세계의 신생항원 암백신 시장 : 네오안치겐타입, 치료 표적, 백신 플랫폼, 투여 경로, 최종사용자별 - 예측(2025-2030년)

The Neoantigen Cancer Vaccine Market was valued at USD 378.66 million in 2024 and is projected to grow to USD 434.55 million in 2025, with a CAGR of 15.01%, reaching USD 876.78 million by 2030.

Neoantigen cancer vaccines are emerging as a promising approach in the fight against cancer by harnessing the potential of the body's immune system to target tumor-specific antigens. This innovative therapeutic strategy is built around the concept of tailoring treatments to individual patients, thereby addressing the unique mutational profile of each tumor. The evolution of this field has been driven by breakthroughs in genomic sequencing and bioinformatics, enabling a more precise identification of neoantigens that can provoke an immune response. As a result, clinicians and researchers are increasingly able to design vaccines that stimulate the immune system to recognize and eliminate cancer cells, which have previously evaded standard treatment methods.

Recent advancements have not only enhanced our understanding of tumor immunology but have also paved the way for integrating personalized therapies into standard oncology protocols. The promise of improving patient outcomes while mitigating systemic toxicity makes this approach an attractive alternative to conventional treatments. Moreover, the scientific community's intensified focus on both personalized and shared neoantigens has underscored the transformative potential of these vaccines. This executive summary provides a detailed overview of current market dynamics, transformative technological shifts, and segmentation insights, building a clear picture of the roadmap ahead in the neoantigen cancer vaccine arena.

Transformative Shifts Redefining the Neoantigen Vaccine Landscape

The landscape of neoantigen cancer vaccines is undergoing profound change, driven by a series of transformative shifts in research, technology, and clinical application. Early preclinical success has now transitioned into multiple stages of clinical evaluation, reflecting a concerted global effort to translate scientific breakthroughs into tangible therapies. The integration of artificial intelligence and advanced bioinformatics tools has enabled a more rapid identification of potential neoantigen targets, enhancing both the precision and speed of vaccine development. In parallel, evolving regulatory frameworks are adapting to the unique challenges posed by personalized treatments, thereby facilitating faster, yet rigorous, approval processes.

Simultaneously, partnerships among academic institutions, biotech firms, and pharmaceutical companies have accelerated innovation through collaborative research efforts. This multidisciplinary approach is redefining traditional treatment paradigms, leading to a more holistic understanding of immune response mechanisms in cancer. As researchers decipher the complex interplay between tumor genetics and immune evasion, they are also uncovering novel pathways that can be targeted to enhance the efficacy of vaccines. Additionally, technological advancements in vaccine platforms, ranging from RNA to peptide-based modalities, are further expanding treatment options. These transformative shifts not only promise improved outcomes but also drive a more adaptable and resilient market ecosystem that is poised to address the diverse needs of oncology patients worldwide.

Deep Dive Into Segmentation Insights for the Neoantigen Cancer Vaccine Market

A comprehensive analysis of the neoantigen cancer vaccine market reveals insights that are rooted in robust segmentation across multiple dimensions. In examining the neoantigen type, the market analysis distinguishes between personalized neoantigens and shared neoantigens. For personalized neoantigens, the focus intensifies on the nuances of immune escape mutations versus somatic mutations, which provide critical benchmarks for efficacy and patient-specific customization. In the realm of shared neoantigens, attention is directed to affinity peptides and common tumor mutations, emphasizing the value of targets that are not only recurrent across different patient profiles but also hold potential for broad applicability in vaccine design.

