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2형 당뇨병 : 시장 인사이트, 역학 및 시장 예측(2036년)

Type 2 Diabetes - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 200 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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2형 당뇨병(T2DM)에 대한 인사이트 및 동향

  • 2형 당뇨병(T2DM)은 인슐린 저항성과 진행성 β세포 기능 장애를 특징으로 하며, 지속적인 고혈당을 유발하는 만성 대사성 질환입니다. 1형 당뇨병과 달리, T2DM은 주로 인슐린 작용 장애로 인해 발병하며, 초기에는 인슐린 분비 증가로 보상되지만, 결국 β세포 기능 부전으로 이어집니다. 전 세계 환자 수의 증가는 고령화, 운동 부족, 고칼로리 식단 등 생활 습관의 변화에 의해 촉진되고 있으며, 이러한 요인들은 심각한 미세혈관 및 대혈관 합병증의 원인이 되고 있습니다.
  • 2형 당뇨병은 소아기를 포함해 모든 연령대에서 발병할 가능성이 있지만, 중장년층에서 많이 나타납니다. 발병 위험은 나이가 들수록, 특히 45세 이후에 높아지며, 당뇨병 가족력이나 과체중·비만이 있는 경우에도 높아집니다.
  • 4,000만 명 이상의 미국인이 당뇨병을 앓고 있으며, 이는 인구의 약 8명 중 1명에 해당합니다. 그중 약 90%-95%가 2형 당뇨병입니다. 2형 당뇨병은 45세 이상에서 가장 많이 발병하지만, 소아, 사춘기, 젊은 성인에서도 발병하는 사례가 증가하고 있습니다.
  • GLP-1은 혈당 조절에 그치지 않고, 보다 광범위한 심혈관 및 대사 기능에 관여할 가능성이 있습니다. GLP-1 수용체 신호 전달은 혈압 조절 및 교감신경 활동에 관여할 가능성이 있으며, 이로 인해 GLP-1 기반 치료법이 혈당 조절과 심혈관 위험 인자 모두에 효과를 발휘할 가능성이 시사되고 있습니다.
  • 실제 임상 증거에 따르면, GLP-1 치료에서 약물 복용 순응도 문제가 두드러지게 나타나며, 최대 64%의 환자가 1년 이내에, 74%가 2년 이내에 치료를 중단하는 것으로 나타났습니다. 이는 주사의 부담을 줄이고 장기적인 치료 지속률을 향상시킬 가능성이 있는, 편의성이 더 높은 경구 대체 요법의 필요성을 강조하는 것입니다.
  • 2형 당뇨병(T2DM)을 위한 GLP-1 파이프라인에는 레타톨티드(Eli Lilly), 카글리세마(Novo Nordisk), 서보두티드(Boehringer Ingelheim) 등 유망한 차세대 후보 약물이 포함되어 있습니다. 이러한 치료법은 다중 수용체 작용 및 상호 보완적인 대사 경로를 활용하여 혈당 조절 개선, 체중 감량 효과, 그리고 더 광범위한 심혈관 및 대사적 이점을 제공하는 것을 목표로 하며, 2형 당뇨병 관리에 있어 중요한 미충족 의료 수요를 충족시킬 가능성이 있습니다.
  • 시판 중인 2형 당뇨병 치료제에는 세마글루티드(OZEMPIC, RYBELSUS), 릴라글루티드(VICTOZA), 듀라글루티드(TRULICITY), 틸제파티드(MOUNJARO),엠파글리플로진(자르디안스), 다파글리플로진(팔시기가), 카나글리플로진(인보카나), 시타글립틴(자누비아), 리나글립틴(트라젠타), 그리고 삭사글립틴(옹글리자) 등이 있습니다. 이러한 치료법은 확립된 혈당 조절 효과를 제공할 뿐만 아니라, 그중 일부는 체중 관리, 심혈관계 및 신장 관련 이점도 보여주고 있어, 지속적으로 진화하는 2형 당뇨병(T2DM) 치료 환경에서 이러한 약물의 지속적인 사용을 뒷받침하고 있습니다.

주요 7개국 2형 당뇨병(T2DM) 시장 규모 및 전망

본 T2DM 시장 보고서는 표준 치료, 임상 실무 및 진화하는 치료 알고리즘을 포함한 현재 시장 상황에 대한 종합적인 분석을 제공합니다. T2DM 환자의 부담 동향, 매출 및 시장 점유율 동향, 피크 시 환자 점유율 및 치료법 보급 현황 분석을 평가하여, 전 세계 시장 규모에 대한 상세한 평가와 성장률 예측(과거 데이터 및 2022-2036년 예측)을 제시합니다. 본 보고서는 2형 당뇨병(T2DM) 분야의 주요 미충족 요구 사항을 부각시키고, 경쟁 구도 및 임상 상황을 정리함으로써 고부가가치 성장 기회를 밝혀내고, 향후 시장 성장 가능성에 대한 명확한 전망을 제시합니다.

