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그레이브스 안병증 : 시장 인사이트, 역학 및 시장 예측(2036년)

Graves Ophthalmopathy - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 161 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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그레이브스 안병증에 대한 인사이트와 동향

  • DelveInsight의 분석에 따르면, 2025년 기준 주요 시장(미국, EU4(독일, 프랑스, 이탈리아, 스페인), 영국 및 일본)의 그레이브스병 시장 규모는 약 35억 달러인 것으로 나타났습니다.
  • 그레이브스 안병증은 그레이브스병 환자의 약 25-50%에서 발병하는 질환으로, 일반적으로 희귀질환 또는 드문 질환으로 간주됩니다.
  • 유럽 그레이브스 안병증 그룹(EUGOGO)의 2021년판 임상 실무 지침에 따르면, 중등도에서 중증 및 급성기 그레이브스 안병증에 대한 1차 치료법은 메틸프레드니솔론의 정맥 내 투여와 경구용 미코페놀산나트륨(또는 모페틸)의 병용 요법으로 규정되어 있습니다.
  • FDA가 승인한 유일한 질환 특이적 치료제는 앰젠(Amgen)사가 판매하는 테프로줌맙(TEPEZZA)입니다. 이 약물은 IGF-1 억제제로, 질환의 병태에 직접 작용하는 최초의 표적 치료제로서, 임상시험에서 안구 돌출 및 복시의 완화에 높은 유효성을 보여주고 있습니다.
  • 린시치닙의 경구 투여는 피하 투여(SC)나 정맥 내 투여(IV) 요법보다 편의성이 높으며, 그레이브스 안병증에 대한 승인은 이 약물의 입증된 임상적 유용성과 안전성 프로파일을 뒷받침하고 있습니다.
  • 그레이브스 안병증 치료제 개발 파이프라인은 매우 활발하며 경쟁이 치열한 상황입니다. 주요 기업으로는 빌리디안 테라퓨틱스(엘레그로버트), 로슈(사트랄리주맙), 슬링 테라퓨틱스(린시티닙) 등이 있습니다.

본 ‘그레이브스 안병증 시장 보고서’에서는 표준 치료, 임상 실무, 진화하는 치료 알고리즘 등 현재의 치료 현황에 대한 종합적인 분석을 제공합니다. 또한, 그레이브스 안병증 환자의 부담 추이, 수익 및 시장 점유율 추이, 정점 시기의 환자 점유율 및 치료 도입률 분석을 평가함과 동시에, 세계 각 지역 시장 규모에 대한 상세한 평가 및 성장률 예측(과거 데이터 및 2022년-2036년 예측)을 제시하고 있습니다. 본 보고서는 그레이브스 안병증의 주요 미충족 요구 사항을 부각시키고, 경쟁 환경 및 임상 상황을 분석하여 고부가가치 성장 기회를 도출함으로써, 향후 시장 성장 가능성에 대한 명확한 전망을 제시하고 있습니다.

그레이브스 안병증 시장을 주도하는 주요 요인

질병의 유병률 및 인지도 상승

그레이브스 안병증의 유병률 증가와 진단 기법의 발전으로 인해 환자층이 확대되고 있습니다. 또한, 임상의들 사이에서 이에 대한 인식이 높아짐에 따라 조기 발견 및 조기 치료로 이어지고 있습니다.

연구개발(R&D) 확대 및 전략적 제휴

로슈, 앰젠, 슬링 테라퓨틱스 등의 기업들은 혁신적인 투여 방법(피하 투여, 경구 투여) 및 신약 개발에 투자하고 있습니다.

그레이브스 안병증의 이해와 치료 알고리즘

그레이브스 안병증의 개요와 진단

그레이브스 안병증(갑상선 안증: TED라고도 함)은 그레이브스병에 수반되는 자가면역성 염증성 질환으로, 면역 매개성 안와 섬유아세포의 활성화로 인해 안외근 및 안와 지방의 비대가 발생합니다. 그 결과, 안구 돌출, 안검 후퇴, 안와 주위의 부종과 같은 특징적인 증상이 나타나며, 중증의 경우 시신경 압박을 유발합니다. 이 질환은 일반적으로 활동성 염증기를 거쳐 만성 섬유화기로 진행되며, 그 중증도는 경미한 불편감부터 시력을 위협하는 합병증에 이르기까지 다양합니다. 위험 요인으로는 흡연, 갑상선 기능 이상, 그리고 갑상선 자극 면역글로불린 수치 상승 등이 있습니다.

