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위마비 : 시장 인사이트, 역학 및 시장 예측(2036년)

Gastroparesis - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 129 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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위마비에 대한 인사이트와 동향

  • 당뇨병성 위마비가 가장 흔한 아형이며, 그 다음으로 수술 후 사례가 뒤를 잇습니다. 개발 중인 치료법의 대부분은 유병률이 높고 상업적 잠재력도 있기 때문에 특발성 및 당뇨병성 유형을 대상으로 하고 있습니다.
  • NORD에 따르면, 위마비에는 성별 차이가 나타나며, 남성보다 여성에게서 더 많이 발병하고 있습니다. 특발성 사례의 약 80%는 여성입니다.
  • 미국에서는 2025년 기준으로, 원인별 환자 수에서 가장 많은 비중을 차지하는 것은 당뇨병(57%)이며, 그 다음으로 수술 후 환자(15%), 약물 유발성 환자(11%) 순입니다.
  • 위 배출 지연의 중증도에 따라, 위마비 증례는 경증(위 내용물 체류율 20% 미만), 중등도(20-29%), 중증(30% 이상)으로 분류됩니다. 추산에 따르면, 미국에서는 경증 사례가 위마비의 전체 사례 중 43%를 차지해 가장 많으며, 그 다음으로 중증 사례가 뒤를 잇습니다.
  • 아시아인 집단에서 위마비의 유병률에 관한 조사는 진단 누락이 우려되고 관심도가 낮은 탓에 제한적입니다.
  • 경구용 메토클로프라미드는 오랫동안 당뇨병성 위마비에 대해 미국 식품의약국(FDA)이 승인한 유일한 치료 옵션이었습니다. 2020년 6월, GIMOTI는 FDA 승인을 받은 최초의 비강 스프레이가 되어 증상 완화를 더욱 신속하게 할 수 있을 뿐만 아니라, 위 배출 지연으로 인한 흡수 문제도 극복했습니다. 다만, 그 사용은 여전히 지연성 운동이상증의 위험 및 치료 기간에 관한 지침에 의해 제한되고 있습니다.
  • 다른 질환에 대해 승인된 몇몇 약물이 위마비 증상을 완화하기 위해 임상의들에 의해 적응증 외로 사용되고 있습니다. 여기에는 노르트립틸린(삼환계 항우울제), 밀타자핀, 부스피론 등의 약물이 포함됩니다.
  • 식이 요법은 위마비의 1차 치료법이며, 일반적으로 질환의 중증도와 관계없이 모든 환자에게 적용됩니다.
  • 위마비의 치료법으로는 생활 습관 및 식이 요법의 조절, 운동 촉진제나 구토 억제제 등의 약물, 그리고 통증 관리 및 외과적 치료 등이 포함됩니다.
  • 현재의 치료 옵션은 여전히 제한적이지만, 운동 촉진제 및 구토 억제제 치료 분야의 지속적인 임상 개발과 혁신을 통해 치료 옵션이 확대될 것이며, 향후 몇 년 동안 주요 시장 전반에 걸쳐 새로운 기회가 창출될 것으로 전망됩니다.
  • 위마비 치료제 시장에서 신흥 치료법으로는 나로나프리드, CIN-102, PCS12852, PCS12852(YH12852) 등이 있으며, 기타에도 임상 개발의 중기-후기 단계에 있는 약물들이 개발되고 있습니다.

미국 위마비 시장 규모 및 전망

  • 2025년 위마비 시장 규모 : 약 1억 5,000만
  • 2036년 위마비 시장 규모(예측) : 약 9억 7,000만
  • 위마비 시장 성장률(2026년-2036년) : 연평균 성장률(CAGR) 약 18%

본 위마비 시장 보고서에서는 표준 치료, 임상 실무, 진화하는 치료 알고리즘 등 현재의 치료 현황에 대한 종합적인 분석을 제공합니다. 위마비 환자의 부담 동향, 수익 및 시장 점유율 동향, 피크 시기의 환자 점유율 및 치료 도입률 분석을 평가하는 한편, 세계 각 지역의 상세한 시장 규모 평가 및 성장률 예측(과거 데이터 및 2022년-2036년 예측)을 제시하고 있습니다. 본 보고서에서는 위마비 분야에서 주요 미충족 요구 사항을 부각시키고, 경쟁 구도와 임상 환경을 분석하여 고부가가치의 성장 기회를 도출하는 한편, 향후 시장 성장 가능성에 대한 명확한 전망을 제시하고 있습니다.

