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골관절염 : 시장 인사이트, 역학 및 시장 예측(2036년)

Osteoarthritis - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 289 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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퇴행성 관절염 시장 인사이트와 동향

  • 퇴행성 관절염은 노화와 밀접한 관련이 있으며, 65세까지 대다수의 사람과 75세를 넘긴 사람의 75% 이상에서 X선 검사를 통해 퇴행성 관절염 소견이 확인됩니다. 많은 관련성이나 기전은 아직 충분히 밝혀지지 않았지만, 고령 여성에서 퇴행성 관절염의 유병률이 높다는 보고가 있습니다.
  • DelveInsight의 분석에 따르면, 2025년 주요 시장(미국, EU4(독일, 프랑스, 이탈리아, 스페인), 영국, 일본)의 퇴행성 관절염 시장 규모는 약 325억으로 추산됩니다.
  • 현재 퇴행성 관절염 치료에 사용되는 약물로는 NSAIDs, 오피오이드, 관절 내 스테로이드, 관절 내 히알루론산 등이 있습니다. FDA가 승인한 무릎 퇴행성 관절염 치료용 히알루론산 제제에는 SUPARTZ, ORTHOVISC, EUFLEXXA 및 GEL-ONE이 있습니다. 2017년 10월에 승인된 ZILRETTA는 퇴행성 무릎 관절염을 대상으로 한 제3상 주요 임상시험에서 통증의 유의미한 감소가 입증된 코르티코스테로이드입니다.
  • 퇴행성 관절염의 새로운 치료법으로는 TRPV1 수용체 작용제, 범-CLK/DYRK 억제제, 줄기세포를 이용한 치료법, GLP-1 수용체 작용제, 선택적 COX-2 억제제 등의 신약이 있습니다. 주목할 만한 개발 후보 약물로는 LEVI-04(Levicept), ZILOSUL(펜타산 폴리황산나트륨; Paradigm Biopharmaceuticals), TissueGene-C(TG-C; Kolon TissueGene), AMZ001(Amzell), 그리고 SAR446959(사노피) 등이 있습니다.
  • BioSenic사의 관절 내 투여형 퇴행성 관절염 치료제인 JTA-004는 제3상 임상시험 전체적으로는 실패로 끝났으나, 중증 염증성 3형 퇴행성 관절염에 대한 사후 분석에서 유망한 효과가 확인되어, 현재 라이선싱 대상에 포함되어 있습니다.
  • Mestex사로부터 확보한 강력한 TRPV1 작용제인 레지니페라톡신은 퇴행성 관절염 통증을 대상으로 한 두 건의 3상 임상시험에서 주요 평가 지표를 달성하지 못했으며, 이에 따라 Grunenthal사는 2025년에 진행 중인 안전성 시험을 완료한 후 해당 프로그램을 종료하기로 결정했습니다.
  • 보존적 치료에 저항성을 보이지만, 관절 치환술이 필요할 정도로 중증은 아닌 경증에서 중등도의 퇴행성 슬관절염은 치료상 특유의 과제이며, 매우 큰 미충족 의료 수요가 되고 있습니다.

G7 국가들의 퇴행성 관절염 시장 규모 및 전망

  • 2025년 퇴행성 관절염 시장 규모 : 약 325억 달러
  • 2036년 퇴행성 관절염 시장 규모 전망: 약 470억 달러
  • 퇴행성 관절염의 성장률(2026년-2036년) : 연평균 성장률(CAGR) 3%

본 퇴행성 관절염 시장 보고서에서는 현재의 치료 현황, 신약, 개별 치료법 시장 점유율, 그리고 2022년부터 2036년까지 주요 7개국에서의 퇴행성 관절염 시장 현황 및 전망 규모에 대해 설명하고 있습니다. 또한, 본 보고서에서는 최적의 비즈니스 기회를 파악하고 시장의 잠재력을 평가하기 위해, 현재 퇴행성 관절염의 치료 현황 및 치료 알고리즘과 미충족 의료 수요에 대해서도 종합적으로 다루고 있습니다.

퇴행성 관절염 시장을 견인하는 주요 요인

세계 질병 부담 증가:

퇴행성 관절염은 고령화, 비만율 증가, 생활습관적 요인에 기인하여 전 세계적으로 심각하고 점점 더 커지는 건강상의 부담이 되고 있으며, 전 세계적으로 만성 통증 및 신체 장애의 유병률 증가로 이어지고 있습니다. 이러한 환자 수 증가와 장기적인 질환 관리에 대한 필요성이 효과적인 대증 요법 및 질환 수정 요법에 대한 지속적인 수요를 이끌고 있습니다.