Further segmentation by therapeutic target underscores a bifurcation between immersive strategies centered on immune checkpoint blockade and those targeting tumor neoantigens. The immune checkpoint pathway is further refined with analyses centered on CTLA-4 and PD-1 inhibitors. The subdivision of tumor neoantigens into mutated versus non-mutated variants offers additional granularity, affording insights into potential vaccine responsiveness. Another important layer of segmentation is derived from the diversity of the vaccine platforms available. The market is segmented into cell-based vaccines, DNA-based vaccines, peptide-based vaccines, and RNA-based vaccines. Within these categories, cell-based approaches delve into dendritic cell vaccines and T-cell vaccines, whereas DNA platforms explore both circular and plasmid-based strategies. Likewise, peptide platforms address long and synthetic peptides, and RNA-based technologies are ranked by traditional mRNA vaccines alongside next-generation RNA platforms. Consideration is also given to the route of administration-spanning intradermal, intravenous, oral, and subcutaneous methods-and the end user, which includes cancer treatment centers, hospitals, and research institutes. These segmentation insights collectively form the cornerstone for strategic market investments and targeted research initiatives.

Based on Neoantigen Type, market is studied across Personalized Neoantigens and Shared Neoantigens. The Personalized Neoantigens is further studied across Immune Escape Mutations and Somatic Mutations. The Shared Neoantigens is further studied across Affinity Peptides and Common Tumor Mutations.

Based on Therapeutic Target, market is studied across Immune Checkpoint Blockade and Tumor Neoantigens. The Immune Checkpoint Blockade is further studied across CTLA-4 Inhibitors and PD-1 Inhibitors. The Tumor Neoantigens is further studied across Mutated Neoantigens and Non-Mutated Neoantigens.

Based on Vaccine Platform, market is studied across Cell-Based Vaccines, DNA-Based Vaccines, Peptide-Based Vaccines, and RNA-Based Vaccines. The Cell-Based Vaccines is further studied across Dendritic Cell Vaccines and T-Cell Vaccines. The DNA-Based Vaccines is further studied across Circular DNA Platforms and Plasmid DNA Vaccines. The Peptide-Based Vaccines is further studied across Long Peptides and Synthetic Peptides. The RNA-Based Vaccines is further studied across mRNA Vaccines and Next-Gen RNA Platforms.

Based on Administration Route, market is studied across Intradermal, Intravenous, Oral, and Subcutaneous.

Based on End User, market is studied across Cancer Treatment Centers, Hospitals, and Research Institutes.

Key Regional Insights Highlighting Global Market Variations

A regional analysis reveals distinct trends and growth potentials across key global markets. In the Americas, robust research infrastructures and established pharmaceutical markets have accelerated the clinical adoption of neoantigen vaccines. This region benefits from extensive clinical trials and significant investments in biotechnology, fostering an environment where personalized treatments are rapidly integrated into treatment protocols.

In Europe, the evolution of stringent yet adaptive regulatory frameworks, combined with a focus on precision medicine, is driving the uptake of innovative vaccine therapies. Markets in the Middle East and Africa, though emerging, are beginning to carve out niches as partnerships with international research bodies encourage technology transfer and skill development. Meanwhile, the Asia-Pacific region is experiencing a surge in market activity attributed to rapid economic growth and increased healthcare spending. The diverse regulatory landscapes and the high prevalence of cancer cases in this region underscore the strategic importance of harnessing advanced vaccine platforms and localized manufacturing capabilities. These regional insights illustrate not only varying levels of technological readiness and market maturity but also reveal opportunities for expanding the reach of neoantigen cancer vaccines into new and promising territories.

Based on Region, market is studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas is further studied across Argentina, Brazil, Canada, Mexico, and United States. The United States is further studied across California, Florida, Illinois, New York, Ohio, Pennsylvania, and Texas. The Asia-Pacific is further studied across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Taiwan, Thailand, and Vietnam. The Europe, Middle East & Africa is further studied across Denmark, Egypt, Finland, France, Germany, Israel, Italy, Netherlands, Nigeria, Norway, Poland, Qatar, Russia, Saudi Arabia, South Africa, Spain, Sweden, Switzerland, Turkey, United Arab Emirates, and United Kingdom.