위마비 시장을 주도하는 주요 요인

당뇨병 유병률 증가

위마비는 당뇨병, 특히 장기간 지속되는 증상과 밀접한 관련이 있습니다. 전 세계적으로 당뇨병 유병률이 증가함에 따라 위마비 환자 수도 늘어나고 있으며, 진단 및 치료에 대한 수요가 높아지고 있습니다.

고령화

고령자는 위마비를 비롯한 위장 질환에 걸리기 쉬운 경향이 있습니다. 고령 인구 증가는 환자 수 증가와 의료 수요 증가에 크게 기여하고 있습니다.

충족되지 않은 의료 수요

현재의 치료법으로는 증상 완화가 제한적인 경우가 많으며, 부작용이 동반되기도 합니다. 보다 효과적이고 안전한 치료법에 대한 수요가 혁신과 시장의 관심을 지속적으로 견인하고 있습니다.

위마비에 대한 이해와 치료 알고리즘

위마비의 개요와 진단

위 배출 지연증은 기계적인 폐색이 없음에도 불구하고 위 내용물의 배출이 지연되는 것을 특징으로 하는 만성 위장 질환입니다. 장기간 당뇨병을 앓고 있는 사람들에게서 흔히 나타나지만, 수술 후 합병증, 약물, 또는 특발성 원인에 의해서도 발병할 수 있습니다. 환자는 일반적으로 메스꺼움, 구토, 조기 포만감, 복부 팽만감, 복통을 호소하며, 이러한 증상은 영양 상태와 삶의 질에 중대한 영향을 미칠 수 있습니다. 이 질환은 특히 당뇨병 환자의 경우, 영양실조, 탈수, 혈당 변동과 같은 합병증을 유발할 우려가 있습니다. 이러한 만성적이고 재발하기 쉬운 특성 때문에 장기적인 관리와 경과 관찰이 필요한 경우가 많습니다.

진단을 위해서는 기계적 폐색을 배제하고, 위 배출 지연을 확인해야 합니다. 일반적인 검사 방법으로는 위 배출 신티그래피(골드 스탠다드), 호기 검사, 상부 내시경 검사 등이 있습니다. 의사는 또한 당뇨병 등의 근본적인 원인을 평가하고, 위 운동 기능을 저해할 가능성이 있는 약물을 확인하는 등, 위마비로 진단하기 전에 종합적인 평가를 실시합니다. 복잡한 증상의 경우, 무선 운동 기능 캡슐이나 영상 검사 등의 추가 검사가 실시되기도 합니다. 위마비를, 유사한 증상을 보이는 다른 기능성 위장 장애와 구별하기 위해서는 정확한 진단이 필수적입니다.

위마비의 현재 치료 현황

치료는 증상 관리, 식이요법, 그리고 위 운동 기능 개선에 중점을 두고 있습니다. 환자분들께는 소량으로 저지방·저섬유질 식사를 섭취하도록 지도합니다. 약물 요법에는 위마비에 대해 FDA가 유일하게 승인한 약물인 메토클로프라미드(GIMOTI)와, 적응증 외로 사용되는 에리스로마이신 등의 운동 촉진제 및 구토 억제제가 포함됩니다. 구토 억제제 등 기타 대증 요법 약물은 메스꺼움이나 구토를 억제하는 데 도움이 될 수 있습니다. 중증 또는 난치성 환자의 경우, 영양 상태를 유지하고 삶의 질(QOL)을 향상시키기 위해 위 전기 자극, 공장루 영양 튜브, 또는 외과적 시술 등의 치료 옵션이 고려될 수 있습니다. 환자의 반응에는 개인차가 있으므로, 지속적인 경과 관찰과 맞춤형 치료 계획이 필수적입니다.

위마비의 역학

위마비에 대한 역학 분석 및 예측과 관련된 주요 조사 결과

  • G7 국가 중 2025년에는 미국이 위마비 진단 유병 사례 수에서 가장 많아져 약 724,000건에 달할 것으로 예측됩니다.
  • 2025년 미국에서 연령별 환자 수가 가장 많았던 연령대는 65세 이상이었으며, 그 다음은 48-57세, 가장 적었던 연령대는 18-27세였습니다.
  • 위마비는 주로 여성에게 발병하는 질환으로, 진단을 받은 환자의 약 70%가 여성인 반면, 남성은 약 30%에 불과합니다.
  • 주요 7개국에서 병인별 사례를 살펴보면, 당뇨병의 유병률이 가장 높고, 그 다음으로 수술 후 요인, 약물 유발성, 그리고 특발성 순으로 나타납니다.