2형 당뇨병(T2DM) 시장을 견인하는 주요 요인

2형 당뇨병(T2DM) 유병률 증가

2형 당뇨병(T2DM) 유병률의 증가는 T2DM 시장 확대의 주요 촉진요인입니다. 이는 비만율 상승, 앉아 있는 생활 습관, 고령화, 질병에 대한 인식 및 진단 향상, 혈당 조절 효과는 물론, 체중 관리, 심혈관계 및 신장에 유익한 효과를 가져오는 새로운 치료법의 채택 확대에 의해 뒷받침되고 있습니다.

신규 2형 당뇨병 치료법에서의 기회 확대

2형 당뇨병 분야에서 해결되지 않은 주요 요구 사항은 혈당 조절 개선, 지속적인 체중 감량 지원, 심혈관 및 신장 관련 합병증 완화, 그리고 치료 순응도 향상을 목표로 하는 차세대 치료법, 경구용 치료제, 그리고 다중 표적 대사 접근법에 대한 기회를 창출하고 있으며, 이를 통해 기존의 2형 당뇨병 치료법에 수반되는 한계를 해결하고 있습니다.

2형 당뇨병(T2DM)의 이해와 치료 알고리즘

2형 당뇨병(T2DM)의 개요 및 진단

2형 당뇨병(T2DM)은 인슐린 저항성과 인슐린 분비 부족을 특징으로 하는 만성적이고 진행성인 대사 장애로, 그 결과 혈당 수치가 지속적으로 상승하고 미세혈관 및 대혈관 합병증의 위험이 높아집니다. 일반적으로 성인기에 발병하지만, 소아, 사춘기, 젊은 성인에서의 진단도 증가하는 추세입니다. 주요 위험 요인으로는 과체중이나 비만, 운동 부족, 노화, 당뇨병 가족력, 그리고 특정 대사 이상이 포함됩니다. 장기적인 관리에는 생활 습관 개선, 혈당 강하 요법 및 정기적인 모니터링이 포함되며, 이를 통해 혈당 조절을 달성하고 심혈관, 신장, 망막 및 신경 장애와 같은 합병증의 위험을 줄입니다.

2형 당뇨병(T2DM)은 특징적인 증상을 보이는 환자에 대해 HbA1c, 공복 혈장 포도당, 경구 포도당 부하 검사 또는 임의 혈장 포도당 검사 등의 혈당 검사를 통해 진단됩니다. 진단은 확립된 임상 기준에 따라 이루어지며, 명백한 고혈당이 확인되지 않는 경우에는 비정상적인 결과를 확인하기 위해 일반적으로 재검사가 실시됩니다. 종합적인 질환 관리 및 치료 계획을 지원하기 위해 지질 프로파일, 신기능, 혈압 및 당뇨병 관련 합병증 선별 검사 등의 추가 평가가 이루어질 수 있습니다.

2형 당뇨병(T2DM)의 치료

2형 당뇨병(T2DM) 치료의 주요 목표는 혈당 조절의 달성 및 유지, 당뇨병 관련 합병증 위험 감소, 건강한 체중 관리 지원, 그리고 장기적인 삶의 질 향상입니다. 현재의 관리 방법에는 생활 습관 개선과 혈당 강하 요법이 포함되며, 세마글루타이드(OZEMPIC, RYBELSUS), 틸제파티드(MOUNJARO),엠파글리플로진(JARDIANCE), 다파글리플로진(FARXIGA), 시타글립틴(JANUVIA), 인슐린 등의 약물이 질환 관리의 다양한 단계에서 널리 사용되고 있습니다. 경구 대사약, 차세대 인크레틴계 치료제, 그리고 레타톨티드,카글리세마, 서보두티드 등의 다중 수용체 작용제를 포함한 새로운 치료법은 혈당 조절 향상, 체중 감소 촉진, 더 광범위한 심혈관 및 신장에 대한 유익한 효과를 가져오는 것을 목표로 하는 동시에, 치료의 편의성과 복약 순응도 향상도 도모하고 있습니다.

2형 당뇨병(T2DM)의 역학

2형 당뇨병(T2DM)의 역학적 분석 및 예측에 관한 주요 조사 결과

  • 미국 질병통제예방센터(CDC)에 따르면, 3,800만 명 이상의 미국인, 즉 약 10명 중 1명이 당뇨병을 앓고 있으며, 그중 90%에서 95%가 2형 당뇨병입니다. 일반적으로 45세 이상의 성인에게 발병하지만, 현재는 어린이, 10대, 젊은 성인의 진단 사례도 증가하고 있습니다.
  • 한 연구에 따르면, 독일의 2형 당뇨병 유병률은 약 9.9%를 기록할 것으로 예상됩니다. 유병률은 50세부터 80세에 걸쳐 급격히 상승하며, 신규 진단 건수가 가장 많은 시기는 85세 전후입니다.
  • 프랑스에서는 일반 인구 중 2형 당뇨병 유병률이 4.6%이며, 나이가 들수록 그 비율은 크게 증가하고 있습니다. 70세에서 85세 사이 남성의 약 5명 중 1명, 75세에서 85세 사이 여성의 약 7명 중 1명이 2형 당뇨병 약물 치료를 받고 있습니다.
  • 미국 질병통제예방센터(CDC)는 국민건강영양조사(NHANES) 데이터를 바탕으로, 2023년 미국 12-17세 청소년의 32.7%가 전당뇨 상태에 있을 것으로 추정했습니다.

