골다공증 치료제 시장 : 점유율 분석, 업계 동향과 통계, 성장 예측(2026-2031년)

According to Mordor Intelligence, the osteoporosis drugs market size is expected to grow from USD 16.88 billion in 2025 to USD 17.67 billion in 2026 and is forecast to reach USD 22.22 billion by 2031 at 4.68% CAGR over 2026-2031.

This report Segments the Industry Into by Drug Class (Bisphosphonates, Selective Estrogen Receptor Modulators (SERMs), and More), by Route of Administration (Oral, Intravenous, Others), and by Distribution Channel (Hospital Pharmacies, Retail Pharmacies & Drug Store, S and More), Geography (North America, Europe, Asia-Pacific, and More). The Market Forecasts are Provided in Terms of Value (USD).

Global Osteoporosis Drugs Market Trends and Insights

Ageing Population & Fracture-Risk Burden

Individuals aged 50 and above constitute the dominant risk group, and annual osteoporotic fractures are expected to reach 6.3 million by 2050, with Asia-Pacific carrying most of the future caseload. Hip-fracture mortality runs at 20% within 12 months, spurring demand for therapies that act quickly to rebuild bone and avert secondary fractures. In Japan, bone-density testing rates remain only 14% in rural hospitals despite 41% osteoporosis diagnoses, underscoring the diagnostic gap. Medicare spent USD 5.7 billion on fracture care for 1.8 million beneficiaries in 2016, and 80% of post-fracture patients still went untreated, highlighting cost pressures to expand access. These demographic forces cement a multi-year demand floor for every drugs class within the osteoporosis drugs market.

Rising Adoption of Anabolic Agents

Anabolic drugs such as teriparatide and abaloparatide achieve vertebral-fracture reductions of 65% and 86%, respectively, outperforming antiresorptives and attracting premium reimbursement medpagetoday.com. The FDA's 2024 expansion of abaloparatide to treat male patients increased the addressable pool by 12% in the United States managedhealthcareexecutive.com. Sequential regimens that start with romosozumab then transition to denosumab preserve fracture-risk reductions over five years ucb.com. Japanese real-world evidence confirms that high-risk cohorts receive romosozumab with cardiovascular monitoring, signifying clinical trust despite label warnings springer.com. Stronger insurance coverage and updated guidelines legitimize the anabolic first-line approach, enriching the osteoporosis drugs market.

Adverse Effects & Poor Long-Term Compliance

Average medication-possession ratios sit at only 61.9% after two years, and abrupt denosumab discontinuation triggers rebound bone resorption with a 20% higher fracture risk. Denosumab also shows hypocalcemia and dermatologic safety signals clustering in the first 30 days of use. Romosozumab carries boxed warnings for myocardial infarction and stroke; 0.8% of treated subjects experienced MI versus 0.3% on alendronate drugs.com. Bisphosphonate non-adherence still averages 23.3% in Japan despite monthly or quarterly dosing options. These compliance gaps shave growth from the osteoporosis drugs market, particularly in oral segments.

Other drivers and restraints analyzed in the detailed report include:

1. Surge in Monoclonal Antibody Use
2. AI-Enabled Primary-Care Fracture-Risk Screening
3. Patent Expiries Triggering Generic Erosion

For complete list of drivers and restraints, kindly check the Table Of Contents.

Segment Analysis

Bisphosphonates retained a 36.95% osteoporosis drugs market share in 2025, yet growth slowed to less than 1% annually as payers and physicians pivoted toward higher-value options. Sclerostin inhibitors, chiefly romosozumab, exhibited the fastest 5.06% CAGR as clinicians prioritized rapid bone-formation gains for severe-risk patients. RANKL inhibitors, anchored by denosumab, remained the top-selling biologic because six-month dosing supports adherence.

Selective estrogen receptor modulators held niche roles for women unable to tolerate bisphosphonates, while parathyroid hormone analogues served as bridge therapy before antiresorptive maintenance. Pipeline attention shifted to microRNA modulators and Wnt-signaling activators that promise dual bone-building and resorption-control profiles. Declining calcitonin use, owing to questionable efficacy, shortened product life-cycles and redirected R&D budgets toward next-generation biologics that can lengthen treatment duration and sustain the osteoporosis drugs market's value proposition.

