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건성 황반변성 : 시장 동향, 역학 및 시장 예측(2036년)

Dry Age-related Macular Degeneration - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 246 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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건성 노화성 황반변성(AMD)에 대한 인사이트와 동향

  • DelveInsight의 분석에 따르면, 2025년 주요 7개국(미국, EU4(독일, 프랑스, 이탈리아, 스페인), 영국, 일본)의 건성 AMD 시장 규모는 약 21억 5,000만 달러인 것으로 나타났습니다.
  • 건성 AMD는 지리적 위축으로 진행될 가능성이 있으며, 황반부의 망막색소상피(RPE), 광수용체 및 맥락막 모세혈관층의 변성으로 인해 돌이킬 수 없는 시력 상실을 초래할 우려가 있습니다. 따라서, 질환의 진행을 늦추고 종합적인 질환 관리를 위해서는 조기 진단, 정기적인 경과 관찰, 그리고 생활 습관의 개선이 매우 중요합니다.
  • 2025년 기준으로, 미국 내 지리적 위축증 환자 총수는 약 83만 1,000명이었습니다. 이러한 사례 수는 2036년까지 증가할 것으로 예측됩니다.
  • 미국에서 연령별 지리적 위축증의 총 환자 수는 85세 이상이 가장 많았고, 그 다음으로 65-84세, 64세 이하 연령층 순이었습니다.
  • FDA의 페그세타코플란(SYFOVRE) 및 아바신카프타드 페골(IZERVAY) 승인은 보체계 조절이 연령 관련 황반변성(AMD)에서 지리적 위축의 진행을 완화하는 유망한 치료법으로 자리매김했음을 보여주는 중요한 진전입니다.
  • 건성 AMD를 대상으로 개발 중인 후보 약물의 대부분은 초기 및 중간 단계에 초점을 맞추기보다는 진행 단계인 지리적 위축을 표적으로 삼고 있습니다.
  • 지리적 위축 치료를 위한 최초의 치료 후보물질인 ANX007이 EU에서 PRIME 지정을 획득했습니다.
  • Belite Bio, Alkeus Pharmaceuticals, Aviceda Therapeutics, Allegro Ophthalmics, Johnson &Johnson Innovative Medicine 등의 신생 기업들이 혁신적인 치료법을 통해 건성 AMD 파이프라인을 적극적으로 구축하고 있습니다.

주요 7개국 건성 연령 관련 황반변성(AMD) 시장 규모 및 전망

  • 2025년 건성 AMD 시장 규모 : 약 21억 5,000만
  • 2036년 건성 AMD 시장 규모 전망: 145억
  • 건성 AMD의 성장률(2026년-2036년) : 연평균 성장률(CAGR) 약 19.2

본 '건성 AMD 시장 보고서'에서는 표준 치료, 임상 실무, 진화하는 치료 알고리즘 등 현재의 치료 현황에 대한 종합적인 분석을 제공합니다. 또한, 건성 AMD 환자의 부담 추이, 수익 및 시장 점유율 추이, 정점 시기의 환자 점유율 및 치료 도입률 분석을 평가하는 한편, 전 세계 각 지역 시장 규모에 대한 상세한 평가 및 성장률 전망(과거 데이터 및 2022년-2036년 전망)을 제시하고 있습니다. 본 보고서는 건성 AMD 분야의 주요 미충족 의료 수요를 부각하고, 경쟁 구도 및 임상 환경을 분석하여 고부가가치의 성장 기회를 도출함으로써, 향후 시장 성장 가능성에 대한 명확한 전망을 제시하고 있습니다.

건성 연령 관련 황반변성(AMD) 시장을 주도하는 주요 요인

  • 세계의 고령화

건성 AMD는 주로 60세 이상, 특히 85세 이상의 사람들에게 발병합니다. 전 세계 고령 인구의 급격한 증가는 환자 수의 직접적인 증가로 이어지고 있습니다.

  • 질병 유병률 및 위험 요인 증가

건성 AMD는 이미 전체 AMD 사례의 약 85-90%를 차지하고 있으며, 시장 규모를 확대되고 있습니다. 지리적 위축(진행성 건성 AMD) 증가로 인해 치료 수요는 더욱 확대되고 있습니다.

  • 진단 기술의 발전

광간섭 단층촬영(OCT)이나 안저 영상 진단과 같은 첨단 영상 진단 기술 덕분에 더욱 조기적이고 정확한 진단이 가능해지면서, 치료를 받는 환자 수가 증가하고 있습니다.