위마비 시장 전망

위마비의 치료는 그동안 식이요법, 구토 억제제, 운동 촉진제 등의 대증요법에 의존해 왔습니다. 치료 과정에서 중요한 전환점이 된 것은 도파민 수용체 길항 작용을 통해 위 운동성을 높이는 메토클로프라미드(GIMOTI)의 승인입니다. 그 효과에도 불구하고, 장기 사용은 안전성 문제로 인해 제한되고 있어, 내약성이 더 높고 지속성이 있는 치료법의 필요성이 부각되고 있습니다.

위마비의 치료 파이프라인은 점차 발전하고 있으며, 새로운 작용기전을 통해 위장 운동 기능 및 증상 조절을 목표로 하는 임상시험용 약물이 개발되고 있습니다. 선택적 5-HT4 수용체 작용제인 나로나프리드(ATI-7505)는 기존 약물에 비해 심장에 대한 안전성을 높이는 동시에 위 내용물의 배출을 촉진하는 것을 목적으로 개발이 진행되고 있습니다. CIN-102(데우돈페리돈)은 중추신경계에 미치는 부작용을 줄이면서 운동 촉진 효과를 발휘하는 것을 목표로 하고 있습니다. 또한, NG101(메토피마진)에 대해서도 구토 억제 작용에 대한 연구가 진행 중이며, 위마비와 관련된 지속적인 메스꺼움이나 구토를 완화할 가능성이 있습니다.

전반적으로, 보다 안전하고 표적화된 치료법의 등장과 더불어 진단 능력의 향상 및 질환에 대한 인식 제고에 힘입어, 2022년부터 2036년에 걸쳐 주요 7개국 전체에서 꾸준한 시장 성장이 예상되며, 이는 기존 제품 및 파이프라인 후보들에게 큰 상업적 기회를 가져다줄 것으로 전망됩니다.

  • 주요 7개국 중 미국은 위마비 시장에서 가장 큰 비중을 차지하고 있으며, 2025년에는 약 1억 5,000만 달러 규모 시장에 도달할 것으로 예상되며, 2036년까지 높은 연평균 성장률(CAGR)을 기록하며 성장할 것으로 전망됩니다.
  • 현재 주로 처방되는 치료제의 분류는 증상을 관리하기 위한 경구용 또는 정맥주사용 메토클로프라미드 계열의 구토 억제제나 신경 조절제 등의 운동 촉진제입니다.
  • 저분자 화합물: 현재 위마비 치료 파이프라인에서는 위장 운동 기능이나 신경전달물질의 경로를 조절하도록 설계된 저분자 화합물을 이용한 치료법이 주류를 이루고 있습니다. 나로나프리드(ATI-7505)는 아세틸콜린의 방출을 자극하는 선택적 5-HT4 수용체 작용제로, 위 내용물의 배출을 촉진하는 동시에 기존 약제에서 나타났던 심혈관계 위험을 최소화하는 것을 목표로 하고 있습니다. CIN-102(데우돈페리돈)과 NG101(메토피마진)은 각각 도파민 D2 수용체를 표적으로 하여, 운동 기능 개선과 메스꺼움·구토 억제를 도모합니다.

전반적으로, 위마비 치료 분야의 혁신은 운동 촉진 작용이나 구토 억제 작용 등 상호 보완적인 작용기전을 표적으로 하는 이미 승인되었거나 개발 중인 저분자 치료제에 의해 주도되고 있습니다. 개발 파이프라인의 후보 약물이 개발 단계를 거치면서, 메토클로프라미드 이외의 치료 옵션을 확대하여 중요한 미충족 의료 수요를 충족시키는 동시에, 주요 지역 전반에 걸쳐 꾸준한 시장 성장을 뒷받침할 것으로 기대됩니다.

자주 묻는 질문

  • 위마비의 주요 원인은 무엇인가요?
  • 위마비의 치료 옵션은 어떤 것들이 있나요?
  • 2025년 위마비 시장 규모는 어떻게 되나요?
  • 위마비 시장의 연평균 성장률(CAGR)은 어떻게 되나요?
  • 위마비 환자에서 성별 차이는 어떻게 나타나나요?
  • 위마비의 진단 방법은 무엇인가요?
  • 위마비 치료제 시장에서 신흥 치료법은 어떤 것들이 있나요?