Analysis of Key Market Players Driving Innovation in Neoantigen Vaccines

The competitive landscape within the neoantigen cancer vaccine market is marked by the active involvement of several leading organizations that are driving innovation and market growth. Prominent firms such as Agenus Inc., AstraZeneca PLC, and Avidea Technologies are at the forefront of developing next-generation immunotherapies through robust research and development initiatives. Several other companies, including Ayala Pharmaceuticals, Inc. and BioLineRx Ltd., are also making significant strides by exploring novel vaccine formulations that offer improved immunogenic profiles. The rise of BioNTech SE and BioVaxys Technology Corp. as key innovators reflects the industry's shift towards rapidly scalable vaccination platforms coupled with high precision targeting.

Additional contributions from Brightpath Biotherapeutics Co., Ltd., CureVac N.V., and Elicio Therapeutics Inc. illustrate a diversified approach to vaccine development, balancing both traditional and cutting-edge delivery systems. F. Hoffmann-La Roche Ltd. and Geneos Therapeutics, Inc. by Inovio Pharmaceuticals, Inc. further amplify market innovation by leveraging their expansive global networks and multidisciplinary research teams. Emerging companies like Genocea Biosciences Inc. and GenScript Biotech Corporation are challenging long-held treatment paradigms with breakthrough research, while established firms such as Gilead Sciences, Inc. and Merck & Co., Inc. continue to expand their portfolios with strategic investments. The presence of Gritstone bio, Inc., Immunomic Therapeutics, Inc., and ISA Pharmaceuticals B.V. underscores the competitive dynamism in this sector, paralleled by Medigene AG, Moderna, Inc., and Neophore Limited stepping in to address diversified market needs. Companies such as Nouscom AG, Nykode Therapeutics ASA, OSE Immunotherapeutics, and Takis S.r.l. bring specialized skills and insights that help to balance market offerings, ensuring that innovations are both scientifically robust and clinically impactful. This broad spectrum of players is collectively advancing the field while contributing to a vibrant, competitive environment.

The report delves into recent significant developments in the Neoantigen Cancer Vaccine Market, highlighting leading vendors and their innovative profiles. These include Agenus Inc., AstraZeneca PLC, Avidea Technologies, Ayala Pharmaceuticals, Inc., BioLineRx Ltd., BioNTech SE, BioVaxys Technology Corp., Brightpath Biotherapeutics Co., Ltd., CureVac N.V., Elicio Therapeutics Inc, F. Hoffmann-La Roche Ltd., Geneos Therapeutics, Inc. by Inovio Pharmaceuticals, Inc., Genocea Biosciences Inc, GenScript Biotech Corporation, Gilead Sciences, Inc., Gritstone bio, Inc., Immunomic Therapeutics, Inc., ISA Pharmaceuticals B.V., Medigene AG, Merck & Co., Inc., Moderna, Inc., Neophore Limited, Nouscom AG, Nykode Therapeutics ASA, OSE Immunotherapeutics, and Takis S.r.l.. Strategic Recommendations for Capitalizing on Neoantigen Vaccine Opportunities

Industry leaders are encouraged to adopt a multifaceted strategy that emphasizes both innovation and collaboration. Investment in cutting-edge research and the integration of advanced bioinformatics tools are critical to stay ahead in vaccine development. Embracing modular vaccine platforms that allow rapid customization and scalability will enable stakeholders to better address the variability in tumor profiles and patient-specific needs. Strategic partnerships with academic institutions and research laboratories can further accelerate the pace of discovery, while clinical collaborations will help validate promising approaches in real-world settings. Additionally, streamlining regulatory pathways and investing in robust clinical trial designs will serve to reduce time-to-market, ensuring that breakthrough therapies reach patients without unnecessary delays. The convergence of these strategies will not only foster growth but also cement a competitive edge in the dynamic field of neoantigen cancer vaccines.

