시장보고서
상품코드
2082948

만성 판상 건선 : 시장 인사이트, 역학 및 시장 예측(2036년)

Chronic Plaque Psoriasis - Market Insight, Epidemiology, and Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 200 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




■ 보고서에 따라 최신 정보로 업데이트하여 보내드립니다. 배송일정은 문의해 주시기 바랍니다.

가격
PDF (Single User License) help
PDF 보고서를 1명만 이용할 수 있는 라이선스입니다. 인쇄 가능하며 인쇄물의 이용 범위는 PDF 이용 범위와 동일합니다.
US $ 7,990 금액 안내 화살표 ₩ 11,488,000
PDF & Excel (2-3 User License) help
PDF 및 Excel 보고서를 동일 사업장에서 3명까지 이용할 수 있는 라이선스입니다. PDF·Excel 내 텍스트 등의 복사 및 붙여넣기는 가능하나, 사내 이용으로만 제한됩니다. 인쇄 가능하며 인쇄물의 이용 범위는 PDF 이용 범위와 동일합니다.
US $ 9,988 금액 안내 화살표 ₩ 14,360,000
PDF & Excel (Site License) help
PDF 및 Excel 보고서를 동일 사업장(소재지) 내 모든 분이 이용할 수 있는 라이선스입니다. PDF·Excel 내 텍스트 등의 복사 및 붙여넣기는 가능하나, 사내 이용으로만 제한됩니다. 인쇄 가능하며 인쇄물의 이용 범위는 PDF 이용 범위와 동일합니다.
US $ 13,983 금액 안내 화살표 ₩ 20,104,000
PDF & Excel (Global License) help
PDF 및 Excel 보고서를 동일 기업의 모든 분이 이용할 수 있는 라이선스입니다. PDF·Excel 내 텍스트 등의 복사 및 붙여넣기는 가능하나, 사내 이용으로만 제한됩니다. 인쇄 가능하며 인쇄물의 이용 범위는 PDF 이용 범위와 동일합니다.
US $ 17,978 금액 안내 화살표 ₩ 25,848,000
※ 부가세 별도
한글목차
영문목차

만성 판상 건선의 인사이트와 동향

  • 만성 판상 건선은 면역계의 조절 이상, 특히 IL-23/Th17 축의 이상에 의해 유발되는 만성 면역매개성 염증성 피부 질환으로, 각화세포의 과도한 증식 및 표피의 비정상적인 분화를 초래합니다. 그 결과, 경계가 뚜렷한 홍반성 반점과 은백색의 비늘 모양 각질이 나타나며, 지속적인 염증이나 전신으로의 확산이 관찰될 수 있습니다.
  • 임상 증상으로는 경계가 뚜렷한 비늘을 동반한 반점, 홍반, 가려움증, 피부 비후 등이 일반적이며, 보통 팔꿈치, 무릎, 두피, 허리 부위에 주로 발생합니다. 중등도에서 중증의 경우, 손발톱 건선(피팅, 손발톱 박리)이나 건선성 관절염이 발생할 수도 있으며, 통증, 가려움증 및 심리사회적 부담으로 인해 삶의 질이 저하될 가능성이 있습니다.
  • PASI 점수, 조직병리학, 피부경 검사, 그리고 건선성 관절염의 영상 진단(초음파 검사 및 MRI 등)과 같은 피부과적 평가 도구의 활용이 증가함에 따라, 진단의 정확도와 질환 중증도 평가가 향상되고 있습니다. 그러나 진단은 여전히 주로 임상적 판단에 의존하고 있어, 경증 사례나 비정형적인 사례에서는 진단이 늦어질 가능성이 있습니다.
  • 비만, 대사증후군, 스트레스, 흡연, 음주 및 유전적 소인 증가에 힘입어 만성 판상 건선의 유병률은 전 세계적으로 지속적으로 증가하고 있으며, 이는 임상적, 경제적 및 삶의 질(QOL) 측면에서의 부담 증가에 기여하고 있습니다.
  • 만성 판상 건선의 관리에는 외용 요법, 광선 요법, 전신 요법 및 생물학적 제제를 병용함으로써, 장기적인 질환 조절, 피부 병변의 완화, 재발 예방, 그리고 삶의 질 향상에 중점을 두고 있습니다.
  • 만성 판상 건선의 치료법에는 외용 코르티코스테로이드, 비타민 D 유사체, 메토트렉세이트, 사이클로스포린, 아시트레틴 등의 기존 전신 요법, 아프레밀라스트 등의 경구용 저분자 약물, 그리고 특정 염증 경로를 표적으로 하는 생물학적 제제가 포함됩니다.
  • 승인된 생물학적 제제에는 TNF-α 억제제(아달리무맙, 에타넬셉트, 인플릭시맙, 셀트리주맙 페골), IL-17 억제제(섹티니맙, 익세키주맙, 브로달맙, 비메키주맙), 그리고 IL-23 억제제(구셀쿠맙, 리산키주맙, 틸드라키주맙)가 포함됩니다.
  • 만성 판상 건선의 현재 표준 치료법은 중등도에서 중증의 경우 IL-17 및 IL-23 경로를 표적으로 하는 생물학적 제제를 중심으로 이루어지고 있으나, 경증의 경우 여전히 외용제나 광선 요법이 1차 치료법으로 사용되고 있습니다. 자원이 제한된 환경이나 특정 환자의 경우, 전신용 비생물학적 제제가 여전히 사용되고 있습니다.
  • 만성 판상 건선의 개발 파이프라인에는 차세대 IL-23 억제제, TYK2 억제제(예: 데우크라바시티닙), 경구용 저분자 약물, 그리고 유효성, 안전성, 편의성 및 장기적인 질환 관리 향상을 목표로 하는 신규 생물학적 제제 등 새로운 치료법이 포함되어 있습니다.
  • 치료법의 발전에도 불구하고, 만성 판상 건선은 만성적인 재발을 동반하는 경과, 일부 환자에서 나타나는 치료 무효, 장기간에 걸친 면역 억제에 따른 안전성 우려, 복약 순응도 문제, 그리고 삶의 질 및 심리사회적 웰빙에 미치는 지속적인 영향으로 인해 여전히 해결되지 않은 큰 의료적 요구 사항으로 남아 있습니다.

