siRNA 약물 시장 : 시장 점유율과 순위, 전체 판매 및 수요 예측(2025-2031년)

The global market for siRNA Drugs was estimated to be worth US$ 2443 million in 2024 and is forecast to a readjusted size of US$ 16238 million by 2031 with a CAGR of 28.9% during the forecast period 2025-2031.

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20-24 (normally 21) base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. siRNA plays a crucial role in gene silencing and regulation of gene expression. siRNA-based therapeutics have gained significant attention in recent years due to their potential to target specific genes involved in diseases such as cancer, genetic disorders, viral infections, and neurodegenerative diseases. The scope of siRNA drug products encompasses various aspects, including their design, development, testing, and regulatory approval.

Core manufacturers of siRNA Drugs include Alnylam, Novartis, Novo Nordisk, Genzyme and Arrowhead. USA is the largest consumption region, accounting for approximately 57% of the global market, followed by Europe. In terms of product type, subcutaneous injection are the largest market segment, with a share of more than 77%. In terms of product application, the largest application market is nervous system therapy, with a share of approximately 52%.

In-depth analysis of siRNA drug market driving factors

I. Technological breakthroughs: the leap from laboratory to clinic

Delivery system innovation

Lipid nanoparticle (LNP) technology optimization: Early siRNA drugs were limited to the field of rare diseases due to low delivery efficiency and insufficient targeting. In recent years, through technological breakthroughs such as ionized lipid component improvement and PEG modification, LNP can achieve liver-targeted delivery (such as Alnylam's Onpattro) or cross the blood-brain barrier (such as Denali's RVT-1201), significantly broadening the scope of indications.

Popularization of GalNAc coupling technology: This technology achieves efficient liver-targeted delivery by binding to asialoglycoprotein receptors, reducing the frequency of administration (such as Novartis' Leqvio subcutaneous injection once every six months), and promoting siRNA to penetrate into chronic diseases such as cardiovascular and metabolic diseases.

Mature chemical modification technology

Improved stability: Through 2'-O-methyl modification, thiophosphate backbone and other technologies, the half-life of siRNA is extended to several weeks, reducing the risk of immunogenicity.

Reduced off-target effects: AI-assisted sequence design (such as Sirnaomics' AI algorithm) combined with bioinformatics screening improves siRNA specificity and significantly improves clinical safety.

2. Market demand: The outbreak of unmet clinical needs

Indications expand from rare diseases to common diseases

Breakthrough in chronic diseases: Among the approximately 1 billion cardiovascular disease patients worldwide, the market potential for hypercholesterolemia is huge.

New paradigm for tumor treatment: siRNA combined with PD-1 inhibitors (such as Arrowhead's ARO-HIF2) shows synergistic effects in the treatment of renal cancer, pushing tumor immunotherapy into the era of gene regulation.

The rise of personalized medicine: siRNA therapy based on genotyping (such as Alzheimer's disease drugs for patients with APOE4 mutations) meets the needs of precision treatment and increases patients' willingness to pay.

3. Policy support: Improvement of the global regulatory framework

China's policy dividends

"The 14th Five-Year Plan for the Development of the Pharmaceutical Industry": Clearly support the development of new delivery systems and nucleic acid drugs, and provide tax incentives and research and development subsidies.

Priority review channel: CDE implements fast approval for innovative siRNA drugs, such as Sirnaomics' STP705 (treatment of squamous cell skin cancer) included in the breakthrough therapy.

International regulatory coordination

FDA accelerated approval: Onpattro (2018) was approved as the first siRNA drug, turning on the regulatory green light.

EMA adaptive path: Allows conditional approval based on alternative endpoints (such as biomarker changes) to shorten the R&D cycle.

4. Capital influx: catalytic effect of industrial ecology

Increased investment and financing activity

Global capital layout: 33 financings in the field of small nucleic acid drugs in 2022, with an amount of nearly US$6 billion (such as Sirnaomics IPO raising US$150 million).

MNC giants enter the market: Roche acquires Dicerna for US$2.8 billion, and Novartis and Alnylam reach a US$3.5 billion cooperation to accelerate pipeline development.

CDMO service ecosystem matures

RiboBio, WuXi AppTec: Provide "one-stop" services from sequence design to cGMP production, reducing R&D costs by more than 50%.

Breakthrough in large-scale production: Through continuous flow synthesis technology, the annual production capacity of siRNA has been increased from grams to kilograms, and the cost per dose has been reduced to less than $100.

5. Competitive landscape: From technical barriers to ecological barriers

Strengthening of patent layout

Core patents for delivery systems: Alnylam owns key technology patent clusters such as LNP and GalNAc, forming a technological monopoly.

