세계의 골전이 치료 시장 : 유형별, 치료별, 주요 브랜드별, 지역별, 기회, 예측(2018-2032년)

Global bone metastasis treatment market is projected to witness a CAGR of 8.40% during the forecast period 2025-2032, growing from USD 19.38 billion in 2024 to USD 36.94 billion in 2032. The market is driven by the growing global prevalence of cancer, which increases the risk of bone metastases. Advances in treatment technologies, such as radiopharmaceuticals and targeted biologics, are improving patient outcomes and expanding therapeutic options. Furthermore, rising pediatric cancer cases and North America's innovation-led healthcare infrastructure are contributing significantly to market growth.

For instance, in November 2024, Zetagen Therapeutics, Inc., a private biopharmaceutical company in the clinical stage dedicated to creating innovative therapies through local administration for metastatic breast cancer affecting bone and soft tissues, announced the enrollment of the first two patients in phase 2a study. This study will assess the efficacy of ZetaMet (Zeta-BC-003) in treating spinal metastatic lytic breast cancer lesions.

Rising Global Cancer Burden Fuels Demand for Bone Metastasis Treatment

The increasing prevalence of primary cancers, particularly breast cancer, prostate cancer, and lung cancer, is a significant driver of the bone metastasis treatment market. As these cancers frequently metastasize to bones, the need for early diagnosis and effective treatment of skeletal-related complications is escalating. Advanced imaging modalities and improvements in diagnostics have enabled earlier detection of bone metastases, leading to better therapeutic outcomes. Furthermore, increasing awareness of palliative care and the rising emphasis on quality of life for advanced cancer patients have encouraged the use of bone-targeted therapies such as bisphosphonates and RANK ligand inhibitors. Pharmaceutical companies are also actively investing in innovative drug development to enhance effectiveness and reduce side effects of current treatments. For instance, the American Cancer Society projects that in 2025, there will be approximately 3,770 new cases of primary bone and joint cancers, comprising 2,150 cases in males and 1,620 in females, along with an estimated 2,190 fatalities, including 1,240 in males and 950 in females. This data encompasses both pediatric and adult populations. Primary bone cancers, which originate in the bones, are relatively rare, representing less than 1% of all cancer cases. In adults, cancers that metastasize bones from other sites are significantly more prevalent than primary bone cancers.

Technological Advancements in Targeted Therapies and Radiopharmaceuticals

Ongoing innovations in targeted therapies and radiopharmaceuticals significantly reshape the bone metastasis treatment landscape. Radiopharmaceuticals like Xofigo (radium-223 dichloride) offer more focused approaches, delivering localized radiation therapy that spares healthy tissue and minimizes systemic toxicity. The emergence of combination therapies-pairing bone-targeted agents with immunotherapies or chemotherapy-is enhancing efficacy in managing skeletal metastases. Additionally, artificial intelligence and precision medicine aid in patient stratification and personalized treatment plans, increasing success rates. These advancements not only improve clinical outcomes but also lower the burden of skeletal-related events such as fractures, spinal compression, and pain. Companies are actively launching and refining novel drugs to maintain a competitive advantage. For instance, in March 2023, a team of researchers from the University of Sheffield and the University of East Anglia introduced a novel medication named CADD522 to treat individuals with primary bone cancers. This medication demonstrated a 50% improvement in survival rates in preclinical studies.

Rising Incidences of Bone Metastasis in Pediatric Oncology Accelerates Treatment Needs

Although bone metastasis is more common in adults, its occurrence in pediatric cancers such as neuroblastoma, Ewing sarcoma, and osteosarcoma is growing attention. As pediatric oncology sees rising case detection due to improved diagnostics and awareness, the need for age-specific bone metastasis treatment is becoming critical. Children with metastatic cancer often face rapid disease progression and complications involving bones, demanding early and aggressive intervention. The treatment approach in pediatric cases emphasizes minimizing long-term toxicity while effectively managing skeletal-related complications. Drug developers are now focusing on pediatric clinical trials and safety profiles tailored for children.

