The peptide synthesis market is expected to register a CAGR of 5.5 % over the forecast period.
Owing to the current COVID-19 situation, peptides are increasingly being developed and repurposed in search of therapeutics for the treatment of COVID-19. In February 2020, the FDA updated its definition of a biologic to include chemically synthesized polypeptides greater than 40 amino acids but less than 100 amino acids in size (synthetic proteins) and synthetic peptides 40 amino acids or less. As per the data on Clinical Trials.gov, in May 2020, 21 peptide drugs were in the development for the treatment of COVID-19, including 15 synthetic peptides for Acute Respiratory Distress Syndrome (ARDS), a life-threatening condition where the lungs cannot provide the body's vital organs with enough oxygen, and other respiratory illnesses caused by SARS-Cov-2 infection.
The major propelling the growth of the market is a steep rise in the adoption of peptides in the pharmaceutical and consumer healthcare industries. The peptides have a wide range of applications in the treatment of various lifestyle disorders such as cancers, diabetes, and obesity. The increasing incidence of these metabolic and lifestyle disorders is paving the way for the application of peptide therapeutics in oncology and metabolic disorders. According to the International Diabetes Federation report published in 2020, around 463 million people were living with diabetes in 2019 and by 2045 the prevalence will reach 700 million. Among the prevalence Type 2 diabetes is the most common type of diabetes, accounting for around 90% of all diabetes globally. Diabetes mellitus (Type 2 diabetes) is a group of metabolic disorders of carbohydrate metabolism. Several peptide therapies such as Glucagon-like peptide-1amide release postprandially, which stimulates insulin secretion and is popular pancreatic therapy. Thus, due to the rise in the volume of the patient pool with Type 2 diabetes, the demand for peptides is expected to increase which is likely to fuel the market over the forecast period. Also, the increased research activities and novel product approvals due to the rise in funding for R&D and the advantages of advanced peptide synthesizers have further boosted the growth of the peptide synthesis market throughout the period. For instance, in 2018, Novartis and Amgen have received approval in European Union countries for Aimovig (erenumab), a calcitonin gene related-peptide inhibitor that helps in the treatment of migraine in adults. As per the Novartis, patients administered with erenumab during the clinical studies were reported with almost 50% reduction of migraine attacks. Thus, such significant developments in peptide drugs are expected to boost the demand.
Key Market Trends
Pharmaceutical & Biotechnology Companies is Expected to Hold the Significant Market Share Over the Forecast Period
Based on the end-user, pharmaceutical & biotechnology companies is expected to hold the significant market due to the increasing adoption of peptide for therapeutic development in this industry. The research and developments of peptide therapies are increasing as they are cost-effective, efficient, and have lower toxicity. These peptides are also a major part of the COVID-19 related research these days. Swiss-based Relief Therapeutics is conducting an FDA-approved clinical trial, which is part of the FDA's Coronavirus Treatment Acceleration Program (CTAP), at New York University Langone (NYU Langone Health) to assess the effect of Aviptadil, a patented synthetic form of a human vasoactive intestinal polypeptide (VIP) for COVID-19-related ARDS. New oral drugs are being developed by various pharmaceutical and biotechnology companies, which is expected to boost the demand for this segment.
For instance, in 2019, the US FDA approved Rybelsus oral tablets for controlling the blood sugar in Type-2 diabetes patients. It is a glucagon-like peptide (GLP-1) receptor protein treatment developed by Novo Nordisk. Also, in November 2019, AstraZeneca announced large-scale initiatives in China to advance global research and development (R&D) for innovative medicines including peptide therapies.All these developments are expected to propel the growth of the pharmaceutical & biotechnology companies end-user segment.
The graph below suggests that the prevelnace of diabetes is increasing in the world which is also fueling the demand for the treatment of this metabolic disorder, which in turn is expected to drive the market growth.
North America is Expected to Dominate the Market Over the Forecast Period
North America is expected to dominate the overall peptide synthesis market throughout the forecast period. The dominance is due to the growing prevalence of obesity with a rise in sedentary deskbound lifestyle and lack of proper diet along with physical activity resulting in various chronic diseases like diabetes in the United States necessitated the efficient treatment. For instance, according to the International Diabetes Federation in 2019, about 48 million adults in North America are living with diabetes and are expected to continue resulting in higher demand for peptide therapeutics driving the market in the region.
