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KOL Insight - Chronic Lymphocytic Leukaemia

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ÀÌ º¸°í¼­´Â ºÏ¹Ì¿Í À¯·´ÀÇ KOL(Key Opinion Leader)µéÀÇ ÀǰßÀ» ¹ÙÅÁÀ¸·Î ÁøÈ­ÇÏ´Â ¸¸¼º ¸²ÇÁ±¸¼º ¹éÇ÷º´(CLL)ÀÇ Ä¡·á ÇöȲÀ» »ó¼¼ÇÏ°Ô ºÐ¼®ÇÕ´Ï´Ù. ÀÌ º¸°í¼­¿¡¼­´Â BTK ºÐÇØÁ¦, T¼¼Æ÷¸¦ °ü¿©½ÃŰ´Â ÀÌÁ߯¯À̼ºÇ×ü µî ȯÀÚ ¿¹Èĸ¦ °³¼±ÇÒ ¼ö ÀÖ´Â »õ·Î¿î Ä¡·á¹ýÀÇ °¡´É¼ºÀ» ¸ð»öÇϰí ÀÖ½À´Ï´Ù. ¶ÇÇÑ µ¶¼ºÀ» ÃÖ¼ÒÈ­Çϸ鼭 È¿´ÉÀ» À¯ÁöÇϵµ·Ï ¼³°èµÈ ÀÏÁ¤ ±â°£ÀÇ Ä¡·á ¿ä¹ýÀ¸·ÎÀÇ ÀüȯÀÌ ÁøÇàµÇ°í ÀÖÀ½À» Á¶»çÇß½À´Ï´Ù. ¶ÇÇÑ Ä¡·á ±âÁØÀ» ÀçÁ¤ÀÇÇϰí Àü ¼¼°è ó¹æ ÇàÅ¿¡ ¿µÇâÀ» ¹ÌÄ¥ °ÍÀ¸·Î ±â´ëµÇ´Â Áß¿äÇÑ ÀÓ»ó½ÃÇè¿¡ ´ëÇØ¼­µµ ´Ù·ç°í ÀÖÀ¸¸ç, CLL °ü¸®ÀÇ Ãֽе¿Çâ°ú ¹Ì·¡ ¹æÇâ¿¡ ´ëÇÑ ¸íÈ®ÇÑ ÀÌÇØ¸¦ ÅëÇØ Ç×»ó ¾Õ¼­ ³ª°¥ ¼ö ÀÖµµ·Ï µµ¿Íµå¸³´Ï´Ù.

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  • 1.¸¸¼º ¸²ÇÁ±¸¼º ¹éÇ÷º´(CLL)¿¡¼­ ÇöÀç ¼±Åõǰí ÀÖ´Â Ä¡·á¹ý°ú ÁÖ¿ä Æ¯Â¡Àº ¹«¾ùÀΰ¡?
  • 2.CLL Ä¡·á¿¡ °¡Àå À¯¸ÁÇÑ ÈÄ±â ÆÄÀÌÇÁ¶óÀÎ Á¦Ç°Àº ¹«¾ùÀΰ¡?
  • 3.»õ·Î¿î Ä¡·á¹ýÀº ¾ÈÀü¼º, À¯È¿¼º, »ç¿ë ÆíÀǼº Ãø¸é¿¡¼­ ¾î¶»°Ô ºñ±³µÇ´Â°¡?
  • 4.ÇöÀçÀÇ CLL Ä¡·áÁ¦¿Í °æÀïÇϱâ À§ÇØ ÆÄÀÌÇÁ¶óÀÎ Á¦Ç°Àº ¾î¶² À¯È¿¼º ¹× ³»¾à¼º Æò°¡ÁöÇ¥¸¦ ´Þ¼ºÇØ¾ß Çϴ°¡?
  • 5.CELESTIAL, AMPLIFY, MAJIC µî ÁøÇà ÁßÀÎ ÀÓ»ó½ÃÇèÀº ÇâÈÄ Ã³¹æ µ¿Çâ¿¡ ¾î¶² ¿µÇâÀ» ¹ÌÄ¡´Â°¡?
  • 6.ÇâÈÄ 3-5³â µ¿¾È CLL Ä¡·áÀÇ »óȲÀº ¾î¶»°Ô º¯È­ÇÒ °ÍÀ¸·Î ¿¹»óÇϽʴϱî?

