극저온 전자현미경 시장 보고서 : 동향, 예측, 경쟁 분석(-2031년)

The future of the global cryo-electron microscopy market looks promising, with opportunities in life science research & academia, cancer research, omics research, pharma & biotech manufacturing, cell & gene therapy, vaccines, preclinical & clinical research, and healthcare/medical applications markets. The global cryo-electron microscopy market is expected to reach an estimated $3.1 billion by 2031, with a CAGR of 12.4% from 2025 to 2031. The major drivers for this market are increasing demand for high-resolution structural biology data, ongoing technological advancements in cryo-EM instrumentation and software, and growing healthcare expenditure across the globe.

• Lucintel forecasts that, within the technology category, single particle will remain the largest segment over the forecast period due to growing adoption of technical advanced instruments neurodegenerative research and rising requirement of small amount of purified sample.
• Within the application category, life science research & academia will remain the largest segment due to the increasing funding to promote research and development in structural biology.
• In terms of regions, North America will remain the largest region during the forecast period due to growing funding to support research activities and an increasing number of clinical trials in the region.

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Emerging Trends in the Cryo-Electron Microscopy Market

The Cryo-Electron Microscopy market is growing with certain emerging trends that are revolutionizing the sector. These trends are the forces of modernization powered by advancements in technologies and methods that affect cryo-EM features and usage.

• Linkage to Artificial Intelligence: AI and machine learning models are becoming an integral part of cryo-EM workflows. These technologies enhance the imaging processes, reduce the time taken to process data, and improve resolution through automated and advanced reconstruction techniques. This linkage contributes to the increased usability and effectiveness of cryo-EM, thus accelerating the structural biology research process.
• Improvements in Detector Technology: Current developments in detector technology, including the introduction of direct electron detectors, have resulted in significant improvements in the sensitivity and resolution of cryo-EM systems. These newly developed detectors lower the electron dose required and improve imaging capabilities, enabling more accurate structural investigations of biomolecules and materials.
• Construction of Faster and More Automated Systems: Cryo-EM systems are becoming faster and more automated, meaning that less time is spent on sample preparation and data acquisition. This development has been sparked by innovations in robotic systems and automated imaging protocols, which increase throughput and enhance reproducibility, benefiting both general-purpose and high-throughput research initiatives.
• Expansion into New Applications: Cryo-EM is expanding into additional developmental tracks and non-structural biology areas. These include, but are not limited to, materials science, drug discovery, and nanotechnology. This diversification stems from cryo-EM's ability to resolve and objectively visualize these materials and biological forms, thus creating new industrial and scientific opportunities.
• Increased Accessibility and Cost Reduction: Efforts to reduce costs and enhance user access to various forms of cryo-EM technologies are ongoing. This includes the availability of easy-to-acquire cryo-EM instruments and resource mobilization projects to support research institutions. This trend has made cryo-EM technologies more accessible, ensuring their proper application in the relevant academic and industrial sectors.

These trends are enhancing the capabilities of Cryo-EM, broadening its applications, and making it more accessible. The incorporation of AI, improvements in detector design, and the invention of automated systems are enhancing the quality and speed of research activities. The growing interest in new fields of application and the desire to reduce costs are also contributing to the increasing use of Cryo-EM equipment across various industries and disciplines.

Recent Developments in the Cryo-Electron Microscopy Market

Cryo-Electron Microscopy has seen notable developments recently, driven by technological advancements and widening research applications. This advancement in imaging technology is improving processes, expanding application areas, and enhancing access.

