핵산 표지 : 시장 점유율 분석, 산업 동향, 통계, 성장 예측(2025-2030년)

The nucleic acid labeling market size stood at USD 2.65 billion in 2025 and is on course to reach USD 3.81 billion by 2030, reflecting a 7.57% CAGR.

Momentum is shifting from legacy radioactive workflows toward copper-free click-chemistry and other bioorthogonal platforms that mark DNA and RNA without damaging living cells. Three intertwined forces underpin growth: record public genomics funding such as the United Kingdom's USD 190 million program in 2024, attomolar-sensitive CRISPR diagnostics that remove upstream amplification steps, and new commercial bio-orthogonal reagents that bypass copper toxicity. Fluorescent labeling remains the workhorse because of safety and automation readiness, yet better shielding and targeting strategies are igniting a radioactive renaissance for next-generation radiopharmaceuticals. Meanwhile, contract research organizations (CROs) expand fastest as drug makers outsource sophisticated labeling tasks to partners with regulatory-grade infrastructure.

Global Nucleic Acid Labeling Market Trends and Insights

Expansion of Genomics and Proteomics Research Funding

Generous public investment fuels an ever-larger experimental footprint. The NIH Centers of Excellence in Genomic Science program is channeling substantial grants into transformative sequencing technologies. Parallel efforts such as Human Genome Project II aim to genotype more than 1% of the global population, driving demand for scalable labeling reagents that can handle huge sample volumes while keeping error rates low. Proteomics consortia are pushing multiplexed labeling that distinguishes hundreds of proteins in a single run, raising reagent consumption across academic core facilities. Funding also supports diversity initiatives, meaning reagents must perform consistently across varied ancestries and biosources. In aggregate, better-funded laboratories translate directly into elevated procurement of high-margin labeling kits and enzymes.

Increasing Adoption of Precision Medicine and Companion Diagnostics

Healthcare providers are embedding molecular readouts into routine decision-making. QIAGEN recently broadened its QIAstat-Dx panel to include chronic disease biomarkers, illustrating how multiplex PCR diagnostics rely on robust labeling chemistry for simultaneous detection. Over 30 biopharma partnerships now co-develop companion diagnostics beyond oncology, each demanding standardized, globally accepted labeling workflows. Regulatory agencies push harmonized guidelines, so suppliers able to validate reagents across multiple jurisdictions gain traction. Asia-Pacific uptake is accelerating in step with expanding molecular pathology capacity, creating fresh revenue pools for premium-priced probes. As personalized therapy narrows dosing windows, clinicians need labels that deliver unambiguous signal readouts at very low analyte levels.

High Cost of Advanced Labeling Reagents and Instruments

Premium fluorophores and specialized instrumentation can price out smaller laboratories. A high-end automated label-incorporation system exceeds USD 100,000, a steep barrier for facilities without large capital budgets. Global supply disruptions, such as recent technetium-99m shortages, expose reliance on single-source isotopes and drive up pricing for alternative kits. Businesses counter by multisourcing raw materials and launching value-tier products, but margin pressure persists, especially where local currencies depreciate against USD.

Other drivers and restraints analyzed in the detailed report include:

1. Rapid Growth of Next-Generation Sequencing Workflows
2. Rising Utilization of Fluorescent Probes in Molecular Diagnostics
3. Technical Complexity and Skill Gap in Low-Resource Settings

For complete list of drivers and restraints, kindly check the Table Of Contents.

Segment Analysis

Fluorescent reagents captured 46.54% of the nucleic acid labeling market in 2024, underscoring their status as the default solution for high-throughput microscopy, flow cytometry, and qPCR workflows. This leadership reflects lower biosafety requirements, streamlined disposal, and tight integration with automated optics systems. Radioactive approaches, although regulated, are climbing at 9.54% CAGR as next-generation radiopharmaceuticals leverage isotopic precision for oncological imaging. Copper-free click-labels and tetrazine ligation now let researchers track nucleic acids inside living cells without photo-bleaching or toxicity.

The segment illustrates convergence. Fluorescent platforms increasingly touch attomolar sensitivity once reserved for isotope tracers, while modern isotopes adopt antibody or aptamer targeting to limit off-target radiation. Bio-Rad's 32-colour StarBright expansion exemplifies how suppliers tailor brightness and emission spectra to specific cytometers. Conversely, VERAXA Biotech's pre-targeted Affilin radio conjugates rely on click chemistry to attach isotopes only after antibody binding, lowering background uptake. Such cross-pollination blurs traditional label boundaries and sustains innovation momentum across both subsegments.