ÁÖ¿ä ºê·£µå

  • Calquence(acalabrutinib)
  • Brukinsa(zanubrutinib)
  • Imbruvica(ibrutinib)
  • Jaypirca(pirtobrutinib)
  • nemtabrutinib
  • NX-5948
  • NX-2127
  • BGB-16673
  • Venclexta/Venclyxto(venetoclax)
  • sonrotoclax
  • lisaftoclax
  • Breyanzi(lisocabtagene maraleucel)
  • Epkinly/Tepkinly(epcoritamab)

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Ä¡·á µ¿Çâ º¸°í¼­´Â ÁÖ¿ä Áúȯ ºÐ¾ßÀÇ ÇöÀç¿Í ¹Ì·¡ Ä¡·á ÇöȲ¿¡ ´ëÇØ ¼¼°è À¯¼öÀÇ KOL(Key Opinion Leader)°úÀÇ ½ÉÃþ ÀÎÅͺ並 ÅëÇØ ÀÛ¼ºµÇ¸ç, KOLÀº ¼¼°è Æò°¡, ÀÓ»óÀû Àü¹®¼º, Ä¡·á ºÐ¾ß¿¡¼­ÀÇ ¿µÇâ·Â µî ¾ö°ÝÇÑ ½É»ç ±âÁØ¿¡ µû¶ó ¾ö¼±µË´Ï´Ù. ¾ö°ÝÇÑ ½É»ç ±âÁØ¿¡ µû¶ó ¾ö¼±µË´Ï´Ù. °¢ ÀÎÅͺä´Â ¸é¹ÐÇÏ°Ô ÀÛ¼ºµÈ Åä·Ð °¡À̵带 ¹ÙÅÁÀ¸·Î ÁøÇàµË´Ï´Ù. ÀÌ °¡À̵å´Â KOL°ú °øµ¿À¸·Î °³¹ßµÇ¾úÀ¸¸ç, ¾÷°è Àü¹®°¡µéÀÇ °ËÅ並 °ÅÃÄ Áú¹® ³»¿ëÀÌ Á¾ÇÕÀûÀ̰í ÇöÀç ½ÃÀå ¿ªÇп¡ ÀûÇÕÇÑÁö È®ÀÎÇÕ´Ï´Ù. °¢ º¸°í¼­ ¹ßÇà ÈÄ 12°³¿ù µ¿¾È Áö¼ÓÀûÀÎ ½ÃÀå ¸ð´ÏÅ͸µÀ» ÅëÇØ Áß¿äÇÑ ´º½º À̺¥Æ®, ½ÃÀå º¯È­, ½ÃÀå °³¹ß¿¡ ´ëÇÑ KOLÀÇ ÃֽŠÁ¤º¸¸¦ Àû½Ã¿¡ Á¦°øÇÕ´Ï´Ù.

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FirstWord Reports´Â Á¦¾à ºÎ¹®¿¡ ƯȭµÈ ½Å·ÚÇÒ ¼ö ÀÖ´Â ¾÷°è ¸®´õ·Î¼­ ¹ÙÀÌ¿ÀÁ¦¾à Àü¹®°¡¿Í ÀÇ»ç°áÁ¤±ÇÀÚ¸¦ À§ÇÑ »ó¼¼ÇÏ°í ½Ç¿ëÀûÀÎ ÀλçÀÌÆ®¸¦ Á¦°øÇÕ´Ï´Ù. ´ç»çÀÇ ½ÉÃþÀûÀÎ ¾÷°è Áö½ÄÀ» ¹ÙÅÁÀ¸·Î °í°´ÀÌ »õ·Î¿î µ¿ÇâÀ» ÆÄ¾ÇÇÏ°í º¹ÀâÇÑ ¹®Á¦¸¦ È¿°úÀûÀ¸·Î ÇØ°áÇÒ ¼ö ÀÖµµ·Ï ÀûÀýÇÏ°í °¡Ä¡ ÀÖ´Â ÀλçÀÌÆ®¸¦ Á¦°øÇÒ ¼ö ÀÖ½À´Ï´Ù. ±¤¹üÀ§ÇÑ Á¶»ç¿Í ÃÖ°í Àü¹®°¡ ¹× KOLÀÇ µ¶¸³ÀûÀÌ°í °øÁ¤ÇÑ ÀλçÀÌÆ®¸¦ ¹ÙÅÁÀ¸·Î ÇÑ ´ç»çÀÇ º¸°í¼­´Â °í°´ÀÌ ÇÊ¿ä·Î ÇÏ´Â Á¤È®¼º°ú ½Å·Ú¼ºÀ» Á¦°øÇÕ´Ï´Ù. ´Ù¸¥ °÷¿¡¼­´Â ¾òÀ» ¼ö ¾ø´Â ÀÎÅͺä¿Í µ¥ÀÌÅÍ¿¡ ´ëÇÑ µ¶Á¡Àû Á¢±Ù, Áö¼ÓÀûÀÎ ½ÃÀå ¸ð´ÏÅ͸µÀ» ÅëÇØ ½ÃÀå ¿ªÇп¡ ´ëÇÑ Á¾ÇÕÀûÀÎ ÀλçÀÌÆ®¸¦ Á¦°øÇÕ´Ï´Ù. 40 ÀÌ»óÀÇ KOL ÀλçÀÌÆ®¿Í Á¤·®Àû ÀÇ»ç Á¶»ç¸¦ Æ÷ÇÔÇÑ ÀÇ»ç ÀÎÅÚ¸®Àü½º, ±×¸®°í ÀÇ·á ¹®Á¦, µðÁöÅÐ Çコ, ¿µ¾÷ ¹× ¸¶ÄÉÆÃ, ½ÃÀå Á¢±Ù ¹× ±âŸ ºÐ¾ßÀÇ À̽´¿¡ ´ëÇÑ ¾÷°è Àü¹®°¡µéÀÇ °ßÇØ¸¦ Á¦°øÇÏ´Â ´ç»çÀÇ º¸°í¼­ ´Â º¸´Ù ½º¸¶Æ®ÇÏ°í µ¥ÀÌÅͺ£À̽ºÀÇ ÀÇ»ç°áÁ¤À» ³»¸®°í ±Þº¯ÇÏ´Â ¾÷°è¿¡¼­ °æÀï·ÂÀ» À¯ÁöÇÒ ¼ö ÀÖµµ·Ï µ½½À´Ï´Ù.