North America Maintains Market Leadership

North America dominates the global bone metastasis treatment market due to its high cancer burden, advanced healthcare infrastructure, and strong pharmaceutical R&D ecosystem. The U.S., in particular, reports many cancer cases that often progress to metastatic stages, necessitating robust bone-targeted interventions. Favorable reimbursement policies and fast-track regulatory approvals further facilitate the availability and adoption of advanced therapies. Moreover, patient awareness, widespread access to oncology specialists, and a strong network of cancer treatment centers support proactive treatment. The region is also a hub for clinical trials and drug innovation, contributing significantly to new approvals. The FDA has granted approval for Wyost/Jubbonti (denosumab-bddz; GP2411) in March 2024, marking it as the first biosimilar to the reference drugs Xgeva/Prolia (denosumab) in the United States. This medication will be utilized for the treatment of osteoporosis and hypercalcemia, in addition to preventing skeletal-related events linked to bone metastases from solid tumors.

Future Market Scenario (2025-2032F)

The global bone metastasis treatment market is poised for significant growth driven by the rising global cancer burden and growing awareness of metastatic complications. As cancer survival rates improve due to early diagnosis and advanced treatments, the number of patients at risk for bone metastases is also increasing. Continuous innovations in radiopharmaceuticals, targeted biologics, and minimally invasive surgical techniques enhance treatment efficacy and patient outcomes. Additionally, rising investments in oncology research, increasing use of AI in treatment planning, and growing clinical focus on pediatric metastatic cases are expected to expand market potential. North America will continue to dominate due to high healthcare spending and innovation, while emerging economies in Asia-Pacific are projected to offer substantial opportunities through improved access to oncology care.

Key Players Landscape and Outlook

The key players in the market are significantly investing in the development of bone metastasis treatment and are utilizing strategies such as mergers, acquisitions, partnerships, and new product launches to improve their services and competitiveness. Such efforts will propel significant growth in the market, allowing large-cap industry players to increase their presence and, therefore, find new opportunities in this market.

For example, in November 2023, Telix proposed an acquisition of Qsam Biosciences for USD 33.1 million, aiming to enhance its product portfolio with a phase 1 radiopharmaceutical for bone cancer. This medication aids in the treatment of cancer that has spread to the bone from various organs, including the breast, lung, and prostate.

Table of Contents

1. Project Scope and Definitions

2. Research Methodology

3. Impact of U.S. Tariffs

4. Executive Summary

5. Global Bone Metastasis Treatment Market Outlook, 2018-2032F

• 5.1. Market Size Analysis & Forecast
  • 5.1.1. By Value
• 5.2. Market Share Analysis & Forecast
  • 5.2.1. By Type
    • 5.2.1.1. Osteolytic
    • 5.2.1.2. Osteoblastic
    • 5.2.1.3. Mixed
  • 5.2.2. By Treatment
    • 5.2.2.1. Medication
    • 5.2.2.2. Surgery
  • 5.2.3. By Major Brands
    • 5.2.3.1. Xgeva
    • 5.2.3.2. Zometa
    • 5.2.3.3. Xofigo
    • 5.2.3.4. Others
  • 5.2.4. By Region
    • 5.2.4.1. North America
    • 5.2.4.2. Europe
    • 5.2.4.3. Asia-Pacific
    • 5.2.4.4. South America
    • 5.2.4.5. Middle East and Africa
  • 5.2.5. By Company Market Share Analysis (Top 5 Companies and Others - By Value, 2024)
• 5.3. Market Map Analysis, 2024
  • 5.3.1. By Type
  • 5.3.2. By Treatment
  • 5.3.3. By Major Brands
  • 5.3.4. By Region

