세계의 RNA 치료제 시장 : 유형별, 제품별, 적응증별, 최종사용자별, 지역별, 기회 및 예측(2017-2031년)

Global RNA therapeutics market size was valued at USD 10.1 billion in 2023, which is expected to reach USD 27.33 billion in 2031, with a CAGR of 13.25% for the forecast period between 2024 and 2031F. Factors impacting the global RNA therapeutics market include progress in RNA technology, augmented research funding, heightened incidence of chronic diseases, demand for personalized medicine, effectiveness of RNA-based drugs in treating previously incurable conditions, and the substantial influence of regulatory support and collaborations among pharmaceutical firms, all contributing to market expansion.

Multiple pivotal factors significantly impact global RNA therapeutics market, each wielding a crucial role in its expansion and progression. Primarily, ongoing advancements in RNA technology serve as the cornerstone for market growth. Continuous innovations in messenger RNA (mRNA), small interfering RNA (siRNA), antisense oligonucleotides, and related techniques consistently bolster the precision and effectiveness of therapeutic approaches. These strides address historical challenges concerning drug stability, target accuracy, and optimized delivery methods. Augmented research funding represents another fundamental catalyst. The surge in financial support drives progressive RNA-centered studies, hastening breakthroughs and translating discoveries into viable clinical applications in the global RNA therapeutics market. The increased funding allows for deeper exploration, fostering innovation and expediting the conversion of RNA discoveries into practical therapies.

Additionally, the escalation in chronic diseases intensifies the need for effective treatments, aligning seamlessly with the adaptability of RNA-based interventions significantly driving the global RNA therapeutics market. RNA therapeutics offer promising potential in addressing previously insurmountable conditions, providing hope in scenarios where traditional medications fall short. The burgeoning demand for personalized medicine further fuels market expansion. RNA-based drugs present tailored solutions, leveraging individual genetic profiles to craft customized treatments that more precisely meet patients' distinct needs. Moreover, the significant influence of regulatory backing and collaborations among pharmaceutical firms remains pivotal. Favorable regulatory environments, coupled with strategic partnerships, create an environment conducive to research, development, and commercialization, ultimately propelling the growth of global RNA therapeutics market.

Progress in RNA Technology

Advancements in RNA technology are the primary catalyst driving the global RNA therapeutics market. These technological strides, encompass messenger RNA (mRNA), small interfering RNA (siRNA), antisense oligonucleotides, and other RNA-based methods, fueling the creation of inventive therapeutic remedies. They improve drug stability, target precision, and delivery systems, effectively tackling persistent challenges in precision medicine. Moreover, refined manufacturing processes and increased scalability fortify the practicality of RNA-based therapies, rendering them more attainable for large-scale manufacturing and commercial viability. The precision in gene expression manipulation via RNA interventions unlocks new avenues for addressing previously untreatable diseases, instilling hope in conditions lacking viable treatment options. The continuous evolution of RNA technology amplifies therapeutic potential and garners substantial investments, collaborations, and research endeavors, driving forward the growth and expansion of global RNA therapeutics market.

Augmented Research Funding

Increased funding for research plays a crucial role in propelling the global RNA therapeutics market. This boost in financial support infuses vital resources into pioneering RNA-centered studies, hastening breakthroughs and pushing discoveries toward practical clinical applications. It cultivates an environment ideal for experimenting, exploring, and validating various RNA-based therapeutic methods. Moreover, heightened funding draws in top-tier talent, sparks collaborative initiatives, and streamlines the transition of promising RNA technologies from lab settings to clinical trials. Consequently, this amplifies market growth potential and fosters the prospect of groundbreaking medical interventions.

For example, Flanders Innovation & Entrepreneurship (VLAIO) granted Flamingo Therapeutics a research grant of USD 1.9 million (EUR 1.7 million) in June 2023. The grant amounts to 60% of the project's total budget of USD 3.2 million (EUR 2.9 million). The award money will go towards expanding Flamingo Therapeutics' RNA-targeting oncology portfolio. It includes preclinical work on the company's long non-coding RNA (LncRNA) program targeting MALAT-1 and translational research for its lead clinical program, Danvatirsen, which is now in phase II trials for head and neck squamous cell carcinoma.