Reagents and ready-to-use kits represented 55.67% share of the nucleic acid labeling market in 2024 because consumables are replenished with every batch run. Researchers favor all-inclusive boxes that bundle probes, buffers, and controls, cutting qualification time. Yet engineered enzymes and polymerases show the briskest 9.32% CAGR as thermostable, fidelity-enhanced variants incorporate labels during synthesis rather than after amplification.

Value creation is moving upstream. Merck's Aptegra CHO genetic stability assay combines whole-genome sequencing with streamlined labeling, trimming 66% off biosafety testing time and 43% off costs. Dual-incorporation polymerases allow orthogonal end labeling that surpasses chemical post-synthesis methods in uniformity and yield. Services supplying custom oligos with embedded click-handles fill specialty gaps for spatial transcriptomics or single-cell multiomics where catalog SKUs fall short.

The Nucleic Acid Labeling Market Report is Segmented by Label Type (Biotin-Based, and More), Product (Reagents & Kits, and More), Method (Direct Chemical Labeling, and More), Application (Microarray & Gene Expression, and More). End User (Academic & Research Institutes, and More), Geography (North America, Europe, and More). The Market Forecasts are Provided in Terms of Value (USD).

Geography Analysis

North America contributed 43.45% of the nucleic acid labeling market size in 2024 on the strength of robust NIH budgets, venture funding, and an FDA framework that clarifies labeling reagent classification. The United States leads with mature sequencing infrastructure, widespread CRISPR diagnostic pilots, and a vibrant biotech supply chain. Canadian centers add depth through specialized stem-cell and epigenetics programs, while Mexico expands biomanufacturing corridors that source labeling consumables regionally.

Asia-Pacific is the fastest-growing arena at 8.54% CAGR to 2030. China alone set aside USD 1.12 billion for nucleic acid drug development, accelerating reagent uptake across research institutes and CDMOs. Japan's innovation in heat-stable mRNA storage broadens kit durability, critical for tropical deployment. India's CRO sector scales rapidly, demanding cost-optimized fluorescent and click reagents. South Korea and Australia contribute high-resolution imaging talent and harmonized IVD regulations that shorten approval timelines.

Europe maintains steady, policy-driven expansion. Germany and the United Kingdom anchor R&D with strong pharmaceutical ecosystems, while France, Italy, and Spain invest in regional manufacturing to mitigate post-Brexit logistics hurdles. Sustainability rules encourage moves away from radioactive workflows toward greener fluorophores and copper-free click chemistries. EU-wide initiatives supporting precision oncology ensure continued progression but with heightened scrutiny on waste management and supply transparency.

1. Thermo Fisher Scientific
2. Merck
3. PerkinElmer
4. GE Healthcare / Cytiva
5. Promega
6. Enzo Biochem
7. Vector Laboratories
8. New England Biolabs
9. Agilent Technologies
10. Integrated DNA Technologies (IDT)
11. LGC Biosearch Technologies
12. Takara Bio
13. QIAGEN
14. Roche
15. Bio-Rad Laboratories
16. Bioneer Corp.
17. Jena Bioscience
18. TriLink BioTechnologies
19. Lucigen
20. Tocris Bioscience
21. Marker Gene Technologies
22. Other Emerging Players

Additional Benefits:

• The market estimate (ME) sheet in Excel format
• 3 months of analyst support

TABLE OF CONTENTS

1 Introduction

• 1.1 Study Assumptions & Market Definition
• 1.2 Scope of the Study

2 Research Methodology

3 Executive Summary

4 Market Landscape

• 4.1 Market Overview
• 4.2 Market Drivers
  • 4.2.1 Expansion of Genomics and Proteomics Research Funding
  • 4.2.2 Increasing Adoption of Precision Medicine and Companion Diagnostics
  • 4.2.3 Rapid Growth of Next-Generation Sequencing Workflows
  • 4.2.4 Rising Utilization of Fluorescent Probes in Molecular Diagnostics
  • 4.2.5 Emergence of Click-Chemistry and Bio-Orthogonal Labeling Technologies
  • 4.2.6 Integratioon f CRISPR-Based Point-Of-Care Diagnostics
• 4.3 Market Restraints
  • 4.3.1 High Cost of Advanced Labeling Reagents and Instruments
  • 4.3.2 Technical Complexity and Skill Gap in Low-Resource Settings
  • 4.3.3 Regulatory Restrictions on Radioactive Labeling Methods
  • 4.3.4 Supply Chain Vulnerabilities for Specialty Fluorophores
• 4.4 Regulatory Landscape
• 4.5 Porter's Five Forces Analysis
  • 4.5.1 Threat of New Entrants
  • 4.5.2 Bargaining Power of Buyers
  • 4.5.3 Bargaining Power of Suppliers
  • 4.5.4 Threat of Substitutes
  • 4.5.5 Industry Rivalry