6. North America Bone Metastasis Treatment Market Outlook, 2018-2032F

• 6.1. Market Size Analysis & Forecast
  • 6.1.1. By Value
• 6.2. Market Share Analysis & Forecast
  • 6.2.1. By Type
    • 6.2.1.1. Osteolytic
    • 6.2.1.2. Osteoblastic
    • 6.2.1.3. Mixed
  • 6.2.2. By Treatment
    • 6.2.2.1. Medication
    • 6.2.2.2. Surgery
  • 6.2.3. By Major Brands
    • 6.2.3.1. Xgeva
    • 6.2.3.2. Zometa
    • 6.2.3.3. Xofigo
    • 6.2.3.4. Others
  • 6.2.4. By Country Share
    • 6.2.4.1. United States
    • 6.2.4.2. Canada
    • 6.2.4.3. Mexico
• 6.3. Country Market Assessment
  • 6.3.1. United States Bone Metastasis Treatment Market Outlook, 2018-2032F*
    • 6.3.1.1. Market Size Analysis & Forecast
      • 6.3.1.1.1. By Value
    • 6.3.1.2. Market Share Analysis & Forecast
      • 6.3.1.2.1. By Type
        • 6.3.1.2.1.1. Osteolytic
        • 6.3.1.2.1.2. Osteoblastic
        • 6.3.1.2.1.3. Mixed
      • 6.3.1.2.2. By Treatment
        • 6.3.1.2.2.1. Medication
        • 6.3.1.2.2.2. Surgery
      • 6.3.1.2.3. By Major Brands
        • 6.3.1.2.3.1. Xgeva
        • 6.3.1.2.3.2. Zometa
        • 6.3.1.2.3.3. Xofigo
        • 6.3.1.2.3.4. Others
  • 6.3.2. Canada
  • 6.3.3. Mexico

All segments will be provided for all regions and countries covered

7. Europe Bone Metastasis Treatment Market Outlook, 2018-2032F

• 7.1. Germany
• 7.2. France
• 7.3. Italy
• 7.4. United Kingdom
• 7.5. Russia
• 7.6. Netherlands
• 7.7. Spain
• 7.8. Turkey
• 7.9. Poland

8. Asia-Pacific Bone Metastasis Treatment Market Outlook, 2018-2032F

• 8.1. India
• 8.2. China
• 8.3. Japan
• 8.4. Australia
• 8.5. Vietnam
• 8.6. South Korea
• 8.7. Indonesia
• 8.8. Philippines

9. South America Bone Metastasis Treatment Market Outlook, 2018-2032F

• 9.1. Brazil
• 9.2. Argentina

10. Middle East and Africa Bone Metastasis Treatment Market Outlook, 2018-2032F

• 10.1. Saudi Arabia
• 10.2. UAE
• 10.3. South Africa

11. Demand Supply Analysis

12. Value Chain Analysis

13. Porter's Five Forces Analysis

14. PESTLE Analysis

15. Pricing Analysis

16. Market Dynamics

• 16.1. Market Drivers
• 16.2. Market Challenges

17. Market Trends and Developments

18. Regulatory Framework and Innovation

• 18.1. Regulatory Approvals
• 18.2. Clinical Trials

19. Patent Landscape

20. Case Studies

21. Competitive Landscape

• 21.1. Competition Matrix of Top 5 Market Leaders
• 21.2. SWOT Analysis for Top 5 Players
• 21.3. Key Players Landscape for Top 10 Market Players
  • 21.3.1. Bayer AG
    • 21.3.1.1. Company Details
    • 21.3.1.2. Key Management Personnel
    • 21.3.1.3. Products and Services
    • 21.3.1.4. Financials (As Reported)
    • 21.3.1.5. Key Market Focus and Geographical Presence
    • 21.3.1.6. Recent Developments/Collaborations/Partnerships/Mergers and Acquisitions
  • 21.3.2. Amgen Inc.
  • 21.3.3. F. Hoffmann-La Roche Ltd
  • 21.3.4. Pfizer Inc.
  • 21.3.5. Merck & Co., Inc.
  • 21.3.6. Novartis AG
  • 21.3.7. Pharmalucence Inc.
  • 21.3.8. Koninklijke Philips N.V.
  • 21.3.9. Eli Lilly and Company
  • 21.3.10. Medtronic PLC

Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work.

22. Strategic Recommendations

23. About Us and Disclaimer