퇴행성 관절염의 새로운 기회:

퇴행성 관절염 분야는 질환 수정 요법, 재생 의학 접근법, 새로운 통증 관리법의 발전은 물론, 영상 진단 및 진단 도구의 개선에 힘입어 진화를 거듭하고 있습니다. 조사에 대한 관심이 높아지고, 바이오의약품 기업의 투자가 확대되며, 미충족 의료 수요에 대한 인식이 높아짐에 따라 혁신이 가속화되고, 퇴행성 관절염 치료 시장에서 새로운 기회가 창출되고 있습니다.

퇴행성 관절염의 이해와 치료 알고리즘

퇴행성 관절염의 개요와 진단

퇴행성 관절염은 관절염 중 가장 흔한 형태로, 주로 중장년층에 영향을 미치는 만성적이고 퇴행성인 관절 질환입니다. 손, 무릎, 고관절, 척추 등에서 가장 흔히 나타나는 관절 연골의 진행성 파괴를 특징으로 하며, 원발성과 이차성으로 분류되고, 0단계(정상)에서 4단계(중증)로 진행됩니다. 퇴행성 관절염의 진단은 단일한 결정적인 임상 검사에만 의존하는 것이 아니라, 임상 평가와 진단 도구를 종합적으로 활용하여 이루어집니다. 일반적으로 CBC, ESR, 류마티스 인자, ANA 등의 혈액 검사 수치는 정상 범위에 속하지만, X선이나 초음파 검사 등의 영상 진단 기술을 통해 연골 손실, 골극, 활막 염증, 관절액 축적 등의 구조적 변화를 확인할 수 있습니다.

퇴행성 관절염 치료의 현황

퇴행성 관절염은 진행성이자 퇴행성 질환으로, 손상된 구조가 회복되거나 재생될 가능성은 낮습니다. 따라서 중증도에 따라 인공관절 치환술 등의 외과적 시술이 필요하다고 판단되지 않는 한, 현재의 치료법은 증상 관리에 중점을 두고 있습니다. 퇴행성 관절염의 현재 치료법으로는 비스테로이드성 항염증제(NSAIDs), 알코시아(에트리코시브), 오피오이드, 그리고 현재는 듀로렌, 젤신-3, 싱갈, 조이크루 등이 포함됩니다.

퇴행성 관절염의 역학

퇴행성 관절염에 대한 역학 분석 및 예측을 통해 얻은 주요 인사이트

  • Nalamachu 등(2020)의 연구에 따르면, 미국의 퇴행성 무릎 관절염 환자 중 경도의 통증을 호소하는 환자는 41%, 중등도의 통증을 호소하는 환자는 37%, 중증의 통증을 호소하는 환자는 22%인 것으로 보고되었습니다.
  • Schild 등(2021)의 연구에서는 독일의 Institut fur Angewandte Gesundheitsforschung(InGef) 데이터베이스에서 환자 수준 데이터를 추출했습니다. 조사 대상이었던 493만 2,543명 중 23만 8,306명의 퇴행성 관절염 환자가 분석 대상으로 선정되었습니다. 이 중 8만 55명(34%)은 만성 통증이 있는 것으로 분류되었으며(이 중 2만 4,463명은 오피오이드를 처방받았습니다), 15만 8,251명(66%)은 만성 통증이 없는 것으로 분류되었습니다.
  • 퇴행성 관절염은 고령층에서 가장 흔한 만성 질환 중 하나로, 퇴행성 관절염 전체 환자(40세 이상)의 약 90-95%를 차지하며, 그 유병률은 나이가 들수록 증가합니다.
  • 고령화의 진행과 비만 증가로 인해 향후 수년 동안 퇴행성 관절염의 환자 수가 증가할 것으로 추정되며, 이는 퇴행성 슬관절염의 총 환자 수에도 영향을 미칠 것으로 보입니다.
  • 2025년, 주요 7개국에서 퇴행성 관절염의 총 진단 건수는 약 99,000건이었으나, 이는 예측 기간(2026-2036년) 동안 증가할 것으로 예측됩니다.
  • Iolascon 등(2024)에 따르면, 이탈리아에서는 퇴행성 무릎 관절염이 국가 의료 제도와 사회에 중대한 영향을 미치고 있습니다. 퇴행성 무릎 관절염 환자 수는 500만 명을 넘어섰으며, 연령 조정 유병률은 10만 명당 4,066건입니다.
  • 일본에서는 2025년 무릎 관절 퇴행성 관절염의 총 진단 건수가 1,150만 건에 달했습니다.

