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지역사회 획득성 세균성 폐렴(CABP) : 시장 인사이트, 역학 및 예측(2036년)

Community-Acquired Bacterial Pneumonia (CABP) - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 160 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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지역사회 획득성 세균성 폐렴(CABP)에 대한 인사이트 및 동향

  • 지역사회 획득성 세균성 폐렴(CABP)은 전 세계적으로 여전히 가장 흔하고 임상적으로 중요한 하기도 감염증 중 하나입니다. 세균성 병원체 중에서는 폐렴연쇄구균(Streptococcus pneumoniae)이 전 세계적으로 가장 주요하고 빈도가 높은 원인균이며, CAPB 사례 및 이와 관련된 유병률·사망률의 상당 부분을 차지하고 있습니다.
  • CABP의 원인이 되는 그 밖의 주목할 만한 병원체로는 헤모필루스 인플루엔자균(Haemophilus influenzae)과 마이코플라스마 폐렴균(Mycoplasma pneumoniae)이 있습니다. 특히, 클라미디아나 마이코플라스마에 의한 폐렴은 다른 유형의 폐렴과 유사한 증상을 보이는 경우가 많아, 진단상 어려움이 되고 있습니다.
  • 패혈증을 유발할 가능성이 있는 감염증 중, CABP는 성인의 사망률에 크게 기여하고 있습니다. '세계 질병 부담 연구(Global Burden of Disease Study)'에서 사망 원인 및 손실된 수명 연수 2위로 지목된 하부기도 감염증(LRTI)에는 폐렴이 주요 구성 요소로 포함되어 있습니다.
  • CABP에 대해 승인된 주요 치료법으로는 Nabriva Therapeutics사의 레파무린(XENLETA)과 Paratek Pharmaceuticals사의 오마다사이클린(NUZYRA) 등이 있습니다. 레파무린은 최초의 플레우로무틸린계 항생제이며, 오마다사이클린은 광범위 스펙트럼의 아미노메틸사이클린계 항생제입니다. 이들 모두 일반적인 호흡기 병원체 및 약물 내성 병원체에 대해 효능을 보여주고 있으며, CABP의 치료 선택지를 확대되고 있습니다.
  • CABP의 새로운 치료제 후보로는 이글 파마슈티컬스(Eagle Pharmaceuticals)와 콤비옥신 SA(Combioxin SA)가 공동 개발한 CAL02와 APTARION 바이오테크(APTARION Biotech)의 AON-D21 등이 있습니다. 이러한 후보 약물은 항생제 내성에 대응하고 중증 CABP 환자의 예후를 개선하기 위한 새로운 접근 방식을 채택하고 있습니다.
  • 몇 가지 항생제가 승인됨에 따라, 특히 1차 합병증이 동반된 사례에서 CAP의 치료 선택지가 확대되고 있습니다. CAP의 일반적인 항생제 선택지에는 마크로라이드계(단독 또는 β-락탐계와 병용), 아목시실린(단독 또는 마크로라이드계와 병용), 플루오로퀴놀론계, 그리고 마크로라이드계와 병용되는 제3세대 세팔로스포린계 등이 포함됩니다.

'지역사회 획득성 세균성 폐렴(CABP)' 시장 보고서는 표준 치료, 임상 실무 및 진화하는 치료 알고리즘을 포함하여 현재의 치료 현황에 대한 종합적인 분석을 제공합니다. 본 보고서에서는 CABP 환자의 부담 동향, 수익 및 시장 점유율의 추이, 피크 시기의 환자 점유율 및 치료법 채택 현황에 대한 분석을 평가함과 동시에, 전 세계 각 지역 시장 규모에 대한 상세한 평가 및 성장률 예측(과거 데이터 및 2022-2036년 예측)을 제공합니다. 또한, CABP 분야의 주요 미충족 의료 수요를 부각시키고, 경쟁 구도와 임상 환경을 분석하여 고부가가치 기회를 도출함으로써, 향후 시장 성장 가능성에 대한 명확한 전망을 제시하고 있습니다.

지역사회 획득성 세균성 폐렴(CABP) 시장을 주도하는 주요 요인

  • 항생제 내성(AMR)의 심각화 및 신규 항생제에 대한 필요성

호흡기 병원체의 항생제 내성 증가에 더해, 고령화, 동반 질환, 환경적 위험 요인으로 인해 CABP의 부담이 커지고 있어, 새롭고 효과적인 항생제 치료법에 대한 수요가 크게 증가하고 있습니다. 진단 기술의 향상과 질병 인식의 발전으로 인해, 치료 대상이 되는 환자층은 더욱 확대되고 있습니다.