• Resolution Improvements: The latest achievements in detection devices and imaging software have significantly increased the resolution of cryo-EM. New systems have reached near-atomic resolution, enabling the visualization of biomolecules and cellular structures in much greater detail, which is beneficial for drug discovery and molecular biology studies.
• Improved Sample Preparation Methods: Automated sample preparation methods have streamlined cryo-EM processes. New developments like plunging devices and systems for intra- and extra-sample transport are standardizing samples and reducing time, making research more efficient and repeatable.
• Analysis of Images Using Artificial Intelligence: Artificial intelligence is also being applied to analyze cryo-EM images. AI algorithms are enhancing the cycles of data processing and reconstruction, enabling quicker and more precise understanding of complex structures. This development significantly shortens research time while improving structural quality.
• New Centers and Facilities for Cryo-EM: New cryo-EM facilities and centers have been established, increasing the penetration of modern imaging capabilities. Initiatives have been developed to create centers with the latest cryo-EM units, promoting researcher collaboration and advancing the progress of science while facilitating large studies.
• Cost Reduction and Accessibility: Efforts to lower the cost of cryo-EM systems are attracting more players to the market. System design changes and increased competition among manufacturers have addressed pricing issues, thus improving access and encouraging broader adoption.

These developments are important for the Cryo-EM market, such as increasing resolution, novel advancements in sample preparation and image analysis, and the establishment of new facilities to overcome barriers to access at reduced costs. These advancements are propelling the field forward and enabling more efficient investigations.

Strategic Growth Opportunities for the Cryo-Electron Microscopy Market

Various sectors are finding strategic growth opportunities from the applications of Cryo-Electron Microscopy. These opportunities stem from improvements in technology and the growing demand for structural details.

• Drug Discovery and Development: Drug development efforts require detailed structural information about drug targets and their interactions. Cryo-EM provides the unique ability to meet this demand. This capability helps to develop new medicines faster and design them more effectively. The growing funding in drug research and development is increasing the need for advanced cryo-EM systems.
• Structural Biology Research: Cryo-EM is increasingly being used in structural biology due to its near-atomic clarity and ability to visualize important molecular components in situ. Research institutions are acquiring cryo-EM systems to study protein super complexes, viruses, and cell biology, further driving expansion in this field.
• Materials Science: Cryo-EM is making significant contributions to materials science, particularly in the study of nanomaterials and complex materials. Researchers are seeking a better understanding of why certain materials have specific properties and behaviors, creating opportunities for growth in this industry.
• Personalized Medicine: Cryo-EM is helping to elucidate the physicochemical mechanisms of diseases and discover biomarkers, enabling the development of targeted therapies. With its superior spatial resolution, cryo-EM provides a more accurate understanding of treatments, thus advancing personalized medicine.
• Educational and Research Institutions: New technologies, especially cryo-EM, are being increasingly adopted by educational and research institutions for academic and scientific purposes. Funding and grants aimed at enhancing research capabilities are encouraging the establishment of cryo-EM units in colleges and research institutions, expanding the market.

The rapid development of the Cryo-EM market is driven by growth opportunities in drug discovery, structural biology, materials science, personalized medicine, and educational institutions. These opportunities align with the growing importance of the technology across a broad range of industries and applications.

Cryo-Electron Microscopy Market Drivers and Challenges

The Cryo-Electron Microscopy market faces both drivers and challenges that will influence its growth and development. In this volatile industry, factors such as technology, economics, and regulation all play a significant role.

The drivers of the cryo-electron microscopy market include:

• Technological Advancements: Improved capabilities, such as higher resolution and the use of automated systems, are expected to fuel market growth. New developments in areas such as detectors, sample preparation, and image analysis will enhance the effectiveness of cryo-EM, leading to increased use in clinical and research studies.
• Rising Demand for Structural Biology: The demand for cryo-EM is increasing due to the need for structural data in drug discovery and molecular biology. Advanced imaging techniques like cryo-EM are in high demand to meet these needs from researchers and pharmaceutical companies.
• Increased Research Funding: Both government and private industries are investing in biomedical and materials research, which is promoting cryo-EM adoption. Funding and grants are enabling the purchase of advanced cryo-EM systems, stimulating innovation in this area.
• Expansion into New Applications: Cryo-EM's application markets extend beyond structural biology to materials science and personalized medicine, among others, driving market growth. The technology's versatility in explaining structures across diverse domains is expanding its market scope.
• Collaborations and Partnerships: Cryo-EM development and adoption are accelerating through partnerships between academic institutions, research organizations, and industry players. These collaborations foster knowledge exchange, reducing the time needed to develop improvements in cryo-EM.