2형 당뇨병(T2DM) 시장의 전망

2형 당뇨병(T2DM)의 치료 상황은 생활 습관 개선, 혈당 모니터링, 약물 요법, 그리고 특정 환자를 대상으로 한 대사 수술을 아우르는 환자 중심의 다각적인 접근 방식으로 진화하고 있습니다. 건강한 식단, 규칙적인 신체 활동, 체중 관리 등의 생활 습관 개입은 여전히 치료의 기반을 이루고 있지만, 2형 당뇨병 유병률의 증가와 지속적인 혈당 조절에 대한 필요성 증대가 약물 요법에 대한 수요를 계속해서 견인하고 있습니다. 메트포르민은 여전히 널리 사용되는 1차 선택 약물이지만, 설포닐우레아계 약물, 글리니드계 약물, 티아졸리딘디온계 약물, DPP-4 억제제, SGLT2 억제제,GLP-1 수용체 작용제, 그리고 인슐린은 혈당 조절의 필요성, 동반 질환, 안전성, 그리고 환자의 희망에 따라 사용되고 있습니다. 시장은 혈당 강하 작용을 넘어서는 효과, 특히 심혈관 및 신장 보호, 체중 감소를 가져오는 치료법으로 점점 더 이동하고 있으며, 이는 SGLT2 억제제와 GLP-1 수용체 작용제의 지속적인 보급을 뒷받침하고 있습니다. 새롭게 등장하고 있는 병용요법 및 멀티 작용제 요법은 혈당 조절과 대사 결과 모두를 목표로함으로써 경쟁을 더욱 심화시킬 것으로 예상됩니다. 인슐린은 비인슐린 요법에도 불구하고 혈당 조절이 불충분한 환자에게 여전히 중요한 치료 선택지인 반면, 지속 혈당 모니터링 및 기타 디지털 도구는 보다 개인화된 치료 최적화를 지원하고 있습니다. 또한, 비만이나 혈당 조절이 불충분한 2형 당뇨병 적격 환자에게는 대사 수술도 확립된 선택지가 되고 있습니다. 전반적으로 2형 당뇨병 시장은 질병 부담의 증가, 치료의 강화, 심혈관 및 대사 효과를 동반하는 치료법에 대한 수요, 그리고 병용요법 및 차세대 치료법에서의 지속적인 혁신에 의해 형성될 것으로 예상됩니다.

  • 인슐린 감수성 증진제 및 인슐린 분비 촉진제: 메트포르민이나 피오글리타존과 같은 확립된 치료법은 주로 간에서 포도당 생성을 억제하고 인슐린 감수성을 높임으로써 혈당 조절을 개선합니다. 설포닐우레아계 약물이나 글리니드계 약물은 췌장에서의 인슐린 분비를 자극하여 효과적인 혈당 강하 작용을 가져오지만, 저혈당이나 체중 증가 등의 위험으로 인해 사용이 제한될 수 있습니다.
  • 인크레틴 계열 치료제: 시타글립틴이나 리나글립틴 등의 DPP-4 억제제는 내인성 인크레틴의 활성을 높입니다. 한편, 세마글루티드, 듀라글루티드, 릴라글루티드 등의 GLP-1 수용체 작용제는 강력한 혈당 강하 작용 외에도 체중 감소 및 심혈관·대사 측면의 이점도 제공합니다. 혈당 조절과 체중 관리를 개선하기 위해 여러 대사 경로를 동시에 표적으로 하는 이중 및 다중 작용제 요법에 대한 혁신이 점점 더 진전되고 있습니다.
  • SGLT2 억제제: 엠파글리플로진이나 카나글리플로진과 같은 약물은 신장에서의 포도당 재흡수를 억제함으로써 소변으로의 포도당 배설을 증가시켜 혈당 수치를 낮춥니다. 혈당 조절 외에도, 이 약물군은 심혈관계 및 신장에 중요한 유익한 효과를 가져오기 때문에 2형 당뇨병(T2DM) 및 이에 수반되는 심혈관질환이나 신장질환을 가진 환자에서 그 역할이 점점 더 중요해지고 있습니다.

