|
시장보고서
상품코드
2082878
골관절염 : 시장 인사이트, 역학 및 시장 예측(2036년)Osteoarthritis - Market Insight, Epidemiology, and Market Forecast - 2036 |
||||||
DelveInsight
G7 국가들의 퇴행성 관절염 시장 규모 및 전망
본 퇴행성 관절염 시장 보고서에서는 현재의 치료 현황, 신약, 개별 치료법 시장 점유율, 그리고 2022년부터 2036년까지 주요 7개국에서의 퇴행성 관절염 시장 현황 및 전망 규모에 대해 설명하고 있습니다. 또한, 본 보고서에서는 최적의 비즈니스 기회를 파악하고 시장의 잠재력을 평가하기 위해, 현재 퇴행성 관절염의 치료 현황 및 치료 알고리즘과 미충족 의료 수요에 대해서도 종합적으로 다루고 있습니다.
세계 질병 부담 증가:
퇴행성 관절염은 고령화, 비만율 증가, 생활습관적 요인에 기인하여 전 세계적으로 심각하고 점점 더 커지는 건강상의 부담이 되고 있으며, 전 세계적으로 만성 통증 및 신체 장애의 유병률 증가로 이어지고 있습니다. 이러한 환자 수 증가와 장기적인 질환 관리에 대한 필요성이 효과적인 대증 요법 및 질환 수정 요법에 대한 지속적인 수요를 이끌고 있습니다.
퇴행성 관절염의 새로운 기회:
퇴행성 관절염 분야는 질환 수정 요법, 재생 의학 접근법, 새로운 통증 관리법의 발전은 물론, 영상 진단 및 진단 도구의 개선에 힘입어 진화를 거듭하고 있습니다. 조사에 대한 관심이 높아지고, 바이오의약품 기업의 투자가 확대되며, 미충족 의료 수요에 대한 인식이 높아짐에 따라 혁신이 가속화되고, 퇴행성 관절염 치료 시장에서 새로운 기회가 창출되고 있습니다.
퇴행성 관절염의 개요와 진단
퇴행성 관절염은 관절염 중 가장 흔한 형태로, 주로 중장년층에 영향을 미치는 만성적이고 퇴행성인 관절 질환입니다. 손, 무릎, 고관절, 척추 등에서 가장 흔히 나타나는 관절 연골의 진행성 파괴를 특징으로 하며, 원발성과 이차성으로 분류되고, 0단계(정상)에서 4단계(중증)로 진행됩니다. 퇴행성 관절염의 진단은 단일한 결정적인 임상 검사에만 의존하는 것이 아니라, 임상 평가와 진단 도구를 종합적으로 활용하여 이루어집니다. 일반적으로 CBC, ESR, 류마티스 인자, ANA 등의 혈액 검사 수치는 정상 범위에 속하지만, X선이나 초음파 검사 등의 영상 진단 기술을 통해 연골 손실, 골극, 활막 염증, 관절액 축적 등의 구조적 변화를 확인할 수 있습니다.
퇴행성 관절염 치료의 현황
퇴행성 관절염은 진행성이자 퇴행성 질환으로, 손상된 구조가 회복되거나 재생될 가능성은 낮습니다. 따라서 중증도에 따라 인공관절 치환술 등의 외과적 시술이 필요하다고 판단되지 않는 한, 현재의 치료법은 증상 관리에 중점을 두고 있습니다. 퇴행성 관절염의 현재 치료법으로는 비스테로이드성 항염증제(NSAIDs), 알코시아(에트리코시브), 오피오이드, 그리고 현재는 듀로렌, 젤신-3, 싱갈, 조이크루 등이 포함됩니다.
퇴행성 관절염에 대한 역학 분석 및 예측을 통해 얻은 주요 인사이트
퇴행성 관절염의 치료와 관리에는 다각적인 접근이 필요합니다. 운동, 체중 관리, 물리치료 등의 비약물 요법은 관절 기능 개선과 통증 완화를 목적으로 합니다. 약물 요법에는 진통제, NSAIDs(비스테로이드성 항염증제), 그리고 통증 완화 및 염증 억제를 위한 관절 내 주사 등이 포함됩니다. 중증 환자의 경우, 인공관절 치환술과 같은 외과적 치료가 고려될 수 있습니다. 침 치료나 온열·냉열 요법 등의 보완 요법도 증상을 더욱 완화시켜 줍니다. 환자 교육 및 자가 관리 전략은 매우 중요하며, 환자 스스로 병세를 이해하고 대처할 수 있도록 돕습니다.