그레이브스 안병증의 진단은 주로 임상 소견에 근거하지만, 검사 소견 및 영상 소견을 통해 뒷받침됩니다. 환자에서는 일반적으로 눈의 자극감, 충혈, 복시, 진행성 안구 돌출이 나타납니다. 갑상선 기능 검사(TSH, 유리 T4, T3) 및 갑상선 항체 수치, 특히 TSH 수용체 항체의 측정은 기저에 있는 자가면역성 갑상선 질환을 확인하는 데 도움이 됩니다. 안와 CT나 MRI 등의 영상 검사는 안외근의 비대나 안와 조직으로의 확산 여부를 평가하고, 다른 안와 질환을 배제하기 위해 시행됩니다. 질환의 활동성과 중증도는 대부분의 경우 임상 활동성 점수(CAS)를 통해 평가되며, 이는 치료 방침을 결정하는 데 지침이 됩니다.

그레이브스 안병증의 현재 치료 현황

치료법은 질환의 중증도와 활동성에 따라 결정되며, 대증요법, 약물요법 및 외과적 접근법을 병행하여 시행됩니다. 경증의 경우, 윤활제 사용이나 금연 등 위험 요인을 관리함으로써 대처할 수 있지만, 중등도에서 중증의 활동성 질환에서는 대부분의 경우 면역억제요법이 필요하며, 일반적으로 메틸프레드니솔론 등의 정맥 내 코르티코스테로이드가 사용됩니다. 이 질환에 대해 유일하게 승인된 특이적 치료법은 앰젠(Amgen)사가 판매하는 'TEPEZZA'입니다. 이는 IGF-1 수용체를 표적으로 하며, 안구 돌출 및 복시의 완화에서 유의미한 효능이 입증되었습니다. 안와 감압술, 사시 수술, 눈꺼풀 수술 등의 외과적 시술은 일반적으로 비활동기이거나 시력을 위협하는 병태인 경우에 한해 시행됩니다.

그레이브스 안병증의 역학

그레이브스 안병증의 역학 분석 및 예측에 관한 주요 조사 결과

  • DelveInsight사의 추산에 따르면, 2025년 주요 7개국에서 그레이브스 안병증의 총 환자 수는 약 240만 8,800명이었습니다.
  • 2025년, 미국의 그레이브스 안병증 확진 환자 수는 약 103만 명에 달하며, 주요 시장 중 가장 높은 질병 부담을 보이고 있으며, 그 뒤를 EU4, 영국, 일본 순으로 따르고 있습니다.
  • 그레이브스 안병증은 여성에게서 현저히 많이 나타나며, 전체 증례의 약 80%를 차지하고, 남성의 경우 20%를 차지합니다.

그레이브스 안병증 시장 전망

그레이브스 안병증의 치료 방식은 주로 지지 요법이나 수술에서 질환 수정 면역 요법으로 전환되고 있습니다. 기존의 치료법으로는 활동성 질환에 대해 메틸프레드니솔론 등의 고용량 정맥 내 코르티코스테로이드가 사용됩니다. 또한, 토시리주맙이나 리툭시맙 등 일부 적응증 외 사용 생물학적 제제가 난치성 환자에게 사용되고 있지만, 이들 약제는 TED(그레이브스 안병증)에 대해 특별히 승인된 것은 아닙니다.

암젠이 개발한 TED 최초의 표적 치료제인 테프로줌맙(TEPEZZA)의 승인으로 획기적인 진전이 이루어졌습니다. 이 약은 IGF-1R을 억제하여 안구 돌출 및 복시를 현저히 완화시킵니다. 파이프라인은 엘레그로버트와 같은 IGF-1R 항체, 사트랄리주맙과 같은 IL-6 억제제, 린시티닙과 같은 경구용 저분자 화합물 등 표적 치료제를 중심으로 확대되고 있습니다.

