뼈 공극 충전재 시장 규모, 점유율, 성장 및 세계 산업 분석 : 유형별, 용도별, 지역별 인사이트와 예측(2025-2034년)

Growth Factors of bone void fillers Market

The global bone void fillers market was valued at USD 3.73 billion in 2025 and is projected to reach USD 3.97 billion in 2026. According to the report, the market is expected to grow steadily and attain a value of USD 6.74 billion by 2034, registering a compound annual growth rate (CAGR) of 6.8% during the forecast period (2026-2034).

In 2025, North America dominated the global market with a share of 47.3%, supported by a high volume of orthopedic procedures and the strong presence of leading manufacturers.

Bone Void Fillers (BVFs) are biocompatible, bioactive, absorbable, and osteoconductive materials used to fill bone gaps in areas such as extremities, pelvis, and the spine. These materials provide structural stability and promote bone regeneration, making them essential in orthopedic, trauma, and spinal surgeries.

Market Drivers

Rising Burden of Bone Diseases and Fractures

The increasing prevalence of bone tumors, osteomyelitis, fractures, and trauma injuries is a major factor driving market growth. A rapidly aging global population, which is more prone to osteoporosis and fractures, is further accelerating demand for bone void fillers. These products are widely used in the treatment of chronic osteomyelitis, where antibiotic-eluting fillers have shown improved clinical outcomes.

Growing Adoption of Synthetic Bone Void Fillers

Synthetic fillers such as calcium sulfate and tri-calcium phosphate are witnessing strong adoption due to advantages like high sterility, unlimited supply, reduced donor-site morbidity, and chemical similarity to human bone. In 2020, BONESUPPORT AB received FDA approval for CERAMENT, strengthening the adoption of synthetic fillers globally.

Additionally, antibiotic-eluting bone void fillers offer combined antimicrobial and osteoconductive benefits, reducing orthopedic infection rates and driving further market expansion.

Market Trends

Increasing Focus on Antibiotic-Eluting Fillers

One of the key trends shaping the market is the growing focus on antibiotic-eluting bone void fillers to prevent post-surgical infections. In 2022, BONESUPPORT AB received regulatory approvals for antibiotic-mixed fillers, while Elute, Inc. obtained FDA authorization for clinical trials of EP Granules with Tobramycin. Such innovations are expected to significantly boost market growth during the forecast period.

Market Restraints

Despite strong growth prospects, the market faces challenges due to clinical limitations and under-penetration of bone void fillers. Risks such as adverse tissue reactions, incomplete bone formation, infections, and product breakage have limited adoption in some regions.

Moreover, FDA product recalls, such as the recall of OSTEOVATION RMX in 2021, have negatively impacted market confidence. Traditional procedures like autografts and allografts remain widely used, further restricting market penetration.

Segmentation Analysis

By Type

The demineralized bone matrix (DBM) segment held the largest market share and is expected to maintain its dominance due to abundant donor availability, faster healing, and reduced complications.

The calcium sulfate segment is projected to grow at the fastest CAGR due to its antibiotic properties and increasing use in osteomyelitis treatment. Collagen matrix fillers are also gaining traction because of ease of use and faster recovery.

By Form

The putty segment dominated the market in 2025, accounting for approximately 33% share, driven by high adoption in spinal and orthopedic procedures. Paste and granule forms are also expanding due to improved biocompatibility and favorable clinical outcomes.

By End User

Hospitals accounted for the largest market share, 54.91% in 2026, due to the high volume of orthopedic surgeries and availability of advanced surgical infrastructure. Specialty clinics are also expected to grow steadily during the forecast period.

Regional Insights

• North America led the market with USD 1.76 billion in 2025, supported by high surgical volumes and advanced product adoption.
• Europe ranked second, driven by CE approvals and strong players such as BONESUPPORT AB and Biocomposites.
• Asia Pacific is projected to witness the highest CAGR, fueled by rising geriatric populations, trauma cases, and growing awareness in countries such as China, India, and Japan.
• Latin America and Middle East & Africa are expected to grow moderately due to improving healthcare infrastructure.