퇴행성 관절염 시장 전망

퇴행성 관절염의 치료와 관리에는 다각적인 접근이 필요합니다. 운동, 체중 관리, 물리치료 등의 비약물 요법은 관절 기능 개선과 통증 완화를 목적으로 합니다. 약물 요법에는 진통제, NSAIDs(비스테로이드성 항염증제), 그리고 통증 완화 및 염증 억제를 위한 관절 내 주사 등이 포함됩니다. 중증 환자의 경우, 인공관절 치환술과 같은 외과적 치료가 고려될 수 있습니다. 침 치료나 온열·냉열 요법 등의 보완 요법도 증상을 더욱 완화시켜 줍니다. 환자 교육 및 자가 관리 전략은 매우 중요하며, 환자 스스로 병세를 이해하고 대처할 수 있도록 돕습니다.

관절 내 코르티코스테로이드는 무릎 퇴행성 관절염의 통증 관리에 오랫동안 사용되어 왔으며, 단기부터 중기까지 통증 완화를 가져옵니다. 그러나 조사 방법의 차이로 인해 연구 결과에는 편차가 있으며, 그 전반적인 유효성은 불분명합니다. 마찬가지로, 관절 내 히알루론산에 관한 증거도 일관성이 없으며, 그 분자량에 따라 치료 결과가 달라집니다. 일반적인 1차 치료법으로는 코르티코스테로이드 주사, 오피오이드, 생체공학 기술을 이용한 히알루론산, 그리고 NSAIDs가 포함됩니다. 무릎 관절염의 경우, 관절의 염증이 연골 손상에 기여하고 있다는 점을 고려할 때, 코르티코스테로이드 주사는 질환의 진행을 늦추는 데 도움이 될 수 있습니다.

NSAIDs는 그동안 가장 빈번하게 사용되어 온 약물이지만, 이 계열의 약물과 관련된 위장관, 신장, 심장, 혈액계 부작용이 있으므로, 특히 여러 가지 동반 질환을 가진 고령 환자의 경우 장기 사용에 제한이 있습니다. 이와 유사한 효과를 가진 다른 항염증성 진통제로는 셀레콕시브와 에트리콕시브가 있습니다. 이 약들은 COX-2 억제제(또는 코크시브)로, 정제 형태로 복용하거나 젤이나 크림 형태로 통증이 있는 관절에 직접 바르며 사용합니다. '듀로레인(DUROLANE)'은 퇴행성 무릎 관절염에 대한 1회 주사형 히알루론산 요법으로, 관절 기능을 회복시키고 코르티코스테로이드에 비해 더 장기간에 걸쳐 통증 완화 효과를 제공합니다. 퇴행성 무릎 관절염에 대한 새로운 치료법으로는 JTA-004나 AMZ001 등이 있습니다.

퇴행성 관절염 시장은 고령화와 질환 유병률 상승을 배경으로 2022년부터 2036년에 걸쳐 성장할 것으로 전망됩니다. 첨단적이고 효과적인 치료법에 대한 수요가 증가함에 따라 시장 확대가 더욱 가속화되고 있습니다.

  • 주요 7개국의 퇴행성 관절염 시장 규모는 2025년에 325억 달러로 추산되며, 예측 기간(2026년-2036년) 동안 긍정적인 연평균 성장률(CAGR)을 기록하며 성장할 것으로 예상되며, 2036년까지 더욱 확대될 전망입니다.
  • 2025년, 치료법별로는 오피오이드가 퇴행성 관절염 시장에서 가장 큰 시장 규모를 차지했으며, 미국에서는 약 95억 달러에 달했습니다.
  • EU4 및 영국 내에서 2036년에는 독일이 가장 큰 매출 점유율을 차지할 것으로 예상되며, 그 뒤를 스페인, 프랑스가 이을 것으로 보입니다.
  • 앞으로 등장할 퇴행성 관절염 치료법은 퇴행성 관절염 환자들이 현재 직면하고 있는 미충족 의료 수요를 해소할 것으로 기대됩니다.

자주 묻는 질문

  • 퇴행성 관절염 시장 규모는 어떻게 예측되나요?
  • 퇴행성 관절염 치료에 사용되는 주요 약물은 무엇인가요?
  • 퇴행성 관절염의 유병률은 어떻게 되나요?
  • 퇴행성 관절염의 새로운 치료법에는 어떤 것들이 있나요?
  • 퇴행성 관절염 시장의 성장 요인은 무엇인가요?