전반적으로, 표적 치료의 발전에 힘입어 2022년부터 2036년에 걸쳐 주요 7개국의 그레이브스 안병증 시장은 꾸준한 성장을 이룰 것으로 예상되며, 이는 이미 시판 중인 제품과 신약 파이프라인 모두에 큰 상업적 영향을 미칠 것으로 전망됩니다.

  • 주요 7개국 중 미국은 그레이브스 안병증 시장에서 가장 큰 시장 규모를 차지하고 있으며, 2025년에는 약 30억 달러에 달할 것으로 전망됩니다. i.
  • 승인된 치료법 중에서는 TEPEZZA가 안구 돌출 완화 측면에서 높은 유효성을 보이며, 이 질환에 특화된 유일한 승인 치료제라는 위상에 힘입어 앞으로도 주요 수익원으로 자리매김할 것으로 예측됩니다.
  • 엘레그로바트(VRDN-003), 사트랄리주맙(RG6168), 린시티닙과 같은 후기-중기 단계의 후보 약물이 시장에 진입함에 따라 경쟁이 심화될 것이며, 예측 기간 동안 편의성이 더 높은 피하 투여 및 경구 투여 표적 치료제로의 전환이 가속화될 것으로 예측됩니다.
  • 표적 면역요법: TEPEZZA와 같은 승인된 치료제나 엘레그로바트 및 린시티닙과 같은 신약들은 TED에서 안와 섬유아세포의 활성화와 조직 확장의 주요 원인인 IGF-1R 수용체 경로를 표적으로 삼고 있으며, 사트랄리주맙(IL-6 수용체 억제제)은 염증성 신호 전달 경로를 표적으로 삼고 있습니다. 린시치닙은 경구용 표적 치료제 후보 약물로, 단일클론 항체를 대체할 비생물학적 치료법으로 자리매김하고 있으며, 정맥 주사 형태의 IGF-1R 치료법과 비교하여 환자의 편의성을 높이는 것을 목표로 개발이 진행되고 있습니다.

표적 면역요법은 시장 성장을 주도하는 핵심 혁신 동향을 정의하고 있습니다.

자주 묻는 질문

  • 2025년 그레이브스 안병증 시장 규모는 어떻게 예상되나요?
  • 그레이브스 안병증의 주요 치료법은 무엇인가요?
  • 그레이브스 안병증의 유병률은 어떻게 되나요?
  • 그레이브스 안병증의 치료제 개발 현황은 어떤가요?
  • 그레이브스 안병증의 주요 위험 요인은 무엇인가요?
  • 그레이브스 안병증의 진단 방법은 무엇인가요?
  • 그레이브스 안병증의 치료 방식은 어떻게 변화하고 있나요?