건성 노화성 황반변성(AMD)의 이해와 치료 알고리즘

건성 노인성 황반변성(AMD)의 개요와 진단

건성 연령 관련 황반변성(AMD)은 주로 망막의 중심부이자 선명하고 세밀한 시력을 담당하는 황반에 영향을 미치는 만성적이고 진행성인 망막 질환입니다. 이는 노화성 황반변성 중 가장 흔한 형태입니다. 이 질환은 망막 아래에 '드루젠'이라 불리는 세포외 침착물이 축적되어 망막색소상피(RPE) 세포가 서서히 변성되는 것이 특징입니다. 시간이 지남에 따라 이는 중심 시력의 상실로 이어져, 독서, 운전, 얼굴 인식 등의 활동에 영향을 미칩니다. 병세가 진행된 단계에서는 돌이킬 수 없는 망막 세포 손실을 특징으로 하는 중증 형태인 ‘지리적 위축’으로 진행될 가능성이 있습니다. 위험 요인으로는 노화, 흡연, 유전적 소인, 심혈관 질환 등이 있습니다.

건성 AMD의 진단에는 종합적인 안과 검사와 첨단 영상 진단 기술이 활용됩니다. 안과 전문의는 일반적으로 동공 확장 검사를 통해 안저를 검사하여 드루젠이나 색소 변화를 확인합니다. OCT 등의 영상 진단법은 망막의 고해상도 단면 영상을 제공하여, 질환의 조기 발견 및 진행 상황의 경과 관찰을 가능하게 합니다. 또한, 안저 자가형광 검사나 플루오레세인 형광 안저 조영 검사도 망막의 건강 상태를 평가하고, 건성 AMD와 습성 AMD를 구별하기 위해 사용되기도 합니다. 진단 정확도를 높이고 조기 개입을 촉진하기 위해, 인공지능(AI)을 활용한 도구가 진단 워크플로우에 통합되는 사례가 늘고 있습니다.

현재 건성 노인성 황반변성(AMD)의 치료 현황

건성 AMD의 치료 옵션은 기존에 제한적이었으며, 주로 병변의 진행을 늦추는 데 중점을 두었고, 손상을 회복시키는 데는 중점을 두지 않았습니다. 질병 진행 위험을 줄이기 위해, 중간기에는 AREDS 연구의 배합(비타민 C, 비타민 E, 아연, 구리, 루테인, 제아잔틴)을 기반으로 한 영양 보충제 섭취가 일반적으로 권장됩니다. 최근에는 보체 억제제 등의 표적 치료제가 등장하면서, 지리적 위축에 대한 최초의 질환 수정 치료법이 제공되게 되었습니다. 저시력 보조기구나 생활 습관 개선(금연, 건강한 식습관 등)을 포함한 지지 요법은 여전히 치료에 있어 필수적인 요소입니다. 유전자 치료 및 재생 의학에 대한 지속적인 연구를 통해 치료의 전망이 더욱 크게 변화할 것으로 기대됩니다.

건성 노화성 황반변성(AMD)의 역학

건성 연령 관련 황반변성(AMD)의 역학 분석 및 예측에 관한 주요 조사 결과

  • 2025년, 주요 7개국에서 AMD 환자 수는 약 7,210만 3,000명이었습니다. 이러한 사례 수는 2036년까지 증가할 것으로 예측됩니다.
  • AMD의 병기별 유병자 수에서 초기 및 중기 단계가 주요 비중을 차지하고 있습니다. 2025년 기준으로, 미국 내 말기 환자 수는 약 1,846,500명이었습니다.
  • 미국에서 2025년 연령별 지리적 위축증의 총 환자 수는 64세 이하 연령층에서 7만 7,570건이었습니다.
  • 조기 및 중기 AMD는 주로 65-84세 연령대에서 발생하는 것으로 관찰되고 있습니다. 미국에서는 2025년 65-84세 연령층에서 조기 및 중기 AMD의 연령별 총 환자 수가 약 502만 4,900건이었습니다. <=64세 연령대에서 약 502만 4,900건이었습니다.

건성 연령 관련 황반변성(AMD) 시장 전망

건성 연령 관련 황반변성(AMD)의 치료는 그동안 주로 영양 보충제(예: AREDS 제제), 생활 습관 개선, 그리고 질병의 진행을 늦추고 증상을 관리하기 위한 시각 보조 기구와 같은 대증 요법에 국한되어 왔습니다. 승인된 치료법으로는 아바신카프타드 페골(IZERVAY)과 페그세타코플란(SYFOVRE)이 있으며, 둘 다 보체 캐스케이드를 표적으로 합니다. 이러한 치료법은 지리적 위축의 진행을 늦춤으로써 기전에 기반한 치료로의 패러다임 전환을 나타내지만, 상실된 시력을 회복시킬 수는 없으며 정기적인 유리체 내 투여가 필요합니다.