목차

제1장 주요 인사이트

제2장 서론

제3장 주요 요약

제4장 주요 이벤트

제5장 역학 및 시장 조사 방법

제6장 골관절염 : 시장 개요

제7장 골관절염 : 질환 배경과 개요

제8장 골관절염 : 치료와 관리

제9장 골관절염 : 역학 및 환자 인구

제10장 환자 경과

제11장 시판 치료제

제12장 신흥 치료법

제13장 골관절염 : 주요 7개국 분석

제14장 골관절염 : 미충족 요구

제15장 골관절염 : SWOT 분석

제16장 KOL(Key Opinion Leader)의 견해

제17장 골관절염 : 시장 참여 및 상환

제18장 부록

제19장 DelveInsight의 서비스 내용

제20장 면책사항

제21장 DelveInsight에 대해

LSH 26.07.27

Osteoarthritis Market Insights and Trends

  • Osteoarthritis is closely associated with age, as radiographic evidence of osteoarthritis occurs in most people by age 65 years and in more than 75% of people older than age 75 years. Although many associations and mechanisms are not well understood, it has been reported that there is a higher prevalence of osteoarthritis among older women.
  • According to DelveInsight's analysis, the Osteoarthritis market size was found to be ~32,500 million in the leading markets (the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan) in 2025.
  • Currently, the classes used for the treatment of osteoarthritis include NSAIDs, Opioids, Intra Articular-Corticosteroids, Intra Articular-Hyaluronic acid, and others. FDA-approved hyaluronate products for knee OA comprise SUPARTZ, ORTHOVISC, EUFLEXXA, and GEL-ONE. ZILRETTA, approved in October 2017, is a corticosteroid that demonstrated significant pain reduction in its Pivotal Phase III trial for knee OA.
  • Emerging therapies for osteoarthritis include novel agents such as TRPV1 receptor agonists, pan-CLK/DYRK inhibitors, stem cell-based approaches, GLP-1 receptor agonists, selective COX-2 inhibitors, and others. Prominent pipeline candidates include LEVI-04 (Levicept), ZILOSUL (pentosan polysulfate sodium; Paradigm Biopharmaceuticals), TissueGene-C (TG-C; Kolon TissueGene), AMZ001 (Amzell), and SAR446959 (Sanofi)
  • JTA-004, an intra-articular osteoarthritis treatment from BioSenic, failed its Phase III trial overall but showed promising post-hoc benefits in severe, inflammatory type-3 osteoarthritis, and is now available for potential out-licensing.
  • Resiniferatoxin, a potent TRPV1 agonist acquired from Mestex, failed to meet primary endpoints in two Phase III osteoarthritis pain trials, leading Grunenthal to end the program after completing its ongoing safety study in 2025.
  • Mild-to-moderate knee osteoarthritis that is resistant to conservative treatment but is not yet severe enough to warrant joint replacement represents a specific management challenge and a huge unmet need.

Osteoarthritis Market Size and Forecast in the 7MM

  • 2025 Osteoarthritis Market Size: ~USD 32,500 million
  • 2036 Projected Osteoarthritis Market Size: ~USD 47,000 million
  • Osteoarthritis Growth Rate (2026-2036): 3% CAGR

DelveInsight's "Osteoarthritis - Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of Osteoarthritis, historical and forecasted epidemiology as well as Osteoarthritis market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

The Osteoarthritis market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM Osteoarthritis market size from 2022 to 2036. The report also covers current Osteoarthritis treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's potential.

Key Factors Driving the Osteoarthritis Market

Rising Global Disease Burden:

Osteoarthritis represents a significant and growing global health burden, driven by aging populations, increasing obesity rates, and lifestyle factors, leading to a high prevalence of chronic pain and disability worldwide. This expanding patient pool and long-term disease management needs are driving sustained demand for effective symptomatic and disease-modifying therapies.

Emerging Opportunities in Osteoarthritis:

The osteoarthritis landscape is evolving with advancements in disease-modifying therapies, regenerative medicine approaches, and novel pain management options, alongside improved imaging and diagnostic tools. Increasing research focus, growing investments by biopharma companies, and heightened awareness of unmet needs are accelerating innovation and creating new opportunities in the Osteoarthritis treatment market.