목차

제1장 주요 인사이트

제2장 서론

제3장 주요 요약

제4장 주요 이벤트

제5장 그레이브스 안병증 : 역학 및 시장 조사 방법

제6장 그레이브스 안병증 : 시장 개요

제7장 그레이브스 안병증 : 질환 배경과 개요

제8장 그레이브스 안병증 : 역학 및 환자 인구

제9장 그레이브스 안병증 : 환자 경과

제10장 시판 치료제

제11장 신흥 치료법

제12장 그레이브스 안병증 : 주요 7개국 분석

제13장 그레이브스 안병증 : 미충족 요구

제14장 그레이브스 안병증 : SWOT 분석

제15장 그레이브스 안병증 : KOL(Key Opinion Leader)의 견해

제16장 그레이브스 안병증 : 시장 참여 및 상환

제17장 부록

제18장 DelveInsight의 서비스 내용

제19장 면책사항

제20장 DelveInsight에 대해

LSH 26.07.27

Graves Ophthalmopathy Insights and Trends

  • According to DelveInsight's analysis, the Graves Ophthalmopathy market size was found to be ~USD 3,500 million in the leading markets (the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan) in 2025.
  • Graves' ophthalmopathy is generally considered a rare to infrequent disease, although it affects about 25-50% of patients with Graves' disease.
  • According to the European Group on Graves Orbitopathy (EUGOGO) clinical practice guidelines 2021, IV methylprednisolone in combination with oral mycophenolate sodium (or mofetil) represents the first-line treatment for moderate-to-severe and acute Graves ophthalmopathy.
  • The only FDA-approved disease-specific therapy is Teprotumumab (TEPEZZA), marketed by Amgen. It is an IGF-1 inhibitor and represents the first targeted therapy that directly addresses disease pathology, showing strong efficacy in reducing proptosis and diplopia in clinical trials.
  • Linsitinib's oral administration offers greater convenience than SC and IV therapies, while its approval in Graves' ophthalmopathy supports its established clinical utility and safety profile.
  • The pipeline for Graves' ophthalmopathy is highly active and competitive. Key companies include Viridian Therapeutics (elegrobart), Roche (satralizumab), and Sling Therapeutics (linsitinib).

DelveInsight's 'Graves Ophthalmopathy - Market Insights, Epidemiology and Market Forecast - 2036' report delivers an in-depth understanding of the Graves ophthalmopathy, historical and forecasted epidemiology, as well as the Graves ophthalmopathy market trends in the United States, EU4 (Germany, Spain, Italy, and France), and the United Kingdom, and Japan.

The Graves Ophthalmopathy market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates Graves' ophthalmopathy patient burden trends, revenue & market share dynamics, peak patient share & therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in Graves' ophthalmopathy and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.

Key Factors Driving the Graves Ophthalmopathy Market

Rising Disease Prevalence & Awareness

The increasing prevalence of Graves' ophthalmopathy and better diagnostic practices are expanding the patient pool, with improved awareness among clinicians, leading to earlier detection and treatment.

Increased R&D and Strategic Collaborations

Companies like Roche, Amgen, and Sling Therapeutics are investing in innovative delivery methods (subcutaneous, oral) and new drug development.

Graves Ophthalmopathy Understanding and Treatment Algorithm

Graves Ophthalmopathy Overview and Diagnosis

Graves' ophthalmopathy, also known as Thyroid Eye Disease (TED), is an autoimmune inflammatory condition associated with Graves' disease in which immune-mediated activation of orbital fibroblasts leads to expansion of extraocular muscles and orbital fat. This results in characteristic features such as proptosis (eye bulging), eyelid retraction, periorbital edema, and, in severe cases, optic nerve compression. The disease typically follows an active inflammatory phase followed by a chronic fibrotic phase, and its severity can range from mild discomfort to vision-threatening complications. Risk factors include smoking, thyroid dysfunction, and high levels of thyroid-stimulating immunoglobulins.

Diagnosis of Graves' ophthalmopathy is primarily clinical, supported by laboratory and imaging findings. Patients commonly present with eye irritation, redness, diplopia, and progressive proptosis. Thyroid function tests (TSH, free T4, T3) and thyroid antibody levels, particularly TSH receptor antibodies, help confirm the underlying autoimmune thyroid disorder. Imaging studies such as CT or MRI of the orbits are used to assess enlargement of extraocular muscles and orbital tissue involvement, and to rule out other orbital pathologies. Disease activity and severity are often graded using clinical activity scores (CAS), which guide treatment decisions.

Current Graves Ophthalmopathy Treatment Landscape

Management depends on disease severity and activity, combining supportive, medical, and surgical approaches. Mild cases may be managed with lubricants and risk factor control, like smoking cessation, while moderate-to-severe active disease often requires immunosuppression, typically with intravenous corticosteroids such as Methylprednisolone. The only disease-specific approved therapy is TEPEZZA, marketed by Amgen, which targets the IGF-1 receptor and has shown significant efficacy in reducing proptosis and diplopia. Surgical interventions, including orbital decompression, strabismus surgery, or eyelid procedures, are typically reserved for the inactive phase or vision-threatening disease.