목차

제1장 주요 인사이트

제2장 서론

제3장 주요 요약

제4장 주요 이벤트

제5장 위마비 : 역학 및 시장 조사 방법

제6장 위마비 : 시장 개요

제7장 위마비 : 질환 배경과 개요

제8장 위마비 : 역학 및 환자 인구

제9장 위마비 : 환자 경과

제10장 시판 치료제

제11장 신흥 치료법

제12장 위마비 : 주요 7개국 분석

제13장 위마비 : 미충족 요구

제14장 위마비 : SWOT 분석

제15장 위마비 : KOL(Key Opinion Leader)의 견해

제16장 위마비 시장 동향과 상환

제17장 부록

제18장 DelveInsight의 서비스 내용

제19장 면책사항

제20장 DelveInsight에 대해

LSH 26.07.27

Gastroparesis Insights and Trends

  • Diabetic gastroparesis is the most common subtype, followed by postsurgical cases, with most pipeline therapies targeting idiopathic and diabetic forms due to their higher prevalence and commercial potential.
  • As per NORD, gastroparesis demonstrates a gender bias affecting more women than men. Approximately 80% of idiopathic cases are women.
  • In the US, the highest etiology-specific cases accounted for diabetes (57%), followed by postsurgical cases (15%) and drug-induced cases (11%) in 2025.
  • Gastroparesis cases can be categorized based on the severity of delayed gastric emptying as mild (<20% gastric retention), moderate (20-29% gastric retention), and severe (>=30% gastric retention). As per the estimates, in the US, mild cases represent the largest share of gastroparesis at 43%, followed by severe cases.
  • There's limited research on the prevalence of gastroparesis in Asian populations due to potential underdiagnosis and lack of interest.
  • Oral metoclopramide has long been the sole US FDA-approved option for diabetic gastroparesis. In June 2020, GIMOTI became the first FDA-approved nasal formulation, providing faster symptom relief and overcoming absorption issues tied to delayed gastric emptying, while its use is still limited by tardive dyskinesia risks and treatment duration guidelines.
  • Several drugs approved for other conditions are utilized by clinician's off-label to alleviate gastroparesis symptoms. These include medications such as nortriptyline (a tricyclic antidepressant), mirtazapine, buspirone, and others.
  • Dietary modifications represent the first line of treatment for gastroparesis and are generally used for all patients, regardless of disease severity.
  • Therapeutic approaches for gastroparesis include lifestyle and dietary modifications, medications such as prokinetics and antiemetics, as well as pain management and surgical options.
  • While current treatment options remain limited, ongoing clinical development and innovation in prokinetic and antiemetic therapies are likely to expand the therapeutic landscape, creating new opportunities across major markets in the coming years.
  • In the gatroparesis market, a few of the emerging therapies are Naronapride, CIN-102, PCS12852, PCS12852 (YH12852), and others are being developed in the mid-late-stage clinical development.

Gastroparesis Market Size and Forecast in the US

  • 2025 Gastroparesis Market Size: ~150 million
  • 2036 Projected Gastroparesis Market Size: ~970 million
  • Gastroparesis Growth Rate (2026-2036): ~18% CAGR

DelveInsight's 'Gastroparesis - Market Insights, Epidemiology and Market Forecast - 2036' report delivers an in-depth understanding of the gastroparesis, historical and forecasted epidemiology, as well as the gastroparesis market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

The gastroparesis market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates gastroparesis patient burden trends, revenue & market share dynamics, peak patient share & therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in gastroparesis and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.

Key Factors Driving the Gastroparesis Market

Rising Prevalence of Diabetes

Gastroparesis is strongly linked to diabetes, particularly long-standing cases. As diabetes rates increase globally, the number of gastroparesis patients grows, boosting demand for diagnosis and treatment.

Aging Population

Older adults are more prone to gastrointestinal disorders, including gastroparesis. The growing elderly population contributes significantly to rising case numbers and healthcare demand.

Unmet Medical Needs

Current treatments often provide limited relief and may have side effects. The need for more effective and safer therapies continues to drive innovation and market interest.

Gastroparesis Understanding and Treatment Algorithm

Gastroparesis Overview and Diagnosis

Gastroparesis is a chronic gastrointestinal disorder characterized by delayed gastric emptying without any mechanical obstruction. It commonly occurs in people with long-standing diabetes but can also arise from post-surgical complications, medications, or idiopathic causes. Patients typically experience nausea, vomiting, early satiety, bloating, and abdominal pain, which can significantly impact nutrition and quality of life. The condition can lead to complications such as malnutrition, dehydration, and erratic blood glucose levels, particularly in diabetic patients. Its chronic and relapsing nature often requires long-term management and monitoring.