만성 판상 건선 시장 보고서는 표준 치료, 임상 실무, 진화하는 치료 알고리즘 등 현재의 치료 현황에 대한 종합적인 분석을 제공합니다. 본 보고서에서는 만성 판상 건선 환자의 부담 동향, 매출액 및 시장 점유율 동향, 정점 시기의 환자 점유율 및 치료 도입률 분석을 평가함과 동시에, 세계 각 지역 시장 규모에 대한 상세한 평가 및 성장률 예측(과거 데이터 및 2022년-2036년 예측)을 제시하고 있습니다. 본 보고서는 만성 판상 건선 분야의 주요 미충족 의료 수요를 부각시키고, 경쟁 구도 및 임상 현황을 분석하여 고부가가치 성장 기회를 도출함으로써, 향후 시장 성장 가능성에 대한 명확한 전망을 제시하고 있습니다.

만성 판상 건선 시장을 주도하는 주요 요인

건선의 유병률 및 질병 부담 증가

건선 시장은 전 세계 만성 판상 건선의 유병률 증가와 비만, 대사증후군, 당뇨병, 흡연, 스트레스 등 관련 위험 요인 증가로 인해 확대되고 있습니다. 진단율 향상, 질병에 대한 인식 제고, 의료 서비스 접근성 확대가 치료 수요를 더욱 부추기고 있습니다.

생물학적 제제 및 표적 치료의 발전

이 시장의 성장은 TNF-α, IL-17, IL-23 억제제를 포함한 표적형 생물학적 제제 및 면역 조절제의 개발에 힘입어 이루어지고 있습니다. 이러한 조치들은 치료 효과를 높이고 장기적인 질환 관리를 가능하게 합니다. 단일클론 항체 및 경구 치료제 분야의 지속적인 혁신으로 인해 시장 전망은 더욱 밝아질 것으로 예측됩니다.

장기 치료 및 맞춤형 치료 접근법의 보급 확대

생물학적 제제, 유지 요법, 그리고 질환의 중증도 및 환자의 반응에 기반한 맞춤형 치료 전략의 활용 확대가 시장 성장을 뒷받침하고 있습니다. 규제 당국의 긍정적인 승인 및 진행 중인 파이프라인 개발 역시 건선 시장의 성장에 더욱 기여하고 있습니다.

만성 판상 건선의 이해와 치료 알고리즘

만성 판상 건선의 개요와 진단

건선은 홍반을 동반하고 경계가 뚜렷하며 은백색의 비늘을 보이는 만성 면역매개성 염증성 피부 질환으로, 가장 흔한 유형은 만성 판상 건선입니다. 이 질환은 TNF-α, IL-17 및 IL-23 경로와 관련된 면역 조절 이상과 연관되어 있으며, 건선성 관절염, 비만, 당뇨병, 심혈관 질환, 우울증 등의 동반 질환을 동반하는 경우가 빈번합니다. 치료법은 질환의 중증도에 따라 결정되며, 외용 코르티코스테로이드, 비타민 D 유사체, 광선 요법, 전신 요법, 그리고 아달리무맙, 섹티니맙, 우스테키누맙, 익세키주맙 등의 표적 생물학적 제제가 포함됩니다. IL-17, IL-23, TYK2, JAK를 표적으로 하는 치료법의 최근 발전으로 인해 장기적인 질환 관리가 크게 개선되었으나, 전 세계적으로 볼 때 건선은 여전히 진단 및 치료가 미흡한 상태입니다.

만성 판상 건선의 진단

건선의 진단은 주로 임상 평가와 경계가 뚜렷한 홍반성 반점 및 은백색의 비늘과 같은 특징적인 소견을 바탕으로 이루어집니다. 진단이 확정되지 않는 경우에는 피부 생검 및 조직병리학적 검사를 실시하여 진단을 확정함과 동시에, 건선을 다른 염증성 피부 질환과 감별 진단할 수 있습니다. 질환의 중증도, 체표면적에 미치는 범위, 손발톱의 변화, 건선성 관절염의 증상 등에 대한 추가 평가는 치료법 선택 및 장기적인 질환 관리의 지침이 됩니다.

만성 판상 건선의 치료

건선 치료는 주로 염증 억제, 피부 병변 완화, 질환 진행 예방, 그리고 삶의 질 향상에 중점을 둡니다. 경증에서 중등도의 건선은 일반적으로 외용 코르티코스테로이드, 비타민 D 유사체, 광선 요법으로 관리되지만, 중등도에서 중증의 질환의 경우 메토트렉세이트, 사이클로스포린, 아시트레틴, 아프레밀라스트 등의 전신 요법이 필요한 경우가 많습니다. 아달리무맙, 섹티니맙, 우스테키누맙, 이쿠세키즈맙 등 TNF-α, IL-17, IL-23 및 IL-12/23 경로를 표적으로 하는 첨단 생물학적 제제는 중증 또는 난치성 환자에게 널리 사용되고 있습니다. TYK2 억제제나 JAK 억제제 등 새로운 치료법도 치료 선택의 폭을 더욱 넓혀주고 있습니다. 전반적으로, 치료는 질환의 중증도, 체표면적에 미치는 범위, 동반 질환, 그리고 치료에 대한 환자의 반응을 바탕으로 개별화됩니다.