전반적으로 메트포르민, SGLT2 억제제 및 GLP-1 수용체 작용제는 2형 당뇨병(T2DM) 관리의 핵심 축으로 자리 잡고 있지만, 이중 및 다중 표적 대사 요법이 혁신을 주도하고 있습니다. 새로운 병용요법과 차세대 인크레틴 계열 약물의 등장으로 인해, 혈당 조절, 체중 관리, 심혈관 및 신장 예후, 그리고 기존의 혈당 강하 요법을 넘어서는 기타 미충족 의료 수요를 충족시킴으로써 치료 선택지가 확대되고, 2형 당뇨병(T2DM) 시장을 재편할 가능성이 있다고 여겨집니다.

자주 묻는 질문

  • 2형 당뇨병(T2DM)의 주요 원인은 무엇인가요?
  • 2형 당뇨병(T2DM) 환자의 유병률은 어떻게 되나요?
  • GLP-1 치료의 효과는 무엇인가요?
  • 2형 당뇨병 치료제의 주요 종류는 무엇인가요?
  • 2형 당뇨병(T2DM) 시장의 성장 요인은 무엇인가요?
  • 2형 당뇨병(T2DM) 치료의 목표는 무엇인가요?
  • 2형 당뇨병(T2DM) 시장의 미래 전망은 어떻게 되나요?

목차

제1장 주요 인사이트

제2장 소개

제3장 주요 요약

제4장 주요 사건

제5장 역학 및 시장 예측 조사 방법

제6장 2형 당뇨병 : 시장 개요

제7장 2형 당뇨병 : 질환 배경과 개요

제8장 치료와 관리

제9장 2형 당뇨병 : 역학 및 환자 인구

제10장 2형 당뇨병 : 환자 경과

제11장 시판 치료제

제12장 신흥 치료제

제13장 2형 당뇨병 : 주요 7개국 분석

제14장 2형 당뇨병 : 미충족 수요

제15장 2형 당뇨병 : SWOT 분석

제16장 2형 당뇨병 : KOL의 견해

제17장 2형 당뇨병 : 시장 진입 및 보험 상환

제18장 부록

제19장 DelveInsight의 서비스 내용

제20장 면책사항

제21장 DelveInsight 소개

KSM 26.08.31

Type 2 Diabetes Mellitus (T2DM) Insights and Trends

  • Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder marked by insulin resistance and progressive B-cell dysfunction, leading to persistent hyperglycemia. Unlike type 1 diabetes, T2DM develops primarily from impaired insulin action, initially compensated by increased insulin secretion until B-cell failure occurs. Its global rise is driven by aging populations and lifestyle changes such as physical inactivity and high-calorie diets, contributing to significant microvascular and macrovascular complications.
  • Type 2 diabetes can develop at any age, including during childhood, but it is more common among middle-aged and older adults. The risk increases with age, particularly after 45 years, as well as with a family history of diabetes and overweight or obesity.
  • More than 40 million Americans have diabetes, equivalent to approximately 1 in 8 people, and around 90%-95% of these individuals have type 2 diabetes. Type 2 diabetes most commonly develops in people aged 45 years and older; however, an increasing number of children, adolescents, and young adults are also developing the condition.
  • GLP-1 may play a broader cardiometabolic role beyond glucose control, with GLP-1 receptor signaling potentially contributing to blood pressure regulation and sympathetic activity, thereby highlighting the potential of GLP-1-based therapies to address both glycemic control and cardiovascular risk factors.
  • Real-world evidence highlights a significant GLP-1 therapy adherence challenge, with up to 64% of patients discontinuing treatment within 1 year and 74% by year 2, underscoring the need for more convenient oral alternatives that could reduce injection burden and potentially improve long-term treatment persistence.
  • The T2DM GLP-1 pipeline includes promising next-generation candidates such as retatrutide (Eli Lilly), CagriSema (Novo Nordisk), and survodutide (Boehringer Ingelheim), among others. By leveraging multi-receptor agonism and complementary metabolic pathways, these therapies aim to deliver enhanced glycemic control, weight-loss efficacy, and broader cardiometabolic benefits, potentially addressing key unmet needs in T2DM management.
  • The marketed T2DM therapies include semaglutide (OZEMPIC, RYBELSUS), liraglutide (VICTOZA), dulaglutide (TRULICITY), tirzepatide (MOUNJARO), empagliflozin (JARDIANCE), dapagliflozin (FARXIGA), canagliflozin (INVOKANA), sitagliptin (JANUVIA), linagliptin (TRADJENTA), and saxagliptin (ONGLYZA). These therapies provide established glycemic control, with several also demonstrating weight-management, cardiovascular, and kidney-related benefits, supporting their continued use across the evolving T2DM treatment landscape.

Type 2 Diabetes Mellitus (T2DM) Market Size and Forecast in the 7MM

DelveInsight's 'Type 2 Diabetes Mellitus (T2DM) - Market Insights, Epidemiology and Market Forecast - 2036' report delivers an in-depth understanding of the T2DM, historical and forecasted epidemiology, as well as the T2DM market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

The T2DM market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates, T2DM patient burden trends, revenue & market share dynamics, peak patient share & therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in T2DM and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.