관절 내 코르티코스테로이드는 무릎 퇴행성 관절염의 통증 관리에 오랫동안 사용되어 왔으며, 단기부터 중기까지 통증 완화를 가져옵니다. 그러나 조사 방법의 차이로 인해 연구 결과에는 편차가 있으며, 그 전반적인 유효성은 불분명합니다. 마찬가지로, 관절 내 히알루론산에 관한 증거도 일관성이 없으며, 그 분자량에 따라 치료 결과가 달라집니다. 일반적인 1차 치료법으로는 코르티코스테로이드 주사, 오피오이드, 생체공학 기술을 이용한 히알루론산, 그리고 NSAIDs가 포함됩니다. 무릎 관절염의 경우, 관절의 염증이 연골 손상에 기여하고 있다는 점을 고려할 때, 코르티코스테로이드 주사는 질환의 진행을 늦추는 데 도움이 될 수 있습니다.
NSAIDs는 그동안 가장 빈번하게 사용되어 온 약물이지만, 이 계열의 약물과 관련된 위장관, 신장, 심장, 혈액계 부작용이 있으므로, 특히 여러 가지 동반 질환을 가진 고령 환자의 경우 장기 사용에 제한이 있습니다. 이와 유사한 효과를 가진 다른 항염증성 진통제로는 셀레콕시브와 에트리콕시브가 있습니다. 이 약들은 COX-2 억제제(또는 코크시브)로, 정제 형태로 복용하거나 젤이나 크림 형태로 통증이 있는 관절에 직접 바르며 사용합니다. '듀로레인(DUROLANE)'은 퇴행성 무릎 관절염에 대한 1회 주사형 히알루론산 요법으로, 관절 기능을 회복시키고 코르티코스테로이드에 비해 더 장기간에 걸쳐 통증 완화 효과를 제공합니다. 퇴행성 무릎 관절염에 대한 새로운 치료법으로는 JTA-004나 AMZ001 등이 있습니다.
퇴행성 관절염 시장은 고령화와 질환 유병률 상승을 배경으로 2022년부터 2036년에 걸쳐 성장할 것으로 전망됩니다. 첨단적이고 효과적인 치료법에 대한 수요가 증가함에 따라 시장 확대가 더욱 가속화되고 있습니다.
Osteoarthritis Market Size and Forecast in the 7MM
DelveInsight's "Osteoarthritis - Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of Osteoarthritis, historical and forecasted epidemiology as well as Osteoarthritis market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
The Osteoarthritis market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM Osteoarthritis market size from 2022 to 2036. The report also covers current Osteoarthritis treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's potential.
Key Factors Driving the Osteoarthritis Market
Rising Global Disease Burden:
Osteoarthritis represents a significant and growing global health burden, driven by aging populations, increasing obesity rates, and lifestyle factors, leading to a high prevalence of chronic pain and disability worldwide. This expanding patient pool and long-term disease management needs are driving sustained demand for effective symptomatic and disease-modifying therapies.
Emerging Opportunities in Osteoarthritis:
The osteoarthritis landscape is evolving with advancements in disease-modifying therapies, regenerative medicine approaches, and novel pain management options, alongside improved imaging and diagnostic tools. Increasing research focus, growing investments by biopharma companies, and heightened awareness of unmet needs are accelerating innovation and creating new opportunities in the Osteoarthritis treatment market.
Osteoarthritis Overview and Diagnosis
Osteoarthritis is the most common form of arthritis and a chronic, degenerative joint disease that primarily affects middle-aged and older adults, characterized by the progressive breakdown of joint cartilage, most commonly in the hands, knees, hips, and spine; it is classified into primary and secondary types and progresses through stages from 0 (normal) to 4 (severe). Diagnosis of Osteoarthritis does not rely on a single definitive laboratory test but instead involves a combination of clinical evaluation and diagnostic tools, where blood tests such as CBC, ESR, rheumatoid factor, and ANA are typically normal, while imaging techniques like X-rays and ultrasound help confirm structural changes such as cartilage loss, osteophytes, synovial inflammation, and joint effusion.
Osteoarthritis Treatment Landscape
Osteoarthritis is a progressive and degenerative condition, with unlikely regression and restoration of damaged structures. Thus, current management modalities are targeted towards symptom control unless the degree of severity dictates the necessity of surgical intervention with joint replacement. The Current treatment of Osteoarthritis includes Nonsteroidal anti-inflammatory drugs (NSAIDS), Arcoxia (Etoricoxib), Opioids, currently DUROLANE, GELSYN-3, CINGAL, JOYCLU, and others.
Osteoarthritis Unmet Needs
The section "unmet needs of Osteoarthritis" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.
Key Findings from Osteoarthritis Epidemiology Analysis and Forecast
Osteoarthritis Drug Chapters & Competitive Analysis
The Osteoarthritis drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase I-III clinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the Osteoarthritis treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the Osteoarthritis therapeutics market.
Approved Therapies for Osteoarthritis
JOYCLU: Ono Pharmaceutical/Seikagaku
JOYCLU is a formulation in which hyaluronic acid and diclofenac (an anti-inflammatory drug) are chemically bound using Seikagaku's proprietary technology. It is designed to release diclofenac by hydrolysis in the joint. JOYCLU is approved for treating osteoarthritis (knee joint and hip joint) and is expected to improve osteoarthritis symptoms by the intra-articular injection once every 4 weeks. JOYCLU is the first ethical drug indicating osteoarthritis of the hip joint in Japan among the joint function improvement agents. Seikagaku is involved in the manufacturing and marketing of the product, and Ono is responsible for distribution.