건성 AMD 치료법 개발은 급속도로 진화하고 있으며, 보체 억제를 넘어선 새로운 생물학적 경로에 초점을 맞춘 치료법이 등장하고 있습니다. 틴라레반트(LBS-008)는 망막 내 유독한 비타민 A 대사 산물의 축적을 줄이도록 설계된 경구용 치료제로, 이를 통해 망막 변성의 주요 원인을 해결합니다. 마찬가지로, 길데우레티놀 아세테이트(ALK-001)는 비타민 A의 이량체화를 표적으로 하여 유해한 망막 침착물의 형성을 방지합니다. AVD-104는 당 면역 조절을 통해 염증을 완화하고 망막 세포를 보호합니다. 이러한 치료법들은 대사 경로나 염증 경로를 표적으로 하는 혁신적인 작용기전에 더해, 경구 투여 및 비침습적인 치료 옵션으로의 전환을 부각시키고 있습니다.

전반적으로, 승인된 보체 억제제와 다양한 표적 치료제 파이프라인의 등장은 건성 AMD에서 대증 요법에서 질병 수정 전략으로의 중요한 전환을 의미합니다. 임상시험 설계의 개선을 통해 2022년부터 2036년에 걸쳐 주요 7개국 시장 전반에서 혁신과 시장 확대가 촉진되어, 기존 제품 및 파이프라인 후보에 대해 큰 상업적 기회가 창출될 것으로 예측됩니다.

  • 생물학적 제제: IZERVAY나 SYFOVRE와 같은 승인된 치료법은 큰 진전을 상징합니다. 이러한 유리체 내 투여 요법은 보체 단백질(각각 C5 및 C3)을 억제하여 만성 망막 염증을 완화하는 동시에 지리적 위축의 병변 진행을 늦춥니다.
  • 저분자 화합물: Tinlarebant(LBS-008) 및 아세트산 길데우레티놀(ALK-001)과 같은 새로운 파이프라인 치료법은 시각 주기의 조절과, 망막 손상의 원인 중 하나인 비타민 A의 유독한 대사 산물 저감에 초점을 맞추었습니다. AVD-104는 염증 조절과 망막 세포 보호를 목적으로 독자적인 당면역학적 접근법을 도입하고 있습니다. 이러한 치료법에는 치료 부담 경감이나 질환의 초기 단계에서의 적용 범위 확대와 같은 잠재적인 이점이 있습니다.

전반적으로, 건성 AMD 분야의 혁신은 보체 억제와 상호 보완적인 생물학적 경로에 작용하는 대사 및 망막 보호 전략의 결합을 통해 추진되고 있습니다. 이러한 치료법들이 임상 개발을 진행하며 주요 시장으로 확대됨에 따라, 치료 패러다임을 대증요법에서 지속적 질환 수정 치료로 전환하고, 오랫동안 충족되지 않았던 의료적 요구를 해결하며, 견실한 시장 성장을 뒷받침할 것으로 기대됩니다.

자주 묻는 질문

  • 2025년 건성 노화성 황반변성(AMD) 시장 규모는 어떻게 되나요?
  • 2036년 건성 노화성 황반변성(AMD) 시장 규모 전망은 어떻게 되나요?
  • 건성 노화성 황반변성(AMD)의 연평균 성장률(CAGR)은 어떻게 되나요?
  • 건성 노화성 황반변성(AMD) 환자의 주요 위험 요인은 무엇인가요?
  • 현재 건성 노화성 황반변성(AMD) 치료 현황은 어떤가요?
  • 건성 노화성 황반변성(AMD) 시장을 주도하는 주요 요인은 무엇인가요?
  • 건성 노화성 황반변성(AMD) 치료법의 발전 방향은 어떻게 되나요?