Graves' Ophthalmopathy Unmet Needs

The section "unmet needs of Graves' ophthalmopathy" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Limited treatment options

2. Limitations of guidelines

3. Disease burden

4. Access barriers, and others.....

Graves Ophthalmopathy Epidemiology

Key Findings from Graves Ophthalmopathy Epidemiological Analysis and Forecast

  • According to DelveInsight's estimates, in 2025, the total prevalent cases of Graves' ophthalmopathy in the 7MM were ~2,408,800.
  • In 2025, the United States accounted for approximately 1.03 million diagnosed prevalent cases of Graves' ophthalmopathy, representing the highest disease burden among major markets, followed by the EU4 and the UK, and Japan.
  • Graves' ophthalmopathy is significantly more prevalent in females, accounting for approximately 80% of cases, compared with 20% in males.

Graves Ophthalmopathy Drug Analysis & Competitive Landscape

The Graves' ophthalmopathy drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase III-I clinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the graves ophthalmopathy treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the graves ophthalmopathy therapeutics market.

Approved Therapies for Graves Ophthalmopathy

Teprotumumab (TEPEZZA): Amgen

Teprotumumab, marketed as TEPEZZA, is an insulin-like growth factor-1 receptor (IGF-1R) inhibiting monoclonal antibody originally developed by Horizon Therapeutics and now part of Amgen following its 2023 acquisition. It is the first and only FDA-approved therapy specifically for TED, targeting the underlying autoimmune pathway rather than just symptoms. TEPEZZA has demonstrated strong efficacy in reducing proptosis and diplopia in clinical trials.

Graves Ophthalmopathy Pipeline Analysis

Elegrobart (VRDN-003): Viridian Therapeutics

Elegrobart is an investigational monoclonal antibody developed by Viridian Therapeutics for the treatment of TED. It targets and blocks the IGF-1R, a key pathway involved in the disease process. It is being developed as a potential best-in-class subcutaneous anti-IGF-1R therapy for self-administration at home using a low-volume autoinjector, with every-4-week or every-8-week dosing. The company, in its SEC filing, anticipated that Elegrobart is on track for a BLA submission anticipated in Q1 2027.

Linstinitb: Sling Therapeutics

Linsitinib is developed for TED that will ease the treatment burden for patients, caregivers, and physicians. Linsitinib is the first and only oral small-molecule therapy to establish statistical and clinical significance in TED. Linsitinib works by inhibiting the IGF-1R target, which is the only validated clinical target in TED and the only target for current FDA-approved therapies. Activation of the IGF-1R target leads to inflammation and proptosis seen in TED. Linsitinib has an established safety profile through treatment of more than 900 patients in fifteen clinical trials in multiple diseases.

Graves Ophthalmopathy Key Players, Market Leaders, and Emerging Companies

  • Viridian Therapeutics
  • Roche
  • Sling Therapeutics
  • Amgen
  • Horizon Therapeutics, and others

Graves Ophthalmopathy Drug Updates

  • In March 2026, Viridian Therapeutics announced positive topline data from the elegrobart REVEAL-1 phase III clinical trial in patients with active thyroid eye disease (TED). REVEAL-1 met the primary endpoint of Q4W proptosis responder rate (PRR) and Complete resolution of diplopia in 51% of patients treated Q4W versus 16% placebo at week 24.
  • In January 2025, Sling Therapeutics announced topline efficacy and safety data from the Phase II/III LIDS trial of linsitinib in patients with active, moderate to severe TED. The trial met the primary endpoint of proptosis reduction with statistical significance at the 150mg BID dose.
  • In October 2023, Amgen announced that it had completed its acquisition of Horizon Therapeutics.

Graves Ophthalmopathy Market Outlook

The treatment landscape of Graves' ophthalmopathy has shifted from mainly supportive care and surgery toward disease-modifying immunotherapy. Conventional management includes high-dose intravenous corticosteroids such as Methylprednisolone for active disease. In addition, several off-label biologics, such as Tocilizumab and Rituximab, are used in refractory patients, although they are not specifically approved for TED.

A breakthrough came with the approval of Teprotumumab (TEPEZZA) by Amgen, the first targeted therapy for TED. It inhibits IGF-1R, leading to significant reductions in proptosis and diplopia. The pipeline is expanding with targeted approaches, including IGF-1R antibodies like elegrobart, IL-6 inhibitors such as satralizumab, and oral small molecules like linsitinib.