Osteoarthritis Understanding and Treatment Algorithm

Osteoarthritis Overview and Diagnosis

Osteoarthritis is the most common form of arthritis and a chronic, degenerative joint disease that primarily affects middle-aged and older adults, characterized by the progressive breakdown of joint cartilage, most commonly in the hands, knees, hips, and spine; it is classified into primary and secondary types and progresses through stages from 0 (normal) to 4 (severe). Diagnosis of Osteoarthritis does not rely on a single definitive laboratory test but instead involves a combination of clinical evaluation and diagnostic tools, where blood tests such as CBC, ESR, rheumatoid factor, and ANA are typically normal, while imaging techniques like X-rays and ultrasound help confirm structural changes such as cartilage loss, osteophytes, synovial inflammation, and joint effusion.

Osteoarthritis Treatment Landscape

Osteoarthritis is a progressive and degenerative condition, with unlikely regression and restoration of damaged structures. Thus, current management modalities are targeted towards symptom control unless the degree of severity dictates the necessity of surgical intervention with joint replacement. The Current treatment of Osteoarthritis includes Nonsteroidal anti-inflammatory drugs (NSAIDS), Arcoxia (Etoricoxib), Opioids, currently DUROLANE, GELSYN-3, CINGAL, JOYCLU, and others.

Osteoarthritis Unmet Needs

The section "unmet needs of Osteoarthritis" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Need for developing the ability to phenotype and stratify patients for inclusion in clinical trials

2. Challenging diagnosis

3. High disease burden & economic impact

4. Insufficient knowledge regarding the disease paradigm, and others.....

Osteoarthritis Epidemiology

Key Findings from Osteoarthritis Epidemiology Analysis and Forecast

  • As per the study by Nalamachu et al. (2020), 41%, 37%, and 22% of the patients with knee osteoarthritis were reported for mild, moderate, and severe pain, respectively, in the US.
  • In a study by Schild et al. (2021), patient-level data was extracted from the German Institut fur Angewandte Gesundheitsforschung (InGef) database. Of 4,932,543 individuals sampled, 238,306 patients with osteoarthritis were included in the analysis: 80,055 (34%) categorised as having chronic pain (24,463 via opioid prescription) and 158,251 (66%) categorised as not having chronic pain.
  • Osteoarthritis is one of the most common chronic diseases in the elderly population, contributing approximately 90-95% of all osteoarthritis cases (people above 40), and its prevalence increases with age.
  • It is estimated that the number of cases of osteoarthritis will rise in the coming years because of the rising aging population and obesity, affecting the total pool of knee osteoarthritis.
  • In 2025, the total number of diagnosed cases of osteoarthritis was around 99,000 cases in the 7MM, which is anticipated to increase during the forecast period [2026-2036].
  • According to Iolascon et al. (2024), in Italy, the knee osteoarthritis burden significantly affects the national healthcare system and society. Knee osteoarthritis accounts for over 5 million prevalent cases and an age-standardized prevalence rate of 4066 cases per 100,000.
  • In Japan, the total diagnosed cases of knee osteoarthritis reached 11,500,000 in 2025.

Osteoarthritis Drug Chapters & Competitive Analysis

The Osteoarthritis drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase I-III clinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the Osteoarthritis treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the Osteoarthritis therapeutics market.

Approved Therapies for Osteoarthritis

JOYCLU: Ono Pharmaceutical/Seikagaku

JOYCLU is a formulation in which hyaluronic acid and diclofenac (an anti-inflammatory drug) are chemically bound using Seikagaku's proprietary technology. It is designed to release diclofenac by hydrolysis in the joint. JOYCLU is approved for treating osteoarthritis (knee joint and hip joint) and is expected to improve osteoarthritis symptoms by the intra-articular injection once every 4 weeks. JOYCLU is the first ethical drug indicating osteoarthritis of the hip joint in Japan among the joint function improvement agents. Seikagaku is involved in the manufacturing and marketing of the product, and Ono is responsible for distribution.

Osteoarthritis Pipeline Analysis

Pentosan polysulfate sodium (ZILOSUL): Paradigm Biopharma

ZILOSUL, or pentosan polysulfate sodium (PPS), is a semi-synthetic drug manufactured from the wood chips of European beech trees. Key features of the activity of PPS are its anti-inflammatory and tissue regenerative properties, as well as its mild anti-thrombotic activity. Due to PPS having multiple mechanisms of action, Paradigm's broader focus is exploring the use of PPS in treating a wide spectrum of conditions that begin with and are sustained by inflammation, such as osteoarthritis.

Paradigm has a longstanding relationship with Bene PharmaChem, the only FDA-approved manufacturer/supplier of PPS. Through the extensive interaction and collaboration with Bene PharmaChem and Paradigm's European manufacturers of the injectable formulation of PPS (iPPS), Paradigm has been able to develop its clinical product for trials.