Competitive Landscape

Key players include Zimmer Biomet, Stryker, DePuy Synthes, BONESUPPORT AB, Biocomposites, and Collagen Matrix. Market leaders are focusing on product launches, mergers & acquisitions, and geographic expansion to strengthen their market position.

Conclusion

In conclusion, the bone void fillers market is set for steady growth, increasing from USD 3.73 billion in 2025 to USD 6.74 billion by 2034. Growth is driven by rising orthopedic procedures, increasing bone disease burden, and strong innovation in synthetic and antibiotic-eluting fillers. While clinical risks and product recalls remain challenges, continuous R&D, regulatory approvals, and expanding applications are expected to sustain long-term market expansion.

Segmentation By Type

• Demineralized Bone Matrix
• Collagen Matrix
• Calcium Sulfate
• Tri-calcium Phosphate
• Others

By Form

• Gel
• Granules
• Paste
• Putty
• Others

By End-user

• Hospitals
• Specialty Clinics
• Others

By Region

• North America (By Type, By Form, By End-user, By Country)
  • U.S. (By Type)
  • Canada (By Type)
• Europe (By Type, By Form, By End-user, By Country/sub-region)
  • Germany (By Type)
  • U.K. (By Type)
  • France (By Type)
  • Italy (By Type)
  • Spain (By Type)
  • Scandinavia (By Type)
  • Rest of Europe (By Type)
• Asia Pacific (By Type, By Form, By End-user, By Country/sub-region)
  • China (By Type)
  • India (By Type)
  • Japan (By Type)
  • Australia (By Type)
  • Southeast Asia (By Type)
  • Rest of Asia Pacific (By Type)
• Latin America (By Type, By Form, By End-user, By Country/sub-region)
  • Brazil (By Type)
  • Mexico (By Type)
  • Rest of Latin America (By Type)
• Middle East & Africa (By Type, By Form, By End-user, By Country/sub-region)
  • South Africa (By Type)
  • GCC (By Type)
  • Rest of Middle East & Africa (By Type)

Table of Content

1. Introduction

• 1.1. Market Scope
• 1.2. Market Segmentation
• 1.3. Research Methodology
• 1.4. Definitions and Assumptions

2. Executive Summary

3. Market Dynamics

• 3.1. Market Drivers
• 3.2. Market Restraints
• 3.3. Market Opportunities
• 3.4. Market Trends

4. Key Insights

• 4.1. Epidemiology of Bone Tumors
• 4.2. New Product Launches, Key Players
• 4.3. Overview of Guidelines for Bone Void Fillers
• 4.4. Key Industry Developments (Mergers, Acquisitions, and Partnerships, etc.)
• 4.5. Bone Void Fillers: Indication and Site of Placement
• 4.6. COVID-19 Impact on the Market

5. Global Bone Void Fillers Market Analysis, Insights and Forecast, 2021-2034

• 5.1. Market Analysis, Insights and Forecast - By Type
  • 5.1.1. Demineralized Bone Matrix
  • 5.1.2. Collagen Matrix
  • 5.1.3. Calcium Sulphate
  • 5.1.4. Tri-calcium Phosphate
  • 5.1.5. Others
• 5.2. Market Analysis, Insights and Forecast - By Form
  • 5.2.1. Gel
  • 5.2.2. Granules
  • 5.2.3. Paste
  • 5.2.4. Putty
  • 5.2.5. Others
• 5.3. Market Analysis, Insights and Forecast - By End-user
  • 5.3.1. Hospitals
  • 5.3.2. Specialty Clinics
  • 5.3.3. Others
• 5.4. Market Analysis, Insights and Forecast - By Region
  • 5.4.1. North America
  • 5.4.2. Europe
  • 5.4.3. Asia Pacific
  • 5.4.4. Latin America
  • 5.4.5. Middle East & Africa