Diagnosis involves ruling out mechanical obstruction and confirming delayed gastric emptying. Common tools include gastric emptying scintigraphy (the gold standard), breath tests, and upper endoscopy. Physicians also assess underlying causes such as diabetes and review medications that may impair gastric motility, ensuring a comprehensive evaluation before confirming gastroparesis. Additional tests like wireless motility capsules and imaging studies may be used in complex cases. Accurate diagnosis is crucial to differentiate gastroparesis from other functional gastrointestinal disorders with similar symptoms.

Current Gastroparesis Treatment Landscape

Treatment focuses on symptom management, dietary modifications, and improving gastric motility. Patients are advised to consume small, low-fat, low-fiber meals. Pharmacologic therapy includes prokinetic and antiemetic agents such as Metoclopramide (GIMOTI), the only FDA-approved drug specifically indicated for gastroparesis, and Erythromycin, used off-label. Other supportive medications, like antiemetics, may help control nausea and vomiting. In severe or refractory cases, options such as gastric electrical stimulation, jejunostomy feeding tubes, or surgical interventions may be considered to maintain nutrition and improve quality of life. Continuous monitoring and individualized treatment plans are essential due to variability in patient response.

Gastroparesis Unmet Needs

The section "unmet needs of gastroparesis" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Limited effective treatment option

2. Insufficient clinical guidelines and standardization

3. Need for better biomarkers and diagnostic tools

4. High symptom burden and poor quality of life, and others.....

Gastroparesis Epidemiology

Key Findings from Gastroparesis Epidemiological Analysis and Forecast

  • Among the 7MM, the US accounted for the highest number of diagnosed prevalent cases of gastroparesis with ~724,000 cases in 2025.
  • In the US in 2025, the highest age-specific cases were seen in the 65+ age group, followed by those aged 48-57, while the lowest were in the 18-27 age group.
  • Gastroparesis as a disease predominantly affects women, with ~70% of the diagnosed patients being females, while only ~30% of the diagnosed patients are males.
  • Among etiology-specific cases across the 7MM, diabetes has the highest prevalence, followed by postsurgical causes, drug-induced cases, and then idiopathic cases.

Gastroparesis Drug Analysis & Competitive Landscape

The gastroparesis drug chapter provides a detailed, market-focused review of the emerging pipeline across Phase I-III clinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the gastroparesis treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the gastroparesis therapeutics market.

Approved Therapies for Gastroparesis

Metoclopramide (GIMOTI): EVOKE Pharma/EVERSANA

GIMOTI nasal spray is the first and only FDA-approved non-oral treatment for the relief of symptoms in adults with acute and recurrent diabetic gastroparesis. Metoclopramide hydrochloride is the active ingredient in GIMOTI. It is a dopamine antagonist, 5-HT3 antagonist, and 5-HT4 agonist with promotility and anti-emetic effects, for the relief of symptoms associated with acute and recurrent diabetic gastroparesis. In June 2020, the US FDA approved metoclopramide (GIMOTI) nasal spray. In January 2020, EVOKE Pharma entered into a commercial services agreement with Eversana Life Sciences Services for the commercialization of GIMOTI. According to the Eversana Agreement, Eversana will commercialize and distribute GIMOTI in the US.

Gastroparesis Pipeline Analysis

Naronapride (ATI-7505): Renexxion

Naronapride is an investigational gastrointestinal prokinetic drug. It is designed to treat disorders of gut motility, including gastroparesis. Naronapride works through a differentiated dual mechanism of action- 5-HT4 receptor agonism and dopamine D2 receptor antagonism. Inhibiting D2 receptors removes the "brakes" on the motility of the gut. The high 5-HT4 receptor selectivity minimizes the potential for off-target pharmacological effects. Its dual mechanism of action, minimal systemic bioavailability, and differentiated pharmaceutical and pharmacokinetic profile are designed to deliver targeted activity within the GI tract while limiting systemic exposure. In October 2021, Renexxion Ireland announced that it had entered into a Licensing and Collaboration Agreement with Dr. Falk Pharma GmbH to jointly develop and commercialize Naronapride, a unique late-stage GI prokinetic, initially for gastroparesis.