Chemical modification patent network: Ionis' 2'-MOE modification and Sirnaomics' GalNAc-siRNA coupling technology build a patent moat.

Cross-border cooperation is accelerating

Pharmaceutical company-biotechnology company alliance: For example, AstraZeneca and Silence Therapeutics cooperate to develop cardiovascular siRNA drugs, sharing R&D risks and benefits.

Collaborative innovation between industry, academia and research: Harvard University and Moderna cooperate to develop RNA editing technology to promote the transformation of basic research to clinical practice.

6. Challenges and coping strategies

Breakthrough in technical bottlenecks

Improved tissue penetration: Through cell penetrating peptide (CPP) modification or exosome delivery, the problem of siRNA delivery in organs such as the lungs and brain is solved.

Long-term safety assessment: Establish real-time quantitative PCR to monitor off-target effects, and optimize sequence design in combination with single-cell sequencing technology.

Balance between cost and accessibility

Tiered pricing strategy: Adopt the "patent pool" model (such as MPP) in low-income countries to improve drug accessibility.

In the future, siRNA drugs are expected to become the third largest drug type after small molecules and antibodies, reshaping the biopharmaceutical industry landscape. Companies need to focus on core technology breakthroughs, differentiated indication layout and global cooperation to seize market opportunities.

This report aims to provide a comprehensive presentation of the global market for siRNA Drugs, focusing on the total sales revenue, key companies market share and ranking, together with an analysis of siRNA Drugs by region & country, by Type, and by Application.

The siRNA Drugs market size, estimations, and forecasts are provided in terms of sales revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. With both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding siRNA Drugs.

Market Segmentation

By Company

• Alnylam
• Novartis
• Novo Nordisk
• Genzyme
• Arrowhead
• Silence
• Sylentis
• Avidity Biosciences
• Sirnaomics

Segment by Type

• Intravenous Injection
• Subcutaneous Injection

Segment by Application

• Nervous System Therapy
• Endocrine and Metabolic Therapy
• Others

By Region

• North America
  • United States
  • Canada
• Asia-Pacific
  • China
  • Japan
  • South Korea
  • Southeast Asia
  • India
  • Australia
  • Rest of Asia-Pacific
• Europe
  • Germany
  • France
  • U.K.
  • Italy
  • Netherlands
  • Nordic Countries
  • Rest of Europe
• Latin America
  • Mexico
  • Brazil
  • Rest of Latin America
• Middle East & Africa
  • Turkey
  • Saudi Arabia
  • UAE
  • Rest of MEA

Chapter Outline

Chapter 1: Introduces the report scope of the report, global total market size. This chapter also provides the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.

Chapter 2: Detailed analysis of siRNA Drugs company competitive landscape, revenue market share, latest development plan, merger, and acquisition information, etc.

Chapter 3: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.

Chapter 4: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.

Chapter 5: Revenue of siRNA Drugs in regional level. It provides a quantitative analysis of the market size and development potential of each region and introduces the market development, future development prospects, market space, and market size of each country in the world.

Chapter 6: Revenue of siRNA Drugs in country level. It provides sigmate data by Type, and by Application for each country/region.

Chapter 7: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product revenue, gross margin, product introduction, recent development, etc.

Chapter 8: Analysis of industrial chain, including the upstream and downstream of the industry.

Chapter 9: Conclusion.

Table of Contents

1 Market Overview

• 1.1 siRNA Drugs Product Introduction
• 1.2 Global siRNA Drugs Market Size Forecast (2020-2031)
• 1.3 siRNA Drugs Market Trends & Drivers
  • 1.3.1 siRNA Drugs Industry Trends
  • 1.3.2 siRNA Drugs Market Drivers & Opportunity
  • 1.3.3 siRNA Drugs Market Challenges
  • 1.3.4 siRNA Drugs Market Restraints
• 1.4 Assumptions and Limitations
• 1.5 Study Objectives
• 1.6 Years Considered

2 Competitive Analysis by Company

• 2.1 Global siRNA Drugs Players Revenue Ranking (2024)
• 2.2 Global siRNA Drugs Revenue by Company (2020-2025)
• 2.3 Key Companies siRNA Drugs Manufacturing Base Distribution and Headquarters
• 2.4 Key Companies siRNA Drugs Product Offered
• 2.5 Key Companies Time to Begin Mass Production of siRNA Drugs
• 2.6 siRNA Drugs Market Competitive Analysis
  • 2.6.1 siRNA Drugs Market Concentration Rate (2020-2025)
  • 2.6.2 Global 5 and 10 Largest Companies by siRNA Drugs Revenue in 2024
  • 2.6.3 Global Top Companies by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in siRNA Drugs as of 2024)
• 2.7 Mergers & Acquisitions, Expansion