목차

제1장 주요 인사이트

제2장 서론

제3장 주요 요약

제4장 주요 이벤트

제5장 건성 황반변성(AMD) : 역학 및 시장 조사 방법

제6장 건성 황반변성(AMD) : 시장 개요

제7장 건성 황반변성(AMD) : 질환 배경과 개요

제8장 건성 황반변성(AMD) : 역학 및 환자 인구

제9장 건성 황반변성(AMD) : 환자 경과

제10장 시판 치료제

제11장 신흥 치료법

제12장 건성 황반변성(AMD) : 주요 7개국 분석

제13장 건성 황반변성(AMD) : 미충족 요구

제14장 건성 황반변성(AMD) : SWOT 분석

제15장 건성 황반변성(AMD) : KOL(Key Opinion Leader)의 견해

제16장 건성 황반변성(AMD) : 시장 참여 및 상환

제17장 부록

제18장 DelveInsight의 서비스 내용

제19장 면책사항

제20장 DelveInsight에 대해

LSH 26.07.27

Dry Age-related Macular Degeneration (AMD) Insights and Trends

  • According to DelveInsight's analysis, the Dry AMD market size was found to be ~USD 2,150 million in the 7MM (the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan) in 2025.
  • Dry AMD may progress to geographic atrophy, leading to irreversible vision loss due to degeneration of the retinal pigment epithelium (RPE), photoreceptors, and choriocapillaris in the macula. Therefore, early diagnosis, regular monitoring, and lifestyle modifications are critical to delay disease progression and support comprehensive disease management.
  • In 2025, the total number of prevalent cases of geographic atrophy was ~831,000 in the US. These cases are projected to increase by 2036.
  • In the US, the total age-specific cases of geographic atrophy were the highest in the age group 85+ years followed by 65-84 years and <=64 years age group in 2025.
  • The FDA's approval of Pegcetacoplan (SYFOVRE) and Avacincaptad pegol (IZERVAY) marks a significant advancement, establishing complement system modulation as a promising therapeutic avenue for mitigating the progression of geographic atrophy in AMD.
  • The majority of pipeline candidates for dry AMD target geographic atrophy, an advanced stage, rather than focusing on the early and intermediate stages.
  • ANX007, the inaugural therapeutic contender for treating geographic atrophy, achieves PRIME designation in the EU.
  • Emerging companies such as Belite Bio, Alkeus Pharmaceuticals, Aviceda Therapeutics, Allegro Ophthalmics, and Johnson & Johnson Innovative Medicine are actively shaping the dry AMD pipeline through innovative therapies.

Dry Age-related Macular Degeneration (AMD) Market Size and Forecast in the 7MM

  • 2025 Dry AMD Market Size: ~2,150 million
  • 2036 Projected Dry AMD Market Size: 14,500 million
  • Dry AMD Growth Rate (2026-2036): ~19.2 CAGR

DelveInsight's 'Dry Age-related Macular Degeneration (AMD) - Market Insights, Epidemiology and Market Forecast - 2036' report delivers an in-depth understanding of dry AMD, historical and forecasted epidemiology, as well as the dry AMD market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

The Dry AMD market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates dry AMD patient burden trends, revenue & market share dynamics, peak patient share & therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in dry AMD and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.

Key Factors Driving the Dry Age-related Macular Degeneration (AMD) Market

  • Aging Global Population

Dry AMD predominantly affects people aged 60+ and especially 85+. The rapid growth of the elderly population globally is directly increasing the patient pool.

  • Rising Disease Prevalence & Risk Factors

Dry AMD already accounts for ~85-90% of all AMD cases, amplifying market size. Growth in geographic atrophy (advanced dry AMD) further expands treatment demand.

  • Improved Diagnostic Technologies

Advanced imaging tools such as Optical Coherence Tomography (OCT) and Fundus imaging enable earlier and more accurate diagnosis, increasing the number of treated patients .

Dry Age-related Macular Degeneration (AMD) Understanding and Treatment Algorithm

Dry Age-related Macular Degeneration (AMD) Overview and Diagnosis

Dry AMD is a chronic, progressive retinal disorder that primarily affects the macula, the central part of the retina responsible for sharp, detailed vision. It is the most common form of age-related macular degeneration. The condition is characterized by the accumulation of extracellular deposits called drusen beneath the retina and gradual degeneration of retinal pigment epithelium (RPE) cells. Over time, this leads to central vision loss, impacting activities such as reading, driving, and recognizing faces. Advanced stages may progress to geographic atrophy, a severe form marked by irreversible retinal cell loss. Risk factors include aging, smoking, genetic predisposition, and cardiovascular conditions.

Diagnosis of dry AMD relies on comprehensive ophthalmic evaluation and advanced imaging techniques. Eye care specialists typically use dilated fundus examination to identify drusen and pigmentary changes. Imaging modalities such as OCT provide high-resolution cross-sectional images of the retina, enabling early detection and monitoring of disease progression. Fundus autofluorescence and fluorescein angiography may also be used to assess retinal health and differentiate between dry and wet AMD. Increasingly, artificial intelligence-based tools are being integrated into diagnostic workflows to improve accuracy and facilitate earlier intervention.