만성 판상 건선의 역학

만성 판상 건선의 역학 분석 및 예측에 관한 주요 조사 결과

  • 미국 질병통제예방센터(CDC)에 따르면, 건선은 미국에서 가장 흔한 염증성 질환으로, 약 740만 명의 미국 성인이 이 질환을 앓고 있습니다.
  • 추산에 따르면, 건선을 앓고 있는 사람의 약 80-90%가 만성 판상 건선을 앓고 있습니다.
  • 건선은 전 세계적으로 널리 나타나며, 전 세계 유병률은 1%에서 8%입니다. 증례의 약 3분의 1은 소아기에 발병합니다.
  • 미국 건선 재단에 따르면, 건선의 가장 흔한 형태인 만성 판상 건선은 은백색 각질이 쌓인, 돌출된 붉은 반점으로 나타납니다. 건선 환자의 약 20%가 중등도에서 중증의 만성 판상 건선을 앓고 있습니다.
  • 건선의 가장 흔한 유형은 만성 판상 건선이며, 건선 환자의 약 90%가 이에 해당하고, 그중 약 20%-30%가 중등도 또는 중증의 증상을 보입니다.
  • 만성 판상 건선은 여성보다 남성의 발병률이 약간 더 높은 것으로 추정됩니다.

만성 판상 건선 시장 전망

중등도에서 중증의 만성 판상 건선 시장은 기존의 외용제나 광선 요법에 기반한 관리에서 생물학적 제제나 표적 면역 요법이 주도하는 치료 패러다임으로 전환되고 있으며, TNF 억제제(CIMZIA), IL-17 억제제(SILIQ, TALTZ, COSENTYX), PDE4 억제제(OTEZLA) 등 이미 확립된 약제들이 계속해서 치료의 기반을 형성하고 있습니다. 생물학적 제제 시장이 견조한 성장세를 보이고 있음에도 불구하고, 상당수의 환자가 충분한 증상 조절을 얻지 못하거나, 반응 소실, 안전성 우려, 혹은 주사 투여의 부담을 이유로 치료를 중단하고 있어, 특히 경증에서 중등도 및 국소성 질환의 경우 여전히 충족되지 않은 의료적 요구가 존재한다는 사실이 부각되고 있습니다. 이러한 질환의 경우, 외용 요법이 주류를 이루고 있지만, 질환 경과 조절 효과 측면에서는 여전히 미흡합니다.

치료 동향은 높은 유효성을 유지하면서 편의성, 장기적인 복약 순응도 및 안전성 향상을 목표로 하는 차세대 경구약과 작용기전에 기반한 치료법, 그리고 새로운 비전신적 접근 방식으로 점점 더 전환되고 있습니다. 이러한 상황에서 경구용 선택적 PDE4 억제제인 ME3183(메이지제과), 가시광선에 의해 활성화되는 합성 하이페리신을 이용한 광역학 요법인 SGX302(Soligenix), 그리고 차세대 경구용 TYK2 억제제인 TAK-279(다케다 제약)와 같은 개발 중인 신약 후보들은 만성 판상 건선의 초기 및 중간 치료 단계에서 치료 선택지를 확대할 것으로 기대되고 있습니다.

  • 미국은 높은 유병률, 생물학적 제제의 높은 보급률, 그리고 경증에서 중등도 증례의 진단 증가에 힘입어 만성 판상 건선의 최대 시장 중 하나가 되었습니다.
  • 승인된 생물학적 제제는 다수 존재하지만, 국소성 질환을 앓고 있는 환자, 외용 요법의 복약 순응도가 낮은 환자, 그리고 주사 이외의 치료법을 원하는 환자의 경우, 여전히 치료상의 공백이 존재합니다.
  • 현재의 외용 요법은 증상 완화에는 도움이 되지만, 질환 수정 효과가 미미하기 때문에 새로운 표적 요법이나 비전신 요법에 대한 수요가 높아지고 있습니다.
  • 광선 요법 및 외용 코르티코스테로이드는 국소성 질환의 관리에 있어 여전히 기본적인 치료법이지만, 사용 편의성, 접근성 및 장기적인 복약 순응도 문제 등으로 인해 그 활용에는 한계가 있습니다.
  • 최근의 과학적 연구 결과에 따르면, 국소성 질환에서는 염증성 사이토카인의 활성이 비정상적으로 높아져 있을 가능성이 있으며, 이는 표적화된 중재의 가능성을 뒷받침하고 있습니다.
  • TAK-279, SGX302, ME3183 등 개발 중인 약제들은 예측 기간 동안 경구용 표적 치료 및 비침습적 치료 분야의 혁신을 주도할 것으로 기대됩니다.
  • 외용 요법: 코르티코스테로이드, 비타민 D 유사체(칼시포트리엔), 레티노이드, 콜타르, 보습제 등이 포함되며, 경증에서 중등도 및 국소성 질환에 대한 1차 표준 치료법을 구성하고 있습니다. 이러한 치료법은 증상을 완화시켜 주지만, 질병 진행을 억제하는 효과는 없으며, 재발이나 복약 순응도 문제로 인해 그 효과가 제한되는 경우가 많습니다.
  • 전신용 생물학적 제제 및 경구제: TNF 억제제(CIMZIA), IL-17 억제제(COSENTYX, TALTZ, SILIQ), PDE4 억제제(OTEZLA) 등이 포함됩니다. 이 약물들은 건선의 발병을 촉진하는 주요 염증성 사이토카인 및 면역 경로를 표적으로 삼음으로써, 중등도에서 중증의 질환 관리에 있어 주류로 자리 잡고 있습니다.