  • CABP에 대한 표적 치료의 기회 확대

광역 스펙트럼 항생제를 넘어, 표적 지향적이고 병원체 특이적인 치료법으로의 전환에 따라 CABP 치료의 기회는 확대되고 있습니다. 신속 진단 도구의 발전, 항생제 적정 사용 프로그램, 그리고 내성 병원체를 표적으로 한 새로운 항생제의 개발이 치료 환경을 강화하고 있습니다. 또한, 정밀의료, 보조 요법 및 숙주 지향적 치료에 대한 관심이 높아짐에 따라, 임상 결과 개선과 CABP 관리 분야의 혁신 촉진이 기대됩니다.

지역사회 획득성 세균성 폐렴(CABP)의 이해와 치료 알고리즘

지역사회 획득성 세균성 폐렴(CABP)의 개요와 진단

CABP는 병원 밖에서 발병하는 폐실질의 급성 감염증으로, 가장 흔한 원인균으로는 폐렴구균(Streptococcus pneumoniae), 인플루엔자균(Haemophilus influenzae), 황색포도상구균(Staphylococcus aureus), 그리고 마이코플라스마 폐렴(Mycoplasma pneumoniae) 및 레지오넬라 폐렴(Legionella pneumophila) 등의 비정형 병원체가 있습니다. 일반적으로 발열, 기침, 가래, 호흡곤란, 흉통 등의 증상을 보이며, 그 중증도는 경증부터, 특히 고령자나 기저질환이 있는 환자의 경우 생명을 위협하는 질환에 이르기까지 다양합니다. 진단은 임상 평가 외에도 흉부 영상 검사(예 : 침윤 음영이 관찰되는 흉부 X선 사진), 미생물학적 검사(가래 배양, 혈액 배양 또는 PCR법에 기반한 검사), 그리고 CURB-65와 같은 검증된 점수 체계를 활용한 중증도 평가를 바탕으로 이루어지며, 이를 통해 적시에 적절한 치료가 가능해집니다.

지역사회 획득성 세균성 폐렴(CABP)의 치료

CABP의 치료에는 질환의 중증도, 환자의 위험 인자, 그리고 폐렴구균(Streptococcus pneumoniae)이나 인플루엔자균(Haemophilus influenzae) 등의 추정 병원체에 따라 조정된 경험적 항생제 요법을 신속히 시작하는 것이 포함됩니다. 기저 질환이 없는 외래 환자의 경우, 1차 선택 약제로는 일반적으로 아목시실린, 독시사이클린, 또는 마크로라이드계 항균제(내성이 낮은 경우)가 꼽히지만, 동반 질환이 있는 환자나 중증 환자의 경우 병용 요법(예 : β-락탐계 항균제와 마크로라이드계 항균제의 병용)이나 호흡기용 플루오로퀴놀론계 항균제가 필요할 수 있습니다. 입원 환자에게는 일반적으로 정맥 내 투여하는 β-락탐계 항생제와 마크로라이드계 항생제의 병용, 혹은 플루오로퀴놀론계 항생제의 단독 요법이 시행되지만, 황색포도상구균(MRSA 포함)이나 녹농균 등의 내성균이 존재할 위험이 있는 경우에는 더 광범위한 스펙트럼을 가진 약제로 전환됩니다. 산소 요법, 수분 보충, 해열제 투여, 합병증 관리 등을 포함한 지지 요법은 필수적이며, 그 후 미생물학적 검사 결과와 임상적 반응을 바탕으로 치료를 조정합니다.

지역사회 획득성 세균성 폐렴(CABP)의 역학

지역사회 획득성 세균성 폐렴(CABP)에 대한 역학적 분석 및 예측을 통해 도출된 주요 결과

  • 미국에서 발생한 약 400만 건의 지역사회 획득성 폐렴(CAP) 사례 중 약 80%가 CABP로 분류됩니다. CAP보다 더 넓은 범주 내에서 CABP의 유병률이 이토록 높은 것은 폐렴 사례에서 세균성 병원체의 부담이 매우 크다는 것을 보여줍니다.
  • 2025년, 주요 7개국에서 발생한 CABP 신규 발병 사례의 약 55%를 미국이 차지했습니다.
  • 미국에서는 CABP의 경증 사례가 전체 신규 사례의 약 50%를 차지하여 가장 높은 비율을 보였으며, 그 다음으로 중등증 사례가 약 35%를 차지했습니다. 이러한 분포는 CABP 환자의 대부분이 비교적 중증도가 낮음을 시사하며, 효과적인 조기 발견 및 외래 치료 전략이 효과를 거두고 있을 가능성을 보여줍니다.
  • CABP와 관련된 모든 병원체 중에서 미국에서는 폐렴구균이 가장 흔한 원인균으로 두드러지며, 그 뒤를 다른 세균 균주들이 따르고 있습니다.
  • 2025년 미국의 CABP 성별별 환자 수를 살펴보면, 남성 환자가 CABP 전체 환자의 절반 이상을 차지했습니다.
  • 2022년부터 2036년까지 미국의 CABP 역학적 현황을 살펴보면, 주요 병원체에 의한 환자 수가 증가할 것이라는 우려스러운 추세가 드러나고 있습니다. 폐렴구균(S. pneumoniae), 인플루엔자균(H. influenzae), 황색포도상구균(Staphylococcus aureus), 폐렴마이코플라스마(M. pneumoniae), 폐렴클라미디아(C. pneumoniae), 폐렴레지오넬라(L. pneumophila) 모두에 대해, 환자 수가 대폭 증가할 것으로 예측되고 있습니다.