Current Dry Age-related Macular Degeneration (AMD) Treatment Landscape

Treatment options for dry AMD have historically been limited, focusing mainly on slowing disease progression rather than reversing damage. Nutritional supplementation based on the AREDS Study formulation (vitamins C and E, zinc, copper, lutein, and zeaxanthin) is commonly recommended for intermediate stages to reduce progression risk. Recently, targeted therapies such as complement inhibitors have emerged, offering the first disease-modifying approaches for geographic atrophy. Supportive measures, including low-vision aids and lifestyle modifications (e.g., smoking cessation and healthy diet), remain essential components of care. Ongoing research into gene therapy and regenerative treatments is expected to further transform the therapeutic landscape.

Dry Age-related Macular Degeneration (AMD) Unmet Needs

The section "unmet needs of dry AMD" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Lack of research regarding pathophysiology

2. Lack of clinical endpoints

3. Functional impact of dry AMD on patient's quality of life (QoL)

4. Inadequate risk stratification, and others.....

Dry Age-related Macular Degeneration (AMD) Epidemiology

Key Findings from Dry Age-related Macular Degeneration (AMD) Epidemiological Analysis and Forecast

  • In 2025, the total prevalent cases of AMD were ~72,103,000 in the 7MM. These cases are projected to increase by 2036.
  • The early and intermediate stages of AMD are major contributors among the stage-specific prevalent cases of AMD. In 2025, the late stage accounted for ~1,846,500 cases in the US.
  • In the US, the total age-specific cases of geographic atrophy were 77,570 in the <=64 years age group in 2025.
  • It is observed that early and intermediate AMD occurs majorly in the age group of 65-84 years. In the US, the total age-specific cases of early and intermediate AMD were ~5,024,900 in the <=64 years in 2025.

Dry Age-related Macular Degeneration (AMD) Drug Analysis & Competitive Landscape

The dry AMD drug chapter provides a detailed, market-focused review of the emerging pipeline across Phase III-II/III clinical trials and preclinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the dry AMD treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the dry AMD therapeutics market.

Approved Therapies for Dry Age-related Macular Degeneration (AMD)

Avacincaptad pegol (IZERVAY): Astellas Pharma and Iveric Bio

Avacincaptad pegol (IZERVAY) is a novel ophthalmic therapy developed by Iveric Bio and later commercialized under Astellas Pharma following its acquisition of Iveric Bio in 2023. It is an RNA aptamer-based drug designed for the treatment of geographic atrophy. The drug received US FDA approval in August 2023, marking a significant milestone as one of the first disease-modifying therapies targeting dry AMD progression. Avacincaptad pegol is administered as a monthly intravitreal injection into the affected eye. Its approval was based on Phase III trials (GATHER1 and GATHER2), which demonstrated a statistically significant reduction in the rate of geographic atrophy lesion growth compared with sham treatment.

Pegcetacoplan (SYFOVRE): Apellis Pharmaceuticals

Pegcetacoplan (SYFOVRE) is a first-in-class complement inhibitor approved for the treatment of geographic atrophy. It targets complement component C3, a central protein in the complement cascade. Administered via intravitreal injection either monthly or every other month, SYFOVRE demonstrated clinically meaningful reductions in GA lesion growth in Phase III (OAKS and DERBY) trials, with increasing efficacy observed over time. While it does not restore lost vision, it significantly slows disease progression.

Dry Age-related Macular Degeneration (AMD) Pipeline Analysis

Tinlarebant (LBS-008): Belite Bio

Tinlarebant is a novel oral therapy that is intended to reduce the accumulation of vitamin A-based toxins (known as bisretinoids) that contribute to disease progression in geographic atrophy. Bisretinoids are by-products of the visual cycle, which is dependent on the supply of vitamin A (retinol) to the eye. Tinlarebant works by reducing and maintaining levels of serum retinol binding protein 4 (RBP4), the sole carrier protein for retinol transport from the liver to the eye.

Gildeuretinol acetate (ALK-001): Alkeus Pharmaceuticals

Oral gildeuretinol acetate (ALK-001) is a new molecular entity designed to reduce the dimerization of vitamin A without modulating the visual cycle. Gildeuretinol is being evaluated in clinical trials for the treatment of Stargardt disease and has been studied for geographic atrophy secondary to age-related macular degeneration.