Overall, the advancements in targeted treatments are expected to drive steady growth in the 7MM Graves' Ophthalmopathy market from 2022-2036, with strong commercial implications for both marketed products and emerging pipelines.

  • Among the 7MM, the US accounted for the largest market size of Graves' ophthalmopathy. i.e., USD ~3000 million in 2025.
  • Among approved therapies, TEPEZZA is expected to remain the primary revenue driver, supported by its strong efficacy in reducing proptosis and its position as the only disease-specific approved treatment.
  • The entry of late to mid-stage candidates such as elegrobart (VRDN-003), satralizumab (RG6168), and linsitinib is anticipated to intensify competition and accelerate the shift toward more convenient subcutaneous and oral targeted therapies over the forecast period.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Graves Ophthalmopathy (2022-2036 Forecast)

The Graves' ophthalmopathy market comprises targeted immunotherapies, each targeting different aspects of Graves' ophthalmopathy.

  • Targeted immunotherapies: Approved therapies such as TEPEZZA and emerging therapies such as elegrobart and linsitnib target the IGF-1R receptor pathway, a key driver of orbital fibroblast activation and tissue expansion in TED, and satralizumab (IL-6 receptor inhibitor) targets inflammatory signaling pathways. Linsitinib is an oral targeted therapy candidate, representing a non-biologic alternative to monoclonal antibodies, and is being developed to improve patient convenience compared to intravenous IGF-1R therapies.

Targeted Immunotherapy defines the core innovation landscape driving market growth.

Graves Ophthalmopathy Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the graves ophthalmopathy drug's uptake, performance at peak, factors affecting performance during the prime years of growth, patient uptake by therapy, and anticipated sales generated by each drug.

The uptake of therapies in Graves' ophthalmopathy is expected to vary based on clinical positioning, mechanism of action, and stage of development. One approved therapy, TEPEZZA, is set to experience moderate but meaningful uptake. Its targeted IGF-1R inhibiting mechanism and demonstrated efficacy in reducing proptosis and diplopia support its use in active moderate-to-severe and refractory cases of Thyroid Eye Disease.

In contrast, pipeline candidates such as elegrobart (VRDN-003), satralizumab (RG6168), and linsitinib are likely to demonstrate progressive uptake upon approval, as these therapies are designed to improve upon existing treatment options by targeting key disease pathways such as IGF-1R signaling and IL-6-mediated inflammatory pathways.

Detailed insights into emerging therapies' drug uptake are included in the report

Graves Ophthalmopathy Therapies Price Scenario & Trends

Pricing and analogue assessment of Graves' ophthalmopathy therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and understanding of how pricing influences market access, adherence, and long-term uptake.

  • Pricing of Graves Ophthalmopathy Approved Drugs

The recommended dosing regimen for TEPEZZA consists of an initial intravenous infusion of 10 mg/kg, followed by 20 mg/kg administered every three weeks for a total of seven additional infusions. The total treatment cost is approximately USD 350,000 for a 75 kg patient.

Industry Experts and Physician Views for Graves Ophthalmopathy

To keep up with Graves' ophthalmopathy market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the Graves' ophthalmopathy emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in Graves' ophthalmopathy, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 15+ KOLs to gather insights at the country level. Centers such as the Institute for Genomic Sciences, Florida International University, and Essen University Hospital, etc. were contacted. Their opinion helps understand and validate current and emerging Graves' ophthalmopathy therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in Graves ophthalmopathy.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of Graves' ophthalmopathy, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are mainly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of Graves' ophthalmopathy, explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the Graves' ophthalmopathy market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM Graves' Ophthalmopathy market.