Government Initiatives

Governments worldwide are leading various initiatives that substantially elevate the global RNA therapeutics market. These initiatives encompass a range of strategies, including allocating research grants, establishing supportive regulatory frameworks, and fostering collaborations between public and private entities. Additionally, incentives like financial rewards, tax credits, and streamlined approval procedures reinforce progress in RNA-based advancements. Moreover, public health programs focusing on precision medicine and addressing previously untreatable conditions align with RNA therapeutics, stimulating increased government funding. The concerted effort fosters an environment conducive to research, development, and commercialization, significantly propelling notable growth in global RNA therapeutics market. For example, the Canada First Research Excellence Fund (CFREF) at Concordia University in Montreal would receive USD 1.4 billion in funding for 11 large-scale research activities, according to an announcement made a Minister of Innovation, Science, and Industry, in April 2023. The best programmes in their fields are given CFREF funding following a highly competitive process. To begin DNA to RNA, an Inclusive Canadian Approach to Genomic-based RNA treatments (D2R), a first-of-its-kind international research project focused on the creation and delivery of more inclusive genomic-based RNA treatments, McGill has been awarded a historic USD 165 million CFREF grant.

Treatment of Rare Genetic Disorders

RNA therapeutics significantly drive the expansion of global RNA therapeutics market by being instrumental in treating rare genetic disorders. These conditions, often resistant to conventional treatments, discover promise in RNA-based interventions capable of pinpointing precise genetic irregularities. As RNA therapies prove their efficacy in managing these once untreatable disorders, enthusiasm and investment escalate, fueling market growth. This specific application highlights RNA therapeutics' potential in meeting unaddressed medical demands, propelling both research initiatives and market progress. For instance, in October 2023, Novo Nordisk (NOVOb.CO) announced on Monday that FDA in the United States has approved its treatment for a rare kidney-affecting genetic disorder. It is approved for use in patients of nine years of age and older with a form of primary hyperoxaluria and generally intact kidney function to administer the once-monthly injection, which will be marketed under the brand name Rivfloza. RNA interference technology, or RNAi, is used in the therapy to assist lower urinary oxalate levels by silencing or neutralizing genes that contribute to illness.

Extensive use of RNAi Therapeutics

The global RNA therapeutics market experiences significant demand, particularly in RNA interference (RNAi) therapies. The interest arises from RNAi's distinct ability to target specific genes, impeding disease progression. RNAi's precision in controlling gene expression renders it an appealing option for treating diverse conditions like cancers, genetic disorders, and viral infections. As ongoing research continues to affirm RNAi's therapeutic potential and its effectiveness in both preclinical and clinical settings as the demand intensifies. The growing enthusiasm originates from RNAi's potential to address unmet medical needs, fostering a robust market propelled by the quest for innovative and precise therapeutic resolutions. For example, the industry-leading RNAi therapeutics company Alnylam Pharmaceuticals, Inc. announced in July 2023 that it has entered into a strategic agreement with Roche to develop and commercialize zilebesiran, the company's investigational RNAi therapeutic currently in Phase 2 development, for the treatment of hypertension. Through the agreement, Alnylam's P5x25 approach can move closer to its ambitious development ambition of upending the global paradigm of hypertension therapy.

Future Market Scenario

The forthcoming prospects of global RNA therapeutics market project significant expansion. The upsurge is driven by key elements such as ongoing progress in RNA technology. The fast-growing class of medications known as "RNA therapeutics" will enable personalized therapy, expedite the time it takes for solutions to reach the clinic, and end using the term "undruggable." Many more RNA medications are being developed, and the first ones have been approved. Other elements such as augmented investment in research and development, the escalating prevalence of chronic ailments, broader utilization of personalized medicine, and the potential of RNA-based remedies for formerly untreatable conditions will play a major role. Moreover, partnerships between pharmaceutical firms and favorable regulatory structures add impetus to this expected growth. The market's expansion pivots on the growing need for inventive therapeutic options, signaling a promising and resilient future for RNA-based interventions in tackling unmet medical challenges.