5 Market Size & Growth Forecasts (Value, USD)

• 5.1 By Label Type
  • 5.1.1 Biotin-based
  • 5.1.2 Fluorescent
  • 5.1.3 Radioactive (32P, 35S, etc.)
  • 5.1.4 Other Label Types
• 5.2 By Product
  • 5.2.1 Reagents & Kits
  • 5.2.2 Probes & Primers
  • 5.2.3 Enzymes & Polymerases
  • 5.2.4 Custom Labeling Services
• 5.3 By Method
  • 5.3.1 Direct Chemical Labeling
  • 5.3.2 PCR-based Incorporation
  • 5.3.3 Nick Translation / Random Priming
  • 5.3.4 Click-Chemistry Conjugation
• 5.4 By Application
  • 5.4.1 Microarray & Gene Expression
  • 5.4.2 Next-Generation Sequencing (NGS)
  • 5.4.3 In-situ Hybridization / FISH
  • 5.4.4 Polymerase Chain Reaction (PCR/qPCR)
  • 5.4.5 CRISPR Screening & Diagnostics
  • 5.4.6 Other Applications
• 5.5 By End User
  • 5.5.1 Academic & Research Institutes
  • 5.5.2 Hospitals & Clinics
  • 5.5.3 Diagnostic Laboratories
  • 5.5.4 Biopharma & Biotechnology Companies
  • 5.5.5 CROs & Service Providers
• 5.6 Geography
  • 5.6.1 North America
    • 5.6.1.1 United States
    • 5.6.1.2 Canada
    • 5.6.1.3 Mexico
  • 5.6.2 Europe
    • 5.6.2.1 Germany
    • 5.6.2.2 United Kingdom
    • 5.6.2.3 France
    • 5.6.2.4 Italy
    • 5.6.2.5 Spain
    • 5.6.2.6 Rest of Europe
  • 5.6.3 Asia-Pacific
    • 5.6.3.1 China
    • 5.6.3.2 Japan
    • 5.6.3.3 India
    • 5.6.3.4 Australia
    • 5.6.3.5 South Korea
    • 5.6.3.6 Rest of Asia-Pacific
  • 5.6.4 Middle East & Africa
    • 5.6.4.1 GCC
    • 5.6.4.2 South Africa
    • 5.6.4.3 Rest of Middle East & Africa
  • 5.6.5 South America
    • 5.6.5.1 Brazil
    • 5.6.5.2 Argentina
    • 5.6.5.3 Rest of South America

6 Competitive Landscape

• 6.1 Market Concentration
• 6.2 Market Share Analysis
• 6.3 Company Profiles (includes Global level Overview, Market level overview, Core Business Segments, Financials, Headcount, Key Information, Market Rank, Market Share, Products and Services, and analysis of Recent Developments)
  • 6.3.1 Thermo Fisher Scientific, Inc.
  • 6.3.2 Merck KGaA
  • 6.3.3 PerkinElmer, Inc.
  • 6.3.4 GE Healthcare / Cytiva
  • 6.3.5 Promega Corporation
  • 6.3.6 Enzo Biochem
  • 6.3.7 Vector Laboratories
  • 6.3.8 New England Biolabs
  • 6.3.9 Agilent Technologies
  • 6.3.10 Integrated DNA Technologies (IDT)
  • 6.3.11 LGC Biosearch Technologies
  • 6.3.12 Takara Bio
  • 6.3.13 QIAGEN
  • 6.3.14 Roche Diagnostics
  • 6.3.15 Bio-Rad Laboratories
  • 6.3.16 Bioneer Corp.
  • 6.3.17 Jena Bioscience
  • 6.3.18 TriLink BioTechnologies
  • 6.3.19 Lucigen Corporation
  • 6.3.20 Tocris Bioscience
  • 6.3.21 Marker Gene Technologies
  • 6.3.22 Other Emerging Players

7 Market Opportunities & Future Outlook

• 7.1 White-space & Unmet-need Assessment