Key Factors Driving the Type 2 Diabetes Mellitus (T2DM) Market

Rising T2DM Prevalence

The increasing prevalence of T2DM is a key driver of T2DM market expansion, supported by rising obesity rates, sedentary lifestyles, aging populations, increasing disease awareness and diagnosis, and growing adoption of newer therapies that provide effective glycemic control alongside weight-management, cardiovascular, and kidney benefits.

Rising Opportunities in Novel T2DM Therapies

The substantial unmet need in T2DM is creating opportunities for next-generation therapies, oral treatment options, and multi-target metabolic approaches aimed at improving glycemic control, supporting sustained weight loss, reducing cardiovascular and kidney-related complications, and enhancing treatment adherence, thereby addressing limitations associated with conventional T2DM therapies.

Type 2 Diabetes Mellitus (T2DM) Understanding and Treatment Algorithm

Type 2 Diabetes Mellitus (T2DM) Overview and Diagnosis

T2DM is a chronic, progressive metabolic disorder characterized by insulin resistance and inadequate insulin secretion, resulting in persistently elevated blood glucose levels and an increased risk of microvascular and macrovascular complications. It commonly develops in adulthood but is increasingly diagnosed in children, adolescents, and younger adults. Major risk factors include overweight or obesity, physical inactivity, advancing age, family history of diabetes, and certain metabolic conditions. Long-term management involves lifestyle modification, glucose-lowering therapies, and regular monitoring to achieve glycemic control and reduce the risk of cardiovascular, kidney, retinal, and neuropathic complications.

T2DM is diagnosed through blood glucose testing, including HbA1c, fasting plasma glucose, oral glucose tolerance testing, or random plasma glucose testing in patients with characteristic symptoms. Diagnosis is based on established clinical criteria, with repeat testing generally used to confirm abnormal results in the absence of unequivocal hyperglycemia. Additional assessments may include lipid profile, kidney function, blood pressure, and screening for diabetes-related complications to support comprehensive disease management and treatment planning.

Type 2 Diabetes Mellitus (T2DM) Treatment

The primary goals of T2DM treatment are to achieve and maintain glycemic control, reduce the risk of diabetes-related complications, support healthy weight management, and improve long-term quality of life. Current management includes lifestyle modifications and glucose-lowering therapies, with agents such as semaglutide (OZEMPIC, RYBELSUS), tirzepatide (MOUNJARO), empagliflozin (JARDIANCE), dapagliflozin (FARXIGA), sitagliptin (JANUVIA), and insulin widely used across different stages of disease management. Emerging therapies, including oral metabolic agents, next-generation incretin-based therapies, and multi-receptor agonists such as retatrutide, CagriSema, and survodutide, aim to enhance glycemic control, promote weight loss, and provide broader cardiovascular and kidney benefits while improving treatment convenience and adherence.

Type 2 Diabetes Mellitus (T2DM) Unmet Needs

The section "unmet needs of T2DM" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Durable and Sustained Glycemic Control

2. Effective and Long-Term Weight Management

3. Comprehensive Cardiovascular and Kidney Protection

4. Improved Treatment Adherence and Patient Convenience, and others.....

Type 2 Diabetes Mellitus (T2DM) Epidemiology

Key Findings from Type 2 Diabetes Mellitus (T2DM) Epidemiological Analysis and Forecast

  • According to the Centers for Disease Control and Prevention (CDC), over 38 million Americans around 1 in 10 have diabetes, with 90% to 95% of cases being type 2 diabetes. While it typically develops in adults over 45, an increasing number of children, teens, and young adults are now being diagnosed.
  • As per the research study, the prevalence of T2DM in Germany is approximately 9.9%. The prevalence increases sharply from age 50 to 80, with the highest number of new diagnoses occurring around age 85.
  • In France, the prevalence of T2DM is 4.6% in the general population, with rates increasing substantially with age. Approximately one in five men aged 70 to 85 years and one in seven women aged 75 to 85 years receive pharmacological treatment for T2DM.
  • Using data from the National Health and Nutrition Examination Survey (NHANES), the CDC estimated that 32.7% of US adolescents aged 12-17 years had prediabetes in 2023.

Type 2 Diabetes Mellitus (T2DM) Drug Chapters & Competitive Analysis

The T2DM drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase I-III clinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the T2DM treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the T2DM therapeutics market.

Approved Therapies for Type 2 Diabetes Mellitus (T2DM)

Bexagliflozin (BRENZAVVY): TheracosBio

It is a SGLT2 inhibitor approved by the US FDA in January 2023 as an adjunct to diet and exercise to improve glycemic control in adults with T2DM. By inhibiting SGLT2 in the renal proximal tubule, it reduces glucose reabsorption and lowers the renal threshold for glucose, leading to increased urinary glucose excretion and improved blood sugar control. BRENZAVVY is administered orally. It also stands out as the lowest priced SGLT2 inhibitor currently available in the US market.

