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A형 인플루엔자 감염 : 시장 인사이트, 역학 및 예측(2036년)

Influenza A Infections - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 178 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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A형 인플루엔자 감염 시장의 인사이트 및 동향

  • A형 인플루엔자 바이러스는 인플루엔자 대유행을 일으키는 것으로 알려진 유일한 인플루엔자 바이러스입니다. A형 인플루엔자 바이러스는 사람들 사이에서 효율적으로 감염이 확산되는 능력을 가지고 있으며, 사람들은 이에 대해 면역력이 거의 없거나 아예 없습니다.
  • A형 인플루엔자 바이러스에는 다양한 유형이 있으며, 이들은 헤마글루티닌(H) 및 노이라미니다제(N)라고 불리는 표면의 특정 단백질에 의해 구분됩니다. 현재 사람들 사이에서 일상적으로 유행하고 있는 A형 인플루엔자 바이러스의 아형에는 A(H1N1) 및 A(H3N2)가 포함됩니다.
  • 2025년 남반구 아메리카 대륙의 독감 시즌에는 3월 중순까지 감염이 계절적 임계치를 넘어섰으며, 대체로 낮은 수준에서 중간 수준 사이를 오갔습니다. 감염 확산은 주로 A(H1N1)pdm09형 인플루엔자에 의해 주도되었으며, 검사 양성률은 최고 19%에 달했습니다.
  • 추산에 따르면, 2025년 주요 7개국(주요 7개 시장)에서 A형 인플루엔자 감염 시장 규모가 가장 컸던 곳은 미국이었고, 가장 작았던 곳은 스페인이었습니다. 앞으로 등장할 A형 인플루엔자 치료법은 환자들이 현재 직면하고 있는 미충족 의료 수요를 해소하고, A형 인플루엔자 감염 시장 규모의 전반적인 성장에 기여할 것으로 기대됩니다.
  • 모더나(Moderna)사가 개발을 진행 중인 차세대 mRNA 기반 인플루엔자 백신은 개발의 후기 단계 및 규제 당국의 심사 단계에 접어들었으며, 바이러스 변이주에 대한 대응이 더욱 신속하게 이루어질 가능성과 생산 규모 확대가 기대되고 있습니다.
  • 백신 접종은 중증으로 진행될 수 있는 바이러스성 호흡기 질환으로부터 몸을 보호하기 위한 가장 효과적인 대책입니다. 백신 접종 대상자, 특히 중증화 위험이 높은 분들은 각국의 권고에 따라 접종을 받는 것이 권장됩니다.
  • 2026년 계절성 인플루엔자에 관한 임상 권고에 따라, CDC는 2025년부터 2026년까지의 인플루엔자 유행 기간 동안 소아, 임산부 및 성인은 방부제로 티메로살이 포함되지 않은 1회 투여형 계절성 인플루엔자 백신만을 접종해야 한다고 권고하고 있습니다.
  • 2025년 3월 13일, 미국 식품의약국(FDA)은 2025-2026년 미국용 인플루엔자 백신의 성분을 업데이트할 것을 권고했습니다.
  • 약리학적 개입 외에도, 위생 습관 준수를 독려하거나 백신 접종을 장려하는 등의 행동 관리 전략은 고위험군을 중증화로부터 보호하기 위해 필수적입니다.
  • A형 인플루엔자 분야의 주요 기업으로는 로슈, 바이오크리스트 파마슈티컬스, 세키라스, 모더나, 시다라 테라퓨틱스, 글락소스미스클라인, 코크리스탈 파마 등이 있습니다.
  • A형 인플루엔자 파이프라인에는 CD388, Flu Pandemic mRNA(GSK4382276A), CC-42344 등 유망한 후기 및 중기 단계의 치료법(의약품 및 백신)이 포함되어 있습니다.
  • 이 새로운 파이프라인은 A형 인플루엔자에 대한 효과적인 치료 옵션을 제공합니다. 인식 제고와 진단 기술의 발전은 조기 발견과 환자의 예후 개선에 있어 매우 중요합니다.

미국의 A형 인플루엔자 감염 시장 규모 및 전망

  • A형 인플루엔자 감염 시장 규모(2025년) : 약 50억 달러
  • A형 인플루엔자 감염 시장 규모(예측) : 약 100억 달러
  • A형 인플루엔자 성장률(2026-2036년) : 연평균 성장률(CAGR) 7.9%

본 A형 인플루엔자 감염 시장 보고서에서는 현재의 치료 현황, 신약, 개별 치료법 시장 점유율, 그리고 2022년부터 2036년까지 주요 7개국(700만 명) 단위의 A형 인플루엔자 감염 시장 규모(현황 및 전망)에 대해 설명하고 있습니다. 또한, 본 보고서에서는 최적의 비즈니스 기회를 파악하고 시장의 잠재력을 평가하기 위해, 현재 A형 인플루엔자의 치료 현황 및 치료 알고리즘과 미충족 의료 수요에 대해서도 다루고 있습니다.