전반적으로, 중등도에서 중증의 만성 판상 건선에서는 생물학적 제제가 현재의 표준 치료법으로 자리 잡고 있지만, 경증에서 중등도의 질환에서는 외용 요법이나 광선 요법이 여전히 중심적인 역할을 하고 있습니다. 그러나 국소성 및 경증에서 중등도의 건선에서는 여전히 큰 미충족 의료 수요가 존재하며, 치료가 주로 대증 요법에 그치고 있기 때문에 경구용 저분자 화합물이나 광역학 요법(예: TAK-279, ME3183, SGX302)과 같은 새롭고 비침습적이며 표적화된 치료법에 대한 수요가 높아지고 있습니다.

자주 묻는 질문

  • 만성 판상 건선의 주요 원인은 무엇인가요?
  • 만성 판상 건선의 주요 증상은 무엇인가요?
  • 만성 판상 건선의 진단 방법은 무엇인가요?
  • 만성 판상 건선의 치료 방법에는 어떤 것들이 있나요?
  • 만성 판상 건선 시장의 성장 요인은 무엇인가요?
  • 만성 판상 건선의 시장 규모는 어떻게 되나요?
  • 만성 판상 건선 치료에 사용되는 주요 생물학적 제제는 무엇인가요?

목차

제1장 주요 인사이트

제2장 서론

제3장 주요 요약

제4장 주요 이벤트

제5장 만성 판상 건선 : 역학 및 시장 조사 방법

제6장 만성 판상 건선 : 시장 개요

제7장 만성 판상 건선 : 질환 배경과 개요

제8장 치료와 가이드라인

제9장 만성 판상 건선 : 역학 및 환자 인구

제10장 만성 판상 건선 : 환자 경과

제11장 시판 치료제

제12장 신흥 치료법

제13장 만성 판상 건선 : 주요 7개국 분석

제14장 만성 판상 건선 : 미충족 요구

제14장 만성 판상 건선 : SWOT 분석

제15장 만성 판상 건선 : KOL(Key Opinion Leader)의 견해

제16장 만성 판상 건선 : 시장 참여 및 상환

제17장 부록

제18장 DelveInsight의 서비스 내용

제19장 면책사항

제20장 DelveInsight에 대해

LSH 26.07.27

Chronic Plaque Psoriasis Insights and Trends

  • Chronic Plaque Psoriasis is a chronic immune-mediated inflammatory skin disorder driven by dysregulation of the immune system, particularly the IL-23/Th17 axis, leading to excessive keratinocyte proliferation and abnormal epidermal differentiation. This results in well-demarcated erythematous plaques with silvery scales, along with persistent inflammation and potential systemic involvement.
  • Clinical presentation commonly includes well-defined scaly plaques, erythema, pruritus, and skin thickening, typically affecting the elbows, knees, scalp, and lower back. In moderate-to-severe cases, patients may also develop nail psoriasis (pitting, onycholysis), psoriatic arthritis, and impaired quality of life due to pain, itching, and psychosocial burden.
  • The increasing use of dermatological assessment tools such as PASI scoring, histopathology, dermoscopy, and imaging in psoriatic arthritis (e.g., ultrasound and MRI) has improved diagnostic accuracy and disease severity assessment. However, diagnosis remains primarily clinical and may be delayed in mild or atypical cases.
  • The prevalence of chronic plaque psoriasis continues to rise globally, driven by increasing rates of obesity, metabolic syndrome, stress, smoking, alcohol consumption, and genetic predisposition, contributing to a growing clinical, economic, and quality-of-life burden.
  • Management of Chronic Plaque Psoriasis focuses on long-term disease control, reduction of skin lesions, prevention of flares, and improvement in quality of life through a combination of topical therapies, phototherapy, systemic agents, and biologics.
  • Therapies for chronic plaque psoriasis include topical corticosteroids and vitamin D analogues, conventional systemic treatments including methotrexate, cyclosporine, and acitretin, oral small molecules such as apremilast, and biologic therapies that target specific inflammatory pathways.
  • Approved biologics include TNF-a inhibitors (adalimumab, etanercept, infliximab, and certolizumab pegol), IL-17 inhibitors (secukinumab, ixekizumab, brodalumab, and bimekizumab), and IL-23 inhibitors (guselkumab, risankizumab, and tildrakizumab).
  • The current standard of care for chronic plaque psoriasis is centered on biologic therapies targeting IL-17 and IL-23 pathways for moderate-to-severe disease, while topical agents and phototherapy remain first-line options for mild disease. Systemic non-biologic agents are still used in resource-limited settings or selected patients.
  • The chronic plaque psoriasis pipeline includes emerging therapies such as next-generation IL-23 inhibitors, TYK2 inhibitors (e.g., deucravacitinib), oral small molecules, and novel biologics aimed at improving efficacy, safety, convenience, and long-term disease control.
  • Despite therapeutic advancements, chronic plaque psoriasis continues to represent a significant unmet need due to chronic relapsing disease course, treatment non-response in some patients, safety concerns with long-term immunosuppression, adherence challenges, and the persistent impact on quality of life and psychosocial well-being.