The challenges in the cryo-electron microscopy market include:

• High Costs of Cryo-EM Systems: The high cost of cryo-EM systems presents a barrier to adoption, especially for smaller institutions and developing countries. The large investments required to develop advanced cryo-EM systems slow market growth in regions with limited access to the technology.
• Complexity of Sample Preparation: Sample preparation for cryo-EM remains a time-consuming and challenging process that reduces the efficiency of the technique. Issues with sample preparation and manipulation may degrade results and limit cryo-EM's use in routine practices.
• Data Management and Analysis: Advanced data management and analysis techniques are necessary to handle the large volumes of data generated by cryo-EM. These techniques are time-consuming and can limit the widespread use of cryo-EM in large-scale applications.

Major drivers such as technological advancements, increased research funding, and the expansion of new applications are transforming the Cryo-EM market. However, challenges such as economic factors, complex sample preparation, and data management issues are hindering market growth. These challenges need to be addressed while maintaining focus on the drivers to ensure further development and success of cryo-EM technology.

List of Cryo-Electron Microscopy Companies

Companies in the market compete based on product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. With these strategies, cryo-electron microscopy companies cater to increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the cryo-electron microscopy companies profiled in this report include-

• Thermos Fisher Scientific
• Danaher
• JEOL
• Intertek
• Charles River Laboratories
• Hitachi High-Technologies
• Carl Zeiss

Cryo-Electron Microscopy by Segment

The study includes a forecast for the global cryo-electron microscopy market by product, technology, voltage, application, and region.

Cryo-Electron Microscopy Market by Product [Analysis by Value from 2019 to 2031]:

• Instruments
• Fully Automated Instruments
• Semi-automated Instruments

Cryo-Electron Microscopy Market by Technology [Analysis by Value from 2019 to 2031]:

• Electron Crystallography
• Single Particle Analysis
• Cryo-electron Tomography
• Others

Cryo-Electron Microscopy Market by Voltage [Analysis by Value from 2019 to 2031]:

• 300 kV
• 200 kV
• 120 kV

Cryo-Electron Microscopy Market by Application [Analysis by Value from 2019 to 2031]:

• Life Science Research & Academia
• Cancer Research
• Omics Research
• Pharma & Biotech Manufacturing
• Cell & Gene Therapy
• Vaccines
• Preclinical & Clinical Research
• Healthcare/Medical Applications
• Others

Cryo-Electron Microscopy Market by Region [Analysis by Value from 2019 to 2031]:

• North America
• Europe
• Asia Pacific
• The Rest of the World

Country Wise Outlook for the Cryo-Electron Microscopy Market

Cryo-Electron Microscopy (cryo-EM) technology has seen growing adoption due to innovations and its increasing use in structural biology and materials science. The market is expanding in key regions with focused developments aimed at improving visualization and broadening the scope of research. The following summary provides an overview of the latest updates for Cryo-EM end-user markets in the US, China, Germany, India, and Japan.