Oral drugs still composed 65.05% of 2025 revenue because of generic alendronate's ubiquity, but injectables expanded at a 5.62% CAGR, reflecting biologic uptake. Denosumab's twice-yearly subcutaneous dosing and romosozumab's monthly regimen improved adherence relative to daily pills, particularly among elderly patients managing polypharmacy.

Home-health nurses and self-injection pens reduced hospital visits, while Medicare coverage for in-home injections lowered out-of-pocket costs. Intravenous zoledronic acid maintained relevance for patients seeking once-yearly dosing, yet its usage faced stiff rivalry from subcutaneous biologics. Research into hydrogel micro-depots that release anabolic peptides over 12 weeks could further tilt preferences toward minimally invasive delivery. Cold-chain logistics remained a bottleneck in emerging markets, but investment in passive shipping containers and pharmacy-grade refrigerators is narrowing the gap, unlocking new provincial sales for the osteoporosis drugs market.

Complete Report Scope:

• By Drug Class
  • Bisphosphonates
  • Selective Estrogen Receptor Modulators (SERMs)
  • Parathyroid Hormone Analogues
  • RANK Ligand Inhibitors
  • Calcitonin
  • Sclerostin Inhibitors
  • Others
• By Route of Administration
  • Oral
  • Intravenous
  • Subcutaneous
• By Distribution Channel
  • Hospital Pharmacies
  • Retail Pharmacies & Drug Stores
  • Online Pharmacies
• By Geography
  • North America
    • United States
    • Canada
    • Mexico
  • Europe
    • Germany
    • United Kingdom
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia-Pacific
    • China
    • Japan
    • India
    • South Korea
    • Australia
    • Rest of Asia-Pacific
  • South America
    • Brazil
    • Argentina
    • Rest of South America
  • Middle East and Africa
    • GCC
    • South africa
    • Rest of Middle East and Africa

Geography Analysis

North America preserved its 39.40% revenue share in 2025, anchored by broad insurance coverage, specialty pharmacist networks, and quick uptake of newly approved agents. The Centers for Medicare & Medicaid Services added osteoporosis to its 2025 Medication Therapy Management core list, which is expected to raise adherence and push additional refills into the osteoporosis drugs market. Canada's mandatory fracture registries began linking treatment reimbursement to guideline adherence, improving first-dose capture within 90 days of index fracture.

Asia-Pacific recorded the fastest 6.74% CAGR and is projected to overtake Europe in annual treatment volumes by 2029. Japan's universal coverage reimburses every approved osteoporosis regimen, yet under-diagnosis in rural prefectures leaves a latent cohort untapped. China's tertiary-hospital data show denosumab usage rising 78% year on year, supported by inclusion in the 2024 National Reimbursement Drug List. India's private-sector hospitals introduced bundled fracture-prevention packages that incorporate romosozumab starter doses, suggesting future tailwinds for the osteoporosis drugs market.

Europe remains a stable yet price-sensitive region. The European Medicines Agency now accepts real-world evidence for line-extensions, as seen in abaloparatide's 2024 authorization based on post-marketing data. National health technology assessment bodies negotiate steep discounts-up to 25%-for biologics entering regional formularies, restraining revenue growth but widening patient access. South America and the Middle East & Africa still account for single-digit shares yet post healthy mid-single-digit CAGRs as public-sector screening programs ramp and global NGOs subsidize bisphosphonate supplies. Improved cold-chain corridors are beginning to unlock biologic penetration, seeding long-term expansion for the osteoporosis drugs market.

List of Companies Covered in this Report:

1. Amgen
2. Apotex
3. Dr. Reddy's Laboratories
4. Eli Lilly and Company
5. Roche
6. GlaxoSmithKline
7. Jiangsu Hengrui Medicine Co. Ltd.
8. Kyowa Kirin
9. Merck
10. Novartis
11. Pfizer
12. Radius Health
13. Sanofi
14. Servier Laboratories
15. Sun Pharma Industries Ltd.
16. Takeda Pharmaceuticals
17. Teijin Pharma Ltd.
18. Teva Pharmaceutical Industries
19. UCB
20. Zhejiang Hisun Pharmaceutical Co. Ltd.