Semaglutide (OZEMPIC/RYBELSUS/WEGOVY): Novo Nordisk

Semaglutide is a GLP-1 receptor agonist marketed by Novo Nordisk under different brand names with distinct FDA-approved indications.

OZEMPIC: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, and to reduce the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease.

RYBELSUS: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes who are at high risk for these events.

Type 2 Diabetes Mellitus (T2DM) Pipeline Analysis

CagriSema: Novo Nordisk

CagriSema, developed by Novo Nordisk, is a once-weekly subcutaneous fixed-dose combination of the long-acting amylin analogue cagrilintide (2.4 mg) and the GLP-1 receptor agonist semaglutide (2.4 mg). It is being investigated for the treatment of adults with type 2 diabetes mellitus (T2DM), with the potential to improve glycemic control and provide additional benefits in body weight and cardiometabolic risk factors.

Survodutide (BI 456906): Boehringer Ingelheim

Survodutide (BI 456906), developed by Boehringer Ingelheim, is a glucagon receptor (GCGR)/GLP-1 receptor dual agonist being evaluated for T2DM. By targeting both receptors, survodutide is designed to enhance glucose control while also supporting weight reduction and broader metabolic improvements. The compound is currently in Phase III development.

Type 2 Diabetes Mellitus (T2DM) Key Players, Market Leaders and Emerging Companies

  • TheracosBio
  • Novo Nordisk
  • Eli Lilly
  • Boehringer Ingelheim
  • AstraZeneca
  • Johnson & Johnson
  • Merck, and others.

Type 2 Diabetes Mellitus (T2DM) Drug Updates

  • In June 2026, Novo Nordisk reported positive Phase III results from the REIMAGINE 1-3 trials, demonstrating that CagriSema achieved significant reductions in HbA1c and body weight in adults with type 2 diabetes. The findings were presented at the ADA 2026 Scientific Sessions
  • In April 2026, Eli Lilly reported positive Phase III ACHIEVE-4 results for orforglipron in adults with type 2 diabetes and overweight/obesity at elevated cardiovascular risk. The trial met its primary endpoint, showing non-inferior MACE risk versus insulin glargine, while delivering greater reductions in A1C and body weight through 104 weeks. All-cause mortality was also lower with FOUNDAYO, although this analysis was not multiplicity-controlled.
  • In February 2026, Novo Nordisk announced CagriSema demonstrated superior HbA1c reduction of 1.91%-points and weight loss of 14.2% in adults with type 2 diabetes in the REIMAGINE 2 trial.

Drug Class Insights

Type 2 Diabetes Mellitus (T2DM) Market Outlook

The T2DM treatment landscape is evolving toward a patient-centered, multifaceted approach encompassing lifestyle modification, glucose monitoring, pharmacotherapy, and, in selected patients, metabolic surgery. Lifestyle interventions, including healthy diet, regular physical activity, and weight management, remain the foundation of care; however, the growing prevalence of T2DM and increasing need for durable glycemic control continue to drive demand for pharmacologic therapies. Metformin remains a widely used first-line option, while sulfonylureas, glinides, thiazolidinediones, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists, and insulin are utilized based on glycemic needs, comorbidities, safety, and patient preferences. The market is increasingly shifting toward therapies that provide benefits beyond glucose lowering, particularly cardiovascular and renal protection and weight reduction, supporting continued uptake of SGLT2 inhibitors and GLP-1 receptor agonists. Emerging combination and multi-agonist therapies are expected to further intensify competition by targeting both glycemic control and metabolic outcomes. Insulin remains an important treatment option for patients with inadequate control despite non-insulin therapies, while continuous glucose monitoring and other digital tools are supporting more personalized treatment optimization. Metabolic surgery also represents an established option for eligible patients with obesity and poorly controlled T2DM. Overall, the T2DM market is expected to be shaped by rising disease burden, increasing treatment intensification, demand for therapies with cardiometabolic benefits, and continued innovation in combination and next-generation therapies.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Type 2 Diabetes Mellitus (T2DM) (2022-2036 Forecast)

The T2DM treatment landscape comprises therapies targeting multiple pathways involved in glucose regulation, insulin sensitivity, renal glucose handling, and metabolic control. Established therapies include biguanides, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, thiazolidinediones, GLP-1 receptor agonists, and insulin, while emerging therapies increasingly focus on multi-target mechanisms and improved cardiometabolic outcomes.

