크로마토그래피 레진 : 시장 점유율 분석, 산업 동향, 통계, 성장 예측(2025-2030년)

The Chromatography Resins Market size is estimated at USD 2.56 billion in 2025, and is expected to reach USD 3.62 billion by 2030, at a CAGR of 7.18% during the forecast period (2025-2030).

Steady growth reflects the segment's integral role in biopharmaceutical purification, where downstream steps still consume close to 60% of total drug-manufacturing costs Avantor. Heightened regulatory focus on product purity, rising adoption of continuous bioprocessing that needs high-flow resins, and widening therapeutic pipelines together lift demand. Capacity investments-such as Cytiva and Pall's USD 1.5 billion multiphase expansion-are shortening regional supply gaps and reinforcing secure sourcing strategies. At the same time, developers are moving toward synthetic matrices to gain reproducibility, while natural agarose grades gain niche momentum under sustainability mandates.

Global Chromatography Resins Market Trends and Insights

Rising Demand for Monoclonal-Antibody Production

Global mAb volumes keep climbing at a projected 13.23% CAGR to 2030, and resin consumption rises in parallel as antibody titers top 10 g/L, pushing Protein A beds to capacity limits. High-capacity alternatives such as Toyopearl GigaCap S-650M deliver dynamic binding above 90 g/L, more than doubling traditional media. Oncology indications account for 51% of therapeutic value, with autoimmune pipelines expanding fastest and broadening purification needs. North America retains 41.04% share of antibody output, yet Asia-Pacific advances at 13.24% CAGR, diversifying resin demand centers. In-vitro production now holds 78% of mAb supply, underscoring how downstream resin technology underwrites global access to biologics.

Expanding Vaccine Pipelines Across Emerging Markets

Post-pandemic capacity build-outs in India, China, Brazil and Indonesia keep vaccine demand buoyant, elevating need for resins that efficiently clear viral and plasmid impurities. Bio-Rad's CHT Ceramic Hydroxyapatite captures more than 75% of influenza and dengue viral particles while trimming host proteins by 90%. New ligands such as Repligen/Navigo's spike-protein affinity resin exemplify purpose-built solutions for mRNA and viral-vector vaccines. Regulatory agencies from EMA to WHO now stipulate robust viral clearance studies, driving resin developers to validate higher selectivity and flow robustness for large-scale vaccine platforms.

High Resin Procurement and Validation Cost

Protein A resin prices have climbed to USD 9,000-12,000 per liter, yet most products bind under 40 g/L, stressing budgets for both clinical and commercial runs. Lengthy lead times-often beyond 15 weeks-force firms to raise safety stocks and tie up working capital. Each supplier or lot change triggers comparability testing, extending timelines and requiring extensive documentation that inflates overall validation expenses. Smaller firms and emerging-market plants find it harder to absorb these costs, slowing domestic production scale-up.

Other drivers and restraints analyzed in the detailed report include:

1. Transition Toward Single-Use Downstream Systems
2. Regulatory Push for Higher-Purity Biologics
3. Scarcity of Skilled Downstream-Processing Professionals

For complete list of drivers and restraints, kindly check the Table Of Contents.

Segment Analysis

Synthetic-based materials represented 76.34% of 2024 revenue, reflecting manufacturers' preference for lot-to-lot consistency and high mechanical strength. Such characteristics enable taller columns, faster flow, and straightforward scale-up, vital to the chromatography resins market where production cycles continue to shorten. In contrast, natural media-chiefly agarose-retain gentler chemistries that safeguard labile proteins, positioning them for niche vaccines and gene-therapy vectors. The natural segment's 8.61% forecast CAGR signals renewed interest in renewable feedstocks and lower environmental footprints, especially in Europe where green- manufacturing incentives exist.

Adoption patterns illustrate a two-tier structure: multinationals install synthetic polymethacrylate beds for continuous antibody capture, whereas regional contract manufacturers expand capacity with agarose or cellulose for multi-product suites. The regulatory spotlight on adventitious-agent risk further pivots enterprise preference toward synthetics, yet biocompatibility concerns still pull natural grades into pediatric and cell-therapy pipelines. With both formats strengthening advanced ligand chemistries, competition will revolve less around base matrix and more around performance attributes such as dynamic capacity and alkaline stability in the chromatography resins market.