지역사회 획득성 세균성 폐렴(CABP) 시장 전망

지역사회 획득성 폐렴(CAP)은 발병률과 사망률 양측면에서 전 세계적으로 큰 부담이 되고 있습니다. 그러나 다양한 요인으로 인해 CAP에 대한 가장 효과적인 항생제 치료법을 결정하는 것은 여전히 복잡한 과제입니다. 그 과제 중 하나는 CAP의 역학적 다양성에서 기인합니다. CAP의 역학은 지역이나 국가에 따라 크게 다르며, 그 결과 항생제 내성 유병률이나 감염을 일으키는 병원체의 유형에도 차이가 발생합니다.

또한, 기존 항생제의 안전성 프로파일과 유효성의 변화로 인해, 지역사회 획득성 폐렴(CAP)에 대한 항생제 치료 현황은 끊임없이 변화하고 있습니다. 이러한 변화의 원인 중 하나는 항생제 내성의 출현에 있습니다. 이로 인해, 이전에는 효과가 있었던 항생제가 특정 병원체에 대해서는 효과가 떨어지는 경우가 있습니다. 그 결과, 임상의들은 지역별 내성 양상이나 환자 고유의 요인을 고려하면서, 개별 환자에게 가장 적합한 항생제 치료를 선택해야 하는 딜레마에 직면해 있습니다.

최근, 새로운 항생제의 승인으로 인해 CAP의 치료 선택지가 더욱 확대되었습니다. 오마다사이클린(NUZYRA), 델라플록사신(BAXDELA), 레파무린(XENLETA) 등의 약제는 CAP에 대한 치료 선택지를 확대하여, 기존 치료법에 반응하지 않는 환자나 초기부터 합병증을 동반한 환자에게 대체 치료 수단을 제공합니다. 이러한 새로운 항생제들은 더 넓은 항균 스펙트럼과 새로운 작용기전을 갖추고 있어, 다양한 CAP 병원체에 대한 잠재적 효능을 높이고 있습니다.

또한, 병원 내 획득성 세균성 폐렴(HABP)/인공호흡기 관련 세균성 폐렴(VABP)에 대해 승인된 약물로는 세피데로콜(FETROJA), 세프타지딤·아비박탐(AVYCAZ), 테라반신(VIBATIV), 세프트로잔+타조박탐(ZERBAXA) 등이 포함됩니다. 반면, CAP을 표적으로 하는 새로운 치료법 파이프라인은 여전히 비교적 제한적입니다. 그러나 새로운 치료법 개발을 위한 노력은 계속되고 있으며, 몇 가지 유망한 후보 약물이 임상시험을 통해 평가되고 있습니다.

  • 50S 리보솜 서브유닛 조절제 및 광범위 항생제 : 레파무린(XENLETA), 오마다사이클린(NUZYRA)은 아목시실린이나 아지스로마이신과 같은 기존 약물과 함께 CABP 치료에 일반적으로 사용되며, 전형적 및 비전형적 호흡기 병원체에 대해 광범위한 항균 작용을 발휘합니다. 그러나 항생제 내성 증가와 질병 수정 작용의 부재로 인해, 그 유효성에 대한 문제가 대두되고 있습니다.
  • 숙주 지향형 및 항병원성 치료법 : CAL02 및 AON-D21과 같은 새로운 후보 약물은 세균 독소, 병원성 인자 및 숙주의 염증 반응을 표적으로 삼아, 기존의 항생제 치료를 보완하기 위해 개발되고 있습니다. 이러한 새로운 접근법은 중증 CABP의 임상적 예후를 개선하고, 항생제 내성 및 치료 실패로 인한 문제를 해결하는 것을 목적으로 합니다.

자주 묻는 질문

  • 지역사회 획득성 세균성 폐렴(CABP)의 주요 원인균은 무엇인가요?
  • CABP의 치료에 사용되는 주요 항생제는 무엇인가요?
  • CABP의 유병률은 어떻게 되나요?
  • CABP의 치료 선택지는 어떻게 변화하고 있나요?
  • CABP의 진단 방법은 무엇인가요?
  • CABP의 주요 역학적 특징은 무엇인가요?
  • CABP 시장의 성장 요인은 무엇인가요?

