세포 용해 : 시장 점유율 분석, 산업 동향, 통계, 성장 예측(2025-2030년)

The cell lysis market is valued at USD 4.02 billion in 2025 and is forecast to reach USD 6.05 billion by 2030, advancing at an 8.51% CAGR.

Sustained investment in single-cell omics, continuous bioprocessing, and automated sample-prep platforms anchors this growth trajectory. Broad adoption of gentle yet high-throughput lysis protocols supports expanding gene-therapy pipelines, while scalable mechanical systems protect product integrity in mammalian perfusion runs. Tight alignment with precision-medicine requirements has elevated lysis efficiency and reproducibility to core purchasing criteria. Companies are prioritizing closed, automated hardware to reduce contamination risk and accelerate regulatory filings. Meanwhile, environmental mandates that phase out cytotoxic detergents are steering procurement toward eco-compliant reagents and validated enzyme cocktails.

Global Cell Lysis Market Trends and Insights

Surge in Single-Cell Omics Sample-Prep Demand

Rapid growth in single-cell sequencing and proteomics has recalibrated lysis requirements toward extreme gentleness and contamination control. Advanced droplet and microwell platforms now process thousands of cells in parallel, demanding reagent formulations that preserve RNA and protein integrity for downstream barcoding. Vendors have responded with enzyme buffers tuned for sub-microliter reaction volumes and microfluidic hardware that shortens library-prep cycles to under 10 hours. Clinical labs now leverage these kits for minimal-invasive tumor profiling, expanding the addressable cell lysis market. Continuous feedback between reagent chemistry and consumable design accelerates protocol standardization, driving multi-site reproducibility and regulatory confidence.

Expanding Biologics & Biosimilars Pipeline

Patent expiries on blockbuster antibodies have triggered a manufacturing build-out that raises demand for large-volume, scalable lysis hardware capable of processing high-cell-density mammalian cultures. Asia-Pacific facilities contribute more than 4.7 million L of stainless and single-use capacity, reinforcing regional pull for robust homogenizers and microfluidizers. Regulatory pathways for biosimilars require validated, consistent release of intracellular product, incentivizing producers to adopt closed, automated lysis skids that integrate real-time monitoring. As continuous perfusion achieves titers above 1 g/L/day, gentle lysis becomes essential for maintaining glycosylation patterns and minimizing aggregation. Reagent suppliers benefit from multi-lot qualification programs that lock in long-term purchasing.

Stringent Bioprocess Validation & QA/QC Protocols

Increased FDA emphasis on real-time release tests forces manufacturers to prove lysis consistency across scales and environmental variables, lengthening development timelines and raising cost of goods. Advanced therapy developers must document viral integrity, impurity clearance, and residual-detergent profiles, often requiring multi-year comparability studies. Smaller firms without dedicated quality teams face steep barriers, reinforcing buyer preference for platforms with extensive validation dossiers and historical performance data.

Other drivers and restraints analyzed in the detailed report include:

1. Uptake of High-Throughput Automated Workflows
2. Growing Funding for Cell-Based Vaccines
3. High Capital Cost of Microfluidic Lysis Systems

For complete list of drivers and restraints, kindly check the Table Of Contents.

Segment Analysis

Reagents produced 52.35% of 2024 revenue as routine workflows rely on consumables for every batch, yet instruments are set to outpace with a 12.25% CAGR through 2030, underscoring their strategic importance to automated bioprocessing. Demand for smart homogenizers and bead-mill lysers is climbing as sponsors move toward 24/7 continuous operations that require minimal operator intervention. Ultrasonic disruptors now include embedded sensors that track cavitation intensity, ensuring protein integrity during high-throughput runs.

Instrument growth is also propelled by microfluidizers designed for gentle disruption of viral particles and engineered cells. Suppliers offering single-use flow-paths mitigate cross-contamination risks and streamline cleaning validation, creating long-term recurring revenue from cartridge sales. On the reagent side, enzyme cocktails tailored for plant or algal cells are gaining traction, while eco-friendly detergent replacements address Triton X-100 restrictions. Complete lysis kits integrate buffers, inhibitors, and protocols, enabling small labs to meet regulatory expectations without in-house method development.

Mammalian cells maintained 45.53% of 2024 demand, reflecting their centrality in monoclonal antibody and recombinant protein production. The cell lysis market size for mammalian cultures is projected to expand steadily as intensified perfusion bioreactors raise cell densities that require robust yet gentle disruption. Viral particles, however, represent the fastest-growing opportunity at a 16.85% CAGR, fueled by adeno-associated virus (AAV) and lentiviral vector programs in gene and cell therapy.