Ion-exchange resins accounted for 39.25% of 2024 sales, cementing a decades-long role across capture, intermediate, and polishing stages. Their broad operating window, scalability, and relative affordability suit virtually every therapeutic protein. However, mixed-mode and multimodal media are projected to compound at 8.25% annually, because combined ionic, hydrophobic, and hydrogen-bond interactions allow single-step removal of aggregates and host-cell proteins, trimming buffer usage and skid footprint.

Protein A columns remain essential for IgG capture despite premium pricing, while hydrophobic-interaction units mitigate aggregation in continuous polishing. Size-exclusion devices fulfill buffer exchange or desalting without shear, an area where the chromatography resins market size for this niche is projected to widen steadily with a 8.12% CAGR. Ligand-coupled custom solutions are steadily entering pilot scale, driven by bispecific antibodies and viral vectors. Process-intensification roadmaps suggest multimodal beds will increasingly displace sequential ion-exchange-plus-HIC operations, underscoring shifting value pools inside the chromatography resins market

The Chromatography Resins Market Report is Segmented by Origin (Natural-Based and Synthetic-Based), Technology (Ion Exchange Chromatography Resins, Affinity Chromatography Resins, and More), Product Type (Protein-A, Ion Exchange and More), End-User Industry (Pharmaceuticals, Water and Environmental Agencies, and More), and Geography (Asia-Pacific, North America, Europe, South America, and Middle-East and Africa).

Geography Analysis

North America led with a 42.75% revenue contribution in 2024 and mirrors the fastest regional CAGR at 8.48% through 2030. Aggressive investments-Cytiva and Pall's USD 1.5 billion program and Purolite's new Pennsylvania agarose plant-aim to shorten lead times and insulate bioprocess supply chains. FDA analytical guidelines that tightened in 2024 cascade global expectations for resin consistency, anchoring North America's status as regulatory reference hub.

Europe ranked second in value terms, combining long-standing GMP expertise with rising emphasis on sustainability. EMA process-validation rules force high-resolution separation and lean toward recyclable or lower-waste matrices. Investments such as Merck KGaA's EUR 300 million research hub in Darmstadt and Tosoh Bioscience's German expansion reinforce domestic supply. Green manufacturing incentives further nudge producers toward bio-based agarose and closed-loop solvent systems inside the chromatography resins market.

Asia-Pacific records the briskest structural expansion, spurred by Chinese, Japanese and Korean biologics programs as well as ASEAN vaccine initiatives. Tosoh's new Yokkaichi plant exemplifies capacity alignment with regional demand. Policymakers funnel grants into local mAb and cell-therapy plants, raising consumption of high-capacity resins as multinationals localize production. India and Indonesia add volume in pandemic- readiness stockpiles, extending the customer base for continuous-flow compatible media.

South America sees gradual build-up in Brazil and Argentina, focusing on public-health vaccine needs that increasingly seek dual-ligand mixed-mode beds for viral clearance. The Middle East and Africa remain nascent but exhibit pockets of growth around Gulf state pharma clusters pursuing insulin, plasma, and vaccine self-sufficiency. Collectively, non-OECD regions contribute modest shares today yet represent double-digit growth prospects, underscoring the globalization of the chromatography resins market.

1. Avantor, Inc
2. Bio-Rad Laboratories, Inc.
3. Bio-Works
4. Cytiva
5. Dupont
6. JSR Life Sciences, LLC
7. Kaneka Eurogentec S.A.
8. Merck KGaA
9. Mitsubishi Chemical Corporation
10. Purolite
11. Repligen Corporation
12. Sartorius Stedim Biotech
13. Sepax Technologies
14. Thermo Fisher Scientific
15. Thermo Vectorlabs

Additional Benefits:

• The market estimate (ME) sheet in Excel format
• 3 months of analyst support

TABLE OF CONTENTS

1 Introduction

• 1.1 Study Assumptions and Market Definition
• 1.2 Scope of the Study

2 Research Methodology

3 Executive Summary

4 Market Landscape

• 4.1 Market Overview
• 4.2 Market Drivers
  • 4.2.1 Rising demand for monoclonal-antibody (mAb) production
  • 4.2.2 Expanding vaccine pipelines across emerging markets
  • 4.2.3 Transition toward single-use downstream systems
  • 4.2.4 Regulatory push for higher-purity biologics
  • 4.2.5 Need for high-flow resins in continuous bioprocessing
• 4.3 Market Restraints
  • 4.3.1 High resin procurement and validation cost
  • 4.3.2 Scarcity of skilled downstream-processing professionals
  • 4.3.3 Competition from disposable membrane chromatography
• 4.4 Value Chain Analysis
• 4.5 Porter's Five Forces
  • 4.5.1 Bargaining Power of Suppliers
  • 4.5.2 Bargaining Power of Buyers
  • 4.5.3 Threat of New Entrants
  • 4.5.4 Threat of Substitutes
  • 4.5.5 Degree of Competition