Additional Benefits:

• The market estimate (ME) sheet in Excel format
• 3 months of analyst support

TABLE OF CONTENTS

1 Introduction

2 Research Methodology

3 Executive Summary

4 Market Landscape

• 4.1 Market Overview
• 4.2 Market Drivers
  • 4.2.1 Aging Population & High Fracture-Risk Burden
  • 4.2.2 Adoption of Anabolic Agents
  • 4.2.3 National Osteoporosis Registries & Reimbursement Incentives
  • 4.2.4 Growing Awareness & Screening Programs
  • 4.2.5 Surge in Monoclonal Antibody Use
  • 4.2.6 Technological Advancements in Diagnostics & Digital Health
• 4.3 Market Restraints
  • 4.3.1 Adverse Effects & Poor Long-Term Compliance
  • 4.3.2 Regulatory Scrutiny for Approval
  • 4.3.3 Patent Expiries & Generic Competition
  • 4.3.4 Reimbursement & Pricing Constraints
• 4.4 Supply-Chain Analysis
• 4.5 Regulatory Landscape
• 4.6 Technological Outlook
• 4.7 Porter's Five Forces Analysis
  • 4.7.1 Threat of New Entrants
  • 4.7.2 Threat of Substitutes
  • 4.7.3 Bargaining Power of Suppliers
  • 4.7.4 Bargaining Power of Buyers
  • 4.7.5 Competitive Rivalry

5 Market Size & Growth Forecasts (Value in USD)

• 5.1 By Drug Class
  • 5.1.1 Bisphosphonates
  • 5.1.2 Selective Estrogen Receptor Modulators (SERMs)
  • 5.1.3 Parathyroid Hormone Analogues
  • 5.1.4 RANK Ligand Inhibitors
  • 5.1.5 Calcitonin
  • 5.1.6 Sclerostin Inhibitors
  • 5.1.7 Others
• 5.2 By Route of Administration
  • 5.2.1 Oral
  • 5.2.2 Intravenous
  • 5.2.3 Subcutaneous
• 5.3 By Distribution Channel
  • 5.3.1 Hospital Pharmacies
  • 5.3.2 Retail Pharmacies & Drug Stores
  • 5.3.3 Online Pharmacies
• 5.4 By Geography
  • 5.4.1 North America
    • 5.4.1.1 United States
    • 5.4.1.2 Canada
    • 5.4.1.3 Mexico
  • 5.4.2 Europe
    • 5.4.2.1 Germany
    • 5.4.2.2 United Kingdom
    • 5.4.2.3 France
    • 5.4.2.4 Italy
    • 5.4.2.5 Spain
    • 5.4.2.6 Rest of Europe
  • 5.4.3 Asia-Pacific
    • 5.4.3.1 China
    • 5.4.3.2 Japan
    • 5.4.3.3 India
    • 5.4.3.4 South Korea
    • 5.4.3.5 Australia
    • 5.4.3.6 Rest of Asia-Pacific
  • 5.4.4 South America
    • 5.4.4.1 Brazil
    • 5.4.4.2 Argentina
    • 5.4.4.3 Rest of South America
  • 5.4.5 Middle East and Africa
    • 5.4.5.1 GCC
    • 5.4.5.2 South africa
    • 5.4.5.3 Rest of Middle East and Africa

6 Competitive Landscape

• 6.1 Market Concentration
• 6.2 Market Share Analysis
• 6.3 Company Profiles {(includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products & Services, and Recent Developments)}
  • 6.3.1 Amgen Inc.
  • 6.3.2 Apotex Inc.
  • 6.3.3 Dr. Reddy's Laboratories Ltd.
  • 6.3.4 Eli Lilly and Company
  • 6.3.5 F. Hoffmann-La Roche Ltd.
  • 6.3.6 GSK plc
  • 6.3.7 Jiangsu Hengrui Medicine Co. Ltd.
  • 6.3.8 Kyowa Kirin Co., Ltd.
  • 6.3.9 Merck & Co., Inc.
  • 6.3.10 Novartis International AG
  • 6.3.11 Pfizer Inc.
  • 6.3.12 Radius Health Inc.
  • 6.3.13 Sanofi S.A.
  • 6.3.14 Servier Laboratories
  • 6.3.15 Sun Pharma Industries Ltd.
  • 6.3.16 Takeda Pharmaceutical Co. Ltd.
  • 6.3.17 Teijin Pharma Ltd.
  • 6.3.18 Teva Pharmaceutical Industries Ltd.
  • 6.3.19 UCB S.A.
  • 6.3.20 Zhejiang Hisun Pharmaceutical Co. Ltd.

7 Market Opportunities & Future Outlook

• 7.1 White-space & Unmet-need Assessment