(STS)의 관리에는 다양한 전신 요법이 사용되고 있지만, 폐 전이에 특이적으로 적응증이 있는 치료제는 없습니다. Moleculin Biotech, AstraZeneca와 같은 폐 전이성 연부조직 육종(STS) 부문의 기업들은 임상시험을 진행하고 있습니다.
본 보고서는 폐 전이를 동반한 연부조직 육종(STS)의 주요 7개국(미국, 독일, 스페인, 이탈리아, 프랑스, 영국, 일본) 시장에 대해 조사 분석했으며, 각국의 시장 규모와 예측, 각 치료법의 시장 점유율, 현재 치료법, 미충족 수요 등의 정보를 전해드립니다.
Soft Tissue Sarcoma With Lung Metastasis Market and Epidemiology Analysis
The growing incidence of Soft Tissue Sarcoma, coupled with better diagnostic capabilities, is a major driver of market growth. Advances in imaging technologies such as high-resolution CT scans and PET imaging have significantly improved the early detection of lung metastases, enabling timely intervention and expanding the treated patient pool.
The development of novel targeted therapies, Tyrosine Kinase Inhibitors, and immunotherapies has transformed the treatment landscape for metastatic STS. These therapies offer improved survival outcomes and better tolerability compared to conventional chemotherapy, driving increased adoption and market expansion.
Growing emphasis on molecular profiling and biomarker-driven treatment selection is supporting personalized therapy approaches in STS with lung metastasis. Precision medicine is enabling optimized treatment sequencing, improved response rates, and prolonged disease control, thereby fueling market growth.
Clinical focus is shifting toward aggressive management of lung metastases through multimodal approaches, including systemic therapy, metastasectomy, and stereotactic body radiotherapy. This integrated care approach is improving patient outcomes and increasing demand for advanced therapeutic options.
Pharmaceutical and biotechnology companies are increasingly investing in research and development for rare and aggressive cancers such as STS. The expanding pipeline of novel agents and combination therapies targeting metastatic disease is strengthening the market outlook.
Enhanced awareness among clinicians and patients, along with improved access to specialized sarcoma centers, is leading to higher diagnosis and treatment rates. Multidisciplinary care models are supporting optimal disease management and contributing to sustained market growth.
Favorable regulatory frameworks and orphan drug incentives are encouraging innovation in STS therapeutics. Accelerated approvals and market exclusivity benefits are attracting new entrants and supporting long-term market expansion.
Expected advancement of novel candidates such as Annamycin, IP-001, and a few others may modestly expand future options; however, the overall development landscape for STS-LM continues to be constrained, underscoring a significant unmet need.
DelveInsight's "Soft Tissue Sarcoma With Lung Metastasis Market Insight, Epidemiology and Market Forecast - 2036" report delivers an in-depth analysis of STS with lung metastasis epidemiology, market, and clinical development in STS with lung metastasis with lung metastasis. In addition to this, the report provides historical and forecasted epidemiology and market data as well as a detailed analysis of the STS with lung metastasis with lung metastasis market trends in the United States, EU4 (Germany, France, Italy, and Spain), and the United Kingdom, and Japan.
The STS with lung metastasis with lung metastasis Treatment Market Report provides real-world prescription pattern analysis, emerging drugs assessment, market share, and uptake/adoption pattern of individual therapies, as well as historical and forecasted STS with lung metastasis with lung metastasis market size from 2022 to 2036 in 7MM. The report also covers current STS with lung metastasis with lung metastasis treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's underlying potential.
Soft Tissue Sarcoma With Lung Metastasis Understanding
Soft Tissue Sarcoma With Lung Metastasis Overview and Diagnosis
Soft Tissue Sarcoma is a diverse group of rare malignant tumors that originate in the mesodermal tissues-such as fat, muscle, blood vessels, deep skin layers, tendons, and ligaments-that support and connect various parts of the body. While these tumors can occur anywhere, they most often begin in the arms or legs, but can also develop in the trunk, head and neck, internal organs, or the retroperitoneal space (the area behind the abdominal cavity). One of the major challenges in STS is its potential to spread beyond the original tumor site.