Gastroparesis Key Players, Market Leaders, and Emerging Companies

  • EVOKE Pharma
  • Renexxion
  • CinDome Pharma
  • Neurogastrx
  • Processa Pharmaceuticals
  • Intact Therapeutics, and others

Gastroparesis Drug Updates

  • In April 2026, Dr. Falk Pharma GmbH and Renexxion Ireland announced that data from the Global Phase IIb (MOVE-IT) study of naronapride in 328 adults with moderate-to-severe idiopathic or diabetic gastroparesis had been selected for a late-breaking oral presentation at DDW 2026 in the US.
  • In March 2026, CinDome Pharma announced that enrollment in the Phase II (envisionGI) trial of deudomperidone (CIN-102) for adults with idiopathic gastroparesis had been completed.
  • In September 2025, CinDome Pharma announced that it had completed enrollment in the (envision3D) Phase II clinical trial of deudomperidone in adults with diabetic gastroparesis.
  • In June 2025, Processa Pharmaceuticals announced that it had entered into a binding term sheet with Intact Therapeutics, granting Intact an exclusive option to license PCS12852, a best-in-class 5-HT4 receptor agonist with the potential to become a first meaningful treatment for gastroparesis and other gastrointestinal motility disorders.
  • In March 2024, Renexxion Ireland and Dr. Falk Pharma GmbH announced US FDA clearance of the INDA for naronapride to treat patients with gastroparesis.

Gastroparesis Market Outlook

The treatment landscape for gastroparesis has historically relied on symptomatic management, including dietary modifications, antiemetics, and prokinetic agents. A key milestone in therapy is the approval of metoclopramide (GIMOTI), which enhances gastric motility through dopamine receptor antagonism. Despite its effectiveness, long-term use is limited by safety concerns, highlighting the need for better-tolerated and more durable therapies.

The gastroparesis pipeline is gradually evolving, with investigational agents targeting gastrointestinal motility and symptom control through novel mechanisms. Naronapride (ATI-7505), a selective 5-HT4 receptor agonist, is being developed to enhance gastric emptying with improved cardiac safety versus earlier agents. CIN-102 (deudomperidone) aims to deliver prokinetic effects with fewer central nervous system side effects. NG101 (metopimazine) is also under investigation for its antiemetic action, potentially relieving persistent nausea and vomiting associated with gastroparesis.

Overall, the emergence of safer and more targeted therapies, along with improvements in diagnostic capabilities and increasing disease awareness, is projected to propel steady market growth across the 7MM from 2022 to 2036, yielding significant commercial opportunities for existing products and pipeline candidates.

  • Among the 7MM, the US represented the largest gastroparesis market, valued at approximately USD ~150 million in 2025, and is projected to grow at a significant CAGR through 2036.
  • Currently, the majorly prescribed class of therapies is prokinetics, such as oral or IV metoclopramide antiemetics and neuromodulators to manage symptoms.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Gastroparesis (2022-2036 Forecast)

The gastroparesis market (2022-2036 forecast) is shifting toward mechanism-based therapies that aim to improve gastric motility and control core symptoms such as nausea and vomiting, rather than relying solely on general supportive care.

  • Small molecules: The current gastroparesis pipeline is dominated by small-molecule therapies designed to modulate gastrointestinal motility and neurotransmitter pathways. Naronapride (ATI-7505) is a selective 5-HT4 receptor agonist that stimulates acetylcholine release, enhancing gastric emptying while aiming to minimize cardiovascular risks seen with earlier agents. CIN-102 (deudomperidone) and NG101 (metopimazine) target dopamine D2 receptors to improve motility and control nausea and vomiting, respectively.

Overall, innovation in gastroparesis is driven by approved and investigational small-molecule therapies targeting complementary mechanisms, including prokinetic and antiemetic effects. As pipeline candidates advance, they are expected to broaden treatment options beyond metoclopramide, address key unmet needs, and support steady market growth across major regions.

Gastroparesis Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the gastroparesis drug's uptake, performance at peak, factors affecting performance during prime years of growth, patient uptake by therapy, and anticipated sales generated by each drug.

During the forecast period, the currently FDA-approved therapy Metoclopramide (GIMOTI) is expected to maintain baseline utilization as the first-line pharmacologic option. However, its uptake is likely to plateau due to safety concerns such as extrapyramidal side effects and limitations on long-term use. It will continue to be widely used in acute and short-term management, particularly in newly diagnosed patients and in settings where newer therapies are not yet accessible.

Among pipeline agents, Naronapride (ATI-7505) is expected to see gradual uptake as a next-generation 5-HT4 agonist, driven by its potential to improve gastric motility with a more favorable cardiovascular safety profile. CIN-102 (domperidone) is expected to follow a moderate adoption curve, particularly in regions where domperidone use is established, benefiting from improved pharmacokinetic stability and reduced CNS penetration. Its uptake will likely be driven by chronic symptom management needs. NG101 (metopimazine) is expected to achieve faster early adoption in select patient segments due to its strong antiemetic effect, positioning it as an add-on therapy for refractory nausea and vomiting. Overall uptake will depend on clinical efficacy, safety outcomes, and positioning alongside standard of care therapies.