Osteoarthritis Pipeline Analysis
Pentosan polysulfate sodium (ZILOSUL): Paradigm Biopharma
ZILOSUL, or pentosan polysulfate sodium (PPS), is a semi-synthetic drug manufactured from the wood chips of European beech trees. Key features of the activity of PPS are its anti-inflammatory and tissue regenerative properties, as well as its mild anti-thrombotic activity. Due to PPS having multiple mechanisms of action, Paradigm's broader focus is exploring the use of PPS in treating a wide spectrum of conditions that begin with and are sustained by inflammation, such as osteoarthritis.
Paradigm has a longstanding relationship with Bene PharmaChem, the only FDA-approved manufacturer/supplier of PPS. Through the extensive interaction and collaboration with Bene PharmaChem and Paradigm's European manufacturers of the injectable formulation of PPS (iPPS), Paradigm has been able to develop its clinical product for trials.
Osteoarthritis Key Players, Market Leaders, and Emerging Companies
Osteoarthritis Drug Updates
Drug Class Insights
The treatment and management of osteoarthritis involve a multifaceted approach. Non-pharmacologic interventions, such as exercise, weight management, and physical therapy, aim to improve joint function and alleviate pain. Pharmacologic options include analgesics, NSAIDs, and intra-articular injections for pain relief and inflammation. Surgical interventions, like joint replacement, may be considered in severe cases. Complementary therapies, including acupuncture and heat/cold therapy, offer additional relief. Patient education and self-management strategies are crucial, empowering individuals to understand and cope with the condition.
Intra-articular corticosteroids have long been used to manage knee osteoarthritis pain, offering short- to medium-term relief. However, study results vary due to differing methodologies, making their overall effectiveness unclear. Similarly, evidence on intra-articular hyaluronic acid is inconsistent, with outcomes influenced by its molecular weight. Common first-line treatments include corticosteroid injections, opioids, bioengineered hyaluronic acid, and NSAIDs. Given that joint inflammation contributes to cartilage damage in knee osteoarthritis, corticosteroid injections may help slow disease progression.
NSAIDs have historically been the most often used medication; however, their long-term use is limited, particularly in elderly patients with multiple comorbidities due to associated gastrointestinal, renal, cardiac, and hematologic adverse events linked to this class of medication. Other anti-inflammatory painkillers with similar effects are celecoxib and etoricoxib. These are COX-2 inhibitors (or coxibs) taken as tablets or directly applied to the painful joint as a gel or cream. DUROLANE a single-injection hyaluronic acid therapy for knee osteoarthritis that restores joint function and provides longer-lasting pain relief versus corticosteroids. Some emerging therapies for knee osteoarthritis include JTA-004 and AMZ001.
The osteoarthritis market is projected to grow from 2022 to 2036, driven by an aging population and rising disease prevalence. Increasing demand for advanced and effective therapies is further supporting market expansion.
Drug Class/Insights into Leading Emerging and Marketed Therapies in Osteoarthritis (2022-2036 Forecast)
Glycosaminoglycans: Glycosaminoglycans such as chondroitin sulfate and hyaluronic acid are key components of cartilage and synovial fluid and are utilized in osteoarthritis management to support joint structure and function. These agents work by enhancing cartilage hydration, improving viscoelastic properties of synovial fluid, and inhibiting cartilage degradation pathways, thereby helping to reduce joint pain, inflammation, and stiffness while potentially slowing disease progression.
Osteoarthritis Drug Uptake
This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the Osteoarthritis market's uptake by drugs, patient uptake by therapy, and sales of each drug.
The landscape of Osteoarthritis treatment has experienced a profound transformation with the uptake of novel drugs. These innovative therapies are redefining standards of care. Furthermore, the increased uptake of these transformative drugs is a testament to the unwavering dedication of physicians, professionals, and the entire healthcare community in their tireless pursuit of advancing disease care. This momentous shift in treatment paradigms is a testament to the power of research, collaboration, and human resilience.
Osteoarthritis Therapies Price Scenario & Trends
Pricing and analogue assessment of Osteoarthritis therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and the understanding of how pricing influences market access, adherence, and long-term uptake.
Industry Experts and Physician Views for Osteoarthritis
To keep up with Osteoarthritis market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the Osteoarthritis emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in Osteoarthritis, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.
DelveInsight's analysts connected with 15+ KOLs to gather insights at the country level. Centers such as the Medicine at Harvard Medical School in the US, Oxford University in the UK, University of California, San Francisco, and University of Heidelberg in Germany, etc., were contacted. Their opinion helps understand and validate current and emerging Osteoarthritis therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in Osteoarthritis.
Qualitative Analysis: SWOT and Conjoint Analysis
We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.
In the SWOT analysis of Osteoarthritis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.
Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are mainly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Insights