• United States: In the United States, the cryo-EM market has seen rapid advancements, fueled by major funding from leading research institutions and biotech companies. High-resolution cryo-EM systems have been developed, enhancing the quality of images obtained. Increased budgetary allocations from the National Institutes of Health (NIH) and other private research institutions have stimulated the development and application of cryo-EM in pharmaceuticals and structural biology.
• China: China is investing heavily in cryo-EM technology, with both government and private organizations focusing on advancing research capabilities. The Chinese government's research funds have been instrumental in establishing high-tech cryo-EM labs across leading research universities. The rapid adoption of cryo-EM in the fields of material sciences, structural biology, and drug research is a key driver for market growth in China.
• Germany: Germany's technological innovation leadership is reflected in its advancement of cryo-EM. The country's adoption of cryo-EM for research into biomolecules, viruses, and protein structures continues to grow. Government support for research projects in the biotech industry and collaborations between institutions such as the Max Planck Institutes are contributing to increased demand for cryo-EM in Germany.
• India: India is witnessing significant growth in cryo-EM adoption due to increasing investments in biotechnology and pharmaceutical research. Research institutions, including the Indian Institute of Technology (IIT), are acquiring cryo-EM systems to advance structural biology studies. Government funding initiatives supporting R&D are further increasing the demand for cryo-EM technology.
• Japan: Japan is also enhancing its cryo-EM capabilities, with institutions like the RIKEN Center for Structural Biology leading the way. Investments in new systems and upgrades in cryo-EM facilities are contributing to the growing demand. The increasing interest in drug discovery and protein structural analysis in Japan is providing opportunities for the cryo-EM market to expand.

Features of the Global Cryo-Electron Microscopy Market

Market Size Estimates: Cryo-electron microscopy market size estimation in terms of value ($B).

Trend and Forecast Analysis: Market trends (2019 to 2024) and forecast (2025 to 2031) by various segments and regions.

Segmentation Analysis: Cryo-electron microscopy market size by various segments, such as by product, technology, voltage, application, and region in terms of value ($B).

Regional Analysis: Cryo-electron microscopy market breakdown by North America, Europe, Asia Pacific, and Rest of the World.

Growth Opportunities: Analysis of growth opportunities in different products, technologies, voltage, applications, and regions for the cryo-electron microscopy market.

Strategic Analysis: This includes M&A, new product development, and the competitive landscape of the cryo-electron microscopy market.

Analysis of the competitive intensity of the industry based on Porter's Five Forces model.

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This report answers the following 11 key questions:

• Q.1. What are some of the most promising, high-growth opportunities for the cryo-electron microscopy market by product (instruments, fully automated instruments, and semi-automated instruments), technology (electron crystallography, single particle analysis, cryo-electron tomography, and others), voltage (300 KV, 200 KV, and 120 KV), application (life science research & academia, cancer research, omics research, pharma & biotech manufacturing, cell & gene therapy, vaccines, preclinical & clinical research, healthcare/medical applications, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?
• Q.2. Which segments will grow at a faster pace and why?
• Q.3. Which region will grow at a faster pace and why?
• Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?
• Q.5. What are the business risks and competitive threats in this market?
• Q.6. What are the emerging trends in this market and the reasons behind them?
• Q.7. What are some of the changing demands of customers in the market?
• Q.8. What are the new developments in the market? Which companies are leading these developments?
• Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?
• Q.10. What are some of the competing products in this market, and how big of a threat do they pose for loss of market share by material or product substitution?
• Q.11. What M&A activity has occurred in the last 5 years, and what has its impact been on the industry?

Table of Contents

1. Executive Summary

2. Global Cryo-Electron Microscopy Market : Market Dynamics

• 2.1: Introduction, Background, and Classifications
• 2.2: Supply Chain
• 2.3: Industry Drivers and Challenges

3. Market Trends and Forecast Analysis from 2019 to 2031

• 3.1. Macroeconomic Trends (2019-2024) and Forecast (2025-2031)
• 3.2. Global Cryo-Electron Microscopy Market Trends (2019-2024) and Forecast (2025-2031)
• 3.3: Global Cryo-Electron Microscopy Market by Product
  • 3.3.1: Instruments
  • 3.3.2: Fully Automated Instruments
  • 3.3.3: Semi-automated Instruments
• 3.4: Global Cryo-Electron Microscopy Market by Technology
  • 3.4.1: Electron Crystallography
  • 3.4.2: Single Particle Analysis
  • 3.4.3: Cryo-electron Tomography
  • 3.4.4: Others
• 3.5: Global Cryo-Electron Microscopy Market by Voltage
  • 3.5.1: 300 kV
  • 3.5.2: 200 kV
  • 3.5.3: 120 kV
• 3.6: Global Cryo-Electron Microscopy Market by Application
  • 3.6.1: Life Science Research & Academia
  • 3.6.2: Cancer Research
  • 3.6.3: Omics Research
  • 3.6.4: Pharma & Biotech Manufacturing
  • 3.6.5: Cell & Gene Therapy
  • 3.6.6: Vaccines
  • 3.6.7: Preclinical & Clinical Research
  • 3.6.8: Healthcare/Medical Applications
  • 3.6.9: Others