Viral-specific lysis protocols combine enzymatic digestion and low-shear microfluidics to preserve capsid integrity, a prerequisite for high infectious titers downstream. Microbial cells continue to supply enzymes and industrial metabolites, sustaining solid demand for bead-beating and high-pressure homogenization. Plant cells, driven by molecular-farming initiatives, open niche avenues for proprietary enzymes that break robust cell walls while maintaining glycoprotein quality.

The Cell Lysis Market is Segmented by Product Type (Instruments [Homogenizers, and More], and Reagents), Cell Type (Mammalian Cells, Microbial Cells, and More), Lysis Technique (Mechanical, Enzymatic, and More), Application (Protein Purification & Proteomics, and More), End User (Biotechnology & Biopharma Firms, and More), and Geography (North America, Europe, and More). The Market Forecasts are Provided in Terms of Value (USD).

Geography Analysis

North America captured 38.82% revenue in 2024, supported by a deep biopharmaceutical manufacturing base, significant NIH and BARDA funding, and an FDA framework that rewards validated automation. Large multi-site manufacturers deploy enterprise-wide specifications that harmonize lysis protocols across drug-substance and drug-product facilities. The United States continues to lead new-drug approvals in advanced therapies, reinforcing domestic demand for GMP-grade kits.

Asia-Pacific is forecast to achieve an 11.52% CAGR, driven by aggressive government incentives and rising CDMO activity. China's USD 4.17 billion biomanufacturing commitment for 2025 anchors multiple industrial parks that specify closed, automated lysis modules for monoclonal and gene-therapy programs. India expands as an alternative supply-chain hub, benefiting from policy alignment with the US BioSecure Act and large domestic talent pools. Regional producers target export-grade quality, elevating demand for systems with comprehensive validation packages.

Europe remains a pivotal market where stringent environmental policies shape purchasing decisions. The ban on Triton X-100 forces rapid transition to biodegradable detergents, placing early-mover suppliers at an advantage. Manufacturers adapt by certifying alternative surfactants and updating master batch records, a process that drives reagent sales but slows new-equipment procurement until qualification completes. Northern Europe's focus on circular economy principles encourages adoption of energy-efficient ultrasonic devices.

South America and the Middle East & Africa collectively represent smaller shares but register rising interest in decentralized diagnostic kits and local vaccine fill-finish plants. Brazil's public vaccine institutes allocate capital toward low-shear viral-lysis technology, while Gulf region free zones court CDMOs with tax incentives covering bioprocess equipment importation. Infrastructure constraints, however, temper near-term uptake of high-cost microfluidic instruments, aligning demand toward proven mechanical systems with flexible financing.

1. Thermo Fisher Scientific
2. Danaher
3. Merck
4. Beckton Dickinson
5. Bio-Rad Laboratories
6. Eppendorf
7. Roche
8. Takara Bio
9. QIAGEN
10. Miltenyi Biotec
11. Qsonica
12. Claremont BioSolutions
13. Microfluidics International Corp.
14. Labfreez Instruments Group Co.
15. Cell Signaling Technology
16. PerkinElmer (Revvity)
17. Agilent Technologies
18. Promega
19. New England Biolabs
20. Sigma-Aldrich (SAFC)
21. Illumina
22. Sartorius

Additional Benefits:

• The market estimate (ME) sheet in Excel format
• 3 months of analyst support

TABLE OF CONTENTS

1 Introduction

• 1.1 Study Assumptions & Market Definition
• 1.2 Scope of the Study

2 Research Methodology

3 Executive Summary

4 Market Landscape

• 4.1 Market Overview
• 4.2 Market Drivers
  • 4.2.1 Surge In Single-Cell Omics Sample-Prep Demand
  • 4.2.2 Expanding Biologics & Biosimilars Pipeline
  • 4.2.3 Uptake Of High-Throughput Automated Workflows
  • 4.2.4 Growing Funding For Cell-Based Vaccines
  • 4.2.5 Adoption Of Plant Molecular Farming Platforms
  • 4.2.6 CRISPR-Based Synthetic Biology Toolkits Requiring Gentle Lysis
• 4.3 Market Restraints
  • 4.3.1 Stringent Bioprocess Validation & QA/QC Protocols
  • 4.3.2 High Capital Cost Of Microfluidic Lysis Systems
  • 4.3.3 Cytotoxic Detergent Disposal & ESG Pressures
  • 4.3.4 Scale-Up Inefficiencies For Mammalian-Cell Intensification
• 4.4 Porter's Five Forces
  • 4.4.1 Threat of New Entrants
  • 4.4.2 Bargaining Power of Buyers
  • 4.4.3 Bargaining Power of Suppliers
  • 4.4.4 Threat of Substitutes
  • 4.4.5 Competitive Rivalry