Osteoarthritis Key Players, Market Leaders, and Emerging Companies

  • Ono Pharmaceutical/Seikagaku Corporation
  • Fidia Farmaceutici
  • Hanmi Pharmaceutical/Teva Pharmaceuticals
  • Bioventus
  • Pacira BioSciences/Flexion Therapeutics, and others

Osteoarthritis Drug Updates

  • Paradigm Biopharmaceuticals reported that as it progresses into FY2026, the company remains focused on achieving key clinical milestones, including completion of patient enrolment in the Phase III PARA_OA_012 trial of ZILOSUL for osteoarthritis. The company is also preparing for the planned interim analysis, with a data readout expected in mid-2026.
  • In April 2024, Paradigm submitted key documents to the US FDA for review and agreement on the progression of the Phase III clinical program in osteoarthritis.

Drug Class Insights

Osteoarthritis Market Outlook

The treatment and management of osteoarthritis involve a multifaceted approach. Non-pharmacologic interventions, such as exercise, weight management, and physical therapy, aim to improve joint function and alleviate pain. Pharmacologic options include analgesics, NSAIDs, and intra-articular injections for pain relief and inflammation. Surgical interventions, like joint replacement, may be considered in severe cases. Complementary therapies, including acupuncture and heat/cold therapy, offer additional relief. Patient education and self-management strategies are crucial, empowering individuals to understand and cope with the condition.

Intra-articular corticosteroids have long been used to manage knee osteoarthritis pain, offering short- to medium-term relief. However, study results vary due to differing methodologies, making their overall effectiveness unclear. Similarly, evidence on intra-articular hyaluronic acid is inconsistent, with outcomes influenced by its molecular weight. Common first-line treatments include corticosteroid injections, opioids, bioengineered hyaluronic acid, and NSAIDs. Given that joint inflammation contributes to cartilage damage in knee osteoarthritis, corticosteroid injections may help slow disease progression.

NSAIDs have historically been the most often used medication; however, their long-term use is limited, particularly in elderly patients with multiple comorbidities due to associated gastrointestinal, renal, cardiac, and hematologic adverse events linked to this class of medication. Other anti-inflammatory painkillers with similar effects are celecoxib and etoricoxib. These are COX-2 inhibitors (or coxibs) taken as tablets or directly applied to the painful joint as a gel or cream. DUROLANE a single-injection hyaluronic acid therapy for knee osteoarthritis that restores joint function and provides longer-lasting pain relief versus corticosteroids. Some emerging therapies for knee osteoarthritis include JTA-004 and AMZ001.

The osteoarthritis market is projected to grow from 2022 to 2036, driven by an aging population and rising disease prevalence. Increasing demand for advanced and effective therapies is further supporting market expansion.

  • The total market size in the 7MM for osteoarthritis was estimated to be USD 32,500 million in 2025, which is expected to show positive growth by 2036 at a positive CAGR during the forecast period (2026-2036).
  • In 2025, Opioids captured the highest market size of osteoarthritis by therapies, i.e., around USD 9,500 million in the US.
  • Amongst EU4 and the UK, Germany will capture the maximum revenue share, followed by Spain and France in 2036.
  • The upcoming therapies for osteoarthritis are expected to combat the current unmet needs faced by patients with osteoarthritis.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Osteoarthritis (2022-2036 Forecast)

Glycosaminoglycans: Glycosaminoglycans such as chondroitin sulfate and hyaluronic acid are key components of cartilage and synovial fluid and are utilized in osteoarthritis management to support joint structure and function. These agents work by enhancing cartilage hydration, improving viscoelastic properties of synovial fluid, and inhibiting cartilage degradation pathways, thereby helping to reduce joint pain, inflammation, and stiffness while potentially slowing disease progression.

Osteoarthritis Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the Osteoarthritis market's uptake by drugs, patient uptake by therapy, and sales of each drug.

The landscape of Osteoarthritis treatment has experienced a profound transformation with the uptake of novel drugs. These innovative therapies are redefining standards of care. Furthermore, the increased uptake of these transformative drugs is a testament to the unwavering dedication of physicians, professionals, and the entire healthcare community in their tireless pursuit of advancing disease care. This momentous shift in treatment paradigms is a testament to the power of research, collaboration, and human resilience.

Osteoarthritis Therapies Price Scenario & Trends

Pricing and analogue assessment of Osteoarthritis therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and the understanding of how pricing influences market access, adherence, and long-term uptake.