6. North America Bone Void Fillers Market Analysis, Insights and Forecast, 2021-2034

• 6.1. Market Analysis, Insights and Forecast - By Type
  • 6.1.1. Demineralized Bone Matrix
  • 6.1.2. Collagen Matrix
  • 6.1.3. Calcium Sulphate
  • 6.1.4. Tri-calcium Phosphate
  • 6.1.5. Others
• 6.2. Market Analysis, Insights and Forecast - By Form
  • 6.2.1. Gel
  • 6.2.2. Granules
  • 6.2.3. Paste
  • 6.2.4. Putty
  • 6.2.5. Others
• 6.3. Market Analysis, Insights and Forecast - By End-user
  • 6.3.1. Hospitals
  • 6.3.2. Specialty Clinics
  • 6.3.3. Others
• 6.4. Market Analysis, Insights and Forecast - By Country
  • 6.4.1. U.S.
    • 6.4.1.1. By Type
  • 6.4.2. Canada
    • 6.4.2.1. By Type

7. Europe Bone Void Fillers Market Analysis, Insights and Forecast, 2021-2034

• 7.1. Market Analysis, Insights and Forecast - By Type
  • 7.1.1. Demineralized Bone Matrix
  • 7.1.2. Collagen Matrix
  • 7.1.3. Calcium Sulphate
  • 7.1.4. Tri-calcium Phosphate
  • 7.1.5. Others
• 7.2. Market Analysis, Insights and Forecast - By Form
  • 7.2.1. Gel
  • 7.2.2. Granules
  • 7.2.3. Paste
  • 7.2.4. Putty
  • 7.2.5. Others
• 7.3. Market Analysis, Insights and Forecast - By End-user
  • 7.3.1. Hospitals
  • 7.3.2. Specialty Clinics
  • 7.3.3. Others
• 7.4. Market Analysis, Insights and Forecast - By Country/Sub-region
  • 7.4.1. Germany
    • 7.4.1.1. By Type
  • 7.4.2. U.K.
    • 7.4.2.1. By Type
  • 7.4.3. France
    • 7.4.3.1. By Type
  • 7.4.4. Italy
    • 7.4.4.1. By Type
  • 7.4.5. Spain
    • 7.4.5.1. By Type
  • 7.4.6. Scandinavia
    • 7.4.6.1. By Type
  • 7.4.7. Rest of Europe
    • 7.4.7.1. By Type

8. Asia Pacific Bone Void Fillers Market Analysis, Insights and Forecast, 2021-2034

• 8.1. Market Analysis, Insights and Forecast - By Type
  • 8.1.1. Demineralized Bone Matrix
  • 8.1.2. Collagen Matrix
  • 8.1.3. Calcium Sulphate
  • 8.1.4. Tri-calcium Phosphate
  • 8.1.5. Others
• 8.2. Market Analysis, Insights and Forecast - By Form
  • 8.2.1. Gel
  • 8.2.2. Granules
  • 8.2.3. Paste
  • 8.2.4. Putty
  • 8.2.5. Others
• 8.3. Market Analysis, Insights and Forecast - By End-user
  • 8.3.1. Hospitals
  • 8.3.2. Specialty Clinics
  • 8.3.3. Others
• 8.4. Market Analysis, Insights and Forecast - By Country/Sub-region
  • 8.4.1. China
    • 8.4.1.1. By Type
  • 8.4.2. India
    • 8.4.2.1. By Type
  • 8.4.3. Japan
    • 8.4.3.1. By Type
  • 8.4.4. Australia
    • 8.4.4.1. By Type
  • 8.4.5. Southeast Asia
    • 8.4.5.1. By Type
  • 8.4.6. Rest of Asia Pacific
    • 8.4.6.1. By Type

9. Latin America Bone Void Fillers Market Analysis, Insights and Forecast, 2021-2034

• 9.1. Market Analysis, Insights and Forecast - By Type
  • 9.1.1. Demineralized Bone Matrix
  • 9.1.2. Collagen Matrix
  • 9.1.3. Calcium Sulphate
  • 9.1.4. Tri-calcium Phosphate
  • 9.1.5. Others
• 9.2. Market Analysis, Insights and Forecast - By Form
  • 9.2.1. Gel
  • 9.2.2. Granules
  • 9.2.3. Paste
  • 9.2.4. Putty
  • 9.2.5. Others
• 9.3. Market Analysis, Insights and Forecast - By End-user
  • 9.3.1. Hospitals
  • 9.3.2. Specialty Clinics
  • 9.3.3. Others
• 9.4. Market Analysis, Insights and Forecast - By Country
  • 9.4.1. Brazil
    • 9.4.1.1. By Type
  • 9.4.2. Mexico
    • 9.4.2.1. By Type
  • 9.4.3. Rest of Latin America
    • 9.4.3.1. By Type