Furthermore, the increased availability of advanced healthcare infrastructure along with huge investments by the key players in this region to develop a new peptide synthesis technologies is also likely to fuel the market growth. Also, a favorable earlier approval of peptide drugs owing to the accelerated drug approval initiative by USFDA is also likely to fuel the market growth in this region across the forecast period contributing to its outstanding market share in the global peptide synthesis market.
The peptide synthesis market is moderately competitive and consists of several major players. Some of the companies are expanding their market position by adopting various strategies such as acquisitions and mergers, research collaboration, while others are introducing new products to maintain their market share. For Instance, In May 2019, CEM Corporation launched Liberty PRO, the world's first-ever large-scale automated microwave peptide synthesizer. The system can synthesize 1 kg of crude peptide per batch utilizing reaction vessel, sizes up to 15 liters with unmatched purity, speed, and waste reduction fueling the market revenue share. Few of the major players currently dominating the industry in terms of revenue are AAPPTec, CSBio Company Inc, Biotage AB, Bachem Holding AG, and CEM Corporation.
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TABLE OF CONTENTS
- 1.1 Study Assumptions and Market Definition
- 1.2 Scope of the Study
2 RESEARCH METHODOLOGY
3 EXECUTIVE SUMMARY
4 MARKET DYNAMICS
- 4.1 Market Overview
- 4.2 Market Drivers
- 4.2.1 Rising Investments Along with Huge Funding for R&D of Genomics and Proteomics in Bio-pharmaceutical Industry
- 4.2.2 Rapid Technological Advancements in Peptide synthesizers Coupled by Strong Peptide Therapeutics Pipeline
- 4.3 Market Restraints
- 4.3.1 Issues Pertaining to Large-scale Peptide Synthesis and Lack of Robust Distribution Network
- 4.3.2 Challenges in Development of Peptides and Instability of the Peptides
- 4.4 Porter's Five Force Analysis
- 4.4.1 Threat of New Entrants
- 4.4.2 Bargaining Power of Buyers/Consumers
- 4.4.3 Bargaining Power of Suppliers
- 4.4.4 Threat of Substitute Products
- 4.4.5 Intensity of Competitive Rivalry
5 MARKET SEGMENTATION
- 5.1 By Technology
- 5.1.1 Solid-Phase
- 5.1.2 Liquid-Phase
- 5.1.3 Hybrid & Recombinant
- 5.2 By Product
- 5.2.1 Equipment
- 5.2.2 Reagents & Consumables
- 5.2.3 Others
- 5.3 By End-User
- 5.3.1 Pharmaceutical & Biotechnology Companies
- 5.3.2 Contract Development & Manufacturing Organization (CDMO)
- 5.3.3 Academic & Research Institutes
- 5.4 By Geography
- 5.4.1 North America
- 126.96.36.199 United states
- 188.8.131.52 Canada
- 184.108.40.206 Mexico
- 5.4.2 Europe
- 220.127.116.11 Germany
- 18.104.22.168 United Kingdom
- 22.214.171.124 France
- 126.96.36.199 Italy
- 188.8.131.52 Spain
- 184.108.40.206 Rest of Europe
- 5.4.3 Asia-Pacific
- 220.127.116.11 China
- 18.104.22.168 Japan
- 22.214.171.124 India
- 126.96.36.199 Australia
- 188.8.131.52 South Korea
- 184.108.40.206 Rest of Asia-Pacific
- 5.4.4 Rest of the World
6 COMPETITIVE LANDSCAPE
- 6.1 Company Profiles
- 6.1.1 AAPPTec
- 6.1.2 Amgen Inc.
- 6.1.3 Anaspec Inc
- 6.1.4 Bachem Holding AG
- 6.1.5 Biotage AB
- 6.1.6 Bristol-Myers Squibb
- 6.1.7 CEM Corporation
- 6.1.8 CSBio Company Inc
- 6.1.9 Eli Lilly and Company
- 6.1.10 Ever Neuro Pharma GmbH
- 6.1.11 Gyros Protein Technologies AB
- 6.1.12 Merck KGaA
- 6.1.13 New England Peptide Inc
- 6.1.14 Pfizer Inc.
- 6.1.15 Thermo Fisher Scientific
7 MARKET OPPORTUNITIES AND FUTURE TRENDS