4. Market Trends and Forecast Analysis by Region from 2019 to 2031

• 4.1: Global Cryo-Electron Microscopy Market by Region
• 4.2: North American Cryo-Electron Microscopy Market
  • 4.2.1: North American Market by Technology: Electron Crystallography, Single Particle Analysis, Cryo-electron Tomography, and Others
  • 4.2.2: North American Market by Application: Life Science Research & Academia, Cancer Research, Omics Research, Pharma & Biotech Manufacturing, Cell & Gene Therapy, Vaccines, Preclinical & Clinical Research, Healthcare/Medical Applications, and Others
• 4.3: European Cryo-Electron Microscopy Market
  • 4.3.1: European Market by Technology: Electron Crystallography, Single Particle Analysis, Cryo-electron Tomography, and Others
  • 4.3.2: European Market by Application: Life Science Research & Academia, Cancer Research, Omics Research, Pharma & Biotech Manufacturing, Cell & Gene Therapy, Vaccines, Preclinical & Clinical Research, Healthcare/Medical Applications, and Others
• 4.4: APAC Cryo-Electron Microscopy Market
  • 4.4.1: APAC Market by Technology: Electron Crystallography, Single Particle Analysis, Cryo-electron Tomography, and Others
  • 4.4.2: APAC Market by Application: Life Science Research & Academia, Cancer Research, Omics Research, Pharma & Biotech Manufacturing, Cell & Gene Therapy, Vaccines, Preclinical & Clinical Research, Healthcare/Medical Applications, and Others
• 4.5: ROW Cryo-Electron Microscopy Market
  • 4.5.1: ROW Market by Technology: Electron Crystallography, Single Particle Analysis, Cryo-electron Tomography, and Others
  • 4.5.2: ROW Market by Application: Life Science Research & Academia, Cancer Research, Omics Research, Pharma & Biotech Manufacturing, Cell & Gene Therapy, Vaccines, Preclinical & Clinical Research, Healthcare/Medical Applications, and Others

5. Competitor Analysis

• 5.1: Product Portfolio Analysis
• 5.2: Operational Integration
• 5.3: Porter's Five Forces Analysis

6. Growth Opportunities and Strategic Analysis

• 6.1: Growth Opportunity Analysis
  • 6.1.1: Growth Opportunities for the Global Cryo-Electron Microscopy Market by Product
  • 6.1.2: Growth Opportunities for the Global Cryo-Electron Microscopy Market by Technology
  • 6.1.3: Growth Opportunities for the Global Cryo-Electron Microscopy Market by Voltage
  • 6.1.4: Growth Opportunities for the Global Cryo-Electron Microscopy Market by Application
  • 6.1.5: Growth Opportunities for the Global Cryo-Electron Microscopy Market by Region
• 6.2: Emerging Trends in the Global Cryo-Electron Microscopy Market
• 6.3: Strategic Analysis
  • 6.3.1: New Product Development
  • 6.3.2: Capacity Expansion of the Global Cryo-Electron Microscopy Market
  • 6.3.3: Mergers, Acquisitions, and Joint Ventures in the Global Cryo-Electron Microscopy Market
  • 6.3.4: Certification and Licensing

7. Company Profiles of Leading Players

• 7.1: Thermos Fisher Scientific
• 7.2: Danaher
• 7.3: JEOL
• 7.4: Intertek
• 7.5: Charles River Laboratories
• 7.6: Hitachi High-Technologies
• 7.7: Carl Zeiss