Dry Age-related Macular Degeneration (AMD) Key Players, Market Leaders and Emerging Companies

  • Astellas Pharma/Iveric Bio
  • Apellis Pharmaceuticals
  • Belite Bio
  • Alkeus Pharmaceuticals
  • Aviceda Therapeutics
  • Allegro Ophthalmics
  • Johnson & Johnson Innovative Medicine, and others

Dry Age-related Macular Degeneration (AMD) Drug Updates

  • In December 2025, Alkeus Pharmaceuticals announced that data from its clinical studies of investigational oral gildeuretinol for the treatment of geographic atrophy will be presented at the 13th International FLORetina ICOOR Congress at the Fortezza de Basso in Florence, Italy.
  • In July 2025, Alkeus Pharmaceuticals announced that data from its clinical studies of investigational oral gildeuretinol for the treatment of geographic atrophy secondary to age-related macular degeneration (SAGA) will be presented during the American Society of Retina Specialists (ASRS) 43rd Annual Scientific Meeting.
  • In February 2025, Alkeus Pharmaceuticals announced that results from its clinical studies of investigational oral gildeuretinol for the treatment of geographic atrophy secondary to age-related macular degeneration (SAGA) will be presented at the 48th Annual Meeting of the Macula Society.

Dry Age-related Macular Degeneration (AMD) Market Outlook

The treatment landscape for dry AMD has historically been limited to supportive care, primarily involving nutritional supplementation (e.g., AREDS formulations), lifestyle modifications, and visual aids to slow disease progression and manage symptoms. The approved therapies consist of Avacincaptad pegol (IZERVAY) and Pegcetacoplan (SYFOVRE), both targets the complement cascade. These therapies represent a paradigm shift toward mechanism-based treatment by slowing the progression of geographic atrophy, although they do not restore lost vision and require regular intravitreal administration.

The pipeline for dry AMD is rapidly evolving, with emerging therapies focusing on novel biological pathways beyond complement inhibition. Tinlarebant (LBS-008) is an oral therapy designed to reduce the accumulation of toxic vitamin A byproducts in the retina, thereby addressing a key driver of retinal degeneration. Similarly, Gildeuretinol acetate (ALK-001) targets vitamin A dimerization to prevent the formation of harmful retinal deposits. AVD-104 utilizes glycoimmune modulation to reduce inflammation and protect retinal cells. These therapies highlight a shift toward oral and less invasive treatment options, alongside innovative mechanisms targeting metabolic and inflammatory pathways.

Overall, the emergence of both approved complement inhibitors and a diverse pipeline of targeted therapies marks a significant transition from supportive care to disease-modifying strategies in dry AMD. Improved trial design is expected to drive innovation and market expansion across the 7MM from 2022 to 2036, yielding significant commercial opportunities for existing products and pipeline candidates.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Dry Age-related Macular Degeneration (AMD) (2022-2036 Forecast)

The dry AMD market (2022-2036 forecast) is increasingly transitioning toward mechanism-based therapies that target core disease pathways such as complement-mediated inflammation, retinal toxicity, and metabolic dysfunction. The market consists of small molecules and biologics.

  • Biologics: Approved therapies such as IZERVAY and SYFOVRE represent a major advancement. These intravitreal therapies inhibit complement proteins (C5 and C3, respectively), reducing chronic retinal inflammation and slowing lesion growth in geographic atrophy.
  • Small molecules: The emerging pipeline therapies such as Tinlarebant (LBS-008) and Gildeuretinol acetate (ALK-001), focus on modulating the visual cycle and reducing toxic vitamin A byproducts that contribute to retinal damage. AVD-104 introduces a differentiated glycoimmune approach aimed at controlling inflammation and protecting retinal cells. These therapies offer the potential advantage of reduced treatment burden and broader applicability across earlier disease stages.

Overall, innovation in dry AMD is being driven by a combination of complement inhibition and metabolic/retinal protection strategies acting on complementary biological pathways. As these therapies advance through clinical development and expand across major markets, they are expected to move the treatment paradigm beyond supportive care toward sustained disease modification, addressing longstanding unmet needs and supporting robust market growth.

Dry Age-related Macular Degeneration (AMD) Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the dry AMD drug's uptake, performance at peak, factors affecting performance during prime years of growth, patient uptake by therapy, and anticipated sales generated by each drug.

During the forecast period, approved therapies such as IZERVAY and SYFOVRE are expected to witness increasing uptake as foundational treatments for geographic atrophy. Their adoption is primarily driven by their ability to slow disease progression through complement inhibition (C5 and C3 pathways, respectively).

Among emerging therapies, Tinlarebant (LBS-008) is expected to gain strong traction due to its oral administration and mechanism targeting vitamin A metabolism, offering a less invasive alternative with potential use in earlier-stage disease. Similarly, Gildeuretinol acetate (ALK-001) is projected to show promising uptake driven by its disease-modifying potential in reducing retinal toxicity. Overall uptake will depend on clinical efficacy, safety outcomes, and positioning alongside standard of care therapies.

Dry Age-related Macular Degeneration (AMD) Therapies Price Scenario & Trends

Pricing and analogue assessment of dry AMD therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and the understanding of how pricing influences market access, adherence, and long-term uptake.