KSA 25.05.20

This report provides an in-depth analysis of the evolving treatment landscape for Chronic Lymphocytic Leukemia (CLL), drawing on insights from key opinion leaders across North America and Europe. It explores the promise of emerging therapies-including BTK degraders and T-cell-engaging bispecific antibodies-to improve patient outcomes. The report also investigates the growing shift toward fixed-duration treatment regimens, designed to maintain efficacy while minimizing toxicity. In addition, it highlights pivotal clinical trials that are expected to redefine treatment standards and influence global prescribing behaviors. Stay ahead of the curve with a clear understanding of the latest developments and future directions in CLL management.

Key Questions Answered:

  • 1. What are the current treatments of choice in Chronic Lymphocytic Leukemia (CLL) and their key attributes?
  • 2. Which late-stage pipeline products show the most promise for CLL treatment?
  • 3. How do emerging therapies compare in terms of safety, efficacy, and ease of use?
  • 4. What efficacy and tolerability endpoints must pipeline products achieve to compete with current CLL drugs?
  • 5. How will ongoing clinical trials like CELESTIAL, AMPLIFY, and MAJIC influence future prescribing trends?
  • 6. How is the CLL treatment landscape expected to evolve over the next three to five years?

Key Brands:

  • Calquence (acalabrutinib)
  • Brukinsa (zanubrutinib)
  • Imbruvica (ibrutinib)
  • Jaypirca (pirtobrutinib)
  • nemtabrutinib
  • NX-5948
  • NX-2127
  • BGB-16673
  • Venclexta/Venclyxto (venetoclax)
  • sonrotoclax
  • lisaftoclax
  • Breyanzi (lisocabtagene maraleucel)
  • Epkinly/Tepkinly (epcoritamab)

Partial List of Participating Experts:

  • Director, Lymphoma Division, Levine Cancer Institute, USA
  • Medical Director of Hematology Research, Sarah Cannon Research, USA
  • Professor of Medicine, Division of Hematology and Oncology, Fred Hutchinson Cancer Center, USA
  • Professor of Hematology, Department of Hematology, Amsterdam University Medical Centers, Netherlands
  • Professor, Service d'Hematologie et de Therapie Cellulaire, CHU Estaing, Universite Clermont Auvergne, France
  • Consultant in Hematology, Medical Director, Division of Hematology, Niguarda Hospital, Italy

Methodology:

Therapy Trend reports are developed through in-depth interviews with the world's foremost Key Opinion Leaders (KOLs) on the current and future treatment landscapes in major disease areas. KOLs are carefully selected based on strict screening criteria, including their global reputation, clinical expertise, and influence within their therapeutic area. Each interview is guided by a meticulously crafted discussion guide. These guides are developed in collaboration with KOLs and peer-reviewed by industry experts to ensure that the questions are comprehensive and pertinent to current market dynamics. Through continuous market monitoring over a 12-month period following the publication of each report, we provide timely updates from KOLs on key news events, market shifts, and clinical developments.

What makes our reports different?

FirstWord Reports, a trusted industry leader with an exclusive focus on the pharmaceutical sector, delivers in-depth, actionable insights for biopharma professionals and decision-makers. Our deep industry knowledge enables us to provide relevant and valuable insights that help you identify emerging trends and navigate complex challenges effectively. Backed by extensive research and independent, impartial insights from leading experts and KOLs, our reports deliver the accuracy and reliability you need. With exclusive access to interviews and data unavailable elsewhere, along with ongoing market monitoring, we give you a comprehensive view of market dynamics. Covering over 40 dynamic disease areas and providing physician intelligence, including KOL insights and quantitative physician surveys, as well as industry expert views on issues in medical affairs, digital health, sales & marketing, market access, and other areas, our reports empower you to make smarter, data-driven decisions and maintain a competitive edge in a fast-moving industry.

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