난소암(Ovarian Cancer)의 출시된 약제 4종 및 개발 단계 약제 9종을 채택하여 북미 및 유럽 KOL(Key Opinion Leader) 12명의 각종 견해를 정리하여 전해드립니다.
1. 조사 대상 약제 사례
- 출시된 약제
- Lynparza(olaparib : AstraZeneca)
- Rubraca(rucaparib : Clovis Oncology) 등
- 제III상 단계
- Veliparib(ABT-888 : AbbVie)
- Atezolizumab(Tecentriq : Roche)
- Avelumab(Bavencio : Merck Group/Pfizer)
- Vigil(자가 종양 세포 백신 : Gradalis) 등
- 제II상 단계
- Pembrolizumab(Keytruda : Merck & Co.)
2. 조사 내용 사례
- 급격하게 확대되는 PARP 억제제 시장에서 Lynparza의 전망은?
- ARIEL4 시험과 재발 BRCA 변이 고악성도 난소암 치료의 화학요법 대체로서 Rubraca의 잠재성에 관한 KOL의 견해
- 최근 승인된 Zejula와 기존 PARP 억제제의 경쟁 전망, 제III상 NOVA 시험의 결과에 관한 KOL의 해석
- ATLANTE 시험의 평가로 나타나는 Tecentriq, Avastin, 화학요법의 병용에 관한 과학적 근거의 힘
- Avelumab의 JAVELIN 100 및 200 시험에 대한 종합적 설계와 예견되는 결과에 관한 KOL의 견해
- Keytruda 및 Zejula의 KEYNOTE-162 시험에 대해 KOL이 예측하는 결과와 과학적 근거의 힘
- 난소암에서 Avastin의 중장기적 전망에 관한 KOL의 견해
- 재발성 난소암에서 Cediranib와 Lynparza의 병용에 관한 KOL의 견해
※ 이 페이지에 게재되어 있는 내용은 최신판과 약간 차이가 있을 수 있으므로 영문목차를 함께 참조하여 주시기 바랍니다. 기타 자세한 사항은 문의 바랍니다.
How will new combination regimens impact the ovarian cancer treatment landscape?
PARP inhibitors are firmly entrenched in the treatment algorithm for ovarian cancer, and their role continues to diversify. How will oncologists choose between AstraZeneca/Merck & Co.'s Lynparza, Tesaro/Merck & Co.'s Zejula and Clovis' Rubraca which are now all indicated for the maintenance treatment of recurrent tumours and will the role of BRCA mutation testing diminish? Furthermore, as competition gravitates towards the first-line setting, how do KOLs compare and contrast the multitude of combination regimens vying for approval in this lucrative indication? Immunotherapies are still lagging behind in ovarian cancer, compared with certain other malignancies, but which key trials could finally place them on map? Meanwhile, what opportunities and threats lie ahead for Roche's Avastin, a well-established standard of care? And could ImmunoGen's mAb-drug conjugate mirvetuximab soravtansine also play a role? Twelve of the world's leading KOLs from the US and Europe offer candid insights on four marketed therapies and nine Phase III drugs.
Take a tour of the report now
- The table of contents >
- The key business questions answered >
- The key KOL quotes >
- See the therapies covered >
Find out who the 6 EU & 6 US KOLs are >
- Review an extract from the report - 1 drug profile>
- Could first-line treatment become the next battleground for novel treatment strategies in ovarian cancer? With a number of companies investing in multiple combination regimens, who could emerge victorious?
- What potential do immune checkpoint inhibitors hold in the future treatment of ovarian cancer? Roche, Merck Group and Pfizer are heavily invested in this area, but how do KOLs rate the prospects for combination regimens containing avelumab or atezolizumab?
- PARP inhibitors comprise a cornerstone of treatment for advanced ovarian cancer?How do KOLs see their use evolving?
- AstraZeneca/Merck & Co.'s Lynparza is well established in relapsed disease. But is increasing competition, or the outcome of the PAOLA-1 trial, likely to impact its use?
- As the treatment paradigm matures and PARP inhibitors gain a broader role, what do KOLs see as the key threats and opportunities for Tesaro/Merck & Co.'s Zejula and Clovis' Rubraca?
- Roche's Avastin is firmly entrenched in the treatment algorithm for ovarian cancer. But what opportunities and threats lie ahead?
- Allergan/Amgen's Mvasi is making headlines as the first bevacizumab biosimilar to gain approval. How well accepted will it be among oncologists who treat ovarian cancer and how is pricing likely to influence uptake?
- Could ImmunoGen's antibody-drug conjugate IMGN853 have a potential role in ovarian cancer? KOLs debate the potential advantages and pitfalls to this novel approach to treatment.
- Gradalis' therapeutic vaccine, Vigil, could lead the way in personalised medicine for ovarian cancer. Do KOLs anticipate that its therapeutic benefit will outweigh logistical challenges and potentially high costs?