Industry Experts and Physician Views for Dry Age-related Macular Degeneration (AMD)

To keep up with dry AMD market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the dry AMD emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in dry AMD, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 15+ KOLs to gather insights at the country level. Centers such as the Department of Ophthalmology at NYU Grossman School of Medicine, Saint John's Health Center, and Clinical Research at Sierra Eye Associates, etc. were contacted. Their opinion helps understand and validate current and emerging dry AMD therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in dry AMD.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of dry AMD, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are majorly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of dry AMD, explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the dry AMD market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM dry AMD market.

Report Insights

  • Dry AMD Patient Population Forecast
  • Dry AMD Therapeutics Market Size
  • Dry AMD Pipeline Analysis
  • Dry AMD Market Size and Trends
  • Dry AMD Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-Enabled Market Research Report
  • 11-Year Forecast
  • Dry AMD Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (By Geography)
  • Dry AMD Treatment Addressable Market (TAM)
  • Dry AMD Competitive Landscape
  • Dry AMD Major Companies Insights
  • Dry AMD Price Trends and Analogue Assessment
  • Dry AMD Therapies Drug Adoption/Uptake
  • Dry AMD Therapies Peak Patient Share Analysis

Report Assessment

  • Dry AMD Current Treatment Practices
  • Dry AMD Unmet Needs
  • Dry AMD Clinical Development Analysis
  • Dry AMD Emerging Drugs Product Profiles
  • Dry AMD Market attractiveness
  • Dry AMD Qualitative Analysis (SWOT and conjoint analysis)

FAQs:

Market Insights

  • What was the dry AMD market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of dry AMD?
  • What are the disease risks, burdens, and unmet needs of dry AMD? What will be the growth opportunities across the 7MM concerning the patient population with dry AMD?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of dry AMD? What are the current guidelines for treating dry AMD in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the dry AMD market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarize and simplify complex datasets with in the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Upcoming Key Catalyst
  • 4.2. Key Conferences And Meetings
  • 4.3. Key Transactions And Collaborations
  • 4.4. News Flow

5. Epidemiology and Market Methodology of Dry Age-related Macular Degeneration (AMD)

6. Dry Age-related Macular Degeneration (AMD) Market Overview at a Glance

  • 6.1. Emerging Landscape Analysis (By Molecule Type, Phase, and Route of Administration [ROA])
  • 6.2. Market Share of Dry Age-related Macular Degeneration (AMD) By Therapies (%) in the 7MM in 2026
  • 6.3. Market Share of Dry Age-related Macular Degeneration (AMD) By Therapies (%) in the 7MM in 2036

7. Disease Background And Overview of Dry Age-related Macular Degeneration (AMD)

  • 7.1. Introduction
  • 7.2. Causes
  • 7.3. Signs And Symptoms
  • 7.4. Diagnosis
    • 7.4.1. Differential Diagnosis
    • 7.4.2. Diagnostic Algorithm
  • 7.5. Treatment and Management
    • 7.5.1. Treatment Algorithm

8. Epidemiology and Patient Population of Dry Age-related Macular Degeneration (AMD)

  • 8.1. Key Findings
  • 8.2. Assumption and Rationale
  • 8.3. Total Prevalent Cases of Dry Age-related Macular Degeneration (AMD) in the 7MM
  • 8.4. The United States
    • 8.4.1. Total Prevalent Cases of AMD in the United States
    • 8.4.2. Stage-specific Prevalent Cases of AMD in the United States
    • 8.4.3. Total Prevalent Cases of Geographic Atrophy in the United States
    • 8.4.4. Total Prevalent Cases of Dry AMD in the United States
    • 8.4.5. Total Diagnosed Prevalent Cases of Dry AMD in the United States
    • 8.4.6. Age-specific Cases of Early and Intermediate AMD in the United States
    • 8.4.7. Age-specific Cases of Geographic Atrophy in the United States
    • 8.4.8. Geographic Atrophy Cases by Visual Impairment in the United States
  • 8.5. EU4 and the UK
    • 8.5.1. Total Prevalent Cases of AMD in the EU4 and the UK
    • 8.5.4. Stage-specific Prevalent Cases of AMD in the EU4 and the UK
    • 8.5.5. Total Prevalent Cases of Geographic Atrophy in the EU4 and the UK
    • 8.5.5. Total Prevalent Cases of Dry AMD in the EU4 and the UK
    • 8.5.5. Total Diagnosed Prevalent Cases of Dry AMD in the EU4 and the UK
    • 8.5.5. Age-specific Cases of Early and Intermediate AMD in the EU4 and the UK
    • 8.5.5. Age-specific Cases of Geographic Atrophy in the EU4 and the UK
    • 8.5.5. Geographic Atrophy Cases by Visual Impairment in the EU4 and the UK
  • 8.6. Japan
    • 8.6.1. Total Prevalent Cases of AMD in Japan
    • 8.6.2. Stage-specific Prevalent Cases of AMD in Japan
    • 8.6.5. Total Prevalent Cases of Geographic Atrophy in Japan
    • 8.6.5. Total Prevalent Cases of Dry AMD in Japan
    • 8.6.5. Total Diagnosed Prevalent Cases of Dry AMD in Japan
    • 8.6.5. Age-specific Cases of Early and Intermediate AMD in Japan
    • 8.6.5. Age-specific Cases of Geographic Atrophy in Japan
    • 8.6.5. Geographic Atrophy Cases by Visual Impairment in Japan