목차

제1장 주요 인사이트

제2장 서론

제3장 주요 요약

제4장 주요 이벤트

제5장 역학 및 시장 조사 방법

제6장 지역사회 획득성 세균성 폐렴(CABP) : 시장 개요

제7장 질환 배경 및 개요

제8장 치료 및 관리

제9장 역학 및 환자 인구

제10장 환자 경과

제11장 시판 치료제

제12장 신흥 치료제

제13장 기타 치료법 : 제네릭 의약품

제14장 지역사회 획득성 세균성 폐렴 : 7개 주요 시장 분석

제15장 KOL(Key Opinion Leader)의 견해

제16장 미충족 수요

제17장 SWOT 분석

제18장 시장 참여 및 상환

제19장 부록

제20장 DelveInsight의 서비스 내용

제21장 면책사항

제22장 DelveInsight에 대해

KTH 26.07.24

Community Acquired Bacterial Pneumonia (CABP) Insights and Trends

  • Community-acquired bacterial pneumonia (CABP) remains one of the most common and clinically significant lower respiratory tract infections worldwide. Among bacterial pathogens, Streptococcus pneumoniae is the leading and most prevalent causative organism globally, accounting for a substantial proportion of CABP cases and associated morbidity and mortality
  • Other notable pathogens responsible for CAP include Haemophilus influenzae and Mycoplasma pneumoniae. Notably, pneumonia caused by chlamydia and mycoplasma often presents similarly to other types of pneumonia, posing diagnostic challenges.
  • Among infections that can lead to sepsis, CABP stands as a significant contributor to mortality in adults. Lower respiratory tract infections (LRTIs), identified as the second leading cause of death and years of life lost by the Global Burden of Disease Study, encompass pneumonia as a major component.
  • Key approved therapies for CABP include lefamulin (XENLETA) from Nabriva Therapeutics and omadacycline (NUZYRA) from Paratek Pharmaceuticals. Lefamulin is a first-in-class pleuromutilin antibiotic, while omadacycline is a broad-spectrum aminomethylcycline. Both demonstrate activity against common and resistant respiratory pathogens, expanding available treatment options for CABP.
  • The emerging CABP landscape includes CAL02, developed by Eagle Pharmaceuticals and Combioxin SA, and AON-D21 from APTARION Biotech, and others. These candidates utilize novel approaches to address antimicrobial resistance and improve outcomes in patients with severe CABP.
  • Several antibiotics have received approval, broadening the treatment arsenal for CAP, especially in cases with primary complications. Common antimicrobial options for CAP include macrolides (alone or in conjunction with B-lactams), amoxicillin (alone or in combination with a macrolide), fluoroquinolones, and third-generation cephalosporin's combined with a macrolide.

DelveInsight's 'Community Acquired Bacterial Pneumonia (CABP) - Market Insights, Epidemiology and Market Forecast - 2036' report delivers an in-depth understanding of CABP, historical and forecasted epidemiology, as well as the CABP market trends in the United States, EU4 (Germany, Spain, Italy, and France), the United Kingdom, and Japan.

The Community Acquired Bacterial Pneumonia (CABP) market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates CABP patient burden trends, revenue & market share dynamics, peak patient share & therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in CABP and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.

Key Factors Driving the Community Acquired Bacterial Pneumonia (CABP) Market

  • Escalating antimicrobial resistance (AMR) and need for novel antibiotics

Rising antimicrobial resistance among respiratory pathogens, combined with the increasing burden of CABP driven by aging populations, comorbidities, and environmental risk factors, is creating a strong demand for novel and effective antibiotic therapies. Improved diagnosis and disease recognition are further expanding the treated patient population.

  • Growing Opportunities in Targeted Therapies for CABP

Opportunities in CABP treatment are expanding with a shift toward targeted and pathogen-specific therapies beyond broad-spectrum antibiotics. Advances in rapid diagnostic tools, antimicrobial stewardship programs, and the development of novel antibiotics targeting resistant pathogens are strengthening the treatment landscape. Furthermore, increasing focus on precision medicine, adjunctive therapies, and host-directed treatments is expected to enhance clinical outcomes and drive innovation in CABP management.

Community Acquired Bacterial Pneumonia (CABP) Understanding and Treatment Algorithm

Community Acquired Bacterial Pneumonia (CABP) Overview and Diagnosis

CABP is an acute infection of the lung parenchyma acquired outside hospital settings, most commonly caused by pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, and atypical organisms like Mycoplasma pneumoniae and Legionella pneumophila. It typically presents with symptoms such as fever, cough, sputum production, dyspnea, and chest pain, with severity ranging from mild illness to life-threatening disease, particularly in older adults and individuals with comorbidities. Diagnosis is based on clinical evaluation supported by chest imaging (e.g., chest X-ray showing infiltrates), microbiological testing (sputum culture, blood cultures, or PCR-based assays), and assessment of severity using validated scoring systems such as CURB-65, enabling timely and appropriate management.