DelveInsight's 'Chronic Plaque Psoriasis - Market Insights, Epidemiology and Market Forecast - 2036' report delivers an in-depth understanding of the Chronic Plaque Psoriasis, historical and forecasted epidemiology, as well as the Chronic Plaque Psoriasis market trends in the United States, EU4 (Germany, Spain, Italy, and France), and the United Kingdom, and Japan.

The Chronic Plaque Psoriasis market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates chronic plaque psoriasis patient burden trends, revenue & market share dynamics, peak patient share & therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in chronic plaque psoriasis and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.

Key Factors Driving the Chronic Plaque Psoriasis Market

Rising Prevalence and Disease Burden of Psoriasis

The psoriasis market is growing due to the increasing global prevalence of plaque psoriasis and associated risk factors such as obesity, metabolic syndrome, diabetes, smoking, and stress. Improved diagnosis rates, greater disease awareness, and expanding healthcare access are further increasing treatment demand.

Advancements in Biologics and Targeted Therapies

Market growth is driven by the development of targeted biologics and immunomodulators, including TNF-a, IL-17, and IL-23 inhibitors, which offer improved efficacy and long-term disease control. Continued innovation in monoclonal antibodies and oral therapies is expected to strengthen the treatment landscape.

Growing Adoption of Long-Term and Personalized Treatment Approaches

Increasing use of biologics, maintenance therapies, and personalized treatment strategies based on disease severity and patient response is supporting market expansion. Favorable regulatory approvals and ongoing pipeline development are further contributing to psoriasis market growth.

Chronic Plaque Psoriasis Understanding and Treatment Algorithm

Chronic Plaque Psoriasis Overview and Diagnosis

Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by erythematous, well-demarcated plaques with silvery scales, most commonly presenting as plaque psoriasis. The disease is associated with immune dysregulation involving TNF-a, IL-17, and IL-23 pathways and is frequently linked with comorbidities such as psoriatic arthritis, obesity, diabetes, cardiovascular disease, and depression. Treatment depends on disease severity and includes topical corticosteroids, vitamin D analogs, phototherapy, systemic therapies, and targeted biologics, including adalimumab, secukinumab, ustekinumab, and ixekizumab. Recent advancements in IL-17, IL-23, TYK2, and JAK-targeted therapies have significantly improved long-term disease management, although psoriasis remains underdiagnosed and undertreated globally.

Chronic Plaque Psoriasis Diagnosis

Diagnosis of psoriasis is primarily based on clinical evaluation and characteristic findings such as well-demarcated erythematous plaques with silvery scales. In uncertain cases, skin biopsy and histopathological examination may be performed to confirm the diagnosis and differentiate psoriasis from other inflammatory skin disorders. Additional assessments, including evaluation of disease severity, body surface area involvement, nail changes, and psoriatic arthritis symptoms, help guide treatment selection and long-term disease management.

Chronic Plaque Psoriasis Treatment

Treatment of psoriasis primarily focuses on controlling inflammation, reducing skin lesions, preventing disease progression, and improving quality of life. Mild-to-moderate psoriasis is commonly managed with topical corticosteroids, vitamin D analogs, and phototherapy, while moderate-to-severe disease often requires systemic therapies such as methotrexate, cyclosporine, acitretin, and apremilast. Advanced biologic therapies targeting TNF-a, IL-17, IL-23, and IL-12/23 pathways, including adalimumab, secukinumab, ustekinumab, and ixekizumab, are widely used for patients with severe or refractory disease. Emerging therapies such as TYK2 and JAK inhibitors are further expanding treatment options. Overall, treatment is individualized based on disease severity, body surface area involvement, comorbidities, and patient response to therapy.

Chronic Plaque Psoriasis Unmet Needs

The section "unmet needs of chronic plaque psoriasis" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Need for more effective and durable treatment options

2. Limited long-term efficacy and loss of treatment response

3. High treatment costs and restricted access to biologics

4. Underdiagnoses and under-treatment of psoriasis, and others.....

Chronic plaque psoriasis Epidemiology

Key Findings from Chronic Plaque Psoriasis Epidemiological Analysis and Forecast

  • As per the Centers for Disease Control and Prevention, Psoriasis is the most common inflammatory disease in the United States, affecting approximately as many as 7.4 million American adults.
  • According to estimates, about 80 to 90% of people living with psoriasis experience plaque psoriasis.
  • Psoriasis is prevalent worldwide, with a global prevalence of 1% to 8%. It begins in childhood in approximately one-third of cases.
  • As per the National Psoriasis Foundation, the most common form of psoriasis, plaque psoriasis, appears as raised, red patches covered with a silvery white buildup of dead skin cells. Approximately 20% of people with psoriasis have moderate-to-severe plaque psoriasis.
  • The most common form of Psoriasis is Chronic Plaque Psoriasis, affecting about 90% of psoriasis patients, with about 20%-30% of them suffering from a moderate or severe condition.
  • It is estimated that males are slightly more affected by chronic plaque psoriasis than females.

Chronic Plaque Psoriasis Drug Analysis & Competitive Landscape

The Chronic Plaque Psoriasis drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase I-III clinical trials. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the chronic plaque psoriasis treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the chronic plaque psoriasis therapeutics market.

Approved Therapies for Chronic Plaque Psoriasis

Certolizumab (CIMZIA): UCB

CIMZIA is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. CIMZIA is an Fc-free, PEGylated anti-TNF therapy that selectively neutralizes TNF-a, a key inflammatory cytokine involved in psoriasis pathogenesis. It provides an effective biologic treatment option for patients requiring long-term disease control and improved management of moderate-to-severe plaque psoriasis.