"If we have three negative trials, let's say - JAVELIN 200, JAVELIN 100, the ATALANTE trial - people are going to really begin questioning if immunotherapy has a role. Then we have the next wave of trials with checkpoint and PARP together." US Key Opinion Leader
"Now we've got choices. The issue will be what's the optimal use of some of these agents? So, we use PARP inhibitors up front? If we do, is it for germline or is it somatic? Or do we use HRD assays? When do we use bevacizumab? Ovary is finally getting to where lung and breast cancer have been for quite a while." US Key Opinion Leader
Sample of therapies covered
- Lynparza (olaparib; AstraZeneca/Merck & Co.
- Zejula (niraparib; Tesaro/Merck & Co.
- Rubraca (rucaparib; Clovis)
- Avastin (bevacizumab; Roche)
Phase III Therapies
- Veliparib (ABT-888; AbbVie
- Atezolizumab (Tecentriq; Roche)
- Avelumab (Bavencio; Merck Group/Pfizer)
- Vigil (autologous tumour cell vaccine; Gradalis)
- Nintedanib (Vargatef; Boehringer Ingelheim)
- Ofranergene obadenovec (VB-111; VBL Therapeutics)
- Mvasi (bevacizumab biosimilar; Allergan/Amgen)
- Masitinib (AB Science)
- Mirvetuximab soravtansine (IMGN853; ImmunoGen)
KOLs from North America
- Ronald Alvarez,Professor and Chairman of the Department of Obstetrics & Gynaecology, Vanderbilt University Medical Centre, Nashville, TN.
- Michael J. Birrer, Professor and Director, Gynaecologic Medical Oncology Massachusetts General Hospital Leader, DF/HCC Gynaecologic Cancers Program, Boston, MA.
- Robert A. Burger,Professor of Obstetrics & Gynaecology, Director of Clinical Research and Fellowship Program in Gynaecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA.
- Robert L. Coleman, Professor, Vice Chair of Clinical Research and Ann Rife Cox Chair in Gynaecology, Department of Gynaecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Centre, Houston, TX.
- Thomas Herzog,Deputy Director of the University of Cincinnati Cancer Institute, Professor of Obstetrics & Gynaecology at the University of Cincinnati Cancer Institute, Cincinnati, OH
- Bradley J. Monk,Professor and Director of the Division of Gynaecologic Oncology, Creighton University School of Medicine, St. Joseph's Hospital and Medical Centre, Phoenix, AZ.
KOLs from Europe
- Stan Kaye, Professor and Consultant Medical Oncologist, Head of the Division of Clinical Studies at the Institute of Cancer Research, London, UK.
- Jean-Emmanuel Kurtz, Professor and hospital practitioner at the University of Strasbourg/ University Hospital Strasbourg, Strasbourg, France.
- Christian Marth, Director of Obstetrics and Gynaecology, University Hospital Innsbruck, Innsbruck, Austria.
- Sandro Pignata, Head of Uro-Gynaecological Department, Division of Medical Oncology, IRCCS National Cancer Institute, Naples, Italy.
- Isabelle Ray Coquard, Professor of Medical Oncology and President of the GINECO group, University Claude Bernard, Lyon, France.
- Leading German KOL, Clinic Director at a major university hospital, Germany.
Table of Contents
1. Executive summary
2. Research objectives
3. Research focus
- 3.1 Types of ovarian cancer
- 3.2 Stages of ovarian cancer
- 3.3 Ovarian cancer treatment
- 3.3.1 First-line (adjuvant) treatment
- 3.3.2 Treatment of recurrence
- 3.3.3 Subsequent-line therapy for platinum-sensitive ovarian cancer
- 3.3.4 Subsequent-line therapy for platinum-resistant ovarian cancer
4. Report focus
5. PARP inhibitors
- 5.1 Overview
- 5.2 Marketed drugs
- 5.2.1 Lynparza (olaparib; AstraZeneca/Merck & Co.)
- 5.2.2 Zejula (niraparib; Tesaro/Merck & Co.)
- 5.2.3 Rubraca (rucaparib; Clovis)
- 5.3 Pipeline drugs
- 5.3.1 Veliparib (ABT-888; AbbVie)
- 6.1 Pipeline drugs
- 6.2 Checkpoint inhibitors
- 6.2.1 Overview
- 6.2.2 Atezolizumab (Tecentriq; Roche)
- 6.2.3 Avelumab (Bavencio; Merck Group/Pfizer) 38
- 6.3 Therapeutic vaccines
- 6.3.1 Vigil (autologous tumour cell vaccine; Gradalis)
7. Angiogenesis inhibitors
- 7.1 Marketed drugs
- 7.1.1 Avastin (bevacizumab; Roche)
- 7.2 Pipeline drugs
- 7.2.1 Nintedanib (Vargatef; Boehringer Ingelheim)
- 7.2.2 Ofranergene obadenovec (VB-111; VBL Therapeutics)
- 7.2.3 Mvasi (bevacizumab biosimilar; Allergan/Amgen)
- 7.2.4 Masitinib (AB Science)
8. Other new therapies
- 8.1 Pipeline drugs
- 8.1.1 Mirvetuximab soravtansine (IMGN853; ImmunoGen)
- 10.1 KOL details
- 10.1.1 KOLs from North America
- 10.1.2 KOLs from Europe