Conclusion: Charting the Future of Personalized Cancer Immunotherapy

In conclusion, the neoantigen cancer vaccine market stands at a pivotal juncture, driven by innovative scientific breakthroughs and evolving clinical technologies. The integration of personalized therapies, supported by meticulous segmentation across neoantigen types, therapeutic targets, and vaccine platforms, positions the field for transformative change. Global regional dynamics further amplify market opportunities, while a robust competitive landscape ensures continuous innovation through strategic R&D investments. As the sector advances, stakeholders will increasingly rely on data-driven insights and collaborative approaches to address complex oncological challenges. This comprehensive market review underscores the immense potential of neoantigen vaccines to reshape cancer treatment paradigms and offers a roadmap for achieving sustainable growth and improved patient outcomes.

Table of Contents

1. Preface

• 1.1. Objectives of the Study
• 1.2. Market Segmentation & Coverage
• 1.3. Years Considered for the Study
• 1.4. Currency & Pricing
• 1.5. Language
• 1.6. Stakeholders

2. Research Methodology

• 2.1. Define: Research Objective
• 2.2. Determine: Research Design
• 2.3. Prepare: Research Instrument
• 2.4. Collect: Data Source
• 2.5. Analyze: Data Interpretation
• 2.6. Formulate: Data Verification
• 2.7. Publish: Research Report
• 2.8. Repeat: Report Update

3. Executive Summary

4. Market Overview

5. Market Insights

• 5.1. Market Dynamics
  • 5.1.1. Drivers
    • 5.1.1.1. Growing prevalence of cancer diseases compelling robust research in personalized cancer vaccine solutions
    • 5.1.1.2. Increasing public awareness about the benefits of personalized and preventive cancer treatments
    • 5.1.1.3. Supportive government policies and funding for cancer research and development initiatives
  • 5.1.2. Restraints
    • 5.1.2.1. Concerns associated with significant side effects of neoantigen cancer vaccines
  • 5.1.3. Opportunities
    • 5.1.3.1. Strategic collaborations among biotech companies accelerating advancements in neoantigen vaccine research
    • 5.1.3.2. Innovative technological advancements boosting the potential applications of neoantigen cancer vaccines
  • 5.1.4. Challenges
    • 5.1.4.1. Stringent regulatory environments and compliance for personalized vaccine approval
• 5.2. Market Segmentation Analysis
  • 5.2.1. Neoantigen Type: Increasing need for personalized neoantigen cancer vaccines to target unique mutations specific to an individual's tumor
  • 5.2.2. End User: Expanding utilization of neoantigen vaccines by cancer treatment centers for personalized treatment efficacy
• 5.3. Porter's Five Forces Analysis
  • 5.3.1. Threat of New Entrants
  • 5.3.2. Threat of Substitutes
  • 5.3.3. Bargaining Power of Customers
  • 5.3.4. Bargaining Power of Suppliers
  • 5.3.5. Industry Rivalry
• 5.4. PESTLE Analysis
  • 5.4.1. Political
  • 5.4.2. Economic
  • 5.4.3. Social
  • 5.4.4. Technological
  • 5.4.5. Legal
  • 5.4.6. Environmental

6. Neoantigen Cancer Vaccine Market, by Neoantigen Type

• 6.1. Introduction
• 6.2. Personalized Neoantigens
  • 6.2.1. Immune Escape Mutations
  • 6.2.2. Somatic Mutations
• 6.3. Shared Neoantigens
  • 6.3.1. Affinity Peptides
  • 6.3.2. Common Tumor Mutations

7. Neoantigen Cancer Vaccine Market, by Therapeutic Target

• 7.1. Introduction
• 7.2. Immune Checkpoint Blockade
  • 7.2.1. CTLA-4 Inhibitors
  • 7.2.2. PD-1 Inhibitors
• 7.3. Tumor Neoantigens
  • 7.3.1. Mutated Neoantigens
  • 7.3.2. Non-Mutated Neoantigens