Apremilast (OTEZLA): Amgen

OTEZLA is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels, which are thought to indirectly modulate the production of inflammatory mediators.

Chronic Plaque Psoriasis Pipeline Analysis

SGX302: Soligenix

SGX302 is a topical, synthetic hypericin gel developed for the treatment of mild-to-moderate chronic plaque psoriasis. It utilizes a photodynamic therapy mechanism, where hypericin is activated by UVA light exposure to generate localized anti-inflammatory and immunomodulatory effects in psoriatic lesions. SGX302 targets inflammatory pathways driving keratinocyte hyperproliferation, leading to reductions in erythema, scaling, and plaque thickness. Its mechanism involves reactive oxygen species (ROS)-mediated modulation of T-cell activity, providing localized disease control without systemic immunosuppression.

ME3183: Meiji Seika Pharma

ME3183 is an investigational oral small-molecule therapy being developed by Meiji Seika Pharma for the treatment of psoriasis, including chronic plaque psoriasis. It is designed to modulate key immune-inflammatory signaling pathways involved in keratinocyte hyperproliferation and T-cell-mediated skin inflammation, which are central drivers of psoriasis pathophysiology. ME3183 acts by targeting upstream inflammatory mediators, aiming to reduce psoriatic lesion formation, erythema, and scaling, while improving overall skin clearance and disease control.

Chronic Plaque Psoriasis Key Players, Market Leaders, and Emerging Companies

  • UCB
  • Bausch Health Companies
  • Eli Lilly
  • Novartis
  • Amgen
  • Meiji Seika Pharma
  • Soligenix
  • Takeda, and others

Chronic Plaque Psoriasis Drug Updates

  • In March 2026, Takeda announced new data from two pivotal Phase III studies of zasocitinib (TAK-279), a next-generation, highly selective oral TYK2 inhibitor, in adults with moderate-to-severe plaque psoriasis. Presented as a late-breaking abstract at the 2026 American Academy of Dermatology (AAD) Annual Meeting, the results demonstrated that once-daily oral zasocitinib provided rapid and durable skin clearance, with a safety profile consistent with prior Phase IIb findings.
  • In December 2025, Soligenix announced extended results of its ongoing Phase IIa trial of SGX302 (synthetic hypericin) for the treatment of mild-to-moderate psoriasis. In this extension (Cohort 3) of the exploratory phase of the study, an additional four patients are enrolled and treated with an improved topical gel formulation of synthetic hypericin.
  • In September 2025, Novartis announced the launch of a Direct-to-Patient (DTP) platform in the United States, effective November 1, 2025, enabling cash-paying patients prescribed secukinumab (COSENTYX) to access the therapy at a 55% discount off the list price.

Chronic Plaque Psoriasis Market Outlook

The moderate-to-severe plaque psoriasis market is evolving from conventional topical and phototherapy-based management toward a biologic- and targeted immunology-driven treatment paradigm, with established agents such as TNF inhibitors (CIMZIA), IL-17 inhibitors (SILIQ, TALTZ, COSENTYX), and PDE4 inhibition (OTEZLA) continuing to form the backbone of therapy. Despite the strong biologics landscape, a significant proportion of patients remain inadequately controlled, discontinue therapy due to loss of response, safety concerns, or injection burden, highlighting a persistent unmet need, particularly in mild-to-moderate and localized disease, where topical therapies dominate but remain suboptimal in disease modification.

The treatment landscape is increasingly shifting toward next-generation oral and mechanism-driven therapies and novel non-systemic approaches, aiming to improve convenience, long-term adherence, and safety while maintaining high efficacy. In this context, emerging pipeline assets such as ME3183 (Meiji Seika Pharma), an oral selective PDE4 inhibitor, SGX302 (Soligenix), a photodynamic therapy using synthetic hypericin activated by visible light, and TAK-279 (Takeda), a next-generation oral TYK2 inhibitor, are expected to expand treatment options across earlier and mid-line settings of plaque psoriasis.

  • The United States represents one of the largest plaque psoriasis markets, driven by high disease prevalence, strong biologics penetration, and increasing diagnosis of mild-to-moderate cases.
  • Despite multiple approved biologics, treatment gaps persist in patients with localized disease, poor adherence to topical regimens, and those seeking non-injectable options.
  • Current topical therapies provide symptomatic relief but lack disease-modifying potential, reinforcing the need for novel targeted and non-systemic approaches.
  • Phototherapy and topical corticosteroids remain foundational in localized disease management, but are limited by accessibility, convenience, and long-term compliance challenges.
  • Recent scientific insights suggest that inflammatory cytokine activity may be disproportionately elevated in localized disease, supporting targeted intervention opportunities.
  • Pipeline assets such as TAK-279, SGX302, and ME3183 are expected to drive innovation in oral targeted therapy and non-invasive treatment modalities during the forecast period.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Chronic Plaque Psoriasis (2022-2036 Forecast)

The plaque psoriasis treatment landscape is structured around topical therapies, phototherapy, and systemic biologics/oral agents, each addressing varying disease severity and treatment goals from symptom control to long-term immune modulation.

  • Topical therapies: Include corticosteroids, vitamin D analogs (calcipotriene), retinoids, coal tar, and moisturizers, forming the first-line standard of care for mild-to-moderate and localized disease. These provide symptomatic relief but are non-disease-modifying and often limited by recurrence and adherence challenges.
  • Systemic biologics and oral agents: Include TNF inhibitors (CIMZIA), IL-17 inhibitors (COSENTYX, TALTZ, SILIQ), and PDE4 inhibitors (OTEZLA), which dominate moderate-to-severe disease management by targeting key inflammatory cytokines and immune pathways driving psoriasis pathogenesis.