Gastroparesis Therapies Price Scenario & Trends

Pricing and analogue assessment of gastroparesis therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, closest and most appropriate analogue selection for emerging therapies, and understanding of how pricing influences market gastroparesis, adherence, and long-term uptake.

  • Pricing of Gastroparesis-Approved Drugs

The recommended dosage of GIMOTI for adults with acute and recurrent diabetic gastroparesis is one spray (15 mg) administered into one nostril, 30 minutes before each meal and at bedtime, up to a maximum of four times daily. Treatment duration ranges from 2 to 8 weeks, based on the patient's symptomatic response. A single bottle provides sufficient medication for 28 days of use at the maximum recommended frequency. The cost per bottle is approximately USD 2,276.03, resulting in an estimated total therapy cost of around USD 4,552 for an 8-week course.

Industry Experts and Physician Views for Gastroparesis

To keep up with the gastroparesis market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the Gastroparesis emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in gastroparesis, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 15+ KOLs to gather insights at the country level. Centers such as the Duke Molecular Physiology Institute, Department of Nephrology, Hospital Universitario Fundacion Alcorcon, and Nippon Medical School, etc. were contacted. Their opinion helps understand and validate current and emerging gastroparesis therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in gastroparesis.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of gastroparesis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are majorly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of Gastroparesis, explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the Gastroparesis market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM Gastroparesis market.

Report Insights

  • Gastroparesis Patient Population Forecast
  • Gastroparesis Therapeutics Market Size
  • Gastroparesis Pipeline Analysis
  • Gastroparesis Market Size and Trends
  • Gastroparesis Market Opportunity (Current and Forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-Enabled Market Research Report
  • 11-Year Forecast
  • Gastroparesis Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (By Geography)
  • Gastroparesis Treatment Addressable Market (TAM)
  • Gastroparesis Competitive Landscape
  • Gastroparesis Major Companies Insights
  • Gastroparesis Price Trends and Analogue Assessment
  • Gastroparesis Therapies Drug Adoption/Uptake
  • Gastroparesis Therapies Peak Patient Share Analysis

Report Assessment

  • Gastroparesis Current Treatment Practices
  • Gastroparesis Unmet Needs
  • Gastroparesis Clinical Development Analysis
  • Gastroparesis Emerging Drugs Product Profiles
  • Gastroparesis Market Attractiveness
  • Gastroparesis Qualitative Analysis (SWOT and Conjoint Analysis)

FAQs:

Market Insights

  • What was the Gastroparesis market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of Gastroparesis?
  • What are the disease risks, burdens, and unmet needs of Gastroparesis? What will be the growth opportunities across the 7MM concerning the patient population with Gastroparesis?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of Gastroparesis? What are the current guidelines for treating Gastroparesis in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Gastroparesis market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights into the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarize and simplify complex datasets with in the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Upcoming Key Catalyst
  • 4.2. Key Conferences And Meetings
  • 4.3. Key Transactions And Collaborations
  • 4.4. News Flow

5. Epidemiology and Market Methodology of Gastroparesis

6. Gastroparesis Market Overview at a Glance

  • 6.1. Emerging Landscape Analysis (By Molecule Type, Phase, and Route of Administration [ROA])
  • 6.2. Market Share of Gastroparesis by Therapies (%) in the 7MM in 2025
  • 6.3. Market Share of Gastroparesis by Therapies (%) in the 7MM in 2036

7. Disease Background And Overview of Gastroparesis

  • 7.1. Introduction
  • 7.2. Causes
  • 7.3. Signs And Symptoms
  • 7.4. Diagnosis
    • 7.4.1. Differential Diagnosis
    • 7.4.2. Diagnostic Algorithm
    • 7.4.3. Diagnostic Guidelines
  • 7.5. Treatment and Management
    • 7.5.1. Treatment Algorithm
    • 7.5.2. Treatment Guidelines