Report Insights

  • Graves Ophthalmopathy Patient Population Forecast
  • Graves Ophthalmopathy Therapeutics Market Size
  • Graves Ophthalmopathy Pipeline Analysis
  • Graves Ophthalmopathy Market Size and Trends
  • Graves Ophthalmopathy Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-Enabled Market Research Report
  • 11-Year Forecast
  • Graves Ophthalmopathy Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (By Geography)
  • Graves Ophthalmopathy Treatment Addressable Market (TAM)
  • Graves Ophthalmopathy Competitive Landscape
  • Graves Ophthalmopathy Major Companies Insights
  • Graves Ophthalmopathy Price Trends and Analogue Assessment
  • Graves Ophthalmopathy Therapies Drug Adoption/Uptake
  • Graves Ophthalmopathy Therapies Peak Patient Share Analysis

Report Assessment

  • Graves Ophthalmopathy Current Treatment Practices
  • Graves' Ophthalmopathy Unmet Needs
  • Graves Ophthalmopathy Clinical Development Analysis
  • Graves Ophthalmopathy Emerging Drugs Product Profiles
  • Graves Ophthalmopathy Market Attractiveness
  • Graves Ophthalmopathy Qualitative Analysis (SWOT and conjoint analysis)

FAQs:

Market Insights

  • What was the Graves' ophthalmopathy market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of Graves' ophthalmopathy?
  • What are the disease risks, burdens, and unmet needs of Graves' ophthalmopathy? What will be the growth opportunities across the 7MM concerning the patient population with Graves' ophthalmopathy?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of Graves' ophthalmopathy? What are the current guidelines for treating Graves' ophthalmopathy in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Graves' ophthalmopathy market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights into the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarizes and simplifies complex datasets within the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Upcoming Key Catalysts
  • 4.2. Key Transactions And Collaborations
  • 4.3. News Flow

5. Epidemiology and Market Methodology of Graves Ophthalmopathy

6. Graves Ophthalmopathy Market Overview at a Glance

  • 6.1. Clinical Landscape Analysis (By Molecule Type, Phase, and Route of Administration [ROA])
  • 6.2. Market Share of Graves Ophthalmopathy by Therapies (%) in the 7MM in 2025
  • 6.3. Market Share of Graves Ophthalmopathy by Therapies (%) in the 7MM in 2036

7. Disease Background And Overview of Graves Ophthalmopathy

  • 7.1. Introduction
  • 7.2. Types of Graves Ophthalmopathy
  • 7.3. Causes
  • 7.4. Signs And Symptoms
  • 7.5. Diagnosis
    • 7.5.1. Differential Diagnosis
    • 7.5.2. Diagnostic Algorithm
    • 7.5.3. Diagnostic Guidelines

8. Epidemiology and Patient Population of Graves Ophthalmopathy

  • 8.1. Key Findings
  • 8.2. Assumption and Rationale
  • 8.3. Total Prevalent Cases of Graves Ophthalmopathy in the 7MM
  • 8.4. The United States
    • 8.4.1. Total Prevalent Cases of Graves Ophthalmopathy in the United States
    • 8.4.2. Diagnosed Prevalent Cases of Graves Ophthalmopathy in the United States
    • 8.4.3. Gender-specific Prevalent Cases of Graves Ophthalmopathy in the United States
    • 8.4.4. Diagnosed Prevalent Cases of Graves Ophthalmopathy by Chronicity in the United States
    • 8.4.5. Acute Diagnosed Prevalent Cases of Graves Ophthalmopathy by Severity in the United States
    • 8.4.6. Acute moderate-to-severe Drug-treated Prevalent Cases of Graves Ophthalmopathy in the United States
  • 8.5. EU4 and the UK
    • 8.5.1. Total Prevalent Cases of Graves Ophthalmopathy in EU4 and the UK
    • 8.5.2. Diagnosed Prevalent Cases of Graves Ophthalmopathy in EU4 and the UK
    • 8.5.3. Gender-specific Prevalent Cases of Graves Ophthalmopathy in EU4 and the UK
    • 8.5.4. Diagnosed Prevalent Cases of Graves Ophthalmopathy by Chronicity in EU4 and the UK
    • 8.5.5. Acute Diagnosed Prevalent Cases of Graves Ophthalmopathy by Severity in EU4 and the UK
    • 8.5.6. Acute moderate-to-severe Drug-treated Prevalent Cases of Graves Ophthalmopathy in EU4 and the UK
  • 8.6. Japan
    • 8.6.1. Total Prevalent Cases of Graves Ophthalmopathy in Japan
    • 8.6.2. Diagnosed Prevalent Cases of Graves Ophthalmopathy in Japan
    • 8.6.3. Gender-specific Prevalent Cases of Graves Ophthalmopathy in Japan
    • 8.6.4. Diagnosed Prevalent Cases of Graves Ophthalmopathy by Chronicity in Japan
    • 8.6.5. Acute Diagnosed Prevalent Cases of Graves Ophthalmopathy by Severity in Japan
    • 8.6.6. Acute moderate-to-severe Drug-treated Prevalent Cases of Graves Ophthalmopathy in Japan