Overall, biologics define the current standard in moderate-to-severe plaque psoriasis, while topical and phototherapy approaches remain central in mild-to-moderate disease. However, significant unmet need persists in localized and mild-to-moderate psoriasis, where treatments remain largely symptomatic, driving demand for novel, non-invasive, and targeted therapies such as oral small molecules and photodynamic approaches (e.g., TAK-279, ME3183, SGX302)

Chronic Plaque Psoriasis Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the Chronic Plaque Psoriasis drug's uptake, performance at peak, factors affecting performance during prime years of growth, patient uptake by therapy, and anticipated sales generated by each drug.

The plaque psoriasis treatment uptake landscape is expected to vary across topical therapies, phototherapy, and systemic biologics/oral agents, reflecting differences in disease severity, convenience, and long-term efficacy.

Established topical therapies such as corticosteroids, vitamin D analogs, and combination regimens are expected to maintain consistent and widespread use in mild-to-moderate and localized disease due to their role as first-line treatments, ease of access, and rapid symptomatic relief, despite limitations in long-term disease modification and recurrence control.

In contrast, systemic biologics and oral targeted therapies such as TNF inhibitors, IL-17 inhibitors, IL-23 pathway agents, and PDE4 inhibitors (OTEZLA) are expected to demonstrate strong and sustained uptake in moderate-to-severe plaque psoriasis, driven by superior efficacy, durable skin clearance, and established clinical guidelines.

Next-generation pipeline therapies such as TAK-279 (oral TYK2 inhibitor), SGX302 (photodynamic therapy), and ME3183 (oral PDE4 inhibitor) are anticipated to witness gradual uptake as clinical evidence matures and regulatory positioning evolves, particularly in earlier lines of therapy and mild-to-moderate disease segments. Their future adoption will be influenced by efficacy vs biologics, safety profile, convenience (oral/topical/non-systemic), and long-term disease control potential.

Chronic Plaque Psoriasis Therapies Price Scenario & Trends

Pricing and analogue assessment of Chronic Plaque Psoriasis therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and the understanding of how pricing influences market access, adherence, and long-term uptake.

Further details are provided in the final report....

Industry Experts and Physician Views for Chronic Plaque Psoriasis

To keep up with Chronic Plaque Psoriasis market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the emerging chronic plaque psoriasis therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in chronic plaque psoriasis, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 10+ KOLs to gather insights at the country level. Centers such as the Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, US, and Medical Center-University of Freiburg, Freiburg, Germany, etc., were contacted. Their opinion helps understand and validate current and emerging chronic plaque psoriasis therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in chronic plaque psoriasis.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of Chronic Plaque Psoriasis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are mainly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of chronic plaque psoriasis, explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborate profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the Chronic Plaque Psoriasis market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM chronic plaque psoriasis market.

Report Insights

  • Chronic Plaque Psoriasis Patient Population Forecast
  • Chronic Plaque Psoriasis Therapeutics Market Size
  • Chronic Plaque Psoriasis Pipeline Analysis
  • Chronic Plaque Psoriasis Market Size and Trends
  • Chronic Plaque Psoriasis Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-Enabled Market Research Report
  • 11-Year Forecast
  • Chronic Plaque Psoriasis Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (By Geography)
  • Chronic Plaque Psoriasis Treatment Addressable Market (TAM)
  • Chronic Plaque Psoriasis Competitive Landscape
  • Chronic Plaque Psoriasis Major Companies Insights
  • Chronic Plaque Psoriasis Price Trends and Analogue Assessment
  • Chronic Plaque Psoriasis Therapies Drug Adoption/Uptake
  • Chronic Plaque Psoriasis Therapies Peak Patient Share Analysis

Report Assessment

  • Chronic Plaque Psoriasis Current Treatment Practices
  • Chronic Plaque Psoriasis Unmet Needs
  • Chronic Plaque Psoriasis Clinical Development Analysis
  • Chronic Plaque Psoriasis Emerging Drugs Product Profiles
  • Chronic Plaque Psoriasis Market Attractiveness
  • Chronic Plaque Psoriasis Qualitative Analysis (SWOT and conjoint analysis)

FAQs:

Market Insights

  • What was the Chronic Plaque Psoriasis market size, the market size by therapies, the market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of Chronic Plaque Psoriasis?
  • What are the disease risks, burdens, and unmet needs of Chronic Plaque Psoriasis? What will be the growth opportunities across the 7MM concerning the patient population with Chronic Plaque Psoriasis?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of Chronic Plaque Psoriasis? What are the current guidelines for treating Chronic Plaque Psoriasis in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Chronic Plaque Psoriasis market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights into the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarizes and simplifies complex datasets within the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary

4. Key Events

  • 4.1. Upcoming Key Catalysts
  • 4.2. Key Conferences And Meetings
  • 4.3. Key Transactions And Collaborations
  • 4.4. News Flow

5. Epidemiology and Market Methodology of Chronic Plaque Psoriasis

6. Chronic Plaque Psoriasis Market Overview at a Glance

  • 6.1. Clinical Landscape Analysis (By Molecule Type, Phase, and Route of Administration [ROA])
  • 6.2. Market Share of Chronic Plaque Psoriasis by Therapies (%) in the 7MM in 2025
  • 6.3. Market Share of Chronic Plaque Psoriasis by Therapies (%) in the 7MM in 2036

7. Disease Background And Overview of Chronic Plaque Psoriasis

  • 7.1. Introduction
  • 7.2. Signs and Symptoms
  • 7.3. Causes
  • 7.4. Diagnosis