8. Epidemiology and Patient Population of Gastroparesis

  • 8.1. Key Findings
  • 8.2. Assumption and Rationale
  • 8.3. Total Diagnosed Prevalent Cases of Gastroparesis in the 7MM
  • 8.4. The United States
    • 8.4.1. Total Diagnosed Prevalent Cases of Gastroparesis in the United States
    • 8.4.2. Etiology-specific Cases of Gastroparesis in the United States
    • 8.4.3. Gender-specific Diagnosed Prevalent Cases of Gastroparesis in the United States
    • 8.4.4. Age-specific Diagnosed Prevalent Cases of Gastroparesis in the United States
    • 8.4.5. Total Cases of Gastroparesis by the Severity of Delayed Gastric Emptying in the United States
    • 8.4.6. Treated cases of Gastroparesis in the United States
  • 8.5. EU4 and the UK
    • 8.5.1. Total Diagnosed Prevalent Cases of Gastroparesis in EU4 and the UK
    • 8.5.2. Etiology-specific Cases of Gastroparesis in EU4 and the UK
    • 8.5.3. Gender-specific Diagnosed Prevalent Cases of Gastroparesis in EU4 and the UK
    • 8.5.4. Age-specific Diagnosed Prevalent Cases of Gastroparesis in EU4 and the UK
    • 8.5.5. Total Cases of Gastroparesis by the Severity of Delayed Gastric Emptying in EU4 and the UK
    • 8.5.6. Treated cases of Gastroparesis in EU4 and the UK
  • 8.6. Japan
    • 8.6.1. Total Diagnosed Prevalent Cases of Gastroparesis in Japan
    • 8.6.2. Etiology-specific Cases of Gastroparesis in Japan
    • 8.6.3. Gender-specific Diagnosed Prevalent Cases of Gastroparesis in Japan
    • 8.6.4. Age-specific Diagnosed Prevalent Cases of Gastroparesis in Japan
    • 8.6.5. Total Cases of Gastroparesis by the Severity of Delayed Gastric Emptying in Japan
    • 8.6.6. Treated cases of Gastroparesis in Japan

9. Patient Journey of Gastroparesis

10. Marketed Therapies

  • 10.1. Marketed Competitive Landscape of Gastroparesis
  • 10.2. Metoclopramide (GIMOTI): EVOKE Pharma
    • 10.2.1. Product Description
    • 10.2.2. Regulatory Milestones
    • 10.2.3. Other Developmental Activities
    • 10.2.4. Summary of Pivotal Trials
    • 10.2.5. Analyst Views

11. Emerging Therapies

  • 11.1. Emerging Competitive Landscape of Gastroparesis
  • 11.2. Naronapride (ATI-7505): Renexxion
    • 11.2.1. Product Description
    • 11.2.2. Other Developmental Activities
    • 11.2.3. Clinical Development
      • 11.2.3.1. Clinical Trial Information
    • 11.2.4. Safety and Efficacy
    • 11.2.5. Analyst Views
  • 11.3. CIN-102 (deudomperidone): CinDome Pharma
    • 11.3.1. Product Description
    • 11.3.2. Other Developmental Activities
    • 11.3.3. Clinical Development
      • 11.3.3.1. Clinical Trial Information
    • 11.3.4. Safety and Efficacy
    • 11.3.5. Analyst Views

12. Gastroparesis: Seven Major Market Analysis

  • 12.1. Key Findings
  • 12.2. Market Outlook of Gastroparesis
  • 12.3. Conjoint Analysis of Gastroparesis
  • 12.4. Key Market Forecast Assumptions
    • 12.4.1. Cost Assumptions
    • 12.4.2. Pricing Trends
    • 12.4.3. Analogue Assessment
    • 12.4.4. Launch Year and Therapy Uptakes
  • 12.5. Total Market Size of Gastroparesis in the 7MM
  • 12.6. The United States
    • 12.6.1. Total Market Size of Gastroparesis in the United States
    • 12.6.2. Market Size of Gastroparesis by Therapies in the United States
  • 12.7. EU4 and the UK
    • 12.7.1. Total Market Size of Gastroparesis in EU4 and the UK
    • 12.7.2. Market Size of Gastroparesis by Therapies in EU4 and the UK
  • 12.8. Japan
    • 12.8.1. Total Market Size of Gastroparesis in Japan
    • 12.8.2. Market Size of Gastroparesis by Therapies in Japan

13. Unmet Needs of Gastroparesis

14. SWOT Analysis of Gastroparesis

15. KOL Views of Gastroparesis

  • 15.1. Expert/KOL Interview Highlights

16. Market Gastroparesis and Reimbursement of Gastroparesis

  • 16.1. The US
  • 16.2. In EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. United Kingdom
  • 16.3. Japan
  • 16.4. Summary and Comparison of Market Gastroparesis and Pricing Policy Developments in 2025
  • 16.5. Market Gastroparesis and Reimbursement of Gastroparesis Therapies

17. Appendix

  • 17.1. Bibliography
  • 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

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