Key Players Landscape and Outlook

Major biotech companies worldwide are joining forces to establish an impactful alliance in the global RNA therapeutics market. The joint venture serves a dual purpose: advancing innovation and assuming regulatory roles. Together, these firms aim to combine their knowledge, resources, and research efforts to propel the development of innovative RNA-based therapies. Concurrently, their objective involves setting industry standards and guidelines to maintain quality and endorse the safety and effectiveness of RNA therapeutic solutions. The collaborative alliance signifies a crucial stride towards a cohesive strategy, driving progress and ensuring adherence to standards in the rapidly evolving domain of RNA therapeutics.

For instance, the Alliance for mRNA Medicines (AMM) was established in November 2023 by 31 biotechnology, biopharma, and life science businesses as well as academic institutions at the vanguard of mRNA and next generation encoding RNA medicines and vaccine development. Before legislative and regulatory agencies in North America, Europe, and Asia, AMM was the first and only scientific and policy organization exclusively dedicated to developing and advocating for global mRNA innovation and the sector's main policy objectives.

Table of Contents

1. Research Methodology

2. Project Scope & Definitions

3. Executive Summary

4. Global RNA Therapeutics Market Outlook, 2017-2031F

• 4.1. Market Size & Forecast
  • 4.1.1. Value
  • 4.1.2. Volume
• 4.2. By Type
  • 4.2.1. RNA Interference (RNAi) Therapeutics
  • 4.2.2. mRNA Therapeutics
  • 4.2.3. Antisense Oligonucleotide (ASO)Therapeutics
  • 4.2.4. Others
• 4.3. By Product
  • 4.3.1. Vaccines
  • 4.3.2. Drugs
• 4.4. By Indication
  • 4.4.1. Rare Genetic Diseases/Hereditary Diseases
  • 4.4.2. Infectious Diseases
  • 4.4.3. Others
• 4.5. By End-user
  • 4.5.1. Pharmaceutical and Biotechnology Companies
  • 4.5.2. Academic Research Centers
  • 4.5.3. Contract Research Organizations
  • 4.5.4. Others
• 4.6. By Region
  • 4.6.1. North America
  • 4.6.2. Europe
  • 4.6.3. South America
  • 4.6.4. Asia-Pacific
  • 4.6.5. Middle East and Africa
• 4.7. By Company Market Share (%), 2023

5. Global RNA Therapeutics Market Outlook, By Region, 2017-2031F

• 5.1. North America*
  • 5.1.1. Market Size & Forecast
    • 5.1.1.1. Value
    • 5.1.1.2. Volume
  • 5.1.2. By Type
    • 5.1.2.1. RNA Interference (RNAi) Therapeutics
    • 5.1.2.2. mRNA Therapeutics
    • 5.1.2.3. Antisense Oligonucleotide (ASO)Therapeutics
    • 5.1.2.4. Others
  • 5.1.3. By Product
    • 5.1.3.1. Vaccines
    • 5.1.3.2. Drugs
  • 5.1.4. By Indication
    • 5.1.4.1. Rare Genetic Diseases/Hereditary Diseases
    • 5.1.4.2. Infectious Diseases
    • 5.1.4.3. Others
  • 5.1.5. By End-user
    • 5.1.5.1. Pharmaceutical and Biotechnology Companies
    • 5.1.5.2. Academic Research Centers
    • 5.1.5.3. Contract Research Organizations
    • 5.1.5.4. Others
  • 5.1.6. United States*
    • 5.1.6.1. Market Size & Forecast
    • 5.1.6.1.1. Value
    • 5.1.6.1.2. Volume
    • 5.1.6.2. By Type
    • 5.1.6.2.1. RNA Interference (RNAi) Therapeutics
    • 5.1.6.2.2. mRNA Therapeutics
    • 5.1.6.2.3. Antisense Oligonucleotide (ASO)Therapeutics
    • 5.1.6.2.4. Others
    • 5.1.6.3. By Product
    • 5.1.6.3.1. Vaccines
    • 5.1.6.3.2. Drugs
    • 5.1.6.4. By Indication
    • 5.1.6.4.1. Rare Genetic Diseases/Hereditary Diseases
    • 5.1.6.4.2. Infectious Diseases
    • 5.1.6.4.3. Others
    • 5.1.6.5. By End-user
    • 5.1.6.5.1. Pharmaceutical and Biotechnology Companies
    • 5.1.6.5.2. Academic Research Centers
    • 5.1.6.5.3. Contract Research Organizations
    • 5.1.6.5.4. Others
  • 5.1.7. Canada
  • 5.1.8. Mexico