Industry Experts and Physician Views for Osteoarthritis

To keep up with Osteoarthritis market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the Osteoarthritis emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in Osteoarthritis, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 15+ KOLs to gather insights at the country level. Centers such as the Medicine at Harvard Medical School in the US, Oxford University in the UK, University of California, San Francisco, and University of Heidelberg in Germany, etc., were contacted. Their opinion helps understand and validate current and emerging Osteoarthritis therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in Osteoarthritis.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of Osteoarthritis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are mainly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of Osteoarthritis, explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the Osteoarthritis market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM Osteoarthritis market.

Report Insights

  • Osteoarthritis Patient Population Forecast
  • Osteoarthritis Therapeutics Market Size
  • Osteoarthritis Pipeline Analysis
  • Osteoarthritis Market Size and Trends
  • Osteoarthritis Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-Enabled Market Research Report
  • 11-Year Forecast
  • Osteoarthritis Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (By Geography)
  • Osteoarthritis Treatment Addressable Market (TAM)
  • Osteoarthritis Competitive Landscape
  • Osteoarthritis Major Companies Insights
  • Osteoarthritis Price Trends and Analogue Assessment
  • Osteoarthritis Therapies Drug Adoption/Uptake
  • Osteoarthritis Therapies Peak Patient Share Analysis

Report Assessment

  • Osteoarthritis Current Treatment Practices
  • Osteoarthritis Unmet Needs
  • Osteoarthritis Clinical Development Analysis
  • Osteoarthritis Emerging Drugs Product Profiles
  • Osteoarthritis Market Attractiveness
  • Osteoarthritis Qualitative Analysis (SWOT and conjoint analysis)

FAQs:

Market Insights

  • What was the Osteoarthritis market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of Osteoarthritis?
  • What are the disease risks, burdens, and unmet needs of Osteoarthritis? What will be the growth opportunities across the 7MM concerning the patient population with Osteoarthritis?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of Osteoarthritis? What are the current guidelines for treating Osteoarthritis in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Osteoarthritis market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights into the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarizes and simplifies complex datasets within the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Upcoming Key Catalyst
  • 4.2. Key Transactions and Collaborations
  • 4.3. News Flow

5. Epidemiology and Market Methodology

6. Osteoarthritis Market Overview at a Glance

  • 6.1. Emerging Therapies Analysis (By Phase, RoA, and Molecule Type)
  • 6.2. Market Share by Therapies (%) Distribution of Osteoarthritis in 2025 in the 7MM
  • 6.3. Market Share by Therapies (%) Distribution of Osteoarthritis in 2036 in the 7MM

7. Disease Background and Overview of Osteoarthritis

  • 7.1. Introduction
  • 7.2. Definition and Classification
  • 7.3. Etiology
  • 7.4. Risk Factors
  • 7.5. Pathophysiology
  • 7.6. Relevance to Other Disease States
  • 7.7. Diagnosis and
    • 7.7.1. Diagnostic Guidelines
    • 7.7.2. Diagnostic Algorithm

8. Treatment and Management of Osteoarthritis

9. Epidemiology and Patient Population of Osteoarthritis

  • 9.1. Key Findings
  • 9.2. Assumption and Rationale of Osteoarthritis: The 7MM Analysis
  • 9.3. Total Diagnosed Cases of Osteoarthritis in the 7MM
  • 9.4. The United States
    • 9.4.1. Total Diagnosed Prevalent Cases of Osteoarthritis in the US
    • 9.4.2. Joint site-specific Diagnosed Prevalent Cases of Osteoarthritis in the US
    • 9.4.3. Gender-specific Diagnosed Prevalent Cases of Osteoarthritis in the US
    • 9.4.4. Age-specific Diagnosed Prevalent Cases of Osteoarthritis in the US
    • 9.4.5. Severity-specific Prevalent Cases of Osteoarthritis in the US
  • 9.5. EU4 and the UK
    • 9.5.1. Total Diagnosed Prevalent Cases of Osteoarthritis in EU4 and the UK
    • 9.5.2. Joint site-specific Diagnosed Prevalent Cases of Osteoarthritis in EU4 and the UK
    • 9.5.3. Gender-specific Diagnosed Prevalent Cases of Osteoarthritis in EU4 and the UK
    • 9.5.4. Age-specific Diagnosed Prevalent Cases of Osteoarthritis in EU4 and the UK
    • 9.5.5. Severity-specific Prevalent Cases of Osteoarthritis in EU4 and the UK
  • 9.6. Japan
    • 9.6.1. Total Diagnosed Prevalent Cases of Osteoarthritis in Japan
    • 9.6.2. Joint site-specific Diagnosed Prevalent Cases of Osteoarthritis in Japan
    • 9.6.3. Gender-specific Diagnosed Prevalent Cases of Osteoarthritis in Japan
    • 9.6.4. Age-specific Diagnosed Prevalent Cases of Osteoarthritis in Japan
    • 9.6.5. Severity-specific Prevalent Cases of Osteoarthritis in Japan