Metastasis is not uncommon; in fact, approximately 40% to 50% of individuals with STS will eventually develop metastatic disease. Among all possible sites, the lungs are by far the most common destination for metastases, accounting for nearly 80% of first metastatic occurrences. When STS spreads to the lungs, it typically signals a more advanced stage of the disease, requiring a shift in treatment goals-from curative intent to controlling disease progression, alleviating symptoms, and extending survival. STS with lung metastasis is diagnosed through a combination of imaging scans, biopsies, and sometimes blood tests. Imaging, like chest X-rays, CT scans, or MRIs, can reveal the presence of tumors in the lungs. Biopsies, where tissue samples are examined under a microscope, confirm the diagnosis and determine the specific type of sarcoma.
The STS with lung metastasis report provides an overview of STS with lung metastasis pathophysiology, and diagnostic approaches, along with a real-world scenario of a patient's journey beginning from the first symptom, the time taken for diagnosis to the entire treatment process.
Soft Tissue Sarcoma With Lung Metastasis Treatment
Pulmonary metastases are a sign of advanced disease and are always a challenge in the management of oncologic patients. The mainstay of treatment is the surgical resection of all metastatic nodules which offers a potentially curative option and a significant survival advantage. In the setting of metastatic sarcoma, lung involvement is frequent, and the disease tends to recur with a significantly higher pattern than in any other tumor type. Multiple or even extended operations are often necessary. Alongside the operative approach, medical therapy has been reported with variable results. Currently, single-agent chemotherapy or combinations are reserved for patients with chemosensitive histology or patients considered for multimodality therapy. The role of immunotherapy, instead, despite promising results, is still under investigation. Radiotherapy has been boosted in recent years, with the spread of stereotactic body radiation therapy which overwhelmed the traditional sarcomas' radioresistance.
As the market is derived using a patient-based model, the STS with lung metastasis epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Incident Cases of STS, Total Incident Cases of STS-LM, and Gender-specific Incident Cases of STS-LM in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2022 to 2036.
Key findings from the Soft Tissue Sarcoma With Lung Metastasis Epidemiological Analysis and Forecast
Soft Tissue Sarcoma with Lung Metastasis Epidemiology Segmentation in the 7MM
Soft Tissue Sarcoma With Lung Metastasis Drug Analysis
The drug chapter segment of the STS with lung metastasis Therapeutics Market Report encloses a detailed analysis of STS with lung metastasis marketed drugs and late-stage (Phase III and Phase II) Soft Tissue Sarcoma With Lung Metastasis Pipeline Drugs. It also deep dives into the STS with lung metastasis's pivotal clinical trial details, recent and expected market approvals, patent details, the latest news, and recent deals and collaborations.
Soft Tissue Sarcoma With Lung Metastasis Emerging Drugs
Annamycin is an investigational next-generation anthracycline developed by Moleculin, designed to overcome multidrug resistance. It incorporates lipid-based delivery to enhance tumor uptake while reducing cardiotoxicity, with development focused on aggressive and treatment-refractory cancers, including select sarcoma and hematologic malignancies. Currently in Phase I/II clinical development. In December 2020, Moleculin Biotech reported that the US Food and Drug Administration granted ODD to Annamycin for the treatment of soft tissue sarcomas.
IP-001 is an investigational intratumoral immunotherapy developed by Immunophotonics for soft tissue sarcoma. It employs a photothermal mechanism to induce localized tumor cell death and stimulate systemic anti-tumor immune responses, with development focused on advanced and refractory sarcoma settings. Currently in Phase I/II clinical development for non-small cell lung cancer (NSCLC) and STS, with Phase I enrollment for STS completed. In September 2023, Immunophotonics reported that the first patient was dosed in its multinational clinical trial in France, marking a key milestone in the clinical development of its investigational immunotherapy program.