Community Acquired Bacterial Pneumonia (CABP) Treatment

Treatment of CABP involves prompt initiation of empiric antibiotic therapy tailored to disease severity, patient risk factors, and likely pathogens such as Streptococcus pneumoniae and Haemophilus influenzae. For otherwise healthy outpatients, first-line options typically include amoxicillin, doxycycline, or a macrolide (where resistance is low), while patients with comorbidities or more severe disease may require combination therapy (e.g., a B-lactam plus a macrolide) or a respiratory fluoroquinolone. Hospitalized patients are generally treated with intravenous B-lactams combined with macrolides or monotherapy with fluoroquinolones, with escalation to broader-spectrum agents if risk factors for resistant organisms such as Staphylococcus aureus (including MRSA) or Pseudomonas aeruginosa are present. Supportive care including oxygen therapy, hydration, antipyretics, and management of complications is essential, and treatment is later refined based on microbiological results and clinical response.

Community Acquired Bacterial Pneumonia (CABP) Unmet Needs

The section "unmet needs of CABP" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Lack of rapid and accurate diagnostics

2. Rising antimicrobial resistance

3. Limited personalized treatment approaches, and others.....

Comprehensive unmet needs insights in CABP and their strategic implications are provided in the full report.

Community Acquired Bacterial Pneumonia (CABP) Epidemiology

Key Findings from Community Acquired Bacterial Pneumonia (CABP) Epidemiological Analysis and Forecast

  • Around 80% of the nearly 4 million cases of community-acquired pneumonia (CAP) in the US are classified as CABP. This high prevalence of CABP within the broader category of CAP underscores the significant burden of bacterial pathogens in pneumonia cases.
  • In 2025, the US accounted for approximately 55% of the incidence cases of CABP among the 7MM.
  • In the US, mild cases of CABP constituted the highest proportion, approximately 50% of total incident cases, followed by moderate cases at around 35%. This distribution suggests that a significant majority of CABP cases are relatively less severe, possibly indicating effective early detection and outpatient management strategies.
  • Among all the pathogens associated with CABP, Streptococcus pneumoniae stands out as the most common causative pathogen in the US, followed by other bacterial strains.
  • In 2025, gender-specific cases of CABP in the US showed that male individuals accounted for over half of the total CABP cases.
  • CABP epidemiology in the US from 2022 to 2036 reveals a concerning trend of increasing cases for major pathogens. S. pneumoniae, H. influenzae, Staphylococcus aureus, M. pneumoniae, C. pneumoniae, and L. pneumophila are all projected to experience significant rises in cases.

Community Acquired Bacterial Pneumonia (CABP) Drug Chapters & Competitive Analysis

The CABP drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase I-III clinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the CABP treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the CABP therapeutics market.

Approved Therapies for Community Acquired Bacterial Pneumonia (CABP)

Lefamulin (XENLETA): Nabriva Therapeutics

Lefamulin stands out as a significant addition to the arsenal against bacterial infections due to its unique mechanism of action and dual formulation for oral and intravenous administration. Its semi-synthetic nature allows for tailored modifications, enhancing its efficacy and pharmacokinetic properties. The FDA's approval of lefamulin in both oral and IV forms in August 2019 signals its recognition as a versatile treatment option for a range of bacterial infections.

Omadacycline (NUZYRA): Paratek Pharmaceutical

Omadacycline is a modern, broad-spectrum antibiotic approved by the FDA in October 2018 for both oral and intravenous use. Its mechanism of action involves inhibiting bacterial protein synthesis, offering activity against Gram-positive and Gram-negative pathogens, including drug-resistant strains. With once-daily dosing and efficacy in treating community-acquired pneumonia and skin infections, omadacycline stands as a versatile and promising option in the battle against antimicrobial resistance.

Community Acquired Bacterial Pneumonia (CABP) Pipeline Analysis

CAL02: Eagle Pharmaceutical/Combioxin

CAL02 is a phase II-stage drug designed to combat severe infections, particularly CAP, in ICU patients. It comprises liposomes containing cholesterol and sphingomyelin, with the latter added for its unique anti-infection properties. This combination underscores the importance of understanding the antibacterial roles of antimicrobial lipids.

The drug's approach involves neutralizing virulence effectors, which are key contributors to organ failure and fatal complications in severe infections. By targeting these virulence factors, CAL02 aims to mitigate the progression of infections and improve patient outcomes.

CAL02 received FDA's Fast-Track and Qualified Infectious Disease Product (QIDP) designations, which provide five years exclusivity extension (for a total potential of eight or ten years of exclusivity).