5 Market Size & Growth Forecasts (Value, USD)

• 5.1 By Product Type
  • 5.1.1 Instruments
    • 5.1.1.1 Homogenizers
    • 5.1.1.2 Bead-mill Lyser
    • 5.1.1.3 Ultrasonic Disruptors
    • 5.1.1.4 Microfluidizers
    • 5.1.1.5 Centrifuges
  • 5.1.2 Reagents
    • 5.1.2.1 Detergent Kits
    • 5.1.2.2 Enzymes & Nucleases
    • 5.1.2.3 Chemical Buffers
    • 5.1.2.4 Complete Lysis Kits
• 5.2 By Cell Type
  • 5.2.1 Mammalian Cells
  • 5.2.2 Microbial Cells
  • 5.2.3 Plant Cells
  • 5.2.4 Viral Particles
  • 5.2.5 Others
• 5.3 By Lysis Technique
  • 5.3.1 Mechanical (Physical)
  • 5.3.2 Chemical / Detergent
  • 5.3.3 Enzymatic
  • 5.3.4 Osmotic Shock
• 5.4 By Application
  • 5.4.1 Protein Purification & Proteomics
  • 5.4.2 Nucleic-Acid Extraction & Genomics
  • 5.4.3 Cell-Based Vaccines
  • 5.4.4 Drug Discovery & Screening
  • 5.4.5 Diagnostics
• 5.5 By End User
  • 5.5.1 Biotechnology & Biopharma Firms
  • 5.5.2 Contract Research & Manufacturing Organizations (CRO/CMO)
  • 5.5.3 Academic & Research Labs
  • 5.5.4 Clinical Diagnostics Centers
  • 5.5.5 Others
• 5.6 Geography
  • 5.6.1 North America
    • 5.6.1.1 United States
    • 5.6.1.2 Canada
    • 5.6.1.3 Mexico
  • 5.6.2 Europe
    • 5.6.2.1 Germany
    • 5.6.2.2 United Kingdom
    • 5.6.2.3 France
    • 5.6.2.4 Italy
    • 5.6.2.5 Spain
    • 5.6.2.6 Rest of Europe
  • 5.6.3 Asia-Pacific
    • 5.6.3.1 China
    • 5.6.3.2 Japan
    • 5.6.3.3 India
    • 5.6.3.4 South Korea
    • 5.6.3.5 Australia
    • 5.6.3.6 Rest of Asia-Pacific
  • 5.6.4 Middle East and Africa
    • 5.6.4.1 GCC
    • 5.6.4.2 South Africa
    • 5.6.4.3 Rest of Middle East and Africa
  • 5.6.5 South America
    • 5.6.5.1 Brazil
    • 5.6.5.2 Argentina
    • 5.6.5.3 Rest of South America

6 Competitive Landscape

• 6.1 Market Concentration
• 6.2 Market Share Analysis
• 6.3 Company Profiles (includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products & Services, and Recent Developments)
  • 6.3.1 Thermo Fisher Scientific Inc.
  • 6.3.2 Danaher Corporation
  • 6.3.3 Merck KGaA
  • 6.3.4 Becton, Dickinson & Company
  • 6.3.5 Bio-Rad Laboratories Inc.
  • 6.3.6 Eppendorf AG
  • 6.3.7 F. Hoffmann-La Roche Ltd
  • 6.3.8 Takara Bio Inc.
  • 6.3.9 QIAGEN NV
  • 6.3.10 Miltenyi Biotec
  • 6.3.11 Qsonica LLC
  • 6.3.12 Claremont BioSolutions LLC
  • 6.3.13 Microfluidics International Corp.
  • 6.3.14 Labfreez Instruments Group Co.
  • 6.3.15 Cell Signaling Technology Inc.
  • 6.3.16 PerkinElmer (Revvity)
  • 6.3.17 Agilent Technologies Inc.
  • 6.3.18 Promega Corporation
  • 6.3.19 New England Biolabs
  • 6.3.20 Sigma-Aldrich (SAFC)
  • 6.3.21 Illumina Inc.
  • 6.3.22 Sartorius AG

7 Market Opportunities & Future Outlook

• 7.1 White-space & Unmet-Need Assessment