  • Insulin Sensitizers and Insulin Secretagogues: Established therapies such as metformin and pioglitazone improve glycemic control primarily by reducing hepatic glucose production and enhancing insulin sensitivity. Sulfonylureas and glinides stimulate pancreatic insulin secretion and provide effective glucose lowering, although their use may be limited by risks such as hypoglycemia and weight gain.
  • Incretin-Based Therapies: DPP-4 inhibitors such as sitagliptin and linagliptin enhance endogenous incretin activity, while GLP-1 receptor agonists such as semaglutide, dulaglutide, and liraglutide provide potent glucose lowering with additional weight-loss and cardiometabolic benefits. Increasing innovation is focused on dual and multi-agonist therapies that simultaneously target multiple metabolic pathways to improve glycemic control and weight management.
  • SGLT2 Inhibitors: Agents such as empagliflozin and canagliflozin reduce renal glucose reabsorption, thereby increasing urinary glucose excretion and lowering blood glucose levels. Beyond glycemic control, this class provides important cardiovascular and renal benefits, supporting its growing role in patients with T2DM and associated cardiovascular or kidney disease.

Overall, metformin, SGLT2 inhibitors, and GLP-1 receptor-based therapies remain key pillars of T2DM management, while dual- and multi-target metabolic therapies are driving innovation. The emergence of novel combination therapies and next-generation incretin-based agents is expected to broaden treatment options and potentially reshape the T2DM market by addressing glycemic control, weight management, cardiovascular and renal outcomes, and other persistent unmet needs beyond conventional glucose lowering.

Type 2 Diabetes Mellitus (T2DM) Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the T2DM market's uptake by drugs, patient uptake by therapy, and sales of each drug.

Type 2 Diabetes Mellitus (T2DM) Therapies Price Scenario & Trends

Pricing and analogue assessment of T2DM therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, closest and most appropriate analogue selection for emerging therapies, and understanding of how pricing influences market access, adherence, and long-term uptake.

Industry Experts and Physician Views for Type 2 Diabetes Mellitus (T2DM)

To keep up with T2DM market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the T2DM emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in T2DM, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 6+ KOLs in the 7MM. Centers such as the University of Mississippi Medical Center, University of Bologna, and Teikyo University School of Medicine, etc. were contacted. Their opinion helps understand and validate current and emerging T2DM therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in T2DM.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of T2DM, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are majorly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of T2DM, explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the T2DM market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM T2DM market.

Report Insights

  • T2DM Patient Population Forecast
  • T2DM Therapeutics Market Size
  • T2DM Pipeline Analysis
  • T2DM Market Size and Trends
  • T2DM Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-enabled Market Research Report
  • 11-year Forecast
  • T2DM Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (by geography)
  • T2DM Treatment Addressable Market (TAM)
  • T2DM Competitive Landscape
  • T2DM Major Companies Insights
  • T2DM Price Trends and Analogue Assessment
  • T2DM Therapies Drug Adoption/Uptake
  • T2DM Therapies Peak Patient Share analysis

Report Assessment

  • T2DM Current Treatment Practices
  • T2DM Unmet Needs
  • T2DM Clinical Development Analysis
  • T2DM Emerging Drugs Product Profiles
  • T2DM Market Attractiveness
  • T2DM Qualitative Analysis (SWOT and Conjoint Analysis)

FAQs:

Market Insights

  • What was the T2DM market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of T2DM?
  • What are the disease risks, burdens, and unmet needs of T2DM? What will be the growth opportunities across the 7MM concerning the patient population with T2DM?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of T2DM? What are the current guidelines for treating T2DM in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the T2DM market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarize and simplify complex datasets within the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Upcoming Key Catalysts
  • 4.2. Key Transactions And Collaborations
  • 4.3. News Flow

5. Epidemiology and Market Forecast Methodology

6. Type 2 Diabetes Mellitus (T2DM) Market Overview at a Glance

  • 6.1. Clinical Landscape Analysis (By Phase, Molecule Type, and RoA)
  • 6.2. Market Share (%) Distribution of T2DM By Therapies in the 7MM, in 2025
  • 6.3. Market Share (%) Distribution of T2DM By Therapies in the 7MM, in 2036

7. Disease Background and Overview of Type 2 Diabetes Mellitus (T2DM)

  • 7.1. Introduction
  • 7.2. Sign and symptoms
  • 7.3. Risk Factors
  • 7.4. Subtypes of T2DM
  • 7.5. Pathophysiology
    • 7.5.1. Genetics of T2DM
  • 7.7. Biomarkers
  • 7.8. Diagnosis
    • 7.8.1. Symptoms Rating Scales in T2DM
    • 7.8.2. Algorithm for Differential Diagnosis of Negative Symptoms
    • 7.8.3. Differential Diagnosis