AON-D21 (anti-C5a): APTARION Biotech AG

AON-D21 is currently being tested in Phase II clinical trial. It is described as a PEGylated L-configured aptamer, which is a type of synthetic molecule designed to bind to specific targets in the body. AON-D21 functions by targeting a particular aspect of the immune system known as the complement system. It specifically binds to and neutralizes a component called C5a.

The target C5a plays a central role in regulating the human immune system, acting as an orchestrator of immune responses. This broad function offers the potential to extend the use of therapies aimed at modulating C5a to a wider range of diseases, particularly those where controlling immune system activity is beneficial.

Community Acquired Bacterial Pneumonia (CABP) Key Players, Market Leaders, and Emerging Companies

  • Nabriva Therapeutics
  • Paratek Pharmaceuticals
  • Eagle Pharmaceutical/Combioxin
  • APTARION Biotech, and others

Community Acquired Bacterial Pneumonia (CABP) Drug Updates

  • In January 2026, the international Phase II ADCAP trial for AON-D21 in severe community-acquired pneumonia has completed enrollment.
  • In March 2025, US IND received and extension of the ADCAP trial to 150 patients.

Drug Class Insights

Community Acquired Bacterial Pneumonia (CABP) Market Outlook

Community-acquired pneumonia (CAP) presents a significant burden globally, both in terms of morbidity and mortality. However, determining the most effective antibiotic treatment for CAP remains a complex task due to various factors. One challenge stems from the diverse epidemiology of CAP, which can vary significantly across different regions and countries, leading to differences in the prevalence of antimicrobial resistance and the types of pathogens causing the infection.

Moreover, the landscape of antibiotic treatment for CAP is constantly evolving due to changes in the safety profiles and efficacy of established antibiotics. This evolution is partly driven by the emergence of antimicrobial resistance, which can render previously effective antibiotics less potent against certain pathogens. Consequently, clinicians face the dilemma of selecting the most appropriate antibiotic regimen for individual patients, taking into account local resistance patterns and patient-specific factors.

In recent years, the approval of new antibiotics has offered additional options for the treatment of CAP. Drugs such as omadacycline (NUZYRA), delafloxacin (BAXDELA), and lefamulin (XENLETA) have expanded the armamentarium against CAP, providing alternatives for patients who may not respond to traditional therapies or who have primary complications. These newer antibiotics offer broader spectra of activity and novel mechanisms of action, enhancing their potential effectiveness against a range of CAP pathogens.

In addition, the drugs approved for hospital-acquired bacterial pneumonia (HABP)/ventilator-associated bacterial pneumonia (VABP) comprises cefiderocol (FETROJA), ceftazidime-avibactam (AVYCAZ), telavancin (VIBATIV), and ceftolozane + tazobactam (ZERBAXA), among others. In contrast, the pipeline for emerging therapies targeting CAP remains relatively limited. However, there are ongoing efforts to develop new treatments, with some promising candidates being evaluated in clinical trials.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Community Acquired Bacterial Pneumonia (CABP) (2022-2036 Forecast)

The CABP treatment landscape is steadily evolving from lifelong plasma-derived augmentation toward disease-modifying, RNA-based, and gene-editing approaches aimed at addressing both lung and liver pathology. While current management remains centered on intravenous A1-PI replacement, the pipeline increasingly focuses on reducing mutant protein accumulation, correcting genetic defects, and enabling durable clinical benefit.

  • Protein 50S ribosomal subunit modulators and broad-spectrum antibiotics: Lefamulin (XENLETA), omadacycline (NUZYRA), along with established agents such as amoxicillin and azithromycin, are commonly used for the treatment of CABP, providing broad-spectrum coverage against typical and atypical respiratory pathogens. However, their effectiveness is increasingly challenged by rising antimicrobial resistance and the lack of disease-modifying activity.
  • Host-directed and anti-virulence therapies: Emerging candidates such as CAL02 and AON-D21 are being developed to complement conventional antibiotic treatment by targeting bacterial toxins, virulence factors, and host inflammatory responses. These novel approaches aim to improve clinical outcomes in severe CABP and address challenges associated with antimicrobial resistance and treatment failure.

Community Acquired Bacterial Pneumonia (CABP) Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the CABP market's uptake by drugs, patient uptake by therapy, and sales of each drug.

Market Access and Reimbursement of Community Acquired Bacterial Pneumonia (CABP)

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Reimbursement is a crucial factor that affects the drug's access to the market. Often, the decision to reimburse comes down to the price of the drug relative to the benefit it produces in treated patients. To reduce the healthcare burden of these high-cost therapies, many payment models are being considered by payers and other industry insiders.