9. Patient Journey of Graves Ophthalmopathy

10. Marketed Therapies

  • 10.1. Marketed Competitive Landscape of Graves Ophthalmopathy
  • 10.2. Teprotumumab (TEPEZZA): Amgen
    • 10.2.1. Product Description
    • 10.2.2. Regulatory Milestones
    • 10.2.3. Other Developmental Activities
    • 10.2.4. Summary of Pivotal Trials
    • 10.2.5. Analyst Views

11. Emerging Therapies

  • 11.1. Emerging Competitive Landscape of Graves Ophthalmopathy
  • 11.2. Elegrobart (VRDN-003): Viridian Therapeutics
    • 11.2.1. Product Description
    • 11.2.2. Other Developmental Activities
    • 11.2.3. Clinical Development
      • 11.2.3.1. Clinical Trial Information
    • 11.2.4. Safety and Efficacy
    • 11.2.5. Analyst Views
  • 11.3. Satralizumab (RG6168): Roche
    • 11.3.1. Product Description
    • 11.3.2. Other Developmental Activities
    • 11.3.3. Clinical Development
      • 11.3.3.1. Clinical Trial Information
    • 11.3.4. Safety and Efficacy
    • 11.3.5. Analyst Views
  • 11.4. Linsitinib: Sling Therapeutics
    • 11.4.1. Product Description
    • 11.4.2. Other Developmental Activities
    • 11.4.3. Clinical Development
      • 11.4.3.1. Clinical Trial Information
    • 11.4.4. Safety and Efficacy
    • 11.4.5. Analyst Views

12. Graves Ophthalmopathy: Seven Major Market Analysis

  • 12.1. Key Findings
  • 12.2. Market Outlook of Graves Ophthalmopathy
  • 12.3. Conjoint Analysis of Graves Ophthalmopathy
  • 12.4. Key Market Forecast Assumptions
    • 12.4.1. Cost Assumptions
    • 12.4.2. Pricing Trends
    • 12.4.3. Analogue Assessment
    • 12.4.4. Launch Year and Therapy Uptakes
  • 12.5. Total Market Size of Graves Ophthalmopathy in the 7MM
  • 12.6. The United States
    • 12.6.1. Total Market Size of Graves Ophthalmopathy in the United States
    • 12.6.2. Market Size of Graves Ophthalmopathy by Therapies in the United States
  • 12.7. EU4 and the UK
    • 12.7.1. Total Market Size of Graves Ophthalmopathy in EU4 and the UK
    • 12.7.2. Market Size of Graves Ophthalmopathy by Therapies in EU4 and the UK
  • 12.8. Japan
    • 12.8.1. Total Market Size of Graves Ophthalmopathy in Japan
    • 12.8.2. Market Size of Graves Ophthalmopathy by Therapies in Japan

13. Unmet Needs of Graves Ophthalmopathy

14. SWOT Analysis of Graves Ophthalmopathy

15. KOL Views of Graves Ophthalmopathy

  • 15.1. Expert/KOL Interview Highlights

16. Market Access and Reimbursement of Graves Ophthalmopathy

  • 16.1. The US
  • 16.2. In EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. United Kingdom
  • 16.3. Japan
  • 16.4. Market Access and Reimbursement of Graves Ophthalmopathy Therapies

17. Appendix

  • 17.1. Bibliography
  • 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

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