8. Neoantigen Cancer Vaccine Market, by Vaccine Platform

• 8.1. Introduction
• 8.2. Cell-Based Vaccines
  • 8.2.1. Dendritic Cell Vaccines
  • 8.2.2. T-Cell Vaccines
• 8.3. DNA-Based Vaccines
  • 8.3.1. Circular DNA Platforms
  • 8.3.2. Plasmid DNA Vaccines
• 8.4. Peptide-Based Vaccines
  • 8.4.1. Long Peptides
  • 8.4.2. Synthetic Peptides
• 8.5. RNA-Based Vaccines
  • 8.5.1. mRNA Vaccines
  • 8.5.2. Next-Gen RNA Platforms

9. Neoantigen Cancer Vaccine Market, by Administration Route

• 9.1. Introduction
• 9.2. Intradermal
• 9.3. Intravenous
• 9.4. Oral
• 9.5. Subcutaneous

10. Neoantigen Cancer Vaccine Market, by End User

• 10.1. Introduction
• 10.2. Cancer Treatment Centers
• 10.3. Hospitals
• 10.4. Research Institutes

11. Americas Neoantigen Cancer Vaccine Market

• 11.1. Introduction
• 11.2. Argentina
• 11.3. Brazil
• 11.4. Canada
• 11.5. Mexico
• 11.6. United States

12. Asia-Pacific Neoantigen Cancer Vaccine Market

• 12.1. Introduction
• 12.2. Australia
• 12.3. China
• 12.4. India
• 12.5. Indonesia
• 12.6. Japan
• 12.7. Malaysia
• 12.8. Philippines
• 12.9. Singapore
• 12.10. South Korea
• 12.11. Taiwan
• 12.12. Thailand
• 12.13. Vietnam

13. Europe, Middle East & Africa Neoantigen Cancer Vaccine Market

• 13.1. Introduction
• 13.2. Denmark
• 13.3. Egypt
• 13.4. Finland
• 13.5. France
• 13.6. Germany
• 13.7. Israel
• 13.8. Italy
• 13.9. Netherlands
• 13.10. Nigeria
• 13.11. Norway
• 13.12. Poland
• 13.13. Qatar
• 13.14. Russia
• 13.15. Saudi Arabia
• 13.16. South Africa
• 13.17. Spain
• 13.18. Sweden
• 13.19. Switzerland
• 13.20. Turkey
• 13.21. United Arab Emirates
• 13.22. United Kingdom

14. Competitive Landscape

• 14.1. Market Share Analysis, 2024
• 14.2. FPNV Positioning Matrix, 2024
• 14.3. Competitive Scenario Analysis
  • 14.3.1. Everest Medicines Initiated personalized mRNA cancer vaccines with EVM16 clinical trial for neoantigen targeting
  • 14.3.2. Achilles Therapeutics and Arcturus Therapeutics to collaborate on next-generation personalized mRNA cancer vaccine research
  • 14.3.3. Transgene and NEC expand collaboration to advance TG4050 neoantigen cancer vaccine into Phase I/II trial
• 14.4. Strategy Analysis & Recommendation

Companies Mentioned

• 1. Agenus Inc.
• 2. AstraZeneca PLC
• 3. Avidea Technologies
• 4. Ayala Pharmaceuticals, Inc.
• 5. BioLineRx Ltd.
• 6. BioNTech SE
• 7. BioVaxys Technology Corp.
• 8. Brightpath Biotherapeutics Co., Ltd.
• 9. CureVac N.V.
• 10. Elicio Therapeutics Inc
• 11. F. Hoffmann-La Roche Ltd.
• 12. Geneos Therapeutics, Inc. by Inovio Pharmaceuticals, Inc.
• 13. Genocea Biosciences Inc
• 14. GenScript Biotech Corporation
• 15. Gilead Sciences, Inc.
• 16. Gritstone bio, Inc.
• 17. Immunomic Therapeutics, Inc.
• 18. ISA Pharmaceuticals B.V.
• 19. Medigene AG
• 20. Merck & Co., Inc.
• 21. Moderna, Inc.
• 22. Neophore Limited
• 23. Nouscom AG
• 24. Nykode Therapeutics ASA
• 25. OSE Immunotherapeutics
• 26. Takis S.r.l.