8. Treatment and Management

  • 8.1. Treatment Algorithm
  • 8.2. Guidelines

9. Epidemiology and Patient Population of Type 2 Diabetes Mellitus (T2DM)

  • 9.1. Key Findings
  • 9.2. Assumptions and Rationale
  • 9.3. Type 2 Diabetes Mellitus Prevalent Cases in the 7MM
  • 9.4. The United States
    • 9.4.1. Total Prevalent Cases of Type 2 Diabetes Mellitus in the United States
    • 9.4.2. Total Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in the United States
    • 9.4.3. Age-specific Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in the United States
    • 9.4.4. Gender-specific Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in the United States
    • 9.4.5. Treated Cases of Type 2 Diabetes Mellitus in the United States
  • 9.5. EU4 and the UK
    • 9.5.1. Total Prevalent Cases of Type 2 Diabetes Mellitus in EU4 and the UK
    • 9.5.2. Total Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in EU4 and the UK
    • 9.5.3. Age-specific Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in EU4 and the UK
    • 9.5.4. Gender-specific Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in EU4 and the UK
    • 9.5.5. Treated Cases of Type 2 Diabetes Mellitus in EU4 and the UK
  • 9.6. Japan
    • 9.6.1. Total Prevalent Cases of Type 2 Diabetes Mellitus in Japan
    • 9.6.2. Total Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in Japan
    • 9.6.3. Age-specific Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in Japan
    • 9.6.4. Gender-specific Diagnosed Prevalent Cases of Type 2 Diabetes Mellitus in Japan
    • 9.6.5. Treated Cases of Type 2 Diabetes Mellitus in Japan

10. Patient Journey of Type 2 Diabetes Mellitus (T2DM)

11. Marketed Therapies

  • 11.1. Competitive landscape of marketed therapies
  • 11.2. Semaglutide (OZEMPIC/WEGOVY/RYBELSUS): Novo Nordisk
    • 11.2.1. Drug Description
    • 11.2.2. Regulatory Milestones
    • 11.2.3. Other Developmental Activities
    • 11.2.4. Summary of Pivotal Trials
    • 11.2.5. Clinical Development
      • 11.2.5.1. Clinical Trial Information
    • 11.2.6. Analyst's Views
  • 11.3. Bexagliflozin (BRENZAVVY): TheracosBio
    • 11.3.1. Drug Description
    • 11.3.2. Regulatory Milestones
    • 11.3.3. Other Developmental Activities
    • 11.3.4. Summary of Pivotal Trials
    • 11.3.5. Clinical Development
      • 11.3.5.1. Clinical Trial Information
    • 11.3.6. Analyst's Views

12. Emerging Drugs

  • 12.1. Competitive landscape of emerging therapies
  • 12.2. CagriSema: Novo Nordisk
    • 12.2.1. Drug Description
    • 12.2.2. Other Developmental Activities
    • 12.2.3. Clinical Development
      • 12.2.3.1. Clinical Trials Information
    • 12.2.4. Analyst's Views
  • 12.3. Survodutide (BI 456906): Boehringer Ingelheim
    • 12.3.1. Drug Description
    • 12.3.2. Other Developmental Activities
    • 12.3.3. Clinical Development
      • 12.3.3.1. Clinical Trials Information
    • 12.3.4. Analyst's Views

13. Type 2 Diabetes Mellitus (T2DM): 7MM Analysis

  • 13.1. Key Findings
  • 13.2. Market Outlook of T2DM
  • 13.3. Conjoint Analysis of T2DM
  • 13.4. Key Market Forecast Assumptions
    • 13.4.1. Cost Assumptions
    • 13.4.2. Pricing Trends
    • 13.4.3. Analogue Assessment
    • 13.4.4. Launch Year and Therapy Uptakes
  • 13.5. Total Market Size of T2DM in the 7MM
  • 13.6. Total Market Size of T2DM by Therapies in the 7MM
  • 13.7. The United States
    • 13.7.1. Total Market Size of T2DM in the United States
    • 13.7.2. Total Market Size of T2DM by Therapies in the United States
  • 13.8. EU4 and the UK
    • 13.8.1. Total Market Size of T2DM in EU4 and the UK
    • 13.8.2. Total Market Size of T2DM by Therapies in EU4 and the UK
  • 13.9. Japan
  • 13.1. Total Market Size of T2DM in Japan
    • 13.9.2. Total Market Size of T2DM by Therapies in Japan

14. Unmet Needs of Type 2 Diabetes Mellitus (T2DM)

15. SWOT Analysis of Type 2 Diabetes Mellitus (T2DM)

16. KOL Views of Type 2 Diabetes Mellitus (T2DM)

17. Market Access and Reimbursement of Type 2 Diabetes Mellitus (T2DM)

  • 17.1. The United States
  • 17.2. EU4 and the UK
    • 17.2.1. Germany
    • 17.2.2. France
    • 17.2.3. Italy
    • 17.2.4. Spain
    • 17.2.5. United Kingdom
  • 17.3. Japan
  • 17.4. Summary and comparison of Market Access and Pricing Policy Developments in 2025
  • 17.5. Market Access and Reimbursement of Type 2 Diabetes Mellitus (T2DM) Therapies

18. Appendix

  • 18.1. Bibliography
  • 18.2. Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

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