10. Patient Journey

11. Marketed Therapies

  • 11.1. Marketed Competitive Landscape of Osteoarthritis
  • 11.2. JOYCLU (diclofenac etalhyaluronate sodium): Ono Pharmaceutical/Seikagaku Corporation
    • 11.2.1. Product Description
    • 11.2.2. Regulatory Milestones
    • 11.2.3. Other Development Activities
    • 11.2.4. Summary of Pivotal Trial
    • 11.2.5. Clinical Development
      • 11.2.5.1. Clinical Trial Information
    • 11.2.6. Safety and Efficacy of Ongoing Clinical Trials
    • 11.2.7. Analyst Views
  • 11.3. DUROLANE: Bioventus
    • 11.3.1. Product Description
    • 11.3.2. Regulatory Milestones
    • 11.3.3. Other Development Activities
    • 11.3.4. Summary of Pivotal Trial
    • 11.3.5. Clinical Development
      • 11.3.5.1. Clinical Trial Information
    • 11.3.6. Safety and Efficacy of Ongoing Clinical Trials
    • 11.3.7. Analyst Views

12. Emerging Therapies

  • 12.1. Emerging Competitive Landscape of Osteoarthritis
  • 12.2. ZILOSUL (pentosan polysulfate sodium): Paradigm Biopharmaceuticals
    • 12.2.1. Product Description
    • 12.2.2. Other Developmental Activities
    • 12.2.3. Clinical Development
      • 12.2.3.1. Clinical Trials Information
    • 12.2.4. Safety and Efficacy
    • 12.2.5. Analyst Views
  • 12.3. AMZ001: Amzell
    • 12.3.1. Product Description
    • 12.3.2. Other Developmental Activities
    • 12.3.3. Clinical Development
      • 12.3.3.1. Clinical Trials Information
    • 12.3.4. Safety and Efficacy
    • 12.3.5. Analyst Views
  • 12.4. LEVI-04: Levicept
    • 12.4.1. Product Description
    • 12.4.2. Other Developmental Activities
    • 12.4.3. Clinical Development
      • 12.4.3.1. Clinical Trials Information
    • 12.4.4. Safety and Efficacy
    • 12.4.5. Analyst Views

13. Osteoarthritis: 7MM Analysis

  • 13.1. Key Findings
  • 13.2. Market Outlook
  • 13.3. Conjoint Analysis
  • 13.4. Key Market Forecast Assumptions
    • 13.4.1. Cost Assumptions
    • 13.4.2. Pricing Trends
    • 13.4.3. Analogue Assessment
    • 13.4.4. Launch Year and Therapy Uptake
  • 13.5. Total Market Size of Osteoarthritis in the 7MM
  • 13.6. Total Market Size of Osteoarthritis by Therapies in 7MM
  • 13.7. The United States Market Size
    • 13.7.1. Total Market Size of Osteoarthritis in the United States
    • 13.7.2. Total Market Size of Osteoarthritis by Therapies in the United States
  • 13.8. EU4 and the UK Market Size
    • 13.8.1. Total Market Size of Osteoarthritis in EU4 and the UK
    • 13.8.2. Total Market Size of Osteoarthritis by Therapies in EU4 and the UK
  • 13.9. Japan
    • 13.9.1. Total Market Size of Osteoarthritis in Japan
    • 13.9.2. Total Market Size of Osteoarthritis by Therapies in Japan

14. Unmet Needs of Osteoarthritis

15. SWOT Analysis of Osteoarthritis

16. Key Opinion Leaders' Views

17. Market Access and Reimbursement of Osteoarthritis

  • 17.1. The United States
    • 17.1.1. Centre for Medicare and Medicaid Services (CMS)
  • 17.2. In EU4 and the UK
    • 17.2.1. Germany
    • 17.2.2. France
    • 17.2.3. Italy
    • 17.2.4. Spain
    • 17.2.5. United Kingdom
  • 17.3. Japan
    • 17.3.1. MHLW
  • 17.4. Summary and Comparison of Market Access and Pricing Policy Developments in 2025
  • 17.5. Market Access and Reimbursement of Osteoarthritis

18. Appendix

  • 18.1. Acronyms and Abbreviations
  • 18.2. Bibliography
  • 18.3. Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

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