9. Patient Journey of Dry Age-related Macular Degeneration (AMD)

10. Marketed Therapies

  • 10.1. Competitive Landscape of Marketed Therapies
  • 10.2. Avacincaptad pegol (IZERVAY): Astellas Pharma and Iveric Bio
    • 10.2.1. Product Description
    • 10.2.2. Regulatory Milestones
    • 10.2.3. Other Developmental Activities
    • 10.2.4. Summary of Pivotal Trials
    • 10.2.5. Analyst Views
  • 10.3. Pegcetacoplan (SYFOVRE): Apellis Pharmaceuticals
    • 10.3.1. Product Description
    • 10.3.2. Regulatory Milestones
    • 10.3.3. Other Developmental Activities
    • 10.3.4. Summary of Pivotal Trials
    • 10.3.5. Analyst Views

11. Emerging Therapies

  • 11.1. Competitive Landscape of Emerging Therapies
  • 11.2. Tinlarebant (LBS-008): Belite Bio
    • 11.2.1. Product Description
    • 11.2.2. Other Developmental Activities
    • 11.2.3. Clinical Development
      • 11.2.3.1. Clinical Trial Information
    • 11.2.4. Safety and Efficacy
    • 11.2.5. Analyst Views
  • 11.3. Gildeuretinol acetate (ALK-001): Alkeus Pharmaceuticals
    • 11.3.1. Product Description
    • 11.3.2. Other Developmental Activities
    • 11.3.3. Clinical Development
      • 11.3.3.1. Clinical Trial Information
    • 11.3.4. Safety and Efficacy
    • 11.3.5. Analyst Views

12. Dry Age-related Macular Degeneration (AMD): Seven Major Market Analysis

  • 12.1. Key Findings
  • 12.2. Market Outlook of Dry Age-related Macular Degeneration (AMD)
  • 12.3. Conjoint Analysis of Dry Age-related Macular Degeneration (AMD)
  • 12.4. Key Market Forecast Assumptions
    • 12.4.1. Cost Assumptions
    • 12.4.2. Pricing Trends
    • 12.4.3. Analogue Assessment
    • 12.4.4. Launch Year and Therapy Uptakes
  • 12.5. Total Market Size of Dry Age-related Macular Degeneration (AMD) in the 7MM
  • 12.6. The United States
    • 12.6.1. Total Market Size of Dry Age-related Macular Degeneration (AMD) in the United States
    • 12.6.2. Market Size of Dry Age-related Macular Degeneration (AMD) by Therapies in the United States
  • 12.7. EU4 and the UK
    • 12.7.1. Total Market Size of Dry Age-related Macular Degeneration (AMD) in EU4 and the UK
    • 12.7.2. Market Size of Dry Age-related Macular Degeneration (AMD) by Therapies in EU4 and the UK
  • 12.8. Japan
    • 12.8.1. Total Market Size of Dry Age-related Macular Degeneration (AMD) in Japan
    • 12.8.2. Market Size of Dry Age-related Macular Degeneration (AMD) by Therapies in Japan

13. Unmet Needs of Dry Age-related Macular Degeneration (AMD)

14. SWOT Analysis of Dry Age-related Macular Degeneration (AMD)

15. KOL Views of Dry Age-related Macular Degeneration (AMD)

  • 15.1. Expert/KOL Interview Highlights

16. Market Access and Reimbursement of Dry Age-related Macular Degeneration (AMD)

  • 16.1. The US
  • 16.2. In EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. United Kingdom
  • 16.3. Japan
  • 16.4. Summary and Comparison of Market access and Pricing Policy Developments in 2025
  • 16.5. Market access and Reimbursement of Dry Age-related Macular Degeneration (AMD) Therapies

17. Appendix

  • 17.1. Bibliography
  • 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

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