10. Middle East & Africa Bone Void Fillers Market Analysis, Insights and Forecast, 2021-2034

• 10.1. Market Analysis, Insights and Forecast - By Type
  • 10.1.1. Demineralized Bone Matrix
  • 10.1.2. Collagen Matrix
  • 10.1.3. Calcium Sulphate
  • 10.1.4. Tri-calcium Phosphate
  • 10.1.5. Others
• 10.2. Market Analysis, Insights and Forecast - By Form
  • 10.2.1. Gel
  • 10.2.2. Granules
  • 10.2.3. Paste
  • 10.2.4. Putty
  • 10.2.5. Others
• 10.3. Market Analysis, Insights and Forecast - By End-user
  • 10.3.1. Hospitals
  • 10.3.2. Specialty Clinics
  • 10.3.3. Others
• 10.4. Market Analysis, Insights and Forecast - By Country
  • 10.4.1. South Africa
    • 10.4.1.1. By Type
  • 10.4.2. GCC
    • 10.4.2.1. By Type
  • 10.4.3. Rest of Middle East & Africa
    • 10.4.3.1. By Type

11. Competitive Analysis

• 11.1. Global Market Share Analysis (2025)
• 11.2. Company Profiles
  • 11.2.1. BONESUPPORT AB
    • 11.2.1.1. Overview
    • 11.2.1.2. Products & Services
    • 11.2.1.3. SWOT Analysis
    • 11.2.1.4. Recent Developments
    • 11.2.1.5. Strategies
    • 11.2.1.6. Financials (Based on Availability)
  • 11.2.2. Biocomposites
    • 11.2.2.1. Overview
    • 11.2.2.2. Products & Services
    • 11.2.2.3. SWOT Analysis
    • 11.2.2.4. Recent Developments
    • 11.2.2.5. Strategies
    • 11.2.2.6. Financials (Based on Availability)
  • 11.2.3. Collagen Matrix, Inc.
    • 11.2.3.1. Overview
    • 11.2.3.2. Products & Services
    • 11.2.3.3. SWOT Analysis
    • 11.2.3.4. Recent Developments
    • 11.2.3.5. Strategies
    • 11.2.3.6. Financials (Based on Availability)
  • 11.2.4. Zimmer Biomet
    • 11.2.4.1. Overview
    • 11.2.4.2. Products & Services
    • 11.2.4.3. SWOT Analysis
    • 11.2.4.4. Recent Developments
    • 11.2.4.5. Strategies
    • 11.2.4.6. Financials (Based on Availability)
  • 11.2.5. Stryker
    • 11.2.5.1. Overview
    • 11.2.5.2. Products & Services
    • 11.2.5.3. SWOT Analysis
    • 11.2.5.4. Recent Developments
    • 11.2.5.5. Strategies
    • 11.2.5.6. Financials (Based on Availability)
  • 11.2.6. Arthrex, Inc.
    • 11.2.6.1. Overview
    • 11.2.6.2. Products & Services
    • 11.2.6.3. SWOT Analysis
    • 11.2.6.4. Recent Developments
    • 11.2.6.5. Strategies
    • 11.2.6.6. Financials (Based on Availability)
  • 11.2.7. DePuy Synthes (Johnson & Johnson Services, Inc.)
    • 11.2.7.1. Overview
    • 11.2.7.2. Products & Services
    • 11.2.7.3. SWOT Analysis
    • 11.2.7.4. Recent Developments
    • 11.2.7.5. Strategies
    • 11.2.7.6. Financials (Based on Availability)
  • 11.2.8. Graftys
    • 11.2.8.1. Overview
    • 11.2.8.2. Products & Services
    • 11.2.8.3. SWOT Analysis
    • 11.2.8.4. Recent Developments
    • 11.2.8.5. Strategies
    • 11.2.8.6. Financials (Based on Availability)