All segments will be provided for all regions and countries covered

• 5.2. Europe
  • 5.2.1. Germany
  • 5.2.2. France
  • 5.2.3. Italy
  • 5.2.4. United Kingdom
  • 5.2.5. Russia
  • 5.2.6. Netherlands
  • 5.2.7. Spain
  • 5.2.8. Turkey
  • 5.2.9. Poland
• 5.3. South America
  • 5.3.1. Brazil
  • 5.3.2. Argentina
• 5.4. Asia-Pacific
  • 5.4.1. India
  • 5.4.2. China
  • 5.4.3. Japan
  • 5.4.4. Australia
  • 5.4.5. Vietnam
  • 5.4.6. South Korea
  • 5.4.7. Indonesia
  • 5.4.8. Philippines
• 5.5. Middle East & Africa
  • 5.5.1. Saudi Arabia
  • 5.5.2. UAE
  • 5.5.3. South Africa

6. Market Mapping, 2023

• 6.1. By Type
• 6.2. By Product
• 6.3. By Indication
• 6.4. By End-user
• 6.5. By Region

7. Macro Environment and Industry Structure

• 7.1. Supply Demand Analysis
• 7.2. Import Export Analysis
• 7.3. Value Chain Analysis
• 7.4. PESTEL Analysis
  • 7.4.1. Political Factors
  • 7.4.2. Economic System
  • 7.4.3. Social Implications
  • 7.4.4. Technological Advancements
  • 7.4.5. Environmental Impacts
  • 7.4.6. Legal Compliances and Regulatory Policies (Statutory Bodies Included)
• 7.5. Porter's Five Forces Analysis
  • 7.5.1. Supplier Power
  • 7.5.2. Buyer Power
  • 7.5.3. Substitution Threat
  • 7.5.4. Threat from New Entrant
  • 7.5.5. Competitive Rivalry

8. Market Dynamics

• 8.1. Growth Drivers
• 8.2. Growth Inhibitors (Challenges and Restraints)

9. Regulatory Framework and Innovation

• 9.1. Clinical Trials
• 9.2. Patent Landscape
• 9.3. Regulatory Approvals
• 9.4. Innovations/Emerging Technologies

10. Key Players Landscape

• 10.1. Competition Matrix of Top Five Market Leaders
• 10.2. Market Revenue Analysis of Top Five Market Leaders (in %, 2023)
• 10.3. Mergers and Acquisitions/Joint Ventures (If Applicable)
• 10.4. SWOT Analysis (For Five Market Players)
• 10.5. Patent Analysis (If Applicable)

11. Pricing Analysis

12. Case Studies

13. Key Players Outlook

• 13.1. BioNTech SE
  • 13.1.1. Company Details
  • 13.1.2. Key Management Personnel
  • 13.1.3. Products & Services
  • 13.1.4. Financials (As reported)
  • 13.1.5. Key Market Focus & Geographical Presence
  • 13.1.6. Recent Developments
• 13.2. Moderna, Inc.
• 13.3. Ionis Pharmaceuticals, Inc.
• 13.4. Alnylam Pharmaceuticals, Inc.
• 13.5. Sarepta Therapeutics, Inc.
• 13.6. Abogen Biosciences Co., Ltd
• 13.7. Laronde, Inc.
• 13.8. Sirnaomics, Inc.
• 13.9. Deep Genomics Incorporated
• 13.10. Nutcracker Therapeutics, Inc.
• 13.11. GSK plc.
• 13.12. Bristol-Myers Squibb Company

Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work

14. Strategic Recommendations

15. About Us & Disclaimer