Community Acquired Bacterial Pneumonia (CABP) Therapies Price Scenario & Trends

Pricing and analogue assessment of CABP therapies highlights evolving price dynamics structures. This section summarises the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and the understanding of how pricing influences market access, adherence, and long-term uptake.

Further details are provided in the final report....

Industry Experts and Physician Views for Community Acquired Bacterial Pneumonia (CABP)

To keep up with CABP market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the CABP emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in CABP, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 6+ KOLs in the 7MM. Centres such as the University of North Carolina at Chapel Hill, the University of Tokyo Hospital, and King's College London, etc. were contacted. Their opinion helps understand and validate current and emerging CABP therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritisation in CABP.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of CABP, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyses emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyse the effectiveness of therapy.

The team of analyst's analyses promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are mainly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of Community Acquired Bacterial Pneumonia (CABP), explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborate profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the Community Acquired Bacterial Pneumonia (CABP) market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM Community Acquired Bacterial Pneumonia (CABP) market.

Report Insights

  • Community Acquired Bacterial Pneumonia (CABP) Patient Population Forecast
  • Community Acquired Bacterial Pneumonia (CABP) Therapeutics Market Size
  • Community Acquired Bacterial Pneumonia (CABP) Pipeline Analysis
  • Community Acquired Bacterial Pneumonia (CABP) Market Size and Trends

Community Acquired Bacterial Pneumonia (CABP) Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-enabled Market Research Report
  • 11-year forecast
  • Community Acquired Bacterial Pneumonia (CABP) Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (by geography)
  • Community Acquired Bacterial Pneumonia (CABP) Treatment Addressable Market (TAM)
  • Community Acquired Bacterial Pneumonia (CABP) Competitive Landscape
  • Community Acquired Bacterial Pneumonia (CABP) Major Companies Insights
  • Community Acquired Bacterial Pneumonia (CABP) Price Trends and Analogue Assessment
  • Community Acquired Bacterial Pneumonia (CABP) Therapies Drug Adoption/Uptake
  • Community Acquired Bacterial Pneumonia (CABP) Therapies Peak Patient Share Analysis

Report Assessment

  • Community Acquired Bacterial Pneumonia (CABP) Current Treatment Practices
  • Community Acquired Bacterial Pneumonia (CABP) Unmet Needs
  • Community Acquired Bacterial Pneumonia (CABP) Clinical Development Analysis
  • Community Acquired Bacterial Pneumonia (CABP) Emerging Drugs Product Profiles
  • Community Acquired Bacterial Pneumonia (CABP) Market Attractiveness
  • Community Acquired Bacterial Pneumonia (CABP) Qualitative Analysis (SWOT and Conjoint Analysis)

FAQs:

Market Insights

  • What was the Community Acquired Bacterial Pneumonia (CABP) market size, the market size by therapies, market share (%), distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of Community Acquired Bacterial Pneumonia (CABP)?
  • What are the disease risks, burdens, and unmet needs of Community Acquired Bacterial Pneumonia (CABP)? What will be the growth opportunities across the 7MM concerning the patient population with Community Acquired Bacterial Pneumonia (CABP)?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of Community Acquired Bacterial Pneumonia (CABP)? What are the current guidelines for treating Community Acquired Bacterial Pneumonia (CABP) in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Community Acquired Bacterial Pneumonia (CABP) market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights into the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarizes and simplifies complex datasets within the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Upcoming Key Catalysts
  • 4.2. Key Transactions And Collaborations
  • 4.3. News Flow
  • 4.4. Key Conference Highlights

5. Epidemiology and Market Methodology

6. Community-Acquired Bacterial Pneumonia (CABP) Market Overview at a Glance

  • 6.1. Clinical Landscape Analysis (By Phase, Molecule Type, and RoA)
  • 6.2. Market Share (%) Distribution of CABP by Therapies in the 7MM, in 2025
  • 6.3. Market Share (%) Distribution of CABP by Therapies in the 7MM, in 2036

7. Disease Background and Overview

  • 7.1. Introduction
  • 7.2. Etiology
  • 7.3. Pathophysiology
  • 7.4. Signs and Symptoms of CABP
  • 7.5. Clinical Characteristics
  • 7.6. Immunology & Risk Factors
  • 7.7. Diagnosis
  • 7.8. Prognosis
  • 7.9. Diagnostic Biomarkers for CABP

8. Treatment and Management

  • 8.1. Antibiotic therapy
  • 8.2. Diuretics
  • 8.3. Corticosteroids
  • 8.4. Later management
  • 8.5. Diagnostic and Treatment Guidelines
    • 8.5.1. The American Thoracic Society and the Infectious Diseases Society of America
    • 8.5.2. NICE