3 Segmentation by Type

• 3.1 Introduction by Type
  • 3.1.1 Intravenous Injection
  • 3.1.2 Subcutaneous Injection
• 3.2 Global siRNA Drugs Sales Value by Type
  • 3.2.1 Global siRNA Drugs Sales Value by Type (2020 VS 2024 VS 2031)
  • 3.2.2 Global siRNA Drugs Sales Value, by Type (2020-2031)
  • 3.2.3 Global siRNA Drugs Sales Value, by Type (%) (2020-2031)

4 Segmentation by Application

• 4.1 Introduction by Application
  • 4.1.1 Nervous System Therapy
  • 4.1.2 Endocrine and Metabolic Therapy
  • 4.1.3 Others
• 4.2 Global siRNA Drugs Sales Value by Application
  • 4.2.1 Global siRNA Drugs Sales Value by Application (2020 VS 2024 VS 2031)
  • 4.2.2 Global siRNA Drugs Sales Value, by Application (2020-2031)
  • 4.2.3 Global siRNA Drugs Sales Value, by Application (%) (2020-2031)

5 Segmentation by Region

• 5.1 Global siRNA Drugs Sales Value by Region
  • 5.1.1 Global siRNA Drugs Sales Value by Region: 2020 VS 2024 VS 2031
  • 5.1.2 Global siRNA Drugs Sales Value by Region (2020-2025)
  • 5.1.3 Global siRNA Drugs Sales Value by Region (2026-2031)
  • 5.1.4 Global siRNA Drugs Sales Value by Region (%), (2020-2031)
• 5.2 North America
  • 5.2.1 North America siRNA Drugs Sales Value, 2020-2031
  • 5.2.2 North America siRNA Drugs Sales Value by Country (%), 2024 VS 2031
• 5.3 Europe
  • 5.3.1 Europe siRNA Drugs Sales Value, 2020-2031
  • 5.3.2 Europe siRNA Drugs Sales Value by Country (%), 2024 VS 2031
• 5.4 Asia Pacific
  • 5.4.1 Asia Pacific siRNA Drugs Sales Value, 2020-2031
  • 5.4.2 Asia Pacific siRNA Drugs Sales Value by Region (%), 2024 VS 2031
• 5.5 South America
  • 5.5.1 South America siRNA Drugs Sales Value, 2020-2031
  • 5.5.2 South America siRNA Drugs Sales Value by Country (%), 2024 VS 2031
• 5.6 Middle East & Africa
  • 5.6.1 Middle East & Africa siRNA Drugs Sales Value, 2020-2031
  • 5.6.2 Middle East & Africa siRNA Drugs Sales Value by Country (%), 2024 VS 2031

6 Segmentation by Key Countries/Regions

• 6.1 Key Countries/Regions siRNA Drugs Sales Value Growth Trends, 2020 VS 2024 VS 2031
• 6.2 Key Countries/Regions siRNA Drugs Sales Value, 2020-2031
• 6.3 United States
  • 6.3.1 United States siRNA Drugs Sales Value, 2020-2031
  • 6.3.2 United States siRNA Drugs Sales Value by Type (%), 2024 VS 2031
  • 6.3.3 United States siRNA Drugs Sales Value by Application, 2024 VS 2031
• 6.4 Europe
  • 6.4.1 Europe siRNA Drugs Sales Value, 2020-2031
  • 6.4.2 Europe siRNA Drugs Sales Value by Type (%), 2024 VS 2031
  • 6.4.3 Europe siRNA Drugs Sales Value by Application, 2024 VS 2031
• 6.5 China
  • 6.5.1 China siRNA Drugs Sales Value, 2020-2031
  • 6.5.2 China siRNA Drugs Sales Value by Type (%), 2024 VS 2031
  • 6.5.3 China siRNA Drugs Sales Value by Application, 2024 VS 2031
• 6.6 Japan
  • 6.6.1 Japan siRNA Drugs Sales Value, 2020-2031
  • 6.6.2 Japan siRNA Drugs Sales Value by Type (%), 2024 VS 2031
  • 6.6.3 Japan siRNA Drugs Sales Value by Application, 2024 VS 2031
• 6.7 South Korea
  • 6.7.1 South Korea siRNA Drugs Sales Value, 2020-2031
  • 6.7.2 South Korea siRNA Drugs Sales Value by Type (%), 2024 VS 2031
  • 6.7.3 South Korea siRNA Drugs Sales Value by Application, 2024 VS 2031
• 6.8 Southeast Asia
  • 6.8.1 Southeast Asia siRNA Drugs Sales Value, 2020-2031
  • 6.8.2 Southeast Asia siRNA Drugs Sales Value by Type (%), 2024 VS 2031
  • 6.8.3 Southeast Asia siRNA Drugs Sales Value by Application, 2024 VS 2031
• 6.9 India
  • 6.9.1 India siRNA Drugs Sales Value, 2020-2031
  • 6.9.2 India siRNA Drugs Sales Value by Type (%), 2024 VS 2031
  • 6.9.3 India siRNA Drugs Sales Value by Application, 2024 VS 2031