5 Market Size and Growth Forecasts (Value)

• 5.1 By Origin
  • 5.1.1 Natural-based
    • 5.1.1.1 Agarose
    • 5.1.1.2 Cellulose
  • 5.1.2 Synthetic-based
    • 5.1.2.1 Silica Gel
    • 5.1.2.2 Aluminum Oxide
    • 5.1.2.3 Polystyrene
    • 5.1.2.4 Other Synthetic Based Resins
• 5.2 By Product Type
  • 5.2.1 Protein-A
  • 5.2.2 Ion-Exchange
  • 5.2.3 Mixed-Mode and Multimodal
  • 5.2.4 Hydrophobic-Interaction
  • 5.2.5 Size-Exclusion
  • 5.2.6 Ligand-Coupled Custom Resins
• 5.3 By Technology
  • 5.3.1 Affinity Chromotography Resins
  • 5.3.2 Ion-Exchange Chromotography Resins
  • 5.3.3 Hydrophobic-Interaction Chromotography Resins
  • 5.3.4 Size-Exclusion Chromotography Resins
  • 5.3.5 Other Technologies
• 5.4 By End-user Industry
  • 5.4.1 Pharmaceuticals
    • 5.4.1.1 Biotechnology
    • 5.4.1.2 Drug Discovery
    • 5.4.1.3 Drug Production
  • 5.4.2 Water and Environmental Agencies
  • 5.4.3 Food and Beverages
  • 5.4.4 Other End-user Industries
• 5.5 By Geography
  • 5.5.1 By Geography
    • 5.5.1.1 Asia-Pacific
    • 5.5.1.1.1 China
    • 5.5.1.1.2 Japan
    • 5.5.1.1.3 India
    • 5.5.1.1.4 South Korea
    • 5.5.1.1.5 ASEAN Countries
    • 5.5.1.1.6 Rest of Asia-Pacific
    • 5.5.1.2 North America
    • 5.5.1.2.1 United States
    • 5.5.1.2.2 Canada
    • 5.5.1.2.3 Mexico
    • 5.5.1.3 Europe
    • 5.5.1.3.1 Germany
    • 5.5.1.3.2 United Kingdom
    • 5.5.1.3.3 France
    • 5.5.1.3.4 Italy
    • 5.5.1.3.5 Spain
    • 5.5.1.3.6 Russia
    • 5.5.1.3.7 NORDIC Countries
    • 5.5.1.3.8 Rest of Europe
    • 5.5.1.4 South America
    • 5.5.1.4.1 Brazil
    • 5.5.1.4.2 Argentina
    • 5.5.1.4.3 Rest of South America
    • 5.5.1.5 Middle-East and Africa
    • 5.5.1.5.1 Saudi Arabia
    • 5.5.1.5.2 South Africa
    • 5.5.1.5.3 Rest of Middle-East and Africa

6 Competitive Landscape

• 6.1 Market Concentration
• 6.2 Strategic Moves
• 6.3 Market Share (%)/Ranking Analysis
• 6.4 Company Profiles (includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products and Services, and Recent Developments)
  • 6.4.1 Avantor, Inc
  • 6.4.2 Bio-Rad Laboratories, Inc.
  • 6.4.3 Bio-Works
  • 6.4.4 Cytiva
  • 6.4.5 Dupont
  • 6.4.6 JSR Life Sciences, LLC
  • 6.4.7 Kaneka Eurogentec S.A.
  • 6.4.8 Merck KGaA
  • 6.4.9 Mitsubishi Chemical Corporation
  • 6.4.10 Purolite
  • 6.4.11 Repligen Corporation
  • 6.4.12 Sartorius Stedim Biotech
  • 6.4.13 Sepax Technologies
  • 6.4.14 Thermo Fisher Scientific
  • 6.4.15 Thermo Vectorlabs

7 Market Opportunities and Future Outlook

• 7.1 White-space and unmet-need assessment