9. Epidemiology and Patient Population

  • 9.1. Key Findings
  • 9.2. Assumptions and Rationale
  • 9.3. Total Incident Cases of Community-Acquired Bacterial Pneumonia (CABP) in the 7MM
  • 9.4. The United States
    • 9.5.1. Incident Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.5.2. Gender-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.5.3. Severity-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.5.4. Pathogens--specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.5.5. Age-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.5.6. Total treated Cases of Community-Acquired Bacterial Pneumonia (CABP)
  • 9.6. EU4 and the UK
    • 9.6.1. Incident Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.6.2. Gender-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.6.3. Severity-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.6.4. Pathogens--specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.6.5. Age-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.6.6. Total treated Cases of Community-Acquired Bacterial Pneumonia (CABP)
  • 9.7. Japan
    • 9.7.1. Incident Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.7.2. Gender-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.7.3. Severity-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.7.4. Pathogens--specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.7.5. Age-specific Cases of Community-Acquired Bacterial Pneumonia (CABP)
    • 9.7.6. Total treated Cases of Community-Acquired Bacterial Pneumonia (CABP)

10. Patient Journey

11. Marketed Therapies

  • 11.1. Marketed Competitive Landscape
  • 11.2. Lefamulin (XENLETA): Nabriva Therapeutics
    • 11.2.1. Drug Description
    • 11.2.2. Regulatory Milestones
    • 11.2.3. Other Developmental Activities
    • 11.2.4. Summary of Pivotal Trials
    • 11.2.5. Clinical Development
      • 11.2.5.1. Clinical Trial Information
    • 11.2.6. Safety and Efficacy
    • 11.2.7. Analyst's Views
  • 11.3. Omadacycline (NUZYRA): Paratek Pharmaceuticals
    • 11.3.1. Drug Description
    • 11.3.2. Regulatory Milestones
    • 11.3.3. Other Developmental Activities
    • 11.3.4. Summary of Pivotal Trials
    • 11.3.5. Clinical Development
      • 11.3.5.1. Clinical Trial Information
    • 11.3.6. Safety and Efficacy
    • 11.3.7. Analyst's Views

12. Emerging Drugs

  • 12.1. Emerging Competitive Landscape
  • 12.2. CAL02: Eagle Pharmaceutical/Combioxin SA
    • 12.2.1. Drug Description
    • 12.2.2. Other Developmental Activities
    • 12.2.3. Clinical Development
      • 12.2.3.1. Clinical Trials Information
    • 12.2.4. Safety and Efficacy
    • 12.2.5. Analyst's Views
  • 12.3. AON-D21 (anti-C5a): APTARION Biotech AG
    • 12.3.1. Drug Description
    • 12.3.2. Other Development Activities
    • 12.3.3. Clinical Development
    • 12.3.4. Clinical Trials Information
    • 12.3.5. Safety and efficacy
    • 12.3.6. Analyst's Views

13. Other Therapies: Generics

  • 13.1. Amoxicillin
  • 13.2. Azithromycin
  • 13.3. Clarithromycin
  • 13.4. Doxycycline
  • 13.5. Moxifloxacin
  • 13.6. Vaccine

14. Community-Acquired Bacterial Pneumonia: 7 Major Market Analysis

  • 14.1. Key Findings
  • 14.2. Market Outlook
  • 14.3. Conjoint analysis
  • 14.4. Key market forecast assumptions
    • 14.4.1. Cost Assumptions and Rebates
    • 14.4.2. Pricing Trends
    • 14.4.3. Analogue Assessment
    • 14.4.4. Launch Year and Therapy Uptake
  • 14.5. Total Market Size of Community-Acquired Bacterial Pneumonia (CABP) in the 7 MM
  • 14.6. Market Size of Community-Acquired Bacterial Pneumonia (CABP) by Therapies In 7MM
  • 14.7. The United States Market Size
    • 14.7.1. Total Market Size of Community-Acquired Bacterial Pneumonia (CABP) in the United States
    • 14.7.2. Market Size of Community-Acquired Bacterial Pneumonia (CABP) by Therapies in the United States
  • 14.8. EU4 and the UK
    • 14.8.1. Total Market size of Community-Acquired Bacterial Pneumonia (CABP) in EU4 and the UK
    • 14.8.2. Market Size of Community-Acquired Bacterial Pneumonia (CABP) by Therapies in EU4 and the UK
  • 14.9. Japan Market Size
    • 14.9.1. Total Market size of Community-Acquired Bacterial Pneumonia (CABP) in Japan
    • 14.9.2. Market Size of Community-Acquired Bacterial Pneumonia (CABP) by Therapies in Japan

15. KOL Views

16. Unmet Needs

17. SWOT Analysis

18. Market access and reimbursement

19. Appendix

  • 19.1. Bibliography
  • 19.2. Report Methodology

20. DelveInsight Capabilities

21. Disclaimer

22. About DelveInsight

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