7 Company Profiles

• 7.1 Alnylam
  • 7.1.1 Alnylam Profile
  • 7.1.2 Alnylam Main Business
  • 7.1.3 Alnylam siRNA Drugs Products, Services and Solutions
  • 7.1.4 Alnylam siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.1.5 Alnylam Recent Developments
• 7.2 Novartis
  • 7.2.1 Novartis Profile
  • 7.2.2 Novartis Main Business
  • 7.2.3 Novartis siRNA Drugs Products, Services and Solutions
  • 7.2.4 Novartis siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.2.5 Novartis Recent Developments
• 7.3 Novo Nordisk
  • 7.3.1 Novo Nordisk Profile
  • 7.3.2 Novo Nordisk Main Business
  • 7.3.3 Novo Nordisk siRNA Drugs Products, Services and Solutions
  • 7.3.4 Novo Nordisk siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.3.5 Novo Nordisk Recent Developments
• 7.4 Genzyme
  • 7.4.1 Genzyme Profile
  • 7.4.2 Genzyme Main Business
  • 7.4.3 Genzyme siRNA Drugs Products, Services and Solutions
  • 7.4.4 Genzyme siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.4.5 Genzyme Recent Developments
• 7.5 Arrowhead
  • 7.5.1 Arrowhead Profile
  • 7.5.2 Arrowhead Main Business
  • 7.5.3 Arrowhead siRNA Drugs Products, Services and Solutions
  • 7.5.4 Arrowhead siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.5.5 Arrowhead Recent Developments
• 7.6 Silence
  • 7.6.1 Silence Profile
  • 7.6.2 Silence Main Business
  • 7.6.3 Silence siRNA Drugs Products, Services and Solutions
  • 7.6.4 Silence siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.6.5 Silence Recent Developments
• 7.7 Sylentis
  • 7.7.1 Sylentis Profile
  • 7.7.2 Sylentis Main Business
  • 7.7.3 Sylentis siRNA Drugs Products, Services and Solutions
  • 7.7.4 Sylentis siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.7.5 Sylentis Recent Developments
• 7.8 Avidity Biosciences
  • 7.8.1 Avidity Biosciences Profile
  • 7.8.2 Avidity Biosciences Main Business
  • 7.8.3 Avidity Biosciences siRNA Drugs Products, Services and Solutions
  • 7.8.4 Avidity Biosciences siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.8.5 Avidity Biosciences Recent Developments
• 7.9 Sirnaomics
  • 7.9.1 Sirnaomics Profile
  • 7.9.2 Sirnaomics Main Business
  • 7.9.3 Sirnaomics siRNA Drugs Products, Services and Solutions
  • 7.9.4 Sirnaomics siRNA Drugs Revenue (US$ Million) & (2020-2025)
  • 7.9.5 Sirnaomics Recent Developments

8 Industry Chain Analysis

• 8.1 siRNA Drugs Industrial Chain
• 8.2 siRNA Drugs Upstream Analysis
  • 8.2.1 Key Raw Materials
  • 8.2.2 Raw Materials Key Suppliers
  • 8.2.3 Manufacturing Cost Structure
• 8.3 Midstream Analysis
• 8.4 Downstream Analysis (Customers Analysis)
• 8.5 Sales Model and Sales Channels
  • 8.5.1 siRNA Drugs Sales Model
  • 8.5.2 Sales Channel
  • 8.5.3 siRNA Drugs Distributors

9 Research Findings and Conclusion

10 Appendix

• 10.1 Research Methodology
  • 10.1.1 Methodology/Research Approach
    • 10.1.1.1 Research Programs/Design
    • 10.1.1.2 Market Size Estimation
    • 10.1.1.3 Market Breakdown and Data Triangulation
  • 10.1.2 Data Source
    • 10.1.2.1 Secondary Sources
    • 10.1.2.2 Primary Sources
• 10.2 Author Details
• 10.3 Disclaimer