A형 인플루엔자 감염 시장을 주도하는 주요 요인

세계 질병 부담 증가

A형 인플루엔자는 전 세계적으로 큰 질병 부담의 원인 중 하나이며, 매년 유행이 발생하여 전 세계적으로 수백만 건의 환자와 막대한 사망자를 초래하고 있습니다. 이러한 높은 발병률과 그에 따른 의료비 부담이 예방 백신 및 항바이러스 치료에 대한 지속적인 수요를 이끌고 있습니다.

A형 인플루엔자 감염 시장에서 기회 확대

백신(mRNA 및 범용 플랫폼 등)의 혁신, 신규 항바이러스제, 진단법의 개선에 더해, 코로나19 이후 예방접종 활동의 확대가 시장 기회 확대를 뒷받침하고 있습니다. 또한, 세계보건기구(WHO) 등 기관들의 전 세계적인 관심 증가와 생명공학 분야에 대한 투자 확대가 시장 성장과 팬데믹 대비를 가속화하고 있습니다.

A형 인플루엔자의 이해와 치료 알고리즘

A형 인플루엔자의 개요와 진단

A형 인플루엔자 바이러스는 바이러스 표면에 있는 두 가지 단백질, 즉 헤마글루티닌(H)과 노이라미니다제(N)에 따라 아형으로 분류됩니다. 헤마글루티닌에는 18가지의 서로 다른 아형이 있으며, 뉴라미니다제에는 11가지의 아형이 있습니다(각각 H1부터 H18, N1부터 N11). 자연계에서는 주로 야생조류에서 130종 이상의 인플루엔자 A형 아형 조합이 확인되었으나, 잠재적으로는 이보다 더 많은 조합이 존재할 가능성이 있습니다. A형 인플루엔자의 경우, 때때로 '항원 변이'가 발생합니다. 이는 바이러스 표면 항원(HA 및 NA)에 현저한 변화가 발생하여 새로운 아형이 출현하는 현상으로, 종종 감염률 및 사망률 증가를 동반하는 전 세계적인 대유행을 초래합니다.

A형 인플루엔자를 포함한 인플루엔자 바이러스의 진단은 일반적으로 임상 증상을 바탕으로 이루어지며, 검사를 통해 확정됩니다. 의료 종사자들은 호흡기 검체 내의 바이러스 항원을 검출하여 몇 분 이내에 결과를 확인할 수 있는 ‘인플루엔자 신속 진단 검사(RIDT)’를 자주 이용하고 있습니다. 특히 유행 시기나 중증 환자의 경우, 역전사 중합효소 연쇄반응(RT-PCR) 등 보다 정확한 방법을 사용하여 바이러스의 유형이나 아형을 확인합니다. 상황에 따라 바이러스 배양이나 면역형광검사가 실시되기도 하지만, 이러한 검사들은 더 많은 시간이 소요됩니다. 적절한 치료를 실시하고 바이러스의 확산을 막기 위해서는 조기 및 정확한 진단이 중요합니다. 신속 분자 검사는 상기도 검체를 대상으로 하는 새로운 유형의 분자 인플루엔자 진단 검사로, 높은 민감도와 특이도를 갖추고 있습니다. 미국에서는 FDA 승인을 받은 2종의 신속 분자 검사가 이용 가능합니다. 신속 분자 검사에서는 약 20분 만에 결과를 확인할 수 있습니다.

A형 인플루엔자 치료의 현황

치료법은 질환의 중증도에 따라 다릅니다. 합병증이 없는 계절성 독감 환자에게는 대증 요법이 권장되며, 바이러스의 확산을 막기 위해 자택에서 대기하도록 권고받습니다. 치료는 발열 등 인플루엔자 증상을 완화하는 데 중점을 둡니다. 환자는 자신의 상태를 관찰하여 악화 징후가 없는지 확인하고, 필요에 따라 의료기관을 방문해야 합니다. 고위험군 환자에게는 증상이 나타난 후 48시간 이내에 오셀타미비르 등의 항바이러스제를 투여해야 합니다. 폐렴이나 패혈증과 같은 중증 환자의 경우, 즉시 항바이러스 치료를 실시해야 합니다. 노이라미니다제 억제제는 최소 5일간 처방해야 하며, 코르티코스테로이드는 필요한 경우에만 사용해야 합니다. 백신 접종은 여전히 가장 효과적인 예방법이며, 면역력을 유지하기 위해 매년 접종하는 것이 권장됩니다.