8. Treatment and Guidelines

  • 8.1. Treatment Guidelines and Recommendations

9. Epidemiology and Patient Population of Chronic Plaque Psoriasis

  • 9.1. Key Findings
  • 9.2. Total Diagnosed Prevalent Cases of Chronic Plaque Psoriasis in the 7MM
  • 9.3. The US
    • 9.3.1. Total Prevalent Cases of Plaque Psoriasis in the US
    • 9.3.2. Total Prevalent Cases of Chronic Plaque Psoriasis in the US
    • 9.3.3. Gender-specific Cases of Chronic Plaque Psoriasis in the US
    • 9.3.4. Age-specific Cases of Chronic Plaque Psoriasis in the US
    • 9.3.5. Severity-specific Cases of Chronic Plaque Psoriasis in the US
    • 9.3.6. Total Treated Cases of Chronic Plaque Psoriasis in the US
  • 9.4. EU4 and the UK
    • 9.4.1. Total Prevalent Cases of Plaque Psoriasis in the EU4 and the UK
    • 9.4.2. Total Prevalent Cases of Chronic Plaque Psoriasis in the EU4 and the UK
    • 9.4.3. Gender-specific Cases of Chronic Plaque Psoriasis in the EU4 and the UK
    • 9.4.4. Age-specific Cases of Chronic Plaque Psoriasis in the EU4 and the UK
    • 9.4.5. Severity-specific Cases of Chronic Plaque Psoriasis in the EU4 and the UK
    • 9.4.6. Total Treated Cases of Chronic Plaque Psoriasis in the EU4 and the UK
  • 9.5. Japan
    • 9.5.1. Total Prevalent Cases of Plaque Psoriasis in Japan
    • 9.5.2. Total Prevalent Cases of Chronic Plaque Psoriasis in Japan
    • 9.5.3. Gender-specific Cases of Chronic Plaque Psoriasis in Japan
    • 9.5.4. Age-specific Cases of Chronic Plaque Psoriasis in Japan
    • 9.5.5. Severity-specific Cases of Chronic Plaque Psoriasis in Japan
    • 9.5.6. Total Treated Cases of Chronic Plaque Psoriasis in Japan

10. Patient Journey of Chronic Plaque Psoriasis

11. Marketed Therapies

  • 11.1. Marketed Competitive Landscape of Chronic Plaque Psoriasis
  • 11.2. Bimekizumab-bkzx (BIMZELX): UCB
    • 11.2.1. Product Description
    • 11.2.2. Regulatory Milestones
    • 11.2.3. Other Developmental Activities
    • 11.2.4. Summary of Pivotal Trials
    • 11.2.5. Analyst's View
  • 11.3. Apremilast (OTEZLA): Amgen
    • 11.3.1. Product Description
    • 11.3.2. Regulatory Milestones
    • 11.3.3. Other Developmental Activities
    • 11.3.4. Summary of Pivotal Trials
    • 11.3.5. Analyst's View

12. Emerging Therapies

  • 12.1. Competitive Landscape: Emerging Therapies
  • 12.2. TAK-279: Takeda
    • 12.2.1. Product Description
    • 12.2.2. Other Developmental Activities
    • 12.2.3. Clinical Development
    • 12.2.4. Safety and Efficacy
    • 12.2.5. Analyst's View

13. Chronic Plaque Psoriasis: Seven Major Market Analysis

  • 13.1. Key Findings
  • 13.2. Market Outlook
  • 13.3. Conjoint Analysis
  • 13.4. Key Market Forecast Assumptions
    • 13.4.1. Cost Assumptions and Rebates
    • 13.4.2. Pricing Trends
    • 13.4.3. Analogue Assessment
    • 13.4.4. Launch Year and Therapy Uptakes
  • 13.5. Total Market Size of Chronic Plaque Psoriasis in the 7MM
  • 13.6. The United States Market Size
    • 13.6.1. Total Market Size of Chronic Plaque Psoriasis in the United States
    • 13.6.2. Market Size of Chronic Plaque Psoriasis by Therapies in the United States
  • 13.7. EU4 and the UK Market Size
    • 13.7.1. Total Market Size of Chronic Plaque Psoriasis in EU4 and the UK
    • 13.7.2. Market Size of Chronic Plaque Psoriasis by Therapies in EU4 and the UK
  • 13.8. Japan Market Size
    • 13.8.1. Total Market Size of Chronic Plaque Psoriasis in Japan
    • 13.8.2. Market Size of Chronic Plaque Psoriasis by Therapies in Japan

14. Unmet Needs of Chronic Plaque Psoriasis

14. SWOT Analysis of Chronic Plaque Psoriasis

15. KOL Views of Chronic Plaque Psoriasis

  • 15.1. Expert/KOL Interview Highlights

16. Market Access and Reimbursement of Chronic Plaque Psoriasis

  • 16.1. United States
    • 16.1.1. Centre for Medicare and Medicaid Services (CMS)
  • 16.2. EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. United Kingdom
  • 16.3. Japan
  • 16.4. Summary and comparison of Market Access and Pricing Policy Developments in 2025
  • 16.5. Market Access and Reimbursement of Chronic Plaque Psoriasis Therapies

17. Appendix

  • 17.1. Bibliography
  • 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

샘플 요청 목록
0 건의 상품을 선택 중
목록 보기
전체삭제
문의
원하시는 정보를
찾아 드릴까요?
문의주시면 필요한 정보를
신속하게 찾아드릴게요.
02-2025-2992
email
문의하기