The gold standard for patients with localized STSs is surgical-wide resection with oncologic margins. In contrast, STS patients with metastatic lesions are treated by systemic chemotherapy, radiation, and possibly with resection of the primary tumor or metastatic lesions. Doxorubicin, the first-line palliative chemotherapy, is recommended as a therapeutic option for the majority of STS patients with Lung Metastases. Pulmonary metastasectomy is also a proven standard approach for the management of STS patients with LM, and some published studies have indicated that 5-year overall survival (OS) ranges from 43% to 50.9% in patients following this procedure. In addition, Matsuoka et al reported surgical resection of a primary tumor in the extremities could improve survival for metastatic STS patients. Despite efforts to improve the clinical outcome of these patients, the prognosis remains poor.
There are currently no therapies specifically approved for STS with lung metastases. While various systemic therapies are used to manage metastatic STS, none are uniquely indicated for lung metastases. Soft Tissue Sarcoma With Lung Metastasis Companies are conducting trials for this segment such as Moleculin Biotech, AstraZeneca, and others.
Soft Tissue Sarcoma With Lung Metastasis Competitive Intelligence Analysis
We perform Competitive and Market Intelligence analysis of the Soft Tissue Sarcoma With Lung Metastasis Market by using various Competitive Intelligence tools that include - SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies etc. The inclusion of the analysis entirely depends upon the data availability.
Key Soft Tissue Sarcoma With Lung Metastasis Companies
Moleculin Biotech, Institut Claudius Regaud/AstraZeneca and others.
This section focuses on the uptake rate of potential Soft Tissue Sarcoma With Lung Metastasis drugs expected to be launched in the market during 2024-2034, which depends on the competitive landscape, safety, and efficacy data, along with the order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.
Soft Tissue Sarcoma With Lung Metastasis Clinical Trials Activities
The Soft Tissue Sarcoma With Lung Metastasis Therapeutics Market Report provides insights into different therapeutic candidates in Phase III and Phase II stages. It also analyzes key Soft Tissue Sarcoma With Lung Metastasis Companies involved in developing targeted therapeutics.
Soft Tissue Sarcoma with Lung Metastasis Pipeline Development Activities
The Soft Tissue Sarcoma With Lung Metastasis Therapeutics Market Report covers information on collaborations, acquisitions and mergers, licensing, and patent details for STS with lung metastasis emerging therapies.
Latest KOL Views on Soft Tissue Sarcoma With Lung Metastasis
To keep up with the real-world scenario in current and emerging market trends, we take opinions from Key Industry leaders working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on the evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including Medical/scientific writers, Professors, and Others.
DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 5+ KOLs in the 7MM. Centers such as UT Health San Antonio MD Anderson Cancer Center, University of Michigan, and Sarcoma Oncology Center etc., were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or STS with lung metastasis market trends.
Soft Tissue Sarcoma With Lung Metastasis Qualitative Analysis
We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of gaps in disease diagnosis, patient awareness, physician acceptability, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
In efficacy, the trial's primary and secondary outcome measures are evaluated; for instance, in event-free survival, one of the most important primary outcome measures is event-free survival and overall survival. Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Soft Tissue Sarcoma With Lung Metastasis Market Access and Reimbursement
Reimbursement may be referred to as the negotiation of a price between a manufacturer and payer that allows the manufacturer access to the market. It is provided to reduce the high costs and make the essential drugs affordable. Health technology assessment (HTA) plays an important role in reimbursement decision-making and recommending the use of a drug. These recommendations vary widely throughout the seven major markets, even for the same drug. In the US healthcare system, both Public and Private health insurance coverage are included. Also, Medicare and Medicaid are the largest government-funded programs in the US. The major healthcare programs including Medicare, Medicaid, Health Insurance Program (CHIP), and the state and federal health insurance marketplaces are overseen by the Centers for Medicare & Medicaid Services (CMS). Other than these, Pharmacy Benefit Managers (PBMs), and third-party organizations that provide services, and educational programs to aid patients are also present.
The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of currently used therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Soft Tissue Sarcoma With Lung Metastasis Market Report Scope
Key Questions Answered in the Soft Tissue Sarcoma With Lung Metastasis Market Report
Soft Tissue Sarcoma With Lung Metastasis Market Insights
Reasons to Buy the Soft Tissue Sarcoma With Lung Metastasis Market Report
The table of contents is not exhaustive; the final content may vary.