A형 인플루엔자의 역학

A형 인플루엔자의 역학 분석 및 예측에 관한 주요 연구 결과

  • 미국에서는 2025년 기준 18-49세 성인층의 백신 접종률이 가장 높았고, 임산부의 접종률은 가장 낮은 것으로 확인되었습니다. 전반적으로, 백신 접종 대상자는 소아(0-4세, 5-12세), 청소년(13-17세), 성인(18-49세, 50-64세, 65세 이상) 및 임산부로 분류되었습니다.
  • 2025년 미국의 인플루엔자 백신 실패율은 약 70%로 추정되며, 백신 접종을 받은 사람들의 상당수가 여전히 감염 위험에 노출되어 있는 것으로 나타났습니다.
  • 일본에서 공개된 감시 데이터를 2차 분석한 결과, 후생노동성의 보고에 따르면 2025년 11월에는 주 평균 약 19만 6,895건의 인플루엔자 사례가 보고되었으며, 이는 의료기관 1곳당 평균 51.12건에 해당하여 유행 강도가 높은 것으로 나타났습니다.
  • 유럽에서는 ‘유럽 호흡기 바이러스 감시 요약(ERVISS)’(2025년) 보고서에 따르면, 2024년에 인플루엔자 A형(H1N1) pdm09가 우세한 아형으로 나타났으며, 인플루엔자 A형 전체 사례의 약 57-93%를 차지했습니다.
  • 미국에서는 2022년부터 2036년까지의 조사 기간 동안 A형 인플루엔자 양성 사례의 총 수가 증가할 것으로 예측되며, 이는 시간이 지남에 따라 질병 부담이 커지고 있음을 반영합니다.

A형 인플루엔자 감염 시장 전망

A형 인플루엔자 백신은 가장 널리 유행하는 균주에 대한 예방에 있어 여전히 필수적이며, 전 세계 감시 데이터를 바탕으로 매년 업데이트되고 있습니다. 'FLUZONE'(불활성화 인플루엔자 백신)이나 'FluMist'(약독 생인플루엔자 백신) 등의 백신은 감염 예방 및 질병의 중증도 완화에 도움이 되는 면역 반응을 유도합니다. 최근의 진전으로는 모더나(Moderna, mRNA-1010) 등이 개발한 차세대 mRNA 기반 백신을 들 수 있습니다. 이들은 현재 규제 당국의 심사를 받고 있으나, 기존 플랫폼에 비해 주식 시장에 더 신속하게 적용될 가능성이 있습니다. 이러한 백신들은 계절성 유행의 억제 및 고령자나 기저질환이 있는 사람들을 포함한 고위험군의 보호에 있어 계속해서 중요한 역할을 하고 있습니다.

항바이러스 요법은 특히 증상의 중증도나 지속 기간을 완화하기 위해 조기에 투여될 경우, 인플루엔자 관리의 중요한 요소로 자리 잡고 있습니다. 현재 권장되는 항바이러스제에는 오셀타미비르 인산염(타미플루), 자나미비르 흡입용 분말(레렌자), 페라미비르 주사제(라피바브), 그리고 발록사비르 말보실(XOFLUZA) 등이 있습니다. 이 중 ‘XOFLUZA’는 1회 투여형 경구 제제라는 점과 노출 후 예방 목적으로의 사용이 확대되고 있다는 점에서 주목을 받고 있습니다. 이러한 선택지가 있음에도 불구하고, 최근 몇 년간 주요한 새로운 항바이러스제 계열이 도입되지 않아, 인플루엔자 치료 분야에서 여전히 충족되지 않은 의료적 요구가 존재한다는 사실이 부각되고 있습니다.

A형 인플루엔자에 대한 이해와 관리 면에서는 진전이 보이고 있지만, 항원 드리프트나 시프트와 같은 문제들이 백신의 유효성에 지속적으로 영향을 미치며, 계절성 유행의 위험을 높이고 있습니다. 개발 파이프라인에는 Cocrystal Pharma사의 CC-42344나 Moderna사의 mRNA-1010 등의 임상시험 후보가 포함되어 있지만, 그 대부분은 개발 초기부터 중기 단계에 머물러 있어 항바이러스 치료 분야에서는 단기적으로 큰 변화가 기대되지 않습니다. 2024년 기준, A형 인플루엔자 감염 시장 규모는 EU4 및 영국(독일, 프랑스, 이탈리아, 영국, 스페인)과 일본에 비해 미국이 가장 큰 비중을 차지했습니다.

EU4 및 영국 중에서 2024년 A형 인플루엔자 감염 시장 현황을 살펴보면, 독일이 가장 큰 시장 규모를 기록한 반면, 스페인은 가장 작은 시장 규모를 기록했습니다. A형 인플루엔자의 향후 전망과 관련하여, 개발 파이프라인에서 다양한 치료 옵션이 평가되고 있습니다. 이러한 치료법들의 출시가 예상에 따라, 향후 몇 년 동안 A형 인플루엔자 감염 시장 규모는 확대될 것으로 전망됩니다.

자주 묻는 질문

  • A형 인플루엔자 감염 시장 규모는 어떻게 되나요?
  • A형 인플루엔자 감염 시장에서 주요 기업은 어디인가요?
  • A형 인플루엔자 치료의 현황은 어떤가요?
  • A형 인플루엔자 백신의 중요성은 무엇인가요?
  • A형 인플루엔자 감염의 역학은 어떻게 분석되나요?

목차

제1장 주요 인사이트

제2장 서론

제3장 주요 요약

제4장 주요 이벤트

제5장 A형 인플루엔자 감염 : 역학 및 시장 조사 방법

제6장 A형 인플루엔자 감염 : 시장 개요

제7장 A형 인플루엔자 감염 : 질환 배경 및 개요

제8장 A형 인플루엔자 감염 : 역학 및 환자 인구

제9장 인플루엔자 환자 경과

제10장 시판 치료제

제11장 신흥 치료법

제12장 A형 인플루엔자 감염 : 주요 7개국 분석

제13장 A형 인플루엔자 감염 : 미충족 수요

제14장 A형 인플루엔자 감염 : SWOT 분석

제15장 A형 인플루엔자 감염 : KOL(Key Opinion Leader)의 견해

제16장 A형 인플루엔자 감염 : 시장 참여 및 상환

제17장 부록

제18장 DelveInsight의 서비스 내용

제19장 면책사항

제20장 DelveInsight에 대해

KTH

Influenza A Market Insights and Trends

  • Influenza A viruses are the only influenza viruses known to cause flu pandemics. Influenza A virus has the ability to spread efficiently among people, and against which people have little or no immunity.
  • Influenza A viruses have different forms, which are identified by the specific proteins on their surface called hemagglutinin (H) and neuraminidase (N). Current subtypes of influenza A viruses that routinely circulate in people include A(H1N1) and A(H3N2).
  • During the 2025 Southern Hemisphere influenza season in the Americas, transmission surpassed the seasonal threshold by mid-March and generally remained at low to moderate levels. Activity was predominantly driven by influenza A(H1N1)pdm09, with peak test positivity reaching 19%.
  • According to the estimates, the highest market size of influenza A was found in the US and the least was in Spain across the 7MM in 2025. The upcoming therapies for influenza A are expected to combat the current unmet needs faced by the patients and add to the overall growth of the influenza A market size.
  • Next-generation mRNA-based influenza vaccines, such as those being developed by Moderna, have advanced to late-stage development and regulatory review, offering the potential for faster strain adaptation and improved scalability.
  • Vaccination is the most effective measure for protecting against more severe forms of viral respiratory diseases. Those eligible for vaccination, particularly those at higher risk of severe outcomes, are encouraged to get vaccinated in line with national recommendations.
  • As per the 2026 clinical recommendations for seasonal influenza, the CDC advises that during the 2025-2026 flu season, children, pregnant women, and adults should receive seasonal influenza vaccines exclusively in single-dose formulations that do not contain thimerosal as a preservative.
  • In March 13, 2025, the US Food and Drug Administration (FDA) made recommendations to update the composition of 2025-2026 the US influenza vaccines.
  • Alongside pharmacological interventions, behavioral management strategies, such as encouraging adherence to hygiene practices and promoting vaccination, are vital for protecting high-risk groups from severe disease .
  • The key players in the influenza A include Roche, BioCryst Pharmaceuticals, Seqirus, Moderna, Cidara Therapeutics, GlaxoSmithKline, Cocrystal Pharma, and others.
  • The influenza A pipeline features promising late- and mid-stage therapies (drugs and vaccines) including CD388, Flu Pandemic mRNA (GSK4382276A), CC-42344, and others.
  • Emerging pipeline offers effective management options for influenza A. Growing awareness and improved diagnostic techniques are crucial for early detection and better patient outcomes.

Influenza A Market Size and Forecast in the United States

  • 2025 Influenza A Market Size: ~USD 5000 million
  • 2036 Projected Influenza A Market Size: ~USD 10,000 million
  • Influenza A Growth Rate (2026-2036): 7.9% CAGR

DelveInsight's "Influenza A - Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of influenza A, historical and forecasted epidemiology as well as influenza A market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

The influenza A market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM influenza A market size from 2022 to 2036. The report also covers current influenza A treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's potential.

Key Factors Driving the Influenza A Market

Rise Global Disease Burden

Influenza A contributes to a substantial global disease burden, with annual epidemics resulting in millions of cases and significant mortality worldwide. This high incidence and associated healthcare burden drive sustained demand for preventive vaccines and antiviral therapies.

Rising opportunities in Influenza A

Driven by innovations in vaccines (e.g., mRNA and universal platforms), novel antivirals, and improved diagnostics, alongside expanded immunization efforts post-COVID-19. Additionally, increasing global focus from organizations like the World Health Organization and growing biotech investments are accelerating market growth and pandemic preparedness.

Emerging Influenza A Competitive Landscape

Some of the Influenza A drugs in clinical trials include CD388 (Merck), GSK4382276A (GlaxoSmithKline), CC-42344 (Cocrystal Pharma) and others.

Influenza A Understanding and Treatment Algorithm

Influenza A Overview and Diagnosis

Influenza A viruses are divided into subtypes based on two proteins on the surface of the virus: hemagglutinin (H) and neuraminidase (N). There are 18 different hemagglutinin subtypes and 11 neuraminidase subtypes (H1 through H18 and N1 through N11, respectively). While more than 130 influenza A subtype combinations have been identified in nature, primarily from wild birds, there are potentially many more influenza A subtype combinations. Occasionally with influenza A, an antigenic shift occurs. This is a significant change in the virus surface antigens (HA and NA), which leads to the emergence of a new subtype, often resulting in a global pandemic with increased morbidity and mortality.

Diagnosis of influenza virus, including Influenza A, is typically based on clinical symptoms and can be confirmed with laboratory tests. Healthcare providers often use Rapid Influenza Diagnostic Tests (RIDTs), which detect viral antigens in respiratory samples and provide results within minutes. More accurate methods, such as Reverse Transcription-Polymerase Chain Reaction (RT-PCR), are used to confirm the virus type and subtype, especially during outbreaks or severe cases. In some situations, viral culture or immunofluorescence tests may also be performed, though these take longer. Early and accurate diagnosis is important for proper treatment and to help prevent the spread of the virus. Rapid molecular assays are a new kind of molecular influenza diagnostic test for upper respiratory tract specimens with high sensitivity and specificity. Two FDA-cleared rapid molecular assays are available in the United States. Rapid molecular assays can provide results in approximately 20 min.

Influenza A Treatment Landscape

The treatment depends on the severity of diseases. For patients with uncomplicated seasonal influenza, symptomatic treatment is recommended, with advice to stay home to prevent spreading the virus. Treatment focuses on relieving symptoms of influenza, such as fever. Patients should monitor themselves to detect if their condition deteriorates and seek medical attention. High-risk patients should receive antiviral medications, such as oseltamivir, within 48 hours of symptom onset. Severe cases, including pneumonia or sepsis, require immediate antiviral treatment. Neuraminidase inhibitors should be prescribed for at least 5 days, and corticosteroids should only be used if necessary. Vaccination remains the most effective prevention method, with annual doses recommended to maintain immunity.

Influenza A Unmet Needs

The section "unmet needs of influenza A" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Limited and Variable Vaccine Effectiveness

2. Need for Investment in Modernizing Vaccine Production Technology

3. High Disease Burden & Economic Impact

4. Antiviral Resistance, and others.....

Influenza A Epidemiology

Key Findings from Influenza A Epidemiological Analysis and Forecast

  • In the United States, the vaccinated population was highest among adults aged 18-49 years, while the lowest vaccination uptake was observed in pregnant women in 2025; overall, the vaccinated pool was segmented across children (0-4, 5-12 years), adolescents (13-17 years), adults (18-49, 50-64, >=65 years), and pregnant women.
  • In 2025, the influenza vaccine failure rate in the United States was estimated to be approximately 70%, indicating a substantial proportion of vaccinated individuals remained susceptible to infection.
  • By conducting secondary analysis of publicly available surveillance data In Japan, it was observed that in Japan according to the Ministry of Health, Labour and Welfare, the average approximately 196,895 weekly influenza cases were reported in November 2025, corresponding to an average of 51.12 cases per medical institution, indicating high epidemic intensity
  • In Europe, influenza A (H1N1)pdm09 emerged as the predominant subtype in 2024, accounting for approximately 57-93% of all influenza A cases, as reported by the European Respiratory Virus Surveillance Summary (ERVISS) (2025).
  • In the United States, the total number of influenza A positive cases is projected to increase over the study period from 2022 to 2036, reflecting a rising disease burden over time.

Influenza A Drug Analysis & Competitive Landscape

The influenza A drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase I/II-II clinical trials. It covers mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, strategic partnerships upcoming Key catalyst for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the Influenza A treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the Influenza A therapeutics market.

Approved Therapies for Influenza A

XOFLUZA (baloxavir marboxil): Roche and Shionogi

XOFLUZA is a first-in-class, single-dose oral medicine with an innovative proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. XOFLUZA is the first in a class of antivirals designed to inhibit the cap-dependent endonuclease protein, which is essential for viral replication.

In October 2018, Roche announced that the US FDA had approved XOFLUZA for the treatment of acute, uncomplicated influenza, or flu, in people 12 years of age and older. In August 2022, Genentech announced that the US FDA approved a supplemental New Drug Application for XOFLUZA to treat acute, uncomplicated influenza in healthy children aged 5 to under 12, showing symptoms for no more than 48 hours. The FDA also approved its use for preventing influenza in the same age group after exposure to an infected person. XOFLUZA is approved in the EU for the treatment of uncomplicated influenza and for post-exposure prophylaxis of influenza in children aged one year and above, and in adolescents and adults.

Influenza A Pipeline Analysis

CC-42344: Cocrystal Pharma

CC-42344, a novel PB2 inhibitor, was selected as a preclinical lead as an oral or inhaled treatment of pandemic and seasonal influenza A. This candidate binds to a highly conserved PB2 site of influenza polymerase complex (PB1: PB2: PA) and exhibits a novel mechanism of action. CC-42344 showed excellent in vitro antiviral activity against influenza A strains, including avian pandemic strains and TAMIFLU and XOFLUZA resistant strains, and has favorable pharmacokinetic and drug resistance profiles. The company had received authorization from the United Kingdom Medicines and Healthcare Products Regulatory Agency (MHRA) to conduct a Phase IIa human challenge study with CC-42344.

Influenza A Key Players, Market Leaders and Emerging Companies

  • Roche
  • BioCryst Pharmaceuticals
  • Seqirus
  • Moderna
  • Merck
  • GlaxoSmithKline
  • Cocrystal Pharma, and others

Influenza A Drug Updates

  • In February 2026, Cidara Therapeutics announced MK-1406 (CD388) is currently being evaluated in the Phase 3 ANCHOR study (NCT07159763).
  • In January 2026, Merck announced The company has successfully completed a cash tender offer, conducted via its subsidiary, for the acquisition of all outstanding common shares of Cidara Therapeutics.
  • In March 2026, Cocrystalpharma announced The company plan to continue development of oral CC-42344 as a treatment for pandemic and seasonal influenza A with an additional Phase 2a study.
  • In February 2026, The Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending the granting of a marketing authorisation for mCombriax, a vaccine developed by Moderna, for the prevention of influenza disease.
  • In March 2025, Cidara Therapeutics announced two upcoming presentations on CD388 in Influenza at the 38th International Conference on Antiviral Research (ICAR).
  • In In April 2025, Roche announced that New England Journal of Medicine (NEJM) has published a detailed analysis of the phase III CENTERSTONE trial of Xofluza showing a reduction in the transmission of influenza viruses.

Influenza A Market Outlook

Influenza A vaccines remain essential in protecting against the most prevalent circulating strains, with annual updates guided by global surveillance data. Vaccines such as FLUZONE (inactivated influenza vaccine) and FluMist (live attenuated influenza vaccine) stimulate immune responses that help prevent infection or reduce disease severity. Recent advancements include the development of next-generation mRNA-based vaccines, such as those by Moderna (mRNA-1010), which are currently under regulatory review and offer the potential for faster strain adaptation compared to traditional platforms. These vaccines continue to play a critical role in mitigating seasonal outbreaks and protecting high-risk populations, including the elderly and individuals with comorbidities.

Antiviral therapies remain a key component of influenza management, particularly when administered early to reduce symptom severity and duration. Currently recommended antivirals include oseltamivir phosphate (TAMIFLU), zanamivir inhalation powder (RELENZA), peramivir injection (RAPIVAB), and baloxavir marboxil (XOFLUZA). Among these, XOFLUZA has gained increased attention due to its single-dose oral regimen and expanding use in post-exposure prophylaxis settings. Despite these options, no major new antiviral classes have been introduced in recent years, highlighting a continued unmet need in influenza treatment.

Although progress has been made in understanding and managing Influenza A, challenges such as antigenic drift and shift continue to impact vaccine effectiveness and increase the risk of seasonal outbreaks. The development pipeline includes investigational candidates such as CC-42344 by Cocrystal Pharma and mRNA-1010 by Moderna; however, most remain in early to mid-stage development, with limited near-term disruption expected in the antiviral treatment landscape.The US accounted for the largest market size of influenza A, in comparison to EU4 and the UK (Germany, France, Italy, the UK, and Spain) and Japan in 2024.

Among the EU4 and the UK, Germany had the highest market size, while Spain had the lowest market size for influenza A in 2024.The emerging landscape for influenza A is having many management options that are being evaluated in the pipeline. The expected launch of these therapies is expected to increase the market size of influenza A in the coming years.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Influenza A (2026-2036 Forecast)

PB2 inhibitor: Inhibitors targeting the PB2 subunit of the influenza A virus RNA-dependent RNA polymerase have been developed to disrupt the viral replication cycle. The PB2 protein plays an essential role in the cap-snatching mechanism, wherein the virus cleaves 5'-capped primers from host pre-mRNA to initiate the synthesis of viral mRNA. PB2 inhibitors function by binding to the cap-binding domain of the subunit, thereby preventing the acquisition of host-derived RNA primers and effectively halting viral transcription.

Influenza A Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2022-2036. The landscape of influenza A treatment has experienced a profound transformation with the uptake of novel drugs. These innovative therapies are redefining standards of care. Furthermore, the increased uptake of these transformative drugs is a testament to the unwavering dedication of physicians, professionals, and the entire healthcare community in their tireless pursuit of advancing disease care. This momentous shift in treatment paradigms is a testament to the power of research, collaboration, and human resilience.

Detailed insights of emerging therapies' drug uptake is included in the report

Market Access and Reimbursement of Approved therapies in Influenza A

Globally, influenza A patient families spend an essential proportion of their household income on influenza A care. Influenza A patients have to face economic burden alone without any healthcare coverage or proper reimbursement policies.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of currently used therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Reimbursement is a crucial factor that affects the drug's access to the market. Often, the decision to reimburse comes down to the price of the drug relative to the benefit it produces in treated patients. To reduce the healthcare burden of these high-cost therapies, many payment models are being considered by payers and other industry insiders.

NOTE: Further Details are provided in the final report....

Influenza A Therapies Price Scenario & Trends

Pricing and analogue assessment of Influenza A therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, closest and most appropriate analogue selection for emerging therapies, and understanding of how pricing influences market access, adherence, and long-term uptake.

Industry Experts and Physician Views for Influenza A

To keep up with Influenza A market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the Influenza A emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in Influenza and others.

DelveInsight's analysts connected with 15+ KOLs to gather insights at country level. Centers such as the Medicine at Harvard Medical School in the US, Oxford University in the UK, University of California, San Francisco, and University of Heidelberg in Germany, etc. were contacted.Their opinion helps understand and validate current and emerging Influenza A therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in Influenza A.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of Influenza A , strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are majorly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of Influenza A, explaining their causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the Influenza A market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM Influenza A market.

Report Insights

  • Influenza A Patient Population Forecast
  • Influenza A Therapeutics Market Size
  • Influenza A Pipeline Analysis
  • Influenza A Market Size and Trends
  • Influenza A Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-Enabled Market Research Report
  • 11-Year Forecast
  • Influenza A Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (By Geography)
  • Influenza A Treatment Addressable Market (TAM)
  • Influenza ACompetitive Landscape
  • Influenza A Major Companies Insights
  • Influenza A Price Trends and Analogue Assessment
  • Influenza ATherapies Drug Adoption/Uptake
  • Influenza ATherapies Peak Patient Share Analysis

Report Assessment

  • Influenza A Current Treatment Practices
  • Influenza A Unmet Needs
  • Influenza A Clinical Development Analysis
  • Influenza A Emerging Drugs Product Profiles
  • Influenza A Market attractiveness
  • Influenza A Qualitative Analysis (SWOT and conjoint analysis)

FAQs:

Market Insights

  • What was the Influenza A market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of Influenza A?
  • What are the disease risks, burdens, and unmet needs of Influenza A ? What will be the growth opportunities across the 7MM concerning the patient population with Influenza A?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of Influenza A? What are the current guidelines for treating influenza A in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Influenza A market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarize and simplify complex datasets with in the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Key Conferences And Meetings
  • 4.2. Key Transactions And Collaborations
  • 4.3. News Flow

5. Epidemiology and Market Methodology of Influenza A

6. Influenza A Market Overview at a Glance

  • 6.1. Clinical Landscape Analysis (By Molecule Type, Phase, and Route of Administration [ROA])
  • 6.2. Market Share of Influenza A By Therapies (%) in the 7MM in 2025
  • 6.3. Market Share of Influenza A By Therapies (%) in the 7MM in 2036

7. Disease Background And Overview of Influenza A

  • 7.1. Introduction
  • 7.2. Types of Influenza A
  • 7.3. Molecular Classification of Influenza A
  • 7.4. Causes
  • 7.5. Signs And Symptoms
  • 7.6. Diagnosis
    • 7.6.1. Differential Diagnosis
    • 7.6.2. Diagnostic Algorithm
    • 7.6.3. Diagnostic Guidelines
  • 7.7. Treatment and Management
  • 7.8. Treatment Algorithm
  • 7.9. Treatment Guidelines

8. Epidemiology and Patient Population of Influenza A

  • 8.1. Key Findings
  • 8.2. Assumption and Rationale
  • 8.3. Total Incident Cases of Influenza A in the 7MM
  • 8.4. The United States
    • 8.4.1. Total Incident Cases of Influenza A in the United States
    • 8.4.2. Occurrence or Absence of Mutation in Influenza A in the United States
    • 8.4.3. Age-specific Incident Cases of Influenza A in the United States
    • 8.4.4. Stage-specific Incident Cases of Influenza A in the United States
  • 8.5. EU4 and the UK
    • 8.5.1. Total Incident Cases of Influenza A in EU4 and the UK
    • 8.5.2. Occurrence or Absence of Mutation in Influenza A in EU4 and the UK
    • 8.5.3. Age-specific Incident Cases of Influenza A in EU4 and the UK
    • 8.5.4. Stage-specific Incident Cases of Influenza A in EU4 and the UK
  • 8.6. Japan
    • 8.6.1. Total Incident Cases of Influenza A in Japan
    • 8.6.2. Occurrence or Absence of Mutation in influenza A in Japan
    • 8.6.3. Age-specific Incident Cases of Influenza A in Japan
    • 8.6.4. Stage-specific Incident Cases of Influenza A in Japan

9. Patient Journey of Influenza

10. Marketed Therapies

  • 10.1. Marketed Competitive Landscape of Influenza A
  • 10.2. Baloxavir marboxil (XOFLUZA): Genentech/Roche
    • 10.2.1. Product Description
    • 10.2.2. Regulatory Milestones
    • 10.2.3. Other Developmental Activities
    • 10.2.4. Summary of Pivotal Trials
    • 10.2.5. Analyst Views
  • 10.3. Peramivir injection (RAPIVAB): BioCryst Pharmaceuticals
    • 10.3.1. Product Description
    • 10.3.2. Regulatory Milestones
    • 10.3.3. Summary of Pivotal Trials
    • 10.3.4. Analyst Views

11. Emerging Therapies

  • 11.1. Emerging Competitive Landscape of Influenza A
  • 11.2. CD388: Cidara Therapeutics
    • 11.2.1. Product Description
    • 11.2.2. Other Developmental Activities
    • 11.2.3. Clinical Development
      • 11.2.3.1. Clinical Trial Information
    • 11.2.4. Safety and Efficacy
    • 11.2.5. Analyst Views
  • 11.3. SAB-176: Sab Biotherapeutics
    • 11.3.1. Product Description
    • 11.3.2. Clinical Development
      • 1.1.1.1. Clinical Trial Information
    • 11.3.3. Analyst Views
  • 11.4. VXA-A1.1: Vaxart
    • 11.4.1. Product Description
    • 11.4.2. Other Developmental Activities
    • 11.4.3. Clinical Development
      • 11.4.3.1. Clinical Trial Information
    • 11.4.4. Safety and Efficacy
    • 11.4.5. Analyst Views

12. Influenza A: Seven Major Market Analysis

  • 12.1. Key Findings
  • 12.2. Market Outlook of Influenza A
  • 12.3. Conjoint Analysis of Influenza A
  • 12.4. Key Market Forecast Assumptions
    • 12.4.1. Cost Assumptions
    • 12.4.2. Pricing Trends
    • 12.4.3. Analogue Assessment
    • 12.4.4. Launch Year and Therapy Uptakes
  • 12.5. Total Market Size of Influenza A in the 7MM
  • 12.6. The United States
    • 12.6.1. Total Market Size of Influenza A in the United States
    • 12.6.2. Market Size of Influenza A by Therapies in the United States
  • 12.7. EU4 and the UK
    • 12.7.1. Total Market Size of Influenza A in EU4 and the UK
    • 12.7.2. Market Size of Influenza A by Therapies in EU4 and the UK
  • 12.8. Japan
    • 12.8.1. Total Market Size of Influenza A in Japan
    • 12.8.2. Market Size of Influenza A by Therapies in Japan

13. Unmet Needs of Influenza A

14. SWOT Analysis of Influenza A

15. KOL Views of Influenza A

  • 15.1. Expert/KOL Interview Highlights

16. Market Access and Reimbursement of Influenza A

  • 16.1. The US
  • 16.2. In EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. United Kingdom
  • 16.3. Japan
  • 16.4. Summary and Comparison of Market Access and Pricing Policy Developments in 2025
  • 16.5. Market Access and Reimbursement of Influenza A Therapies

17. Appendix